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| 1 | Oral manifestation in inflammatory bowel disease:A review显示文摘Inflammatory bowel diseases(IBDs),including Crohn’s disease(CD)and ulcerative colitis,not only affect the intestinal tract but also have an extraintestinal involvement within the oral cavity.These oral manifestations may assist in the diagnosis and the monitoring of disease activity,whilst ignoring them may lead to an inaccurate diagnosis and useless and expensive workups.Indurated tag-like lesions,cobblestoning,and mucogingivitis are the most common specific oral findings encountered in CD cases.Aphthous stomatitis and pyostomatitis vegetans are among non-specific oral manifestations of IBD.In differential diagnosis,side effects of drugs,infections,nutritional deficiencies,and other inflammatory conditions should also be considered.Treatment usually involves managing the underlying intestinal disease.In severe cases with local symptoms,topical and/or systemic steroids and immunosuppressive drugs might be used. | Kamran B Lankarani Gholam Reza Sivandzadeh Shima Hassanpour | 2013 | World Journal of Gastroenterology2013，19，46： | 10 |
| 2 | A Vesicular Stomatitis Virus-Based Vaccine Carrying Zika Virus Capsid Protein Protects Mice from Viral Infection显示文摘Dear Editor,Zika virus (ZIKV) is a mosquito-borne virus that belongs to the Flavivirus family along with dengue virus (DENV),yellow fever virus, West Nile virus, and Japanese encephalitis virus (Ming et al. 2016). ZIKV is a singlestranded positive-sense RNA virus encoding three structural proteins, including nucleocapsid protein C, prM/M,envelope glycoprotein E, and seven non-structural proteins.Since 2015. | Xiaodan Shi Jingping Hu Jing Guo Chuanjian Wu Sidong Xiong Chunsheng Dong | 2019 | Virologica Sinica2019，34，1： | 2 |
| 3 | 小儿疱疹性口腔炎临床诊治疗效观察显示文摘小儿疱疹性口炎为单纯疱疹病毒Ⅰ型感染所致。金莲清热泡腾片具有清热解毒,利咽生津,加快口唇疱疹溃疡愈合。药物成分中“大青叶”具有清热解毒,凉血止血功效,治疗温病热盛烦渴,流行性感冒,肺炎喘嗽,丹毒,吐血,衄血,黄疸,喉痹,口疮,痈疽肿毒等。药物成分中“石膏”可解肌清热,除烦止渴,解毒,用于治疗热病壮热不退,口渴咽干,肺热喘急,胃火头痛,牙痛,热毒壅盛,发斑发疹,口舌生疮等。药物成分中“玄参”清热凉血,养阴生津,用于热毒炽盛的各种热证。诸药合用治疗疱疹性口腔炎疗程短、显效快,值得临床应用。 | 张蓓 柴昶虹 武海英 杨立春 牛庆丽 | 2014 | 医学美学美容(中旬刊)2014，23，1： | 2 |
| 4 | Radiation-induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation显示文摘Translational animal models for oral mucositis(OM)are necessary to simulate and assess the bioclinical effects and response in humans.These models should simulate high levels of radiation exposure that leads to oxidative stress and inflammatoryinitiated tissue changes.Hamster models have been extensively studied to observe pathological effects of radiation exposure and help in the development of effective treatments.To successfully evaluate the potential for treatment regimens with consistency and relevance,a radiation-induced OM hamster model was developed using a clinical linear accelerator utilized by cancer patients daily.The dose exposure to the isolated,everted cheek pouch of a hamster,as well as the progression of injury,proinflammatory marker,histological,and elasticity analyses of the buccal pouch were conducted to verify replicability and reproducibility of the injury model.The findings from this model demonstrated its ability to consistently induce injury and resolution over 28 days using an acute dose of 60 Gy.This model was developed to enhance clinical relevance when evaluating potential efficacious treatments and can now be utilized in efficacy studies to better evaluate developed therapeutics in a preclinical model that is easy to translate to clinical studies.. | Carolyn T.Jordan Emily M.Bradford Dennis C.Cheek Mahesh Kudrimoti Craig S.Miller Molly H.Smith J.Zach Hilt Thomas D.Dziubla | 2021 | Animal Models and Experimental Medicine2021，4，1： | 1 |
| 5 | Effect of lead on IL-8 production and cell proliferation in human oral keratinocytes显示文摘Objective:To investigate the effect of lead on the production of IL-8 and cell proliferation in normal human oral keratinocytes(NHKs).Methods:NHKs were prepared as outgrowths from normal human buccal mucosa.The cells were treated with three concentrations of lead glutamate(4.5×10-5M,4.5×10-6M and 4.5×10-7M).NHKs grown in glutamic acid were used as control.The amounts of IL-8 secreted in the culture supernatants were evaluated at 12 and 24 h using enzyme-linked immunospecific assay(ELISA).Cell proliferation was determined by the MTT colorimetric assay.Three cultures were used for each experiment,and three independent experiments were performed.Analysis of variance and Duncan’s multiple range tests were used for statistical analysis.Results:An elevation of IL-8 in culture supernatants of NHKs treated with lead at all concentrations at 12 and 24 h after exposure in a dose-dependent manner was revealed.A significant increase in cell numbers was observed only at 24 h exposed to 4.5×10- 5M lead glutamate.Conclusions:The capacity of NHKs,to secrete IL-8,enhanced by lead glutamate,is demonstrated here.Induction of cell proliferation is revealed only after exposure to high lead concentration.The elevation of secreted IL-8 is a probable initial sign for the acute inflammatory response and may be involved in the pathogenesis of lead stomatitis. | Thaweboon Srosiri Poomsawat Sopee Thaweboon Boonyanit | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 1 |
| 6 | Semireplication-competent vesicular stomatitis virus as a novel platform for oncolytic virotherapy显示文摘Among oncolytic viruses, the vesicular stomatitis virus(VSV) is especially potent and a highly promising agent for the treatment of cancer. But, even though effective against multiple tumor entities in preclinical animal models, replicationcompetent VSV exhibits inherent neurovirulence, which has so far hindered clinical development. To overcome this limitation,replication-defective VSV vectors for cancer gene therapy have been tested and proven to be safe. However, gene delivery was inefficient and only minor antitumor efficacy was observed. Here, we present semireplicationcompetent vector systems for VSV(sr VSV), composed of two trans-complementing, propagation-deficient VSV vectors. The de novo generated deletion mutants of the two VSV polymerase proteins P(phosphoprotein) and L(large catalytic subunit), VSVΔP and VSVΔL respectively, were used mutually or in combination with VSVΔG vectors. These sr VSV systems copropagated in vitro and in vivo without recombinatory reversion to replication-competent virus. The sr VSV systems were highly lytic for human glioblastoma cell lines,spheroids, and subcutaneous xenografts. Especially the combination of VSVΔG/VSVΔL vectors was as potent as wild-type VSV(VSV-WT) in vitro and induced long-term tumor regression in vivo without any associated adverse effects. In contrast, 90% of VSV-WT-treated animals succumbed to neurological disease shortly after tumor clearance. Most importantly, even when injected into the brain, VSVΔG/VSVΔL did not show any neurotoxicity. In conclusion, sr VSVis a promising platform for virotherapeutic approaches and also for VSV-based vector vaccines, combining improved safety with an increased coding capacity for therapeutic transgenes, potentially allowing for multipronged approaches. | Alexander Muik Catherine Dold Yvonne Gei Andreas Volk Marina Werbizki Ursula Dietrich Dorothee von Laer | 2015 | 世界最新医学信息文摘2015，15，5： | 0 |
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