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| 1 | A novel oncolytic virus engineered with PD-L1 scFv effectively inhibits tumor growth in a mouse model显示文摘The adoptive transfer of engineered chimeric antigen receptor(CAR)T cells has yielded impressive clinical results for targeting hematological cancers.1 However,the advancement of CAR T-cell therapy in solid tumors remains limited,due to the scarcity of tumor antigens that are deemed safe for targeting.Moreover,the requirement of patient-specific autologous T cells for the current standard treatment has also hampered its application.Oncolytic virus(OV)therapy has been classified as another form of novel immunotherapy. | Chuanjian Wu Manman Wu Minglong Liang Sidong Xiong Chunsheng Dong | 2019 | Cellular & Molecular Immunology2019，16，9： | 3 |
| 2 | A Vesicular Stomatitis Virus-Based Vaccine Carrying Zika Virus Capsid Protein Protects Mice from Viral Infection显示文摘Dear Editor,Zika virus (ZIKV) is a mosquito-borne virus that belongs to the Flavivirus family along with dengue virus (DENV),yellow fever virus, West Nile virus, and Japanese encephalitis virus (Ming et al. 2016). ZIKV is a singlestranded positive-sense RNA virus encoding three structural proteins, including nucleocapsid protein C, prM/M,envelope glycoprotein E, and seven non-structural proteins.Since 2015. | Xiaodan Shi Jingping Hu Jing Guo Chuanjian Wu Sidong Xiong Chunsheng Dong | 2019 | Virologica Sinica2019，34，1： | 2 |
| 3 | The Influence of Human Heterogeneity to Information Spreading显示文摘 | Zhu Zhiqiang Liu ChuanJian Wu Jianliang | 2014 | Journal of Statistical Physics2014，154，6： | 1 |
| 4 | A single dose of recombinant VSV-RABVG vaccine provides full protection against RABV challenge显示文摘Dear Editor,Rabies virus(RABV)is an enveloped,non-segmented,and singlestranded RNA virus that belongs to the genus Lyssavirus within the Rhabdoviridae family(Douglas et al.,2013).RABV causes rabies,and although vaccines are available,rabies continues to be a global public health concern causing more than 60,000 human deaths each year(WHO,2013).There is a high prevalence especially in developing countries in Asia and Africa(Hampson et al.,2015;Singh et al.,2017). | Minglong Liang Zongmei Wang Chuanjian Wu Sidong Xiong Ling Zhao Chunsheng Dong | 2022 | Virologica Sinica2022，37，3： | 0 |
| 5 | Design and Implementation of Spatial Data Watermarking Service System显示文摘Nowadays, more and more digitalized spatial data are sold and transmitted on the Internet. Thus, there arises an important issue about copyright protection of the digital data. To solve this problem, this paper has designed and implemented a spatial data watermarking service (SDWS) system which can provide a secure framework for data transaction and transfer via the Internet and protect the rights of both copyright owners and consumers at the same time. | WU Baiyan WANG Wei PENG Zhiyong DU Daosheng WANG Chuanjian | 2010 | Geo-Spatial Information Science2010，13，1： | 0 |
| 6 | Antibiotic-induced gut bacteria depletion has no effect on HBV replication in HBV immune tolerance mouse model显示文摘Commensal microbiota is closely related to Hepatitis B virus(HBV)infection.Gut bacteria maturation accelerates HBV immune clearance in hydrodynamic injection(HDI)HBV mouse model.However,the effect of gut bacteria on HBV replication in recombinant adeno-associated virus(AAV)-HBV mouse model with immune tolerance remains obscure.We aim to investigate its role on HBV replication in AAV-HBV mouse model.C57BL/6 mice were administrated with broad-spectrum antibiotic mixtures(ABX)to deplete gut bacteria and intravenously injected with AAV-HBV to establish persistent HBV replication.Gut microbiota community was analyzed by fecal qPCR assay and 16S ribosomal RNA(rRNA)gene sequencing.HBV replication markers in blood and liver were determined by ELISA,qPCR assay and Western blot at indicated time points.Immune response in AAV-HBV mouse model was activated through HDI of HBV plasmid or poly(I:C)and then detected by quantifying the percentage of IFN-γ^(+)/CD8^(+)T cells in the spleen via flow cytometry as well as the splenic IFN-γmRNA level via qPCR assay.We found that antibiotic exposure remarkably decreased gut bacteria abundance and diversity.Antibiotic treatment failed to alter the levels of serological HBV antigens,intrahepatic HBV RNA transcripts and HBc protein in AAV-HBV mouse model,but contributed to HBsAg increase after breaking of immune tolerance.Overall,our data uncovered that antibiotic-induced gut bacteria depletion has no effect on HBV replication in immune tolerant AAV-HBV mouse model,providing new thoughts for elucidating the correlation between gut bacteria dysbiosis by antibiotic abuse and clinical chronic HBV infection. | Yanan Bu Kaitao Zhao Zaichao Xu Yingcheng Zheng Rong Hua Chuanjian Wu Chengliang Zhu Yuchen Xia Xiaoming Cheng | 2023 | Virologica Sinica2023，38，3： | 0 |
| 7 | A Single-Ended Protection Principle for LCC-VSC-MTDC System with High Resistance Fault Tolerance显示文摘Line-commutated converter-voltage source converter(LCC-VSC)power transmission technology does not have the problem of communication failure very usually.It therefore can support the long-distance,long-capacity transmission of electric energy.However,factors such as topology,control strategy,and short-circuit capacities make the traditional protection principles not fully applicable to LCC-VSC hybrid transmission systems.To enhance the reliability of hybrid DC systems,a single-ended principle based on transmission coefficients is proposed and produced.First,the equivalent circuit of the LCC-VSC hybrid DC system is analyzed and the expression of the first traveling wave is deduced accordingly.Then,the concept of multi-frequency transmission coefficients is proposed by analyzing the amplitude-frequency,and the characteristics of each element.Finally,the LCC-VSCDC system model is built to verify the reliability and superiority of the principle itself.Theoretical analysis and experimental verification show that the principle has strong interference resistance. | Dahai Zhang Chuanjian Wu Jinghan He | 2023 | Energy Engineering2023，120，1： | 0 |
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