|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | China Stroke Statistics 2019:A Report From the National Center for Healthcare Quality Management in Neurological Diseases,China National Clinical Research Center for Neurological Diseases,the Chinese Stroke Association,National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations显示文摘China faces the greatest challenge from stroke in the world.The death rate for cerebrovascular diseases in China was 149.49 per 100000,accounting for 1.57 million deaths in 2018.It ranked third among the leading causes of death behind malignant tumours and heart disease.The age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100000 population and 246.8 per 100000 person-years,respectively.According to the Global Burden of Disease Study 2017,the years of life lost(YLLs)per 100000 population for stroke increased by 14.6%;YLLs due to stroke rose from third highest among all causes in 1990 to the highest in 2017.The absolute numbers and rates per 100000 population for all-age disability-adjusted life years(DALYs)for stroke increased substantially between 1990 and 2017,and stroke was the leading cause of all-age DALYs in 2017.The main contributors to cerebrovascular diseases include behavioural risk factors(smoking and alcohol use)and pre-existing conditions(hypertension,diabetes mellitus,dyslipidaemia and atrial fibrillation(AF)).The most prevalent risk factors among stroke survivors were hypertension(63.0%-84.2%)and smoking(31.7%-47.6%).The least prevalent was AF(2.7%-7.4%).The prevalences for major risk factors for stroke are high and most have increased over time.Based on the latest national epidemiological data,26.6%of adults aged≥15 years(307.6 million adults)smoked tobacco products.For those aged≥18 years,age-adjusted prevalence of hypertension was 25.2%;adjusted prevalence of hypercholesterolaemia was 5.8%;and the standardised prevalence of diabetes was 10.9%.For those aged≥40 years,the standardised prevalence of AF was 2.31%.Data from the Hospital Quality Monitoring System showed that 3010204 inpatients with stroke were admitted to 1853 tertiary care hospitals during 2018.Of those,2466785(81.9%)were ischaemic strokes(ISs);447609(14.9%)were intracerebral haemorrhages(ICHs);and 95810(3.2%)were subarachnoid haemorrhages(SAHs).The average age of patients admitted was 66 years old,and nearly 60%were male.A total of 1555(0.1%),2774(0.6%)and 1347(1.4%)paediatric strokes(age<18 years)were identified among IS,ICH and SAH,respectively.Over one-third(1063892(35.3%))of the patients were covered by urban resident basic medical insurance,followed by urban employee basic medical insurance(699513(23.2%))and new rural cooperative medical schema(489361(16.3%)).The leading risk factor was hypertension(67.4%for IS,77.2%for ICH and 49.1%for SAH),and the leading comorbidity was pneumonia or pulmonary infection(10.1%for IS,31.4%for ICH and 25.2%for SAH).In-hospital death/discharge against medical advice rate was 8.3%for stroke inpatients,ranging from 5.8%for IS to 19.5%for ICH.The median and IQR of length of stay was 10.0(7.0-14.0)days,ranging from 10.0(7.0-13.0)in IS to 14.0(8.0-22.0)in SAH.Data from the Chinese Stroke Center Alliance demonstrated that the composite scores of guideline-recommended key performance indicators for patients with IS,ICH and SAH were 0.77±0.21,0.72±0.28 and 0.59±0.32,respectively. | Yong-Jun Wang Zi-Xiao Li Hong-Qiu Gu Yi Zhai Yong Jiang Xing-Quan Zhao Yi-Long Wang Xin Yang Chun-Juan Wang Xia Meng Hao Li Li-Ping Liu Jing Jing Jing Wu An-Ding Xu Qiang Dong David Wang Ji-Zong Zhao On behalf of China Stroke Statistics 2019 Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 181 |
| 2 | Interpretation of Annual Report on Cardiovascular Health and Diseases in China 2019显示文摘The Chinese edition of Annual Report on Cardiovascular Health and Diseases in China 2019 have been published[1],and we present herein an interpretation of the report.Influencing factors on cardiovascular health Tobacco use The smoking prevalence among Chinese residents has shown a downward trend.According to the Chinese Adult Tobacco Survey in 2018,the current smoking prevalence among Chinese residents≥15years of age was 26.6%,which was higher in rural areas(28.9%)than in urban areas(25.1%),and the daily consumption by each smoker was 16.0 cigarettes on average. | The Writing Committee of the Annual Report on Cardiovascular Health and Diseases in China Zengwu Wang Shengshou Hu | 2021 | Cardiology Discovery2021，1，4： | 7 |
| 3 | 一种测量薄膜磁性的表面磁光克尔效应装置显示文摘介绍表面磁光克尔效应谱(SMOKE)的一种新方案。通过适当分光并测量信号束和参考束的光强比,可以明显改善由于激光的光强不稳造成的误差,还使得随机偏振激光器也能用于SMOKE装置。同时该方案中没有采用信号调制,因此对探测器等硬件要求很低。实验结果表明,采用光强稳定度为5%的普通国产He-Ne随机偏振激光器,其测量灵敏度能够达到目前国际上通常用于超薄膜磁性测量的SMOKE的同类水平。 | 朱伟荣 董国胜 陈艳 金晓峰 钱世雄 陈良尧 | 1997 | 真空科学与技术1997，17，4： | 6 |
| 4 | Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice:Involvement of TGF-β1/Smads Signaling Pathway显示文摘Although several studies confirmed that berberine may attenuate airway inflammation in mice with chronic obstructive pulmonary disease(COPD),its underlying mechanisms were not clear until now.We aimed to establish an experiment mouse model for COPD and to investigate the effects of berberine on airway inflammation and its possible mechanism in COPD model mice induced by cigarette smoke extract(CSE).Twenty SPF C57BL/6 mice were randomly divided into PBS control group,COPD model group,low-dose berberine group and high-dose berberine group,5 mice in each group.The neutrophils and macrophages were examined by Wright's staining.The levels of inflammatory cytokines TNF-α and IL-6 in bronchoalveolar lavage fluid(BALF)were detennined by enzyme-linked immunosorbent assay.The expression levels of TGF-β1,Smad2 and Smad3 mRNA and proteins in lung tissues were respectively detected by quantitative real-time polymerase chain reaction and Western blotting.It was found that CSE increased the number of inflammation cells in BALF,elevated lung inflammation scores,and enhanced the TGF-β1/Smads signaling activity in mice.High-dose berberine restrained the alterations in the COPD mice induced by CSE.It was concluded that high-dose berberine ameliorated CSE-induced airway inflammation in COPD mice.TGF-β1/Smads signaling pathway might be involved in the mechanism.These findings suggested a therapeutic potential of high-dose berberine on the CSE-induced airway inflammation. | Wen WANG Gan ZHA Jin-jing ZOU Xun WANG Chun-nian LI Xiao-jun WU | 2019 | Current Medical Science2019，39，5： | 6 |
| 5 | An Overview of the Flame Retardants for Poly(vinyl chloride):Recent States and Perspective显示文摘As a versatile star product,poly(viny chloride)(PVC)has kept active in our dily lif all through since it was invented.However,the severe fire hazard andheavy smoke produced during combustion,particularly the extensively used flexible PC product,have been putzig manufacturers and researchers forages.Over the last decade,multifarious ftame retardants and smoke suppressants were developed for PVC materias.n this review combined literaturewith the results based on the research from our group,recent emerged fame retardants and smoke suppressants for PVC are introduced.Meanwhile,theflame retardant mechanisms and experimental analysis resuts are described to understand the relationship between characters of fame retardants (in-cluding chemical compositions,structures or morphologies)and fire performance of the composites.The potential substitutes for traditional harmfulflame retardant antimony trioxide are discussed aiming to the emphasis on increasing prominent environmental concerns.ln partcular,one section isdedicated to new approaches for the preparation of novel environmentally friendly and high-effciency fame retardants.is hoped that ths review wilnot only summarine the new emerged fame retardants and smoke suppressants for PVC,but also provide the new trend to prompt sequent explorationin both academic research and industrial application. | Ye-Tang Pan Yongshuai Yuan De-Yi Wang Rongjie Yang | 2020 | Chinese Journal of Chemistry2020，38，12： | 5 |
| 6 | Smoking Behavior Among Secondary School Students--China, 2021显示文摘Summary What is already known about this topic?In 2019,China CDC conducted the National Youth Tobacco Survey among secondary school students,and the prevalence rates of ever,current,and frequent smoking were 17.9%,5.9%,and 1.8%,respectively.What is added by this report?The prevalence rate of cigarette use in males decreased largely from 2019 to 2021 in China,while it increased in 18 provincial-level administrative divisions(PLADs)for females.The tobacco control situation remains challenging among vocational senior high school(VSHS)students.Significant geographical disparities existed in cigarette use.What are the implications for public health practice?Targeted tobacco control policies aimed at VSHS students are needed,specifically those PLADs with higher smoking rates.Additionally,close attention should be paid to female smokers. | Xinying Zeng Xinbo Di Shiwei Liu Huiyu Xie Zida Meng Lin Xiao | 2022 | China CDC weekly2022，4，21： | 5 |
| 7 | LC-MS/MS法对卷烟主流烟气中8种羰基化合物的测定显示文摘A liquid chromatography-tandem mass spectroscopy(LC-MS/MS)method was developed for analysis of carbonyl compounds in cigarette mainstream smoke.The cigarette smoke was collected using a Cambridge filter treated with acidic solution of 2,4-dinitrophenylhydrazine,then extracted with acetonitrile.The extract was diluted with acetonitrile-water and analyzed by LC-MS/MS in negative electro-spray ionization mode.Formaldehyde,acetaldehyde,acetone,acrolein,propionaldehyde,methyl ethyl ketone,butyraldehyde and crotonaldehyde in mainstream cigarette smoke were analyzed with the recovery at the range of 83% to 103%.The minimum detectable quantity for the carbonyls ranged from 0.08 to 0.28 μg/L,and relative standard deviations were below 6%.This new method had higher selectivity and sensitivity compared to conventional methods.5 kinds of foreign and domestic cigarette were analyzed. | 郭磊 索卫国 田耀伟 廖堃 | 2008 | 分析测试学报2008，27，S1： | 5 |
| 8 | Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018显示文摘Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging populations.The prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by far.What is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was collected.The overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in females.What are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control. | Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang | 2022 | China CDC weekly2022，4，29： | 4 |
| 9 | The role of antioxidants and pro-oxidants in colon cancer显示文摘This review focuses on the roles antioxidants and prooxidants in colorectal cancer(CRC).Considerable evidence suggests that environmental factors play key roles in the incidence of sporadic CRC.If pro-oxidant factors play an etiological role in CRC it is reasonable to expect causal interconnections between the wellcharacterized risk factors for CRC,oxidative stress and genotoxicity.Cigarette smoking,a high dietary consumption of n-6 polyunsaturated fatty acids and alcohol intake are all associated with increased CRC risk.These risk factors are all pro-oxidant stressors and their connections to oxidative stress,the intestinal microbiome,intestinal microfold cells,cyclooxygenase-2 and CRCare detailed in this review.While a strong case can be made for pro-oxidant stressors in causing CRC,the role of food antioxidants in preventing CRC is less certain.It is clear that not every micronutrient with antioxidant activity can prevent CRC.It is plausible,however,that the optimal food antioxidants for preventing CRC have not yet been critically evaluated.Increasing evidence suggests that RRR-gamma-tocopherol(the primary dietary form of vitamin E)or other'non-alpha-tocopherol'forms of vitamin E(e.g.,tocotrienols)might be effective.Aspirin is an antioxidant and its consumption is linked to a decreased risk of CRC. | William L Stone Koyamangalath Krishnan Sharon E Campbell Victoria E Palau | 2014 | World Journal of Gastrointestinal Oncology2014，6，3： | 4 |
| 10 | Interpretation of the Annual Report on Cardiovascular Health and Diseases in China 2020显示文摘The Chinese edition of the Annual Report on Cardiovascular Health and Diseases in China 2020 has been published.[1]We present herein an interpretation of this report.Factors influencing cardiovascular health Tobacco use About 1.9 million avoidable deaths from coronary heart disease(CHD)per year(approximately one-fifth of all CHD deaths globally)are attributable to tobacco use and exposure to secondhand smoke(SHS).An estimated 382,000 people died of CHD attributable to SHS exposure,representing 4.3%of all deaths from CHD. | Zengwu Wang Shengshou Hu | 2022 | Cardiology Discovery2022，2，4： | 4 |
| 11 | Tobacco Use and Exposure Among Secondary School Students — China, 2019显示文摘Summary What is already known about this topic?Using the framework of the global youth tobacco survey(GYTS),China CDC conducted the first round of a national tobacco survey among junior high school(JHS)students in 2014,indicating that 17.9%and 5.9%of respondents were experimental and current cigarette smokers,respectively. | Shiwei Liu Lin Xiao Xinying Zeng Xinbo Di Xinhua Li | 2020 | China CDC weekly2020，2，22： | 4 |
| 12 | Asymmetric flow effect in a horizontal natural ventilated tunnel with different aspect ratios under the influence of longitudinal fire locations显示文摘This paper has analyzed the asymmetric flow effect of fire-induced thermal flow in a horizontal tunnel under the natural ventilation condition by conducting large eddy simulations (LES). The key objective is to reveal and to have a better understanding of the asymmetric flow effect caused by the upstream and downstream tunnel length difference. The mechanism behind it can be explained based on the conservation of mass and dynamic force analysis on the smoke and fresh air. The strength of the asymmetric flow effect is characterized by the mass flow rate of the induced longitudinal flow (net mass flow rate of a cross-section). An empirical correlation to predict the induced longitudinal mass flow rate is proposed. Furthermore, the law of smoke and air flow distribution within a horizontal tunnel is established. The proportion of smoke (or air) flowing out (or coming in) through the opening increase (or decrease) linearly with the increasing distance between that opening to the fire location. The variation of the air flow with the longitudinal fire location in a tunnel is more sensitive than the smoke flow. Results have shown that as the fire approaches the tunnel exit from the middle of the tunnel, the smoke spilling out through this opening is reduced from 50% to 40%, while the fresh air incoming from this opening is increased from 50% to 100% and vice versa. | Longxing Yu Huaxian Wan Jie Ji | 2021 | Building Simulation2021，14，4： | 3 |
| 13 | Comparative study of the effect of Cu_2O and MoO_3 on flame retardance and smoke emission of PVC by Cone and TGA显示文摘Cuprous and molybdic oxides exhibit extremely effectiveness in smoke suppression for PVC. However, few are the data reported concerning flame retardance and smoke emission of PVC taken from Cone calorimetry relative to the conventional thermal analysis technique. Abundant data from Cone calorimetry have been acquired. Data analysis was achieved through the study of MLR, HRR, SEA tested at irradiance of 25 kWm -2 . The understandable flame retardance of PVC/Cu\-2O and PVC/MoO\-3 relative to pure PVC has been rationalized by their lowered heat release rates and enhanced char residues. The difference in smoke reduction between these two oxides consists in the time scale. As clearly seen under air atmosphere both oxides exert themselves to the afterglow which has been recognized as a dangerous source, in particular in the full_scale fire situation. | LI Bin\+1 and WANG Jianqi\+2 1. Department of Chemistry, Northeast Forestry University, Harbin 150040, China 2. National Laboratory of Flame Retardant Materials, Beijing Institute of Technology, Beijing, 100081, China | 1998 | Chinese Science Bulletin1998，43，13： | 3 |
| 14 | Smoking under hypoxic conditions: a potent environmental risk factor for inflammatory and autoimmune diseases显示文摘Autoimmune disease management presents a significant challenge to medical science. Environmental factors potentially increase the risk of developing inflammatory and autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. Among various environmental stresses, cigarette smoke and hypoxia have both been reported to lead to an enhanced risk of inflammatory and autoimmune diseases. In this review, we shed light on all reported mechanisms whereby cigarette smoke and a hypoxic environment can induce inflammatory and autoimmune diseases and discuss how hypoxic conditions influence the cigarette smoke-induced threat of inflammatory and autoimmune disease development. Cigarette smoke and hypoxia both lead to increased oxidative stress and production of reactive oxygen species and other free radicals, which have various effects including the generation of autoreactive pro-inflammatory T cells and autoantibodies, reductions in T regulatory(Treg) cell activity, and enhanced expression of pro-inflammatory mediators [e.g., interleukin-6(IL-6), interleukin-4(IL-4) and interleukin-8(IL-8)]. Accordingly, smoking and hypoxic environments may synergistically act as potent environmental risk factors for inflammatory and autoimmune diseases. To our knowledge, no studies have reported the direct association of cigarette smoke and hypoxic environments with the risk of developing inflammatory and autoimmune diseases. Future studies exploring the risk of autoimmune disease development in smokers at high altitudes, particularly military personnel and mountaineers who are not acclimatized to high-altitude regions, are required to obtain a better understanding of disease risk as well as its management. | Md.Saddam Hussain Vishwas Tripathi | 2018 | Military Medical Research2018，5，3： | 3 |
| 15 | Modifying NaY Zeolite with Metal Oxide by Microwave Irradiation:Influence on the Adsorption and Decomposition of N-nitrosamines显示文摘Coating MgO or ZrO2 on zeolite NaY accelerated decomposition of N-nitrosodimethylamine and N-nitrosopyrrolidine, resulting from variation of the surface state such as generation of basic sites. | Li Li MA Bin SHEN Jian Hua ZHU Jia Rong XIA Qin Hua XU(Chemistry Department, Nanjing University, Nanjing 210093) | 2000 | Chinese Chemical Letters2000，11，7： | 3 |
| 16 | Long-term Trends and Predictors of Smoking Behaviors among Men Following First-ever Ischemic Stroke显示文摘Continued smoking following stroke is associated with adverse outcomes including increased risk of mortality and secondary stroke. The aim of this study was to examine the long-term trends in smoking behaviors and factors associated with smoking relapse among men who survived their first-ever stroke. Data collection for this longitudinal study was conducted at baseline through face-toface interviews and follow-up was completed every 3 months via telephone, beginning in 2010 and continuing through 2014. Cox proportional hazard regression models were used to identify predictors of smoking relapse behavior. At baseline, 372 male patients were recruited into the study. Totally, 155(41.7%) of these patients stopped smoking for stroke, and 61(39.3%) began smoking again within 57 months after discharge with an increasing trend in the number of cigarettes smoked per day. Exposure to environmental tobacco smoke at places outside of home and work(such as bars, restaurants)(HR, 2.34; 95% CI, 1.04–5.29, P=0.04), not having a spouse(HR, 0.12; 95% CI, 0.04–0.36; P=0.0002) and smoking at least 20 cigarettes per day before stroke(HR, 2.42; 95% CI, 1.14–5.14, P=0.02) were predictors of smoking relapse. It was concluded that environmental tobacco smoke is an important determinant of smoking relapse among men who survive their first stroke. Environmental tobacco smoke should be addressed by smoke-free policies in public places. | 侯利莎 杜旭东 李吉杰 朱萍 闫沛静 詹凤羽 周沐科 朱彩蓉 | 2017 | Journal of Huazhong University of Science and Technology(Medical Sciences)2017，37，3： | 3 |
| 17 | 深圳市环境空气质量数值预报系统介绍显示文摘介绍了深圳市环境空气质量数值预报系统的功能模块构成、内部所采用的数值模式及输入资料、系统的预报范围及空间分辨率和预报时限等情况。本系统的核心模块包括气象场预报模块、源排放估算和处理模块和区域空气质量预报模块,气象场预报采用目前国际上最先进的中尺度气象模式WRF,系统采用自主开发的源排放处理软件并充分利用源排放模式SMOKE的相应模块处理源清单并准备空气质量模式所需源排放场,空气质量场使用目前国际上最为先进的区域尺度的化学传输模式进行预报。 | 梁永贤 廖汝娥 | 2015 | 广州化工2015，43，24： | 2 |
| 18 | Current and Passive Smokers Have Poorer Quantity and Quality of Diet in Shanghai, China: A Crosssectional Survey显示文摘Smoking is a major risk factor for chronic diseases,it has been estimated that 300 million adults currently smoke in China,and the smoking prevalence in males is as high as 52.9%,with 1million smoking-related deaths yearly.Therefore,smoking is also a huge health burden in China[1].Researchers have suggested an association between diet and smoking status with respect to both food and nutrient intakes.According to such studies,smokers tended to have a poor diet. | WANG Zheng Yuan LI Li ZANG Jia Jie SHI Ze Huan JIN Wei QI De Yun TANG Chuan Xi GAO Hong Mei WANG Jin Xiang ZHU Zhen Ni JIA Xiao Dong GUO Chang Yi | 2019 | Biomedical and Environmental Sciences2019，32，10： | 2 |
| 19 | Syndecan 4-c-ros oncogene 1 fusion as a mechanism of acquired resistance in epidermal growth factor receptor mutant lung adenocarcinoma显示文摘To the Editor:A 37-year-old Chinese woman,a nonsmoker,presented with adenocarcinoma of the left lung(stage IV)[Figure 1A],malignant pleural effusion,and multiple bone metastases in December 2014.Deoxyribonucleic acid sequencing of the tumor biopsy revealed an epidermal growth factor receptor(EGFR)exon 19 deletion,and treatment with gefitinib was consequently initiated in December 2014.There were no treatmentrelated side effects except for a grade 1 rash,and stable disease was achieved.Unfortunately,the patient did not experience long-term benefits and developed disease progression after only two months.A follow-up examination showed that extracranial disease and a small intracranial lesion had developed gradually.The patient then received whole-brain radiotherapy(30 Gy in ten fractions)and four cycles of single-agent pemetrexed in April 2015.Stable disease was achieved,which coincided with an improvement in the patient’s cough,shortness of breath,and general condition.The chemotherapy course was changed to two cycles of pemetrexed combined with cisplatin.A partial response(PR)was achieved,and the patient was treated with 14 cycles of pemetrexed alone as maintenance chemotherapy.The follow-up evaluations showed the patient’s condition to be stable;however,the patient’s disease progressed after 23 months.A computed tomography(CT)scan in March 2017 revealed that both the lung lesion and the malignant pleural effusion had increased in size[Figure 1B].The subsequent biopsy specimen was subjected to next-generation sequencing(NGS)and a Syndecan 4-c-ros oncogene 1(SDC4-ROS1)rearrangement was detected[Figure 1C].The patient then received crizotinib in April 2017,and a PR was achieved[Figure 1D].A CT scan done in August 2018 indicated the progression of the primary lesion in the left lung and malignant pleural effusion.However,the growth of the remaining lesions remained stable. | You-Cai Zhu Chun-Wei Xu Qu-Xia Zhang Wen-Xian Wang Lei Lei Wu Zhuang | 2019 | Chinese Medical Journal2019，，24： | 1 |
| 20 | Smoking influences outcome in patients who had thrombolysed ischaemic stroke:the ENCHANTED study显示文摘Background and purpose As studies vary in defining the prognostic significance of smoking in acute ischaemic stroke(AIS),we aimed to determine the relation of smoking and key outcomes in patient participants who had thrombolysed AIS of the international quasi-factorial randomised Enhanced Control of Hypertension and Thrombolysis Stroke Study(ENCHANTED).Methods Post-hoc analyses of ENCHANTED,an international quasi-factorial randomised evaluation of intravenous alteplase-dose comparison and levels of blood pressure control in patients who had thrombolysed AIS.Multivariable logistic regression models with inverse probability of treatment weighting(IPTW)propensity scores were used to determine associations of self-reported smoking status and clinical outcomes,according to 90-day modified Rankin Scale(mRS)scores and symptomatic intracerebral haemorrhage(sICH).Results Of 4540 patients who had an AIS,there were 1008(22.2%)current smokers who were younger and predominantly male,with more comorbidities of hypertension,coronary artery disease,atrial fibrillation and diabetes mellitus,and greater baseline neurological impairment,compared with non-smokers.In univariate analysis,current smokers had a higher likelihood of a favourable shift in mRS scores(OR 0.88,95%CI 0.77 to 0.99;p=0.038)but this association reversed in a fully adjusted model with IPTW(adjusted OR 1.15,95%CI 1.04 to 1.28;p=0.009).A similar trend was also apparent for dichotomised poor outcome(mRS scores 2–6:OR 1.18,95%CI 1.05 to 1.33;p=0.007),but not with the risk of sICH across standard criteria.Conclusion Smoking predicts poor functional recovery in patients who had thrombolysed AIS.Trial registration number NCT01422616. | Lingli Sun Lili Song Jie Yang Richard I Lindley Thompson Robinson Pablo M Lavados Candice Delcourt Hisatomi Arima Bruce Ovbiagele John Chalmers Craig S Anderson Xia Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员