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Dihydroartemisinin regulates the immune system by promotion of CD8^+T lymphocytes and suppression of B cell responses

查看全文 作　　者：Ting [1]Zhang;Yiwei [1]Zhang;Ning [1]Jiang;Xu [1]Zhao;Xiaoyu [1]Sang;Na [1]Yang;Ying [1]Feng;Ran [1]Chen;Qijun [1]Chen 高影响力作者 机构地区：[1]Key Laboratory of Livestock Infectious Diseases in Northeast China,Ministry of Education,Key Laboratory of Zoonosis,Shenyang Agricultural University,Shenyang 110866,China高影响力机构 出　　处：《Science China(Life Sciences)》索引2020年第63卷第5期,共13页高影响力期刊 基　　金：supported by the National Key Research and Development Program of China(2017YFD0500400);the National Natural Science Foundation of China(81420108023,81772219);distinguished scientist grant from Shenyang Agricultural University。 摘　　要：Artemisia annua is an anti-fever herbal medicine first described in traditional Chinese medicine 1,000 years ago.Artemisinin,the extract of A.annua,and its derivatives(dihydroartemisinin(DHA),artemether,and artesunate)have been used for the treatment of malaria with substantial efficacy.Recently,DHA has also been tested for the treatment of lupus erythematosus,indicating that it may function to balance the immune response in immunocompromised individuals.In the present study,the regulatory effect of artemisinin on the murine immune system was systematically investigated in mice infected with two different protozoan parasites(Toxoplasma gondii and Plasmodium berghei).Our results revealed that the mouse spleen index significantly increased(spleen enlargement)in the healthy mice after DHA administration primarily due to the generation of an extra number of lymphocytes and CD8^+T lymphocytes in both the spleen and circulation.DHA could increase the proportion of T helper cells and CD8^+T cells,as well as decrease the number of splenic and circulatory B cells.Further,DHA could reduce the production of proinflammatory cytokines.Our study revealed that apart from their anti-parasitic activity,artemisinin and its derivatives can also actively modulate the immune system to directly benefit the host. 关 键 词：ARTEMISININ immune cells CYTOKINE IMMUNOMODULATION Toxoplasma gondii Plasmodium berghei
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