Research progress of in-situ gelling ophthalmic drug delivery system

查看全文 作　　者：Yumei [1,2]Wu;Yuanyuan [1,2]Liu;Xinyue [1,2]Li;Dereje [1,2,5]Kebebe;Bing [1,2]Zhang;Jing [1,2]Ren;Jun [6]Lu;Jiawei [1,2,3]Li;Shouying [4]Du;Zhidong [1,2]Liu

机构地区：[1]Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique,Ministry of Education,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;[2]Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;[3]Department of Experimental Department,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;[4]School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China;[5]School of Pharmacy,Institute of Health Sciences,Jimma University,Jimma,Ethiopia;[6]School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300193,China

出　　处：《Asian Journal of Pharmaceutical Sciences》索引2019年第14卷第1期,共16页

摘　　要：Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden.Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system.Drug administration to the eye by conventional delivery systems results in poor ocular bioavailability(<5%).The designing of a novel approach for a safe,simple,and effective ocular drug delivery is a major concern and requires innovative strategies to combat the problem.Over the past decades,several novel approaches involving different strategies have been developed to improve the ocular delivery system.Among these,the ophthalmic in-situ gel has attained a great attention over the past few years.This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system. 关键词：IN-SITU gel OCULAR Drug delivery BIOAVAILABILITY Polymer CORNEAL RETENTION

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Research progress of in-situ gelling ophthalmic drug delivery system

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