CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration

查看全文 作　　者：Changyang [1,2]Zhou;Xinde [1,2]Hu;Cheng [1,2]Tang;Wenjia [3]Liu;Shaoran [1,4]Wang;Yingsi [1]Zhou;Qimeng [1]Zhao;Qiyu [3]Bo;Linyu [1,4]Shi;Xiaodong [3]Sun;Haibo [1]Zhou;Hui [1]Yang

机构地区：[1]Institute of Neuroscience,State Key Laboratory of Neuroscience,Key Laboratory of Primate Neurobiology,CAS Center for Excellence in Brain Science and Intelligence Technology,Shanghai Research Center for Brain Science and Brain-Inspired Intelligence,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,China;[2]College of Life Sciences,University of Chinese Academy of Sciences,China;[3]Department of Ophthalmology,Shanghai General Hospital(Shanghai First People’s Hospital),Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Fundus Diseases,China;[4]Hui-Gene Therapeutics Co.,Ltd.China

出　　处：《National Science Review》索引2020年第7卷第5期,共3页

基　　金：This work was supported by the R&D Program of China(2018YFC2000100 and 2017YFC1001302);CAS Strategic Priority Research Program(XDB32060000);National Natural Science Foundation of China(31871502,31522037);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);Shanghai City Committee of science and technology project(18411953700,18JC1410100). 摘　　要：RNA-targeting CRISPR system Cas13 offers an efficient approach for manipulating RNA transcripts in vitro.In this perspective,we provide a proof-of-concept demonstration that Cas13-mediated Vegfa knockdown in vivo could prevent the development of laser-induced CNV in mouse model of Age-related macular degeneration. 关键词：DEGENERATION PROOF MEDIATED

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CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration

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