Cell totipotency:molecular features,induction,and maintenance

查看全文 作　　者：Falong [1,2,3]Lu;Yi [1,2,3,4]Zhang

机构地区：[1]Howard Hughes Medical Institute,Harvard Medical School;[2]Program in Cellular and Molecular Medicine,Boston Children's Hospital,Harvard Medical School;[3]Department of Genetics,Harvard Medical School;[4]Harvard Stem Cell Institute,Harvard Medical School

出　　处：《National Science Review》索引2015年第2卷第2期,共9页

基　　金：supported by National Institutes of Health and Howard Hughes Medical Institute.YZ is an Investigator of the Howard Hughes Medical Institute 摘　　要：In mammals, pluripotent stem cells can give rise to every cell type of embryonic lineage, and hold great potential in regenerative medicine and disease modeling. Guided by the mechanism underlying pluripotency, pluripotent stem cells have been successfully induced through manipulating the transcriptional and epigenetic networks of various diferentiated cell types. However, the factors that confer totipotency, the ability to give rise to cells in both embryonic and extra-embryonic lineages still remain poorly understood. It is currently unknown whether totipotency can be induced and maintained in vitro. In this review, we summarize the current progress in the ield, with the aim of providing a foundation for understanding the mechanisms that regulate totipotency. 关键词：TOTIPOTENCY PLURIPOTENCY EPIGENETICS embryonic stem cell REPROGRAMMING somatic cell nuclear transfer(SCNT)

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Cell totipotency:molecular features,induction,and maintenance

参考文献(93)

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耦合文献(11)

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