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| 1 | Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways显示文摘Inflammatory bowel disease(IBD)refers to a group of disorders characterized by chronic inflammation of the gastrointestinal(GI)tract.The elevated levels of nitric oxide(NO)in serum and affected tissues;mainly synthesized by the inducible nitric oxide synthase(iNOS)enzyme;can exacerbate GI inflammation and is one of the major biomarkers of GI inflammation.Various natural and synthetic agents are able to ameliorate GI inflammation and decrease iNOS expression to the extent comparable with some IBD drugs.Thereby,the purpose of this study was to gather a list of natural or synthetic mediators capable of modulating IBD through the NO pathway.Electronic databases including Google Scholar and PubMed were searched from 1980 to May 2018.We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factorκB(NF-κB)and JAK/STAT signaling pathways.Prebiotics and probiotics can also alter the GI microbiota and reduce NO expression in IBD models through a broad array of mechanisms.A number of synthetic molecules have been found to suppress NO expression either dependent on the NF-κB signaling pathway(i.e.,dexamethasone,pioglitazone,tropisetron)or independent from this pathway(i.e.,nicotine,prednisolone,celecoxib,β-adrenoceptor antagonists).Co-administration of natural and synthetic agents can affect the tissue level of NO and may improve IBD symptoms mainly by modulating the Toll like receptor-4 and NF-κB signaling pathways. | Aida Kamalian Masoud Sohrabi Asl Mahsa Dolatshahi Khashayar Afshari Shiva Shamshiri Nazanin Momeni Roudsari Saeideh Momtaz Roja Rahimi Mohammad Abdollahi Amir Hossein Abdolghaffari | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Promising effect of Magliasa, a traditional Iranian formula, on experimental colitis on the basis of biochemical and cellular findings显示文摘AIM: To investigate the efficacy of Magliasa, a traditional Iranian formula, on experimental colitis. METHODS: After botanical authentication of herbal ingredients, formulation of Magliasa, quantitative determination of total glucosinolates and total phenolic content, and analysis of the thin layer chromatography profile were performed. Colitis was then induced in male rats by instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in all groups, aside from the Sham group.The experimental groups consisted of: the Sham group that received only normal saline; the Mag-50, Mag-100 and Mag-200 groups, which received 50, 100 and 200 mg/kg per day of Magliasa, respectively; the control group, which received vehicle water orally; the infliximab group, which received infliximab (5 mg/kg per day, subcutaneously); and the Dexa group, which received dexamethasone (1 mg/kg per day, orally). After completing the treatment period (2 wk), the rats were sacrificed, the colon was removed, its macroscopic and microscopic changes were recorded, and tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1b), total antioxidant capacity, myeloperoxidase (MPO), and lipid peroxidation (LPO) were assessed in colon homogenate.RESULTS: The mean value of total glucosinolates in one gram of Magliasa was 19 ± 1 μmol. The mean value of the total phenolic content was 293.8 ± 17.6 mg gallic acid equivalents per 100 gram of Magliasa. Macroscopic scores were significantly decreased in Mag-100 (1.80 ± 0.58, P = 0.019) and Mag-200 (1.20 ± 0.20, P = 0.001) compared to the control group (3.40 ± 0.24), although some inflammation and hyperemia were evident. Treatment of rats by dexamethasone (0.33 ± 0.21, P < 0.001) and infliximab (0.83 ± 0.31, P < 0.001) remarkably attenuated scores where mild hyperemia was observed macroscopically. In comparison to the control group (4.00 ± 0.32), only Mag-200 (1.60 ± 0.40) showed a significant decrease in colonic histopathological scores (P = 0.005). Minimal mucosal inflammation was observed in the Dexa group (0.67 ± 0.21, P < 0.001). The levels of TNF-α, IL-1b and MPO were significantly lower in all groups compared to the controls (P < 0.05). A significant decrease in LPO was seen in the Mag-200 (3.27 ± 0.77, P = 0.01) and Dexa (3.44 ± 0.22, P = 0.011) groups in comparison to the control group (6.43 ± 0.61). Only dexamethasone caused a significant increase in antioxidant power in comparison to the control group (346.73 ± 9.9 vs 228.33 ± 2.75, P < 0.001). Infliximab and different doses of Magliasa did not show any remarkable increase in antioxidant capacity (P > 0.05). The effect of Magliasa in all of mentioned parameters, except antioxidant capacity, was dose dependent.CONCLUSION: The effects of Magliasa in TNBS-induced colitis are encouraging and warrant clinical trials for further confirmation. | Roja Rahimi Amir Baghaei Maryam Baeeri Gholamreza Amin Mohammad Reza Shams-Ardekani Mahnaz Khanavi Mohammad Abdollahi | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 3 | Experimental determination of gas holdup and volumetric mass transfer coefficient in a jet bubbling reactor显示文摘The hydrodynamics and mass transfer characteristics of a lab-scale jet bubbling reactor(JBR)including the gas holdup,volumetric mass transfer coefficient and specific interfacial area were assessed experimentally investigating the influence of temperature,pH and superficial gas velocity.The reactor diameter and height were 11 and 30 cm,respectively.It was equipped with a single sparger,operating at atmospheric pressure,20 and 40℃,and two pH values of 3 and 6.The height of the liquid was 23 cm,while the superficial gas velocity changed within 0.010-0.040 m·s^(-1)range.Experiments were conducted with pure oxygen as the gas phase and saturated lime solution as the liquid phase.The liquid-side volumetric mass transfer coefficient was determined under unsteady-state oxygen absorption in a saturated lime solution.The gas holdup was calculated based on the liquid height change,while the specific interfacial area was obtained by a physical method based on the bubble size distribution(BSD)in different superficial gas velocities.The results indicated that at the same temperature but different pH,the gas holdup variation was negligible,while the liquid-side volumetric mass transfer coefficient at the pH value of 6 was higher than that at the pH=3.At a constant pH but different temperatures,the gas holdup and the liquid-side volumetric mass transfer coefficients at 40℃were higher than that of the same at 20℃.A reasonable and appropriate estimation of the liquid-side volumetric mass transfer coefficient(kla)in a pilot-scale JBR was provided which can be applied to the design and scale-up of JBRs. | Mostafa Abbasian-arani Mohammad Sadegh Hatamipour Amir Rahimi | 2021 | Chinese Journal of Chemical Engineering2021，34，6： | 2 |
| 4 | Tuning the metal filling fraction in metal-insulator-metal ultra-broadband perfect absorbers to maximize the absorption bandwidth显示文摘In this paper, we propose a methodology to maximize the absorption bandwidth of a metal-insulator-metal(MIM) based absorber. The proposed structure is made of a Cr-Al_2O_3-Cr multilayer design. At the initial step,the optimum MIM planar design is fabricated and optically characterized. The results show absorption above 0.9 from 400 nm to 850 nm. Afterward, the transfer matrix method is used to find the optimal condition for the perfect light absorption in an ultra-broadband frequency range. This modeling approach predicts that changing the filling fraction of the top Cr layer can extend light absorption toward longer wavelengths. We experimentally proved that the use of proper top Cr thickness and annealing temperature leads to a nearly perfect light absorption from 400 nm to 1150 nm, which is much broader than that of a planar design. Therefore, while keeping the overall process lithography-free, the absorption functionality of the design can be significantly improved. The results presented here can serve as a beacon for future performance-enhanced multilayer designs where a simple fabrication step can boost the overall device response without changing its overall thickness and fabrication simplicity. | AMIR GHOBADI HODJAT HAJIAN ALIREZA RAHIMI RASHED BAYRAM BUTUN EKMEL OZBAY | 2018 | Photonics Research2018，6，3： | 2 |
| 5 | Experimental study of radiat-ion and free convection in an enclosure with under-floor heatingsystem 显示文摘 | Mostafa Rahimi Amir Sabemaeemi | 2011 | Energy Conversion and Management2011，52，7： | 1 |
| 6 | An Analytical Investigation of DC/DC Power Electronic Converters With Constant Power Loads in Vehicular Power Systems显示文摘 | Amir M Rahimi Ali Emadi | | 0，，05： | 1 |
| 7 | Loop-cancellation Technique:A Novel Nonlinear Feedback to Overcome the Destabilizing Effect of Constant-power Loads显示文摘 | Amir M Rahimi Geoffrey A Williamson | | 0，，02： | 1 |
| 8 | A genetic-fuzzy control application to ramp metering and variable speed limit control 显示文摘 | Amir Hosein Ghods Ashkan Rahimi Kian Masoud Tabibi | 2007 | IEEE Transactions on Intelligent Transportation Systems2007，，： | 1 |
| 9 | A game theory approach to optimal coordinated ramp metering and variable speed limits 显示文摘 | Amir Hosein Ghods Ashkan Rahimi Kian | 2008 | IEEETransactions on Intelligent Transportation Systems2008，，： | 1 |
| 10 | Adaptive freeway ramp metering and variable speed limit control~ a genetic-fuzzy approach显示文摘 | Amir I-~osein Ghods Ashkan Rahimi Kian Masou~t Tabibi | 2009 | IEEE Intelligent Transportation Systems Magazine2009，，： | 1 |
| 11 | Balanced fuzzy particle swarm optimization显示文摘 | Amir Robati Gholam Abbas Barani Hossein Nezam Abadi Pour Mohammad Javad Fadaee Javad Rahimi Pour Anaraki | 2011 | Applied Mathematical Modelling2011，，5： | 1 |
| 12 | Experimental study of radiat-ion and free convection in an enclosure with a radiant ceiling hea-ting system显示文摘 | Mostafa Rahimi Amir Sabernaeemi | 2010 | Energy and Buildings2010，42，： | 1 |
| 13 | Emergence of African Swine Fever Virus, North- western Ira n 显示文摘 | Pooneh Rahimi Amir Sohrabi Javad Ashrafihelan et al | 2010 | Emerging infectious diseases2010，12，： | 1 |
| 14 | Biochemical and histopathological evidence on the beneficial effects of Tragopogon graminifolius in TNBS-induced colitis显示文摘 | Mohammad Hosein Farzaei Seyedeh Farnaz Ghasemi-Niri Amir Hosein Abdolghafari Maryam Baeeri Mahnaz Khanavi Mona Navaei-Nigjeh Mohammad Abdollahi Roja Rahimi | 2014 | Pharmaceutical Biology2014，，3： | 1 |
| 15 | AT2R ?1332 G:A polymorphism and its interaction with AT1R 1166 A:C, ACE I/D and MMP-9 ?1562 C:T polymorphisms: Risk factors for susceptibility to preeclampsia显示文摘 | Zohreh Rahimi Ziba Rahimi Amir Aghaei Asad Vaisi-Raygani | 2014 | Gene2014，，1： | 1 |
| 16 | Mathematical mod- eling of a packed-bed air dehumidifier: The impact of em- pirical correlations 显示文摘 | AMIR Rahimi DAVOUD Babakhani | 2013 | Journal of Petroleum Science and Engineering2013，108，： | 1 |
| 17 | A general model for moving-bed reactors with multiple chemical reactions, Part II: Effect of kinetic model显示文摘 | Amir Rahimi Arezou Niksiar | 2013 | International Journal of Mineral Processing2013，，： | 1 |
| 18 | Negative impedance stabilizing pulse adjustment control technique for DC/DC converters operating indiscontinuous conduction mode and driving constant power loads显示文摘 | Alireza Khaligh Amir M Rahimi Ali Emadi | 2007 | IEEE Transactions on Vehicular Technology2007，56，4： | 1 |
| 19 | Mathematical modeling of a packed - bed air dehumidifier:The impact of empir- ical correlations 显示文摘 | Amir Rahimi Davoud Babakhani | 2013 | Journal of Petroleum Science and Engineering2013，，3： | 1 |
| 20 | Experimental study of radiation and free convection in an enclosure with under-floor heating system显示文摘 | Mostafa Rahimi Amir Sabernaeemi | 2011 | Energy Conversion and Management2011，，7： | 1 |
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