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| 1 | Relationship between Temperaments of Medicinal Plants and Their Major Chemical Compounds显示文摘Objective: To determine any relationship between temperaments of medicinal plants referred to traditional Iranian manuscripts and their major chemical compounds. Methods: Plants used in traditional Iranian medicine were categorized based on their major chemical compounds including alkaloids, phenolic compounds, and essential oils. Their temperaments were extracted from traditional herbal pharmacopeias of Iran. The possible relationship between major chemical compounds and temperaments of each group were evaluated. Results: Plants containing phenolic compounds as their major constituents are hot and dry temperaments except those contain tannins with cold and dry temperaments. Plants containing essential oils have hot and dry temperaments except those whose major essential oils with alcoholic structure which have cold and dry temperaments. Alkaloid-containing plants have cold and dry or hot and dry temperaments based on their alkaloidal structures. Conclusions: There is a close relationship between major chemical compounds of medicinal plants and their temperaments mentioned in traditional Iranian manuscripts. | Mohammad Reza Shams Ardekani Roja Rahimi Behjat Javadi Leila Abdi Mahnaz Khanavi | 2011 | Journal of Traditional Chinese Medicine2011，31，1： | 7 |
| 2 | Promising effect of Magliasa, a traditional Iranian formula, on experimental colitis on the basis of biochemical and cellular findings显示文摘AIM: To investigate the efficacy of Magliasa, a traditional Iranian formula, on experimental colitis. METHODS: After botanical authentication of herbal ingredients, formulation of Magliasa, quantitative determination of total glucosinolates and total phenolic content, and analysis of the thin layer chromatography profile were performed. Colitis was then induced in male rats by instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in all groups, aside from the Sham group.The experimental groups consisted of: the Sham group that received only normal saline; the Mag-50, Mag-100 and Mag-200 groups, which received 50, 100 and 200 mg/kg per day of Magliasa, respectively; the control group, which received vehicle water orally; the infliximab group, which received infliximab (5 mg/kg per day, subcutaneously); and the Dexa group, which received dexamethasone (1 mg/kg per day, orally). After completing the treatment period (2 wk), the rats were sacrificed, the colon was removed, its macroscopic and microscopic changes were recorded, and tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1b), total antioxidant capacity, myeloperoxidase (MPO), and lipid peroxidation (LPO) were assessed in colon homogenate.RESULTS: The mean value of total glucosinolates in one gram of Magliasa was 19 ± 1 μmol. The mean value of the total phenolic content was 293.8 ± 17.6 mg gallic acid equivalents per 100 gram of Magliasa. Macroscopic scores were significantly decreased in Mag-100 (1.80 ± 0.58, P = 0.019) and Mag-200 (1.20 ± 0.20, P = 0.001) compared to the control group (3.40 ± 0.24), although some inflammation and hyperemia were evident. Treatment of rats by dexamethasone (0.33 ± 0.21, P < 0.001) and infliximab (0.83 ± 0.31, P < 0.001) remarkably attenuated scores where mild hyperemia was observed macroscopically. In comparison to the control group (4.00 ± 0.32), only Mag-200 (1.60 ± 0.40) showed a significant decrease in colonic histopathological scores (P = 0.005). Minimal mucosal inflammation was observed in the Dexa group (0.67 ± 0.21, P < 0.001). The levels of TNF-α, IL-1b and MPO were significantly lower in all groups compared to the controls (P < 0.05). A significant decrease in LPO was seen in the Mag-200 (3.27 ± 0.77, P = 0.01) and Dexa (3.44 ± 0.22, P = 0.011) groups in comparison to the control group (6.43 ± 0.61). Only dexamethasone caused a significant increase in antioxidant power in comparison to the control group (346.73 ± 9.9 vs 228.33 ± 2.75, P < 0.001). Infliximab and different doses of Magliasa did not show any remarkable increase in antioxidant capacity (P > 0.05). The effect of Magliasa in all of mentioned parameters, except antioxidant capacity, was dose dependent.CONCLUSION: The effects of Magliasa in TNBS-induced colitis are encouraging and warrant clinical trials for further confirmation. | Roja Rahimi Amir Baghaei Maryam Baeeri Gholamreza Amin Mohammad Reza Shams-Ardekani Mahnaz Khanavi Mohammad Abdollahi | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 3 | Cytotoxicactivity of some marine brown algae against cancercell lines 显示文摘 | Khanavi M Nabavi M Sadati N | 2010 | Biological Research2010，43，1： | 1 |
| 4 | Cytotoxic activity of some marine brown algae against cancer cell lines 显示文摘 | Mahnaz Khanavi Maryam Nabavi Nargess Sadati | 2010 | Biological Research2010，43，： | 1 |
| 5 | A Comparative Study of Anti- Candida Activity and Phenolic Contents of the Calluses from Lythrum salicaria L. in Different Treatments显示文摘 | Azadeh Manayi Soodabeh Saeidnia Mohammad Ali Faramarzi Nasrin Samadi Samineh Jafari Mahdi Vazirian Ardeshir Ghaderi Tahmineh Mirnezami Abbas Hadjiakhoondi Mohammad Reza Shams Ardekani Mahnaz Khanavi | 2013 | Applied Biochemistry and Biotechnology2013，，1： | 1 |
| 6 | Biochemical and histopathological evidence on the beneficial effects of Tragopogon graminifolius in TNBS-induced colitis显示文摘 | Mohammad Hosein Farzaei Seyedeh Farnaz Ghasemi-Niri Amir Hosein Abdolghafari Maryam Baeeri Mahnaz Khanavi Mona Navaei-Nigjeh Mohammad Abdollahi Roja Rahimi | 2014 | Pharmaceutical Biology2014，，3： | 1 |
| 7 | Liver tonics:review of plants used in Iranian traditional medicine显示文摘Considering the fact that liver is one of the most important organs in our body,it deserves special attention and protection.Among various recommended supplements,complementary and alternative medicines particularly herbal remedies have received much attention owing to their truly healing properties.This review profits from Iranian traditional medicine and presents advantageous herbal guide directions for liver protection.According to credible Iranian medical literature such as Al Qanun Fil Tibb.Al-Havi and Makhzan-al-Aadvia.a wide spectrum of plants have been found to be useful for cleansing and protecting the liver.Some herbs such as ghafes(Agrimonia eupatoria),kasni(Cichorium intybus),anar(Punica granatum),darchin(Cinnamomum zeylanicum),za'feran(Crocus sativus),gole-sorkh(Rosa damascena) and zereshk(Berberis vulgaris) appeared to get strong consideration and were well documented as outstanding liver tonics.We conducted a comprehensive review of available Iranian medical resources such as scientific information database and medical sciences databases which cover all in vitro and in vivo studies of medicinal plants as liver tonics and hepatoprotcctive candidates.Literature survey was accomplished using multiple databases including PubMed,ISI web of knowledge,and Google Scholar. | Tahmineh Akbarzadeh Reyhaneh Sabourian Mina Saeedi Hossein Rezaeizadeh Mahnaz Khanavi Mohammad Reza Shams Ardekani | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，3： | 1 |
| 8 | Development of a green chromatographic method for simultaneous determination of food colorants 显示文摘 | KHANAVI M HAJIMAHMOODI M RANJBAR A M | 2012 | Food Analytical Methods2012，5，3： | 1 |
| 9 | Development of a Green Chromatographic Method for Simultaneous Determination of Food Colorants显示文摘 | Mahnaz Khanavi Mannan Hajimahmoodi Ali Ranjbar Mohammad Oveisi Mohammad Ardekani Ghazaleh Mogaddam | 2012 | Food Analytical Methods2012，，3： | 1 |
| 10 | Larvicidal activity of essential oil and methanol extract of Nepeta menthoides against malaria vector Anopheles stephensi显示文摘Objective:To investigate the larvicidai activity of essential oil and methanol extract of the Nepeta menthoides(N.menthoides) against main malaria vector,Anopheles stephensi(An. stephensi).Methods:The essential oil of planl was obtained by Clevenger type apparatus and the methanol extract was supplied with Percolation method,larvicidai activity was tested by WHO method.Twenty five fourth-instar larvae of An.stephensi were used in the larvicidai assay and four replicates were tested for each concentration.Five different concentrations of the oil and extract were tested for calculation of LC50 and LC50 values.Results:The LC50 and LC90 values were determined by probit analysis.IC50 was 69.5 and 234.3 ppm and LC50 was 175.5 and 419.9 ppm for the extract and essential oil respectively.Conclusions:According to the results of this study methanolic extract of plant exhibited more larvicidai activity than essential oil.This could be useful for investigation of new natural larvicidai compounds. | Khanavi Mahnaz Fallah Alireza Vatandoost Hassan Sedaghat Mahdi Abai Mohammad Reza Hadjiakhoondi Abbas | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 0 |
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