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| 1 | Effects of moxifloxacin exposure on the conjunctival flora and antibiotic resistance profile following repeated intravitreal injections显示文摘AIM:To evaluate the effects of moxifloxacin exposure on the conjunctival flora and antibiotic resistance profile following repeated intravitreal injections.METHODS:Seventy-two eyes of 36 patients [36 eyes in control group, 36 eyes in intravitreal injection(IVI) group]were enrolled in the study. All the eyes had at least one IVI and had diabetic macular edema(DME) or age-related macular degeneration(ARMD). Moxifloxacin was prescribed to all the patients four times a day for five days following injection. Conjunctival cultures were obtained from the lower fornix via standardized technique with every possible effort made to minimize contamination from the lids, lashes, or skin. Before the application of any ophthalmic medication, conjunctival cultures were obtained from both eyes using sterile cotton culture. An automated microbiology system was used to identify the growing bacteria and determine antibiotic sensitivity.RESULTS:The bacterial cultures were isolated from 72 eyes of 36 patients, sixteen of whom patients(44.4%)were male and twenty(55.6%) were female. Average age was 68.4 ±9.0(range 50-86). The average number of injections before taking cultures was 3.1+1.0. Forty-eight(66.7%) of 72 eyes had at least one significant organism.There was no bacterial growth in 8(20.5%) of IVI eyes and in 16(44.4%) of control eyes(P =0.03). Of the bacteria isolated from culture, 53.8% of coagulase negative staphylococci(CoNS) in IVI eyes and 47.2%CoNS in control eyes. This difference between IVI eyes and control eyes about bacteria isolated from culture was not statistically significant(P =0.2). Eleven of 25 bacteria(44.0%) isolated from IVI eyes and 11(57.9%) of 19 bacteria isolated from control eyes were resistant to oxacillin. The difference in frequency of moxifloxacine resistance between two groups was not statistically significant(12.0% in IVI eyes and 21.1% in control eyes)(P =0.44). There were no cases of resistance to vancomycin, teicoplanin and linezolid.CONCLUSION:There was no difference in species of bacteria isolated from cultures, or in the frequency of resistance to antibiotics between eyes that had recurrent IVI followed by moxifloxacin exposure compared with control eyes. However, the number of eyes that had bacterial growth was higher in IVI group than in the control group. | Mustafa Atas Burhan Baskan Ayse zkse Fatma Mutlu Sarιgüzel Süleyman Demircan Emine Pangal | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 1 |
| 2 | Isolation and characterization of nanofibers from agricultural residues wheat straw and soy hulls 显示文摘 | AYSE A MOHINI S | 2008 | Bioresource Technology2008，99，6： | 1 |
| 3 | A novel solid phase extraction procedure on Amberlite XAD-1180 for speciation of Cr(Ⅲ),Cr(Ⅵ) and total chromium in environmental and pharmaceutical samples显示文摘 | Ibrahim N Ayse K Mustafa S | 2008 | Journal of Hazardous Materials2008，150，： | 1 |
| 4 | Manufacturing Low Den- sity Boards from Waste Cardboards Containing Aluminium 显示文摘 | ATILLA M AYSE S M METING | 2007 | Materials and Design2007，28，7： | 1 |
| 5 | Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin Ddeficient women in short term显示文摘 | Ayse KU Serpil S Aysegul T | 2010 | Eur J Endocrinol2010，163，5： | 1 |
| 6 | Prevalence of snoring and symptoms of sleep-disordered breathing in primary school children in Istanbul显示文摘 | Refika E Ayse R Dilsad S | 2004 | Chest2004，126，1： | 1 |
| 7 | Prevalence of snoring and symptoms of sleep - disordered breathing in primary school children in Istanbul显示文摘 | Refika E Ayse R Dilsad S | 2004 | Chest2004，126，1： | 1 |
| 8 | Vocal cord hemangioma; A rare localization in adults 显示文摘 | Ayse iRiZ Durmaz E Akmansu S H | 2008 | Turk J Med Sci2008，38，1： | 1 |
| 9 | Preparation, properties, and characterization of polymer electrolyte membranes based on poly(1-vinyl-1,2,4 triazole) and poly(styrene sulfonic acid)显示文摘 | AYSE A UNAL S AYHAN B | 2009 | J Electrochem Soc2009，156，10： | 1 |
| 10 | Rheological properties of reduced-fat and low-fat ice cream containing whey protein isolate and inulin显示文摘 | Ayse S A Cem K Gulfem U | 2008 | European Food Research and Technology2008，227，3： | 1 |
| 11 | Kinetic of carbonaceous substrate in an upflow anaerobic sludge sludge blanket (UASB) reactor treating 2, g dichlorophenol(2,4 DCP) 显示文摘 | DELIA T S AYSE U | 2008 | Environ Manage2008，86，： | 1 |
| 12 | Isolation and Characterization of Nanofi- bers from Agricultural Residues-Wheat Straw and Soy Hulls 显示文摘 | AYSE A MOHINI S | 2008 | Bioresource Technology2008，，99： | 1 |
| 13 | Evaluation of biomass residue: Briquetting waste paper and wheat straw mixtures显示文摘 | AYHAN D AYSE S | 1998 | Fuel Processing Technology1998，55，2： | 1 |
| 14 | Prevalence of snoring and symptoms of sleep-disordered breathing in primary school children in Istanbul显示文摘 | Refika E Ayse R Dilsad S | 2004 | Chest2004，126，1： | 1 |
| 15 | Land-based sources of pollution along the Izmit Bay and their effect on the coastal waters显示文摘 | Enis Morkoc Oya S Okay Ayse Edincliler | 2008 | Environ Geol2008，56，： | 1 |
| 16 | Influence of perceived teacher acceptance, selbconcept, and school attitude on the aca demic achievement of school-age children in Turkey显示文摘 | Fatos E Ayse CZ Hande S | 2010 | Cross Cultural Research2010，44，3： | 1 |
| 17 | Synthesis and characterization of novel fluorine containing methacr ylate eopolymers: Reactivity ratios, thermal properties, and antimierobial activity 显示文摘 | BRAHIM I E OZKAN S AYSE D | 2009 | Journal of Applied Polymer Science2009，114，6： | 1 |
| 18 | Loss of ARID1A ex- pression is an early molecular event in tumor progression from o- varian endometriotic cyst to clear cell and endometfioid carcino- ma显示文摘 | Ayse A Tsui-Lien M Tamer S | 2012 | Int J Gynecol Cancer2012，22，8： | 1 |
| 19 | Review of methods to determine antioxidant capacities显示文摘 | AYSE K BERAAT O SAMIM S | | 0，，01： | 1 |
| 20 | Treatment of combined acid mine drainage (AMD)-flotation circuit ef- fluents from copper mine via Fenton' s process 显示文摘 | Ayse M Esra T Y Mehmet F S | 2009 | Journal of Hazardous Materials2009，166，： | 1 |
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