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| 1 | 中国大陆肺炎发病率与死亡率:1985-2008年中英文文献的系统分析显示文摘目的肺炎是全球传染性疾病最主要的死因之一,但中国的肺炎疾病负担还知之甚少,因为很多数据资料都是以非英文文献的形式发表的。方法系统回顾了中国大陆关于肺炎发病率与死亡率的中文和英文文献,这些研究都是具有第一手数据的研究,1985-2008年有37篇论文符合纳入标准。结果各项研究的质量差异较大。5岁以下儿童肺炎发病率为(0.06~0.27)次/人年,肺炎死亡率为184/10万~1 223/10万人口。肺炎的发病率与死亡率随着时间稳定不变或者呈下降趋势,且农村高于城市。结论肺炎仍然是中国儿童的主要公共卫生问题之一。肺炎发病率与死亡率估计的变化差异大。继续降低发病率与死亡率需要可靠的监测数据和新的预防措施的实施,特别是在农村等高发地区。 | 官旭华 Benjamin J Silk Wenkai Li Aaron T. Fleishchauer 邢学森 蒋晓清 余宏杰 Sonja J. Olsen Adam L. Cohen | 2011 | 公共卫生与预防医学2011，22，1： | 54 |
| 2 | Adherence to acne treatment guidelines in the military environment-a descriptive,serial cross-sectional study显示文摘Background:Acne vulgaris,a common skin disease,affects up to 80% of the population.Moderate to severe acne requires treatment with a combination of topical and oral drugs such as antibiotics,hormones and retinoids.Retinoids have many contraindications and adverse effects requiring close monitoring.The study's objectives were to describe prescribing trends in acne medication over time in a military setting,and assess physician adherence to guidelines for acne treatment,including drug precautions,clinical monitoring,and treatment progression.Methods:We conducted a descriptive,serial cross-sectional study of acne drugs prescribed in the Israel Defense Forces(IDF) in the years 2002–2007,analyzing the classes of drugs prescribed and patient characteristics.In addition,the clinical quality of the medical encounter was assessed by examining physician adherence to IDF guidelines.Results:Between 2002 and 2007,64,281 patients were treated for acne.Treatment courses generally persisted for 1–2 months.Over 70% of female patients receiving oral retinoids were not concomitantly receiving oral contraceptives.Conclusions:This study provides a unique perspective of acne treatment in a military setting,overall displaying good adherence to general guidelines.The common prescription of oral retinoids to young females without concomitant contraception is alarming. | Chen Fleischmann Lior Cohen Elimelech Adams Michael Hartal | 2016 | Journal of Medical Colleges of PLA(China)2016，31，1： | 3 |
| 3 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 4 | Human pharmacology of positive GABA-A subtype-selective receptor modulators for the treatment of anxiety显示文摘Anxiety disorders arise from disruptions among the highly interconnected circuits that normally serve to process the streams of potentially threatening stimuli. The resulting imbalance among these circuits can cause a fundamental misinterpretation of neural sensory information as threatening and can lead to the inappropriate emotional and behavioral responses observed in anxiety disorders. There is considerable preclinical evidence that the GABAergic system, in general, and its α2- and/or α5-subunit-containing GABA(A) receptor subtypes, in particular, are involved in the pathophysiology of anxiety disorders. However, the clinical ef?cacy of GABA-A α2-selective agonists for the treatment of anxiety disorders has not been unequivocally demonstrated. In this review, we present several human pharmacological studies that have been performed with the aim of identifying the pharmacologically active doses/exposure levels of several GABA-A subtype-selective novel compounds with potential anxiolytic effects. The pharmacological selectivity of novel α2-subtype-selective GABA(A) receptor partial agonists has been demonstrated by their distinct effect profiles on the neurophysiological and neuropsychological measurements that reflect the functions of multiple CNS domains compared with those of benzodiazepines, which are nonselective, full GABA(A) agonists. Normalizing the undesired pharmacodynamic side effects against the desired on-target effects on the saccadic peak velocity is a useful approach for presenting the pharmacological features of GABA(A)-ergic modulators. Moreover, combining the anxiogenic symptom provocation paradigm with validated neurophysiological and neuropsychological biomarkers may provide further construct validity for the clinical effects of novel anxiolytic agents. In addition, the observed drug effects on serum prolactin levels support the use of serum prolactin levels as a complementary neuroendocrine biomarker to further validate the pharmacodynamic measurements used during the clinical pharmacological study of novel anxiolytic agents. | Xia Chen Joop van Gerven Adam Cohen Gabriel Jacobs | 2019 | Acta Pharmacologica Sinica2019，40，5： | 2 |
| 5 | The nondirected live-kindey donor:ethical considerations and practice guideline:a national conference report显示文摘 | ADAMS P L COHEN D J DANOVITCH G M | 2002 | Transplantation2002，74，4： | 1 |
| 6 | Preservation and Incorporation of Valuable Endoscopic Innovations (PIVI) on the use of endoscopy simulators for training and assessing skill显示文摘 | Jonathan Cohen Brian P. Bosworth Amitabh Chak Brian J. Dunkin Dayna S. Early Lauren B. Gerson Robert H. Hawes Adam V. Haycock Juergen H. Hochberger Joo Ha Hwang John A. Martin Peter R. McNally Robert E. Sedlack Melina C. Vassiliou | 2012 | Gastrointestinal Endoscopy2012，，3： | 1 |
| 7 | Hydrolyzed Casein Decreases Postprandial Glucose Concentrations in T2DM Patients Irrespective of Leucine Content显示文摘 | Bart F. Geerts Marloes G.J. van Dongen Baukje Flameling Matthijs M. Moerland Marieke L. de Kam Adam F. Cohen Johannes A. Romijn Cindy C. Gerhardt Joris Kloek Jacobus Burggraaf | 2011 | Journal of Dietary Supplements2011，，3： | 1 |
| 8 | Antithrombotic Therapy in Acute Coronary Syndromes Research Group Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users:primary end points analysis from the 15ATACS trial显示文摘 | Cohen M Adams PC Parry G | 1994 | Circulation1994，89，1： | 1 |
| 9 | Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 in mammalian cells is an autophosphorylation event显示文摘 | Adam C Frame S Cohen P | 2004 | Biochem J2004，377，1： | 1 |
| 10 | Mass and moment-of-inertia peaks in general relativity显示文摘 | Adams R C Warbton R D H Cohen J M | 1975 | Astrophys J1975，200，： | 1 |
| 11 | Mass and moment - of - inertia peaks in general relativity 显示文摘 | ADAMS R C WARBTON R D H COHEN J M | 1975 | AP J1975，200，： | 1 |
| 12 | Local music policies within a global music industry: cultural quarters in Manchester and Sheffield 显示文摘 | Adam Brown Justin O' Connor Sara Cohen | 2000 | Geoforum2000，，31： | 1 |
| 13 | Safety evaluation of natural flavour complexes 显示文摘 | SMITH R L ADAMS T B COHEN S M | 2004 | Toxicology Letters2004，149，1： | 1 |
| 14 | Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice显示文摘 | Ehud Cohen Johan F. Paulsson Pablo Blinder Tal Burstyn-Cohen Deguo Du Gabriela Estepa Anthony Adame Hang M. Pham Martin Holzenberger Jeffery W. Kelly Eliezer Masliah Andrew Dillin | 2009 | Cell2009，，6： | 1 |
| 15 | The FEMA GRAS assess- merit of benzyl derivatives used as flavor ingredients显示文摘 | Adams T Cohen S Doull J | 2005 | Food Chem Toxicol2005，43，8： | 1 |
| 16 | Back to Square One显示文摘 | | 1998 | Time1998，20，： | 1 |
| 17 | Building social capital: Examining the impact of Street Soccer USA on its volunteers显示文摘 | WELTY PEACHEY JON COHEN ADAM BORLAND JO- HN | 2013 | Int Rev Soc Sport2013，48，1： | 1 |
| 18 | Estimation of ventricular fibrillation to fibrillation through T-wave time series analysis显示文摘 | Akselrod S Cohen RJ | 1981 | Comp in Card1981，307，： | 1 |
| 19 | Period multupling-evidence for nonlinear behaviour of the canine heart显示文摘 | Ritzenberg AL Adam DR Cohen RJ | 1984 | Nature1984，307，5947： | 1 |
| 20 | Category and letter verbal fluency across the adult lifespan:relationship to EEG theta power显示文摘 | Adam M Brickman Robert H Paul Ronald A Cohen | 2005 | Archives of Clinical Neuropsychology2005，，20： | 1 |
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