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| 1 | Dectin- 1 isoforms contribute to distinct Th 1/Th 17 cell activation in mucosal candidiasis显示文摘β 的识别;由 dectin-1 的 -glucans 被显示了调停房间激活, cytokine 生产和许多抗真菌的回答。这里,我们报导在到 Candida albicans 的 mucosal 免疫的 dectin-1 的功能的活动被主人的基因背景影响。Dectin-1 在 C57BL/6,然而并非 BALB/c 老鼠为胃肠、阴道的 candidiasis 的合适的控制被要求;事实上,后者当 dectin-1 不在时显示出增加的抵抗。到感染的 dectin-1-deficient C57BL/6 老鼠的危险性在 IL-17A 和芳基烃受体依赖者 IL-22 生产并且在适应 Th1 回答与缺点被联系。相反, dectin-1-deficient BALB/c 鼠标的抵抗与增加的 IL-17A 和 IL-22 生产并且向提供免疫学的存储器的 Th1/Treg 有免疫力的回答扭曲被联系。迥异的正规 / 不在经典中的 NF-κ dectin-1 下游地表明小径的 B 在二不同老鼠紧张被激活。因此,在抗真菌的 mucosal 免疫的 dectin-1 的网活动依赖于主人的基因背景,它在 dectin-1 发信号之上影响天生的 cytokine 生产和适应 Th1/Th17 房间激活。 | Agostinho Carvalho Gloria Giovannini AntoneUa De Luca Carmen D'Angelo Andrea Casagrande Rossana G Iannitti Giovanni Ricci Cristina Cunha Luigina Romani | 2012 | Cellular & Molecular Immunology2012，9，3： | 10 |
| 2 | 学习设计的处方显示文摘本文主要描述了一种研究活动,此项活动由参与澳洲大学教育委员会“AUTC”资助项目的研究者负责的。AUTC资助的项目为信息和传播技术及其在弹性学习中的作用。此项目旨在研究和开发通用型学习框架,以便为高等教育提供技术增强型高效能学习经验。鉴于此,研究者一直致力于寻求通用型学习设计的处方,来促进建构知识解决问题。本文总结了所做的各项研究工作,并说明了研究过程中开发的通用学习框架。 | Ron Oliver Barry Harper John Hedberg Sandra Wills Shiriey Agostinho 吴文胜 盛群力 | 2007 | 远程教育杂志2007，25，2： | 3 |
| 3 | NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2^(V617F)-positive myeloproliferative neoplasm cells显示文摘Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms(MPN);in this pathway,IRS2 is involved in the malignant transformation induced by JAK2^(V617F),and upregulation of IGF1R signaling induces the MPN phenotype.NT157,a synthetic compound designed as an IGF1R-IRS1/2 inhibitor,has been shown to induce antineoplastic effects in solid tumors.Herein,we aimed to characterize the molecular and cellular effects of NT157 in JAK2^(V617F)positive MPN cell lines(HEL and SET2)and primary patient hematopoietic cells.In JAK2^(V617F)cell lines,NT157 decreased cell viability,clonogenicity,and cell proliferation,resulting in increases in apoptosis and cell cycle arrest in the G2/M phase(p<0.05).NT157 treatment inhibited IRS1/2,JAK2/STAT,and NFκB signaling,and it activated the AP-1 complex,downregulated four oncogenes(CCND1,MYB,WT1,and NFKB1),and upregulated three apoptotic-related genes(CDKN1A,FOS,and JUN)(p<0.05).NT157 induced genotoxic stress in a JAK2/STAT-independent manner.NT157 inhibited erythropoietin-independent colony formation in cells from polycythemia vera patients(p<0.05).These findings further elucidate the mechanism of NT157 action in a MPN context and suggest that targeting IRS1/2 proteins may represent a promising therapeutic strategy for MPN. | Bruna Alves Fenerich Jaqueline Cristina Fernandes Ana Paula Nunes Rodrigues Alves Juan Luiz Coelho-Silva Renata Scopim-Ribeiro Priscila Santos Scheucher Christopher A.Eide Cristina E.Tognon Brian J.Druker Eduardo Magalhães Rego João Agostinho Machado-Neto Fabiola Traina | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 4 | Involvement of oxidative stress in the enhancement of aeetyleholinesterase aetivity indueed by amyloid beta-peptide 显示文摘 | Melo JB Agostinho P Oliv eira CR | 2003 | Neurosei Res2003，45，1： | 1 |
| 5 | Assessment of a large watershed in Brazil using emergy evaluation and geographical information system 显示文摘 | Agostinho F Ambrs L A Ortega E | 2010 | Ecological Modelling2010，221，8： | 1 |
| 6 | The use of emergy assessment and the geographical information system in the diagnosis of small family farms in Brazil 显示文摘 | Agostinho F Diniz G Siche R | 2008 | Ecological Modelling2008，210，12： | 1 |
| 7 | Susceptibility of hip-pocampal neurons to Aβ peptide toxicity is associated with pertur- bation of Ca2+ homeostasis显示文摘 | Resende R Pereira C Agostinho P | 2007 | Brain Res2007，1143，： | 1 |
| 8 | Testing wound dressings using an in vitro wound model显示文摘 | Lipp C Kirker K Agostinho A | | 0，，06： | 1 |
| 9 | Convergence of ecological footprint and emergy analysis as a sustainability indicator of countries:Peru as case study显示文摘 | SICHE R PEREIRA L AGOSTINHO F | 2010 | Communications in Nonlinear Science and Numerical Simulation2010，15，10： | 1 |
| 10 | The efficacy of 2 different doses of dexamethasone to control postoperative swelling, trismus, and pain after third molar extractions 显示文摘 | Agostinho CN de Silva VC Maia Filho EM | 2014 | Gen Dent2014，62，6： | 1 |
| 11 | Dynamic positioning systems:an experimental analysis of sliding mode control显示文摘 | TANNURI E A AGOSTINHO A C MORISHITA H M | | 0，，10： | 1 |
| 12 | The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain显示文摘 | Gislaine Z Réus Helena M Abelaira Fabiano R Agostinho | | 0，，08： | 1 |
| 13 | Insulin oversecretion in MSG-obese rats is related to alterations in cholinergic muscarinic receptor subtypes in pancreatic islets 显示文摘 | MIRANDA R A AGOSTINHO A R TREVENZOLI I H | 2014 | Cell Physiol Biochem2014，33，4： | 1 |
| 14 | Vinpocetine attenuates the metabolic dysfunction induced by amyloid beta-peptides in PC12 cells 显示文摘 | Pereira C Agostinho P Oliveira C R | 2000 | Free Radic Res2000，33，5： | 1 |
| 15 | Neuroprotection strategies: Effect of vinpocetine in vitro oxidative stress models 显示文摘 | Pereira C Agostinho P Moreira P I | 2003 | A cta Mecl Port2003，16，6： | 1 |
| 16 | Food web model of the UpperParanáRiver Floodplain:Description and aggregation effects显示文摘 | Angelini R Agostinho A A | 2005 | Ecological Modelling2005，181，： | 1 |
| 17 | Neuroinflammation,oxidative stress and the pathogenesis of Alzheimer's disease显示文摘 | Agostinho P Cunha RA Oliveira C | | 0，，25： | 1 |
| 18 | Gray-scale image enhancement as an automatic process driven by evo- lution 显示文摘 | CRISTIAN M AGOSTINHO R | 2004 | IEEE Transactions on Systems Man and Cybernetics-Part B: Cybernetics2004，34，2： | 1 |
| 19 | Dynamic Positioning Systems:An Experimental Analysis of Sliding Mode Control显示文摘 | Tannuri E A Agostinho A C | 2010 | Con-trol Engineering Practice2010，18，10： | 1 |
| 20 | Flood regime,dam regulation and fish in the Upper Paran River:effects on assemblage attributes,reproduction and recruitment显示文摘 | Agostinho A A Gomes L C Verissimo S | 2004 | Reviews in Fish Biology and Fisheries2004，14，1： | 1 |
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