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| 1 | Developmental quantitative genetic analysis of body weights and morphological traits in the turbot, Scophthalmus maximus显示文摘In order to elucidate the genetic mechanism of growth traits in turbot during ontogeny, developmental genetic analysis of the body weights, total lengths, standard lengths and body heights of turbots was conducted by mixed genetic models with additive-dominance effects, based on complete diallel crosses with four different strains of Scophthalmus maximus from Denmark, Norway, Britain, and France. Unconditional genetic analysis revealed that the unconditional additive effects for the four traits were more significant than unconditional dominance effects, meanwhile, the alternative expressions were also observed between the additive and dominant effects for body weights, total lengths and standard lengths. Conditional analysis showed that the developmental periods with active gene expression for body weights, total lengths, standard lengths and body heights were 15–18, 15 and 21–24, 15 and 24, and 21 and 27 months of age, respectively. The proportions of unconditional/conditional variances indicated that the narrow-sense heritabilities of body weights, total lengths and standard lengths were all increased systematically. The accumulative effects of genes controlling the four quantitative traits were mainly additive effects, suggesting that the selection is more efficient for the genetic improvement of turbots. The conditional genetic procedure is a useful tool to understand the expression of genes controlling developmental quantitative traits at a specific developmental period(t-1→t) during ontogeny. It is also important to determine the appropriate developmental period(t-1→t) for trait measurement in developmental quantitative genetic analysis in fish. | WANG Xin'an MA Aijun MA Deyou | 2015 | Acta Oceanologica Sinica2015，34，2： | 7 |
| 2 | Regional Characteristics and Causes of Haze Events in Northeast China显示文摘Northeast China experiences severe atmospheric pollution, with an increasing occurrence of heavy haze episodes. However, the underlying forces driving haze formation during different seasons are poorly understood. In this study, we explored the spatio-temporal characteristics and causes of haze events in Northeast China by combining a range of data sources(i.e., ground monitoring, satellite-based products, and meteorological products). It was found that the ‘Shenyang-Changchun-Harbin(SCH)'city belt was the most polluted area in the region on an annual scale. The spatial distribution of air quality index(AQI) values had a clear seasonality, with the worst pollution occurring in winter, an approximately oval-shaped polluted area around western Jilin Province in spring, and the best air quality occurring in summer and most of the autumn. The three periods that typically experienced intense haze events were Period I from mid-October to mid-November(i.e., late autumn and early winter), Period II from late-December to February(i.e., the coldest time in winter), and Period III from April to mid-May(i.e., spring). During Period I, strong PM_(2.5) emissions from seasonal crop residue burning and coal burning for winter heating were the dominant reasons for the occurrence of extreme haze events(AQI > 300). Period II had frequent heavy haze events(200 < AQI < 300) in the coldest months of January and February, which were due to high PM_(2.5) emissions from coal burning and vehicle fuel consumption, a lower atmospheric boundary layer, and stagnant atmospheric conditions. Haze events in Period III, with high PM_(10) concentrations, were primarily caused by the regional transportation of windblown dust from degraded grassland in central Inner Mongolia and bare soil in western Jilin Province. Local agricultural tilling could also release PM_(10) and enhance the levels of windblown dust from tilled soil. Better control of coal burning, fuel consumption, and crop residue burning in winter and autumn is urgently needed to address the haze problem in Northeast China. | CHEN Weiwei ZHANG Shichun TONG Quansong ZHANG Xuelei ZHAO Hongmei MA Siqi XIU Aijun HE Yuexin | 2018 | Chinese Geographical Science2018，28，5： | 7 |
| 3 | Generation of multi-channel chaotic signals with time delay signature concealment and ultrafast photonic decision making based on a globally-coupled semiconductor laser network显示文摘We propose and demonstrate experimentally and numerically a network of three globally coupled semiconductor lasers(SLs)that generate triple-channel chaotic signals with time delayed signature(TDS)concealment.The effects of the coupling strength and bias current on the concealment of the TDS are investigated.The generated chaotic signals are further applied to reinforcement learning,and a parallel scheme is proposed to solve the multiarmed bandit(MAB)problem.The influences of mutual correlation between signals from different channels,the sampling interval of signals,and the TDS concealment on the performance of decision making are analyzed.Comparisons between the proposed scheme and two existing schemes show that,with a simplified algorithm,the proposed scheme can perform as well as the previous schemes or even better.Moreover,we also consider the robustness of decision making performance against a dynamically changing environment and verify the scalability for MAB problems with different sizes.This proposed globally coupled SL network for a multi-channel chaotic source is simple in structure and easy to implement.The attempt to solve the MAB problem in parallel can provide potential values in the realm of the application of ultrafast photonics intelligence. | Yanan Han Shuiying Xiang Yang Wang Yuanting Ma Bo Wang Aijun Wen Yue Hao | 2020 | Photonics Research2020，8，11： | 6 |
| 4 | The fluidity and molding ability of glass-forming Zr-based alloy melt显示文摘The fluidity and filling ability of glass-forming Zr-based alloy melt in copper mould were investigated both theoretically and experimentally. The major factors which affected the flowing behavior of the metallic melt in the mold were determined,which provides the foundation for overcoming the contradiction between the filling and formation of amorphous alloy during the rapid cooling process of the metallic melts. The casting factors to prepare a metallic ring were discussed and selected. As a result,a Zr-based bulk metallic glass ring was prepared successfully. | MA MingZhen ZONG HaiTao WANG HaiYan QI YanPeng LIANG SunXing SONG AiJun ZHANG WeiGuo WANG Qiang ZHANG XinYu JING Qin LI Gong LIU RiPing | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，4： | 6 |
| 5 | Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer显示文摘Histone acetylation is a critical process in the regulation of chromatin structure and gene expression.Histone deacetylases(HDACs)remove the acetyl group,leading to chromatin condensation and transcriptional repression.HDAC inhibitors are considered a new class of anticancer agents and have been shown to alter gene transcription and exert antitumor effects.This paper describes our work on the structural determination and structure-activity relationship(SAR)optimization of tetrahydroisoquinoline compounds as HDAC inhibitors.These compounds were tested for their ability to inhibit HDAC 1,3,6 and for their ability to inhibit the proliferation of a panel of cancer cell lines.Among these,compound 82 showed the greatest inhibitory activity toward HDAC 1,3,6 and strongly inhibited growth of the cancer cell lines,with results clearly superior to those of the reference compound,vorinostat(SAHA).Compound 82 increased the acetylation of histones H3,H4 and tubulin in a concentration-dependent manner,suggesting that it is a broad inhibitor of HDACs. | Danqi Chen Aijun Shen Guanghua Fang Hongchun Liu Minmin Zhang Shuai Tang Bing Xiong Lanping Ma Meiyu Geng Jingkang Shen | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 4 |
| 6 | Bio-removal of mixture of benzene,toluene,ethylbenzene,and xylenes/total petroleum hydrocarbons/trichloroethylene from contaminated water显示文摘Four pure cultures were isolated from soil samples potentially contaminated with gasoline compounds either at a construction site near a gas station in Fai Chi Kei,Macao SAR or in the northern parts of China(Beijing,and Hebei and Shandong).The effects of different concentrations of benzene,toluene,ethylbenzene,and three isomers(ortho-,meta-,and para-) of xylene(BTEX),total petroleum hydrocarbons(TPH),and trichloroethylene(TCE),when they were present in mixtures,on the bio-removal effciencies of microbial isolates were investigated,together with their interactions during the bio-removal process.When the isolates were tested for the BTEX(50-350 mg/L)/TPH(2000 mg/L) mixture,BTEoX in BTEoX/TPH mixture was shown with higher bio-removal effciencies,while BTEmX in BTEmX/TPH mixture was shown with the lowest,regardless of isolates.The TPH in BTEmX/TPH mixture,on the other hand,were generally shown with higher bio-removal effciencies compared to when TPH mixed with BTEoX and BTEpX.When these BTEX mixtures(at 350 mg/L) were present with TCE(5-50 mg/L),the stimulatory effect of TCE toward BTEoX bio-removal was observed for BTEoX/TCE mixture,while the inhibitory effect of TCE toward BTEmX for BTEmX/TCE mixture.The bio-removal effciency for TPH was shown lower in TPH(2000 mg/L)/TCE(5-50 mg/L) mixtures compared to TPH present alone,implying the inhibitory effect of TCE toward TPH bio-removal.For the mixture of BTEX(417 mg/L),TPH(2000 mg/L) along with TCE(5- 50 mg/L),TCE was shown co-metabolically removed more effciently at 15 mg/L,probably utilizing BTEX and/or TPH as primary substrates. | SHIM Hojae MA Wei LIN Aijun CHAN Kaicho | 2009 | Journal of Environmental Sciences2009，21，6： | 3 |
| 7 | Estimation of genetic parameters for upper thermal tolerance and growth-related traits in turbot Scophthalmus maximus using the Bayesian method based on Gibbs sampling显示文摘In order to carry out the genetic improvement of turbot upper thermal tolerance, it is necessary to estimate the genetic parameters of UTT(upper thermal tolerance) and growth-related traits. The objective of this study was to estimate genetic parameters for BW(body weight) and UTT in a two-generational turbot(Scophthalmus maximus L.) pedigree derived from four imported turbot stocks(England, France, Denmark and Norway). A total of 42 families including 20 families from G1 generation and 22 families from G2 generation were used to test upper thermal tolerance(40–50 animals per family) in this study and the body weight of individuals were measured. The heritability of BW and UTT and the correlation between these two traits were estimated based on an individual animal model using Bayesian method based on two types of animal models with and without maternal effects.These results showed that the heritabilities for BW and UTT and phenotypic and genetic correlations between the two traits estimated from model without maternal effects were 0.239±0.141, 0.111±0.080, 0.075±0.026 and–0.019±0.011, respectively. The corresponding values from model with maternal effects were 0.203±0.115,0.055±0.026, 0.047±0.034 and –0.024±0.028, respectively. The maternal effects of BW and UTT were 0.050±0.017 and 0.013±0.004, respectively. The maternal effects had a certain influence on the genetic evaluation of the two traits. The findings of this paper provided the necessary background to determine the best selection strategy to be adopted in the genetic improvement program. | MA Aijun WANG Xin'an HUANG Zhihui LIU Zhifeng CUI Wenxiao QU Jiangbo | 2018 | Acta Oceanologica Sinica2018，37，6： | 3 |
| 8 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 9 | Recent Progress in Atmospheric Chemistry Research in China: Establishing a Theoretical Framework for the “Air Pollution Complex”显示文摘Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 on air pollution(only papers included in the Web of Science Core Collection database were considered),more than 24000 papers were authored or co-authored by scientists working in China.In this paper,we review a limited number of representative and significant studies on atmospheric chemistry in China in the last few years,including studies on(1)sources and emission inventories,(2)atmospheric chemical processes,(3)interactions of air pollution with meteorology,weather and climate,(4)interactions between the biosphere and atmosphere,and(5)data assimilation.The intention was not to provide a complete review of all progress made in the last few years,but rather to serve as a starting point for learning more about atmospheric chemistry research in China.The advances reviewed in this paper have enabled a theoretical framework for the air pollution complex to be established,provided robust scientific support to highly successful air pollution control policies in China,and created great opportunities in education,training,and career development for many graduate students and young scientists.This paper further highlights that developing and low-income countries that are heavily affected by air pollution can benefit from these research advances,whilst at the same time acknowledging that many challenges and opportunities still remain in atmospheric chemistry research in China,to hopefully be addressed over the next few decades. | Tong ZHU Mingjin TANG Meng GAO Xinhui BI Junji CAO Huizheng CHE Jianmin CHEN Aijun DING Pingqing FU Jian GAO Yang GAO Maofa GE Xinlei GE Zhiwei HAN Hong HE Ru-Jin HUANG Xin HUANG Hong LIAO Cheng LIU Huan LIU Jianguo LIU Shaw Chen LIU Keding LU Qingxin MA Wei NIE Min SHAO Yu SONG Yele SUN Xiao TANG Tao WANG Tijian WANG Weigang WANG Xuemei WANG Zifa WANG Yan YIN Qiang ZHANG Weijun ZHANG Yanlin ZHANG Yunhong ZHANG Yu ZHAO Mei ZHENG Bin ZHU Jiang ZHU | 2023 | Advances in Atmospheric Sciences2023，40，8： | 2 |
| 10 | Temperature rise and flow of Zr-based bulk metallic glasses under high shearing stress显示文摘Deformation of the bulk metallic glasses (BMGs) and the creation and propagation of the shear bands are closely interconnected.Shearing force was loaded on Zr 41.2 Ti 13.8 Cu 12.5 Ni 10.0 Be 22.5 (Vit.1) BMGs by cutting during the turning of the BMG rod.The temperature rise of alloy on the shear bands was calculated and the result showed that it could reach the temperature of the super-cooled liquid zone or exceed the melting point.The temperature rise caused viscous fluid flow and brought about the deformation of BMGs.This suggested that the deformation of BMGs was derived,at least to some extent,from the adiabatic shear temperature rise. | ZHANG WeiGuo MA MingZhen SONG AiJun LIANG ShunXing HAO QiuHong TAN ChunLin JING Qin LIU RiPing | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 2 |
| 11 | Design of line-start low speed and high torque PMSM for gearless drive system 显示文摘 | LU Zhongshu ZHANG Aijun MA Lie | 2011 | IEEE Transactions on Magnetics2011，9，4： | 1 |
| 12 | Protein compositionof yak milk显示文摘 | LI Haimei MA Ying DONG Aijun pt al | 2010 | Dairy Soienre & Technology2010，90，： | 1 |
| 13 | Protein composition of yak milk显示文摘 | LI Haimei MA Ying DONG Aijun | 2010 | Dairy Sci Technol2010，90，1： | 1 |
| 14 | The Determination of Canthaxanthin in Feed Ingredients by High Performance Liquid Chromatography显示文摘A series of studies were conducted to establish a methodology for the accurate and efficient determination of can-thaxanthin in feed ingredients.Agilent ZORBAX Eclipse DB-C18 analytical column(4.6×150 mm,5 μm) was used and kept at 25℃.The mobile phase was acetonitrile:methanol(v/v)=95 :5,and eluted compounds were detected by DAD absorbance(470 nm).The flow rate was maintained at 1.0 mL · min-1.The response of the method was linear over the range 1.0-20.0 μg· mL-1 canthaxanthin assay solution(R2=0.9998).Recovery assays done with standard canthaxanthin to feed ingredient resulted in an average recovery of 103%.Variation coefficient was less than 3.53%.This method is proved to be simple,precise,sensitive and reproductive. | ZHANG Hua YANG Xin MA Ying DONG Aijun XU Weili ZHANG Yingchun | 2008 | Journal of Northeast Agricultural University(English Edition)2008，15，2： | 1 |
| 15 | Global dynamics of a viral infection model with full logistic terms and antivirus treatments显示文摘 | Lijuan Song Cui Ma Qiang Li Aijun Fan Kaifa Wang | 2017 | International Journal of Biomathematics2017，10，1： | 1 |
| 16 | Protein composition of yak milk显示文摘 | LI Haimei MA Ying DONG Aijun | 2010 | Dairy Sci Technol2010，，90： | 1 |
| 17 | Protein composition of yak milk显示文摘 | LI Haimei MA Ying DONG Aijun | | 0，，01： | 1 |
| 18 | Estimation of genetic parameters for upper thermal tolerances and growth-related traits in turbot Scophthalmus maximus显示文摘An abnormally high temperature produces a stress response in turbot causing large economic losses in the turbot aquaculture industry of China. A genetic improvement of the upper thermal tolerance (UTT) of turbot could allow cultured fi sh to adapt. A genetic evaluation of UTT is required for determining the practicability of including this trait into a breeding program. In this study, data were recorded from a temperature tolerance test conducted on 3 200 individual turbots from 32 full-sib groups. A cross-sectional linear model and a cross-sectional threshold probit model were used to analyze the test-period survival and a cross-sectional threshold logit model was used to analyze the test-day survival. In addition, phenotypic and genetic correlations between body weight and survival data were estimated. The estimated heritability values obtained from the cross-sectional linear model (CSL), the cross-sectional threshold (probit) model (THRp), and the cross-sectional threshold (logit) model (THRl) were 0.247 9±0.108 3, 0.288 3±0.161 2, and 0.106 9±0.045 2, respectively. The correlation coeffi cients among the full-sib family estimated breeding values (EBVs) obtained from the three models were greater than 0.998 6 and all models produced an almost identical family ranking. The accuracies of selection obtained with the CSL, THRp, and THRl model were 0.773 8, 0.775 4, and 0.784 4, respectively, the greatest from the THRl model. The genetic correlations between body weight and survival data EBVs from the CSL, THRp, and THRl models were 0.020 1,-6.201 1×10^-4 , and -3.115 4×10^-4 , respectively, and the phenotypic correlations between the two traits were -0.837 1 and -0.667 1, respectively. The findings of this study provide background information to determine the best strategy of selection for the genetic improvement of UTT in turbot. | WANG Xin′an MA Aijun HUANG Zhihui SUN Zhibin CUI Wenxiao QU Jiangbo YU Hong | 2019 | Journal of Oceanology and Limnology2019，37，5： | 1 |
| 19 | Protein composition of yak milk显示文摘 | LI HAIMEI MA YING DONG AIJUN | 2010 | Dairy Sci Technol2010，90，1： | 1 |
| 20 | Protein com- position of yak milk显示文摘 | LI Haimei MA Ying DONG Aijun | 2010 | Dairy Sci Technol2010，90，： | 1 |
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