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| 1 | ABO incompatible renal transplants:Good or bad?显示文摘ABO incompatible kidney transplantation(ABOi-KT) was previously considered to be an absolute contraindication for patients with end-stage kidney disease(ESKD) due to hyperacute rejection related to blood type barrier. Since the first successful series of ABOi-KT was reported, ABOi-KT is performed increasingly all over the world. ABOi-KT has led to an expanded donor pool and reduced the number of patients with ESKD awaiting deceased kidney transplantation(KT). Intensified immunosuppression and immunological understanding has helped to shape current desensitization protocols. Consequently, in recent years, ABOi-KT outcome is comparable to ABO compatible KT(ABOc-KT). However, many questions still remain unanswered. In ABOi-KT, there is an additional residual immunological risk that maylead to allograft damage, despite using current diverse but usually intensified immunosuppressive protocols at the expense of increasing risk of infection and possibly malignancy. Notably, in ABOi-KT, desensitization and antibody reduction therapies have increased the cost of KT. Reassuringly, there has been an evolution in ABOiKT leading to a simplification of protocols over the last decade. This review provides an overview of the history, outcome, protocol, advantages and disadvantages in ABOi-KT, and focuses on whether ABOi-KT should be recommended as a therapeutic option of KT in the future. | Masaki Muramatsu Hector Daniel Gonzalez Roberto Cacciola Atsushi Aikawa Magdi M Yaqoob Carmelo Puliatti | 2014 | World Journal of Transplantation2014，4，1： | 18 |
| 2 | Targeted deletion of MMP-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction显示文摘 | Ducharme A Frantz S Aikawa M | 2000 | J Clin Invest2000，106，1： | 1 |
| 3 | Transmission-blocking Activity of a Chitinase Inhibitor and Activation of Malarial Parasite Chitinase by Mosquito Protease显示文摘 | Shahabuddin M Toyoshima T Aikawa M | 1993 | Proc Natl Acad Sci USA1993，90，9： | 1 |
| 4 | Neurosecretory granules in small cell invasive carcinoma of the urinary bladder显示文摘 | CRAMER S F AIKAWA M (~I-EILLIN M | 1981 | Cancer1981，47，4： | 1 |
| 5 | The heal-ing myocardium sequentially mobilizes two monocytesubsets with divergent and complementary functions显示文摘 | Nahrendorf M Swirski F K Aikawa E | 2007 | J Exp Med2007，204，12： | 1 |
| 6 | Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo显示文摘 | Aikawa E Nahrendorf M Figueiredo JL | 2007 | Circulation2007，116，24： | 1 |
| 7 | Hypochlorous acid, a macrophage product induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase mediated oxidant in plaque erosion and thrombogenesis显示文摘 | Sugiyama S Kugiyama K Aikawa M | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 8 | Regeneration of ex- trahepatic bile duct possibility to clinical application by recog- nition of the regenerative process显示文摘 | Aikawa M Miyazawa M Okada K | 2007 | J Smooth Muscle Res2007，43，： | 1 |
| 9 | Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety 显示文摘 | Seto M Aikawa K Miyamoto N | 2006 | JMed Chem2006，49，6： | 1 |
| 10 | Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction显示文摘 | Ducharme A Frantz S Aikawa M | 2000 | J Clin Invest2000，106，： | 1 |
| 11 | The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions 显示文摘 | Nahrendorf M Swirski FK Aikawa EA | 2007 | Journal of Experimental Medicine2007，204，12： | 1 |
| 12 | Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI 3- kinase/Akt 显示文摘 | Aikawa R Nawano M Gu Y | 2000 | Circulation2000，102，23： | 1 |
| 13 | Development of a novel reflux-free bilioenteric anastomosis procedure by using a bioabsorbable polymer tube 显示文摘 | Aikawa M Miyazawa M Okada K | 2009 | J Hepatobiliary Pancreat Surg2009，，： | 1 |
| 14 | Estrogen-mediated,endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury显示文摘 | Iwalura A Luedemann C Shastry S Hanley A Keamey M Aikawa R | 2003 | Circulation2003，108，25： | 1 |
| 15 | An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and vitro 显示文摘 | Aikawa M Rabkin E Sugiyama S | 2001 | Circulation2001，103，2： | 1 |
| 16 | Targeted deletion of MMP - 9 attenuates left vetricular enlargement and collagen accumulation after expedratmtal myocardial infarction显示文摘 | Duchanm A Frantz S Aikawa M | 2000 | J Clin Invest2000，106，1： | 1 |
| 17 | An HMG-CoA reduetase inhibitor suppresses accumulation of macrophages expressing matrix metalloproteinase and tissue factor in atheroma of WHHL rabbit显示文摘 | Aikawa M Rabkin E Sugiyama S | 1998 | Circulation1998，98，1： | 1 |
| 18 | Site-Directed Mu- tagenesis of Conserved Trp39 in Rhizomucor pusillus Pepsin: Possible Role of Trp39 in Maintaining Tyr75 in the Correct Orientation for Maximizing Catalytic Activity显示文摘 | PARK Y N AIKAWA J NISHIYAMA M | 1997 | The Japanese Biochemical Society1997，121，1： | 1 |
| 19 | Simultaneous detection of immuno- globulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) is highly specific for diagnosis of acute HEV infection显示文摘 | Takahashi M Kusakai S Mizuo H Suzuki K Fu- jimura K Masuko K Sugai Y Aikawa T Nishizawa T Okamoto H | 2005 | Journal of Clinical Microbiology2005，43，1： | 1 |
| 20 | Highly integrated three-dimensional MMIC single-chip receiver and transmitter 显示文摘 | TOYODA I TOKUMITSU T AIKAWA M | 1996 | IEEE Trans on Microwave Theory and Techniques1996，44，12： | 1 |
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