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| 1 | Modulatory effects of Bifidobacterium longum BB536 on defecation in elderly patients receiving enteral feeding显示文摘AIM:To investigate the effects of the probiotic Bifidobacterium longum BB536 on the health management of elderly patients receiving enteral feeding.METHODS:Two double-blind,placebo-controlled trials were performed with long-term inpatients receiving enteral tube feeding at Kitakyushu Hospital Group,Fukuoka,Japan.BB536 was administered as BB536-L and BB536-H powders that contained approximately 2.5 × 10 10 and 5 × 10 10 cfu of BB536,respectively.In the first trial,83 patients(age range:67-101 years) were randomized into 2 groups that received placebo(placebo group) or BB536-H(BB536 group) powders.In the second trial,123 patients(age range:65-102years) were randomized into 3 groups,and each group received placebo(placebo group),BB536-L(BB536-L group),or BB536-H(BB536-H group) powders.Each patient received the study medication for 16 wk after 1 wk of pre-observation.Fecal samples were collected from each patient prior to and after the intervention during Trial 2.Clinical observations included body temperature,occurrence of infection,frequency of defecation,and fecal microbiota.RESULTS:No significant changes were observed in the frequency of defecation for either treatment in Trial 1.However,a significant change was noted in the BB536-L group(P = 0.0439) in Trial 2 but not in the placebo or BB536-H groups.Subgroup analyses based on the frequency of defecation for each patient during the pre-observation period for both trials revealed significant increases in bowel movements in patients with a low frequency of defecation and significant decreases in the bowel movements of patients with a high frequency of defecation during the intervention period in the BB536 groups.The combination of Trials 1 and 2 data revealed a modulatory effect of BB536 ingestion on the changes in bowel movements.Significantly increased bowel movements were observed in patients in the low frequency subgroup with significant intergroup differences(P < 0.01).Significantly decreased bowel movements were observed in patients in the high subgroup,but no significant intergroup differences were observed compared with the placebo group.BB536 ingestion increased the prevalence of normally formed stools.BB536 intake also significantly(P < 0.01) increased the cell numbers of bifidobacteria in fecal microbiota,and significant intergroup differences were observed at week 16.No adverse events were reported in any group.CONCLUSION:Our results suggest that BB536 ingestion modulated the intestinal environment and may have improved the health care of elderly patients receiving enteral feeding. | Junko Kondo Jin-Zhong Xiao Akira Shirahata Mieko Baba Akie Abe Koichi Ogawa Taeko Shimoda | 2013 | World Journal of Gastroenterology2013，19，14： | 7 |
| 2 | Long-term outcomes of extended radical resection combined with intraoperative radiation therapy for pancreatic cancer显示文摘 | Hiroshi Takamori Takehisa Hiraoka Keiichiro Kanemitsu Tatsuya Tsuji Hiroshi Tanaka Akira Chikamoto Kei Horino Toru Beppu Masahiko Hirota Hideo Baba | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，6： | 2 |
| 3 | A Pancreaticoduodenectomy Risk Model Derived From 8575 Cases From a National Single-Race Population (Japanese) Using a Web-Based Data Entry System: The 30-Day and In-hospital Mortality Rates for Pancreaticoduodenectomy显示文摘 | Wataru Kimura Hiroaki Miyata Mitsukazu Gotoh Ichiro Hirai Akira Kenjo Yuko Kitagawa Mitsuo Shimada Hideo Baba Naohiro Tomita Tohru Nakagoe Kenichi Sugihara Masaki Mori | 2014 | Annals of Surgery2014，，4： | 2 |
| 4 | A randomized phase-II trial comparing sequential and concurrent paclitaxel with oral or parenteral fluorinated pyrimidines for advanced or metastatic gastric cancer显示文摘 | Kazuhiro Nishikawa Satoshi Morita Takanori Matsui Michiya Kobayashi Yoji Takeuchi Ikuo Takahashi Seiji Sato Yumi Miyashita Akira Tsuburaya Junichi Sakamoto Yoshihiro Kakeji Hideo Baba | 2012 | Gastric Cancer2012，，4： | 2 |
| 5 | Analysis of circulating tumor cells derived from advanced gastric cancer显示文摘 | Kosei Toyoshima Akira Hayashi Masahide Kashiwagi Naoko Hayashi Masaaki Iwatsuki Takatsugu Ishimoto Yoshifumi Baba Hideo Baba Yoshikazu Ohta | 2015 | Int. J. Cancer2015，，4： | 2 |
| 6 | Functional assessment versus conventional volumetric assessment in the prediction of operative outcomes after major hepatectomy显示文摘 | Hiromitsu Hayashi Toru Beppu Hirohisa Okabe Hideyuki Kuroki Shigeki Nakagawa Katsunori Imai Hidetoshi Nitta Akira Chikamoto Takatoshi Ishiko Hideo Baba | 2014 | Surgery2014，，： | 2 |
| 7 | Chemotherapy and Targeted Therapy for Patients with Initially Unresectable Colorectal Liver Metastases, Focusing on Conversion Hepatectomy and Long-Term Survival显示文摘 | Toru Beppu Yuji Miyamoto Yasuo Sakamoto Katsunori Imai Hidetoshi Nitta Hiromitsu Hayashi Akira Chikamoto Masayuki Watanabe Takatoshi Ishiko Hideo Baba | 2014 | Annals of Surgical Oncology2014，，3： | 1 |
| 8 | Tomographic image and visual recovery of acute macula-off rhegmatogenous retinal detachment显示文摘 | Takayuki Baba Akira Hirose Muka Moriyama Manabu Mochizuki | 2004 | Graefe’s Archive for Clinical and Experimental Ophthalmology2004，，7： | 1 |
| 9 | Laparoscopic cholecystectomy in patients with a history of gastrectomy显示文摘 | Akira Sasaki Jun Nakajima Hiroyuki Nitta Toru Obuchi Shigeaki Baba Go Wakabayashi | 2008 | Surgery Today2008，，9： | 1 |
| 10 | Percutaneous radiofrequency ablation‐assisted laparoscopic hepatectomy显示文摘 | Toru Beppu Hidetoshi Nitta Masayo Tsukamoto Katsunori Imai Hiromitsu Hayashi Hirohisa Okabe Daisuke Hashimoto Akira Chikamoto Takatoshi Ishiko Hideo Baba | 2014 | Asian J Endosc Surg2014，，2： | 1 |
| 11 | Carcinogenesis of Intraductal Papillary Mucinous Neoplasm of the Pancreas: Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2显示文摘 | Osamu Nakahara Hiroshi Takamori Masaaki Iwatsuki Yoshifumi Baba Yasuo Sakamoto Hiroshi Tanaka Akira Chikamoto Kei Horino Toru Beppu Keiichiro Kanemitsu Yumi Honda Ken-ichi Iyama Hideo Baba | 2012 | Annals of Surgical Oncology2012，，3： | 1 |
| 12 | Pancreatic schwannoma: Report of a case显示文摘 | Toshiyuki Okuma Masahiko Hirota Hidetoshi Nitta Seiya Saito Takeshi Yagi Satoshi Ida Shigeki Okamura Akira Chikamoto Ken-Ichi Iyama Hiroshi Takamori Keiichiro Kanemitsu Hideo Baba | 2008 | Surgery Today2008，，3： | 1 |
| 13 | Mechanism of Cr(VI) adsorption by coir pith studied by ESR and adsorption kinetic显示文摘 | Parinda Suksabye Akira Nakajima Paitip Thiravetyan Yoshinari Baba Woranan Nakbanpote | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 14 | Mechanism of hexavalent chromium adsorption by persimmon tannin gel显示文摘 | Akira Nakajima Yoshinari Baba | 2004 | Water Research2004，，12： | 1 |
| 15 | High CD44s expression is associated with the EMT expression profile and intrahepatic dissemination of hepatocellular carcinoma after local ablation therapy显示文摘 | Kosuke Mima Hiromitsu Hayashi Katsunori Imai Hideyuki Kuroki Shigeki Nakagawa Hirohisa Okabe Akira Chikamoto Masayuki Watanabe Toru Beppu Hideo Baba | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，4： | 1 |
| 16 | Pancreatoduodenectomy using a no-touch isolation technique显示文摘 | Masahiko Hirota Keiichiro Kanemitsu Hiroshi Takamori Akira Chikamoto Hiroshi Tanaka Hiroki Sugita Juhani Sand Isto Nordback Hideo Baba | 2010 | The American Journal of Surgery2010，，5： | 1 |
| 17 | Cancer cells spread through lymph vessels in the submucosal layer of the common bile duct in gallbladder carcinoma显示文摘 | Akira Chikamoto Tatsuya Tsuji Osamu Nakahara Yasuo Sakamoto Yoshiaki Ikuta Hiroshi Tanaka Hiroshi Takamori Masahiko Hirota Keiichiro Kanemitsu Hideo Baba | 2009 | Journal of Hepato-Biliary-Pancreatic Surgery2009，，4： | 1 |
| 18 | Chemotherapy and Targeted Therapy for Patients with Initially Unresectable Colorectal Liver Metastases, Focusing on Conversion Hepatectomy and Long-Term Survival显示文摘 | Toru Beppu Yuji Miyamoto Yasuo Sakamoto Katsunori Imai Hidetoshi Nitta Hiromitsu Hayashi Akira Chikamoto Masayuki Watanabe Takatoshi Ishiko Hideo Baba | 2014 | Annals of Surgical Oncology2014，，3： | 1 |
| 19 | Electrochemically controlled detection of adrenaline on poly(2‐aminobenzylamine) thin films by surface plasmon resonance spectroscopy and quartz crystal microbalance显示文摘 | Sopis Chuekachang Rapiphun Janmanee Akira Baba Sukon Phanichphant Saengrawee Sriwichai Kazunari Shinbo Keizo Kato Futao Kaneko Nobuko Fukuda Hirobumi Ushijima | 2013 | Surf. Interface Anal2013，，11： | 1 |
| 20 | Mitochondrial Remodeling in Endothelial Cells under Cyclic Stretch is Independent of Drp1 Activation显示文摘Mitochondria in endothelial cells remodel morphologically when supraphysiological cyclic stretch is exerted on the cells.During remodeling,mitochondria become shorter,but how they do so remains elusive.Drp1 is a regulator of mitochondrial morphologies.It shortens mitochondria by shifting the balance from mitochondrial fusion to fission.In this study,we hypothesized that Drp1 activation is involved in mitochondrial remodeling under supraphysiological cyclic stretch.To verify the involvement of Drp1,its activation was first quantified with Western blotting,but Drp1 was not significantly activated in endothelial cells under supraphysiological cyclic stretch.Next,Drp1 activation was inhibited with Mdivi-1,but this did not inhibit mitochondrial remodeling.Intracellular Ca^2+ increase activates Drp1 through calcineurin.First,we inhibited the intracellular Ca^2+ increase with Gd^3+ and thapsigargin,but this did not inhibit mitochondrial remodeling.Next,we inhibited calcineurin with cyclosporin A,but this also did not inhibit mitochondrial remodeling.These results indicate that mitochondrial remodeling under supraphysiological cyclic stretch is independent of Drp1 activation.In endothelial cells under supraphysiological cyclic stretch,reactive oxygen species(ROS)are generated.Mitochondrial morphologies are remodeled by ROS generation.When ROS was eliminated with N-acetyl-L-cysteine,mitochondrial remodeling was inhibited.Furthermore,when the polymerization of the actin cytoskeleton was inhibited with cytochalasin D,mitochondrial remodeling was also inhibited.These results suggest that ROS and actin cytoskeleton are rather involved in mitochondrial remodeling.In conclusion,the present results suggest that mitochondrial remodeling in endothelial cells under supraphysiological cyclic stretch is induced by ROS in association with actin cytoskeleton rather than through Drp1 activation. | Megumi Baba Aya Shinmura Shigeru Tada Taku Amo Akira Tsukamoto | 2019 | Molecular & Cellular Biomechanics2019，16，1： | 1 |
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