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| 1 | Efficacy of thymosin alpha-1 and interferon alpha in treatment of chronic viral hepatitis B:A randomized controlled study显示文摘AIM: To observe the efficiency and safety of thymosin-α1 treatment in patients with hepatitis B e antigen (HBeAg) and HBV DNA positive chronic hepatitis. METHODS: Sixty-two patients were randomly divided into groups A and B. The patients in group A received subcutaneous injection of 1.6 mg thymosin-α1, twice a week (T-α1 group) for six months, and the patients in group B received 5 MU interferon alpha (IFN-α) each day for fifteen days, then three times weekly (IFN-α group) for six months. The results between two groups treated with and the group untreated with IFN-α which was followed up for 12 mo (historical control group consisting of 30 patients) were compared, and three groups were comparable between each other (P > 0.05) at baseline (age, sex, clinical history, biochemical, and serological parameters). RESULTS: At the end of treatment, complete response, which was defined as alanine aminotransferase (ALT) normalization and HBV DNA and HBeAg loss, occurred in 9 of 29 (31.0%) patients in the T-α1 group and in 15 of 33 (45.5%) patients in the IFN-α group (c2 = 1.36, P >0.05). After a follow-up period of six months, a complete response was observed in 14 of 29 (48.3%) patients in the T-α1 group and in 9 of 33 (27.3%) patients in the IFN-α group (c2 = 2.93, P > 0.05). Compared with the results observed in the historical control (HC) group untreated with IFN-α which was followed up for 12 mo, the rate of complete response was significantly higher in IFN-α group at the end of therapy (1 of 30 vs 15 of 33, c2 = 14.72, P < 0.001) and in the T-α1 group at the end of follow-up (1 of 30 vs 14 of 29, c2 = 15.71, P < 0.001). In T-α1 and IFN-α treatment groups, the area under (the plasma concentration time) curve (AUC) of negative HBV DNA and HBeAg was 34%, 17%, 31% and 19% smaller than that in the HC group. By the end of the follow- up period, the proportions of ALT normalization and negative HBV DNA in the T-α1 group were significantly higher than those in the IFN-α and HC groups. The odds of ALT normalization and negative HBV DNA at the end of the follow-up was three-fold higher in the T-α1 group than in the IFN-α group. Unlike IFN-α, T-α1 was well tolerated by all patients, and no side effects appeared in T-α1 group.CONCLUSION: The results suggest that a 6-mo course of T-α1 therapy is effective and safe in patients with chronic hepatitis B. T-α1 is able to reduce HBV replication in patients with chronic hepatitis B. Furthermore, T-α1 is better tolerated than IFN-α and can gradually induce more sustained ALT normalization and HBV DNA and HBeAg loss. However, a response rate of 48.3% is still less ideal. A more effective therapeutic approach warrants further study. | Jing You Lin Zhuang Hong-Ying Cheng Shou-Ming Yan Lan Yu Jun-Hua Huang Bao-Zhang Tang Meng-Ling Huang Yong-Liang Ma Virasakdi Chongsuvivatwong Hutcha Sriplung Alan Geater Yan-Wei Qiao Rong-Xue Wu | 2006 | World Journal of Gastroenterology2006，12，41： | 8 |
| 2 | A deep learning-integrated micro-CT image analysis pipeline for quantifying rice lodging resistance-related traits显示文摘Lodging is a common problemin rice,reducing its yield andmechanical harvesting efficiency.Rice architecture is a key aspect of its domestication and a major factor that limits its high productivity.The ideal rice culm structure,includingmajor_axis_culm,minor axis_culm,andwall thickness_culm,is critical for improving lodging resistance.However,the traditionalmethod ofmeasuring rice culms is destructive,time consuming,and labor intensive.In this study,we used a high-throughput micro-CT-RGB imaging system and deep learning(SegNet)todevelopa high-throughputmicro-CTimageanalysis pipelinethatcanextract 24 riceculmmorphological traits and lodging resistance-related traits.When manual and automatic measurements were compared at themature stage,the mean absolute percentage errors for major_axis_culm,minor_axis_culm,andwall_thickness_culmin 104 indica rice accessionswere 6.03%,5.60%,and 9.85%,respectively,and the R^(2) valueswere 0.799,0.818,and 0.623.We also builtmodels of bending stress using culmtraits at the mature and tillering stages,and the R^(2) values were 0.722 and 0.544,respectively.The modeling results indicated that this method can quantify lodging resistance nondestructively,even at an early growth stage.In addition,we also evaluated the relationships of bending stress toshoot dryweight,culm density,and drought-related traits and found that plants with greater resistance to bending stress had slightly higher biomass,culm density,and culm area but poorer drought resistance.In conclusion,we developed a deep learning-integrated micro-CT image analysis pipeline to accurately quantify the phenotypic traits of rice culms in4.6 min per plant;this pipeline will assist in future high-throughput screening of large rice populations for lodging resistance. | Di Wu Dan Wu Hui Feng Lingfeng Duan Guoxing Dai Xiao Liu Kang Wang Peng Yang Guoxing Chen Alan P.Gay John H.Doonan Zhiyou Niu Lizhong Xiong Wanneng Yang | 2021 | Plant Communications2021，2，2： | 7 |
| 3 | 海口云洞图书馆显示文摘1海口城市新愿景作为中国南端重要的港口城市,海口是海上丝绸之路的重要一站。近年,由于海南国际旅游岛、海南自由贸易港陆续建立,海口的城市经济飞速发展,影响力与日俱增。如何通过提升城市公共空间的独特性和艺术性、为居民带来更具人文气质的生活环境、塑造城市的性格和归属感成为了主要议题。大型国际公共艺术项目“海口·海边的驿站”邀请十余位全球顶尖的建筑师、艺术家以及跨学科专家,共同打造了16座地标性公共驿站,是以“自然·共生·未来”为理念的精品民生工程。海口云洞图书馆是此项目首个建成的公共驿站,将为海口市民及游客带来更独特的城市公共和文化空间。 | 无 傅昌瑞 强思旸 尚立 孙菲菲 Dayie Wu Alan Rodríguez Carrillo 解奇霖 Beatrice Bavuso | 2021 | 建筑学报2021，，6： | 5 |
| 4 | ROR2 gene is associated with risk of non-syndromic cleft palate in an Asian population显示文摘背景受体酷氨酸象kinase一样孤儿受体 2 ( ROR2 )基因最近被显示了在动物模型在腭的开发起重要作用并且居住在连接到的 chromosomal 区域非, syndromic 劈开嘴唇与或没有在学习是调查可能的协会在之间的这的 humans.The 目的劈开腭 ROR2 基因和 non-syndromic 我们测试了的这里的口头的 clefts.Methods 在在 297 non-syndromic 的 ROR2 基因的 38 合格单个核苷酸的多型性( SNP ) | Wang Hong Hetmanski, Jacqueline B. Ruczinski, Ingo Liang, Kung Yee Fallin, M. Daniele Redett, Richard J. Raymond, Gerald V. Chou, Yah-Huei Wu Chen, Philip Kuo-Ting Yeow, Vincent Chong, Samuel S. Cheah, Felicia S. H. Jabs, Ethylin Wang Scott, Alan F. Beaty, Terri H. | 2012 | Chinese Medical Journal2012，，3： | 5 |
| 5 | Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in autumn in Beijing, China显示文摘污水污泥的有效处理和利用上的学习最近是在中国种兴趣的目标。然而,潜在的风险与有毒的 organics,重金属和病原的微生物由于它的污染与污泥的使用被联系。在这研究,一个屏蔽评价在在北京从 17 不同污水处理植物收集的污水污泥样品上被进行,基于批在 vitro 生物鉴定,包括一套 recombinant 基因酵母为内分泌的混乱的试金,并且用为芳基烃受体( Ah-R )的 H4IIE 房间的 ethoxy resorufin-O-deethylase (侵蚀)试金论战的活动。我们的结果建议了那雌激素受体的中等层次论战的活动(0.9 ng E2 愠映杯吗? | Cao LIU Yiping XU Mei MA Bingbin HUANG Jingdong WU Qingyi MENG Zijian WANG Robert Alan GEARHEART | 2014 | Frontiers of Environmental Science & Engineering2014，8，3： | 4 |
| 6 | Clinical significance of hepatic derangement in severe acute respiratory syndrome显示文摘AIM: Elevation of alanine aminotransferase (ALT) level is commonly seen among patients suffering from severe acute respiratory syndrome (SARS). We report the progression and clinical significance of liver derangement in a large cohort of SARS patient.METHODS: Serial assay of serum ALT was followed in patients who fulfilled the WHO criteria of SARS. Those with elevated ALT were compared with those with normal liver functions for clinical outcome. Serology for hepatitis B virus (HBV) infection was checked. Adverse outcomes were defined as oxygen desaturation, need of intensive care unit (ICU) and mechanical ventilation and death.RESULTS: Two hundred and ninety-four patients were included in this study. Seventy (24%) patients had elevated serum ALT on admission and 204 (69%) patients had elevated ALT during the subsequent course of illness. Using peak ALT >5×ULN as a cut-off and after adjusting for potential confounding factors, the odds ratio of peak ALT>5x ULN for oxygen desaturation was 3.24 (95%CI 1.23-8.59, P = 0.018), ICU care was 3.70 (95% CI 1.38-9.89, P = 0.009), mechanical ventilation was 6.64 (95%CI 2.22-19.81, P = 0.001) and death was 7.34(95%CI 2.28-24.89, P = 0.001). Ninety-three percent of the survived patients had ALT levels normalized or were on the improving trend during follow-up. Chronic hepatitis B was not associated with worse clinical outcomes.CONCLUSION: Reactive hepatitis is a common complication of SARS-coronavirus infection. Those patients with severe hepatitis had worse clinical outcome. | Henry Lik-Yuen Chan Ambrose Chi-Pong Kwan Ka-Fai To Sik-To Lai Paul Kay-Sheung Chan Wai-Keung Leung Nelson Lee Alan Wu Joseph Jao-Yiu Sung | 2005 | World Journal of Gastroenterology2005，11，14： | 4 |
| 7 | Hypertrophic adenoids in patients with nasopharyngeal carcinoma:appearance at magnetic resonance imaging before and after treatment显示文摘Introduction:Patients with nasopharyngeal carcinoma(NPC) sporadically develop abnormal adenoids.Nasopharyngeal adenoids are usually included in the gross tumor volume(GTV) but may have different therapeutic responses than tumor tissue.Therefore,distinguishing adenoids from tumor tissue may be required for precise and efficient chemoradiotherapy and radiotherapy.We characterized nasopharyngeal adenoids and investigated the therapeutic responses of NPC and nasopharyngeal adenoids using magnetic resonance imaging(MRI).Methods:MRI data from 40 NPC patients with a coexisting adenoid mass before and after treatment were analyzed.The features of the adenoid masses,including location,striped appearance,size,interface,symmetry/asymmetry,and cysts,were evaluated.Treatment response were scored according to the World Health Organization guidelines.Results:A striped appearance was observed in 36 cases before treatment and in all cases after treatment.In these 36 cases,the average GTVs including and excluding the uninvolved adenoids were 19.8 cm^3 and 14.8 cm^3,respectively.The average percentage change after excluding the uninvolved adenoids from the GTV was 31.0%.Stable disease in the adenoids was identified in 27(96.4%) of 28 patients after neoadjuvant chemotherapy,while NPC clearly regressed.Partial adenoid responses were identified in 33(82.5%) of 40 patients at 3 months after chemoradiotherapy or radiotherapy,whereas complete tumor responses were achieved in all patients.Six months after treatment,the adenoids continued to atrophy but did not disappear,and tumor recurrence was not found.Conclusions:Nasopharyngeal adenoids and carcinoma tissue in NPC patients can be distinguished by using MRI and have different responses to chemoradiotherapy and radiotherapy.These findings contribute to better delineating the GTV of NPC,based on which spatially optimized strategies can be developed to render precise and efficient chemoradiotherapy and radiotherapy.Additionally,we observed a clear difference in the responses of these two tissue types to current therapies.This finding may reduce or avoid unnecessary biopsies or overtreatment. | Yao-Pan Wu Pei-Qiang Cai Li Tian Jie-Hua Xu Richard Alan Mitteer Jr Yi Fan Zhenfeng Zhang | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 8 | Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay显示文摘 | Kiang-Teck J. Yeo Alan H.B. Wu Fred S. Apple Martin H. Kroll Robert H. Christenson Kent B. Lewandrowski Frank A. Sedor Anthony W. Butch | 2003 | Clinica Chimica Acta2003，，1： | 2 |
| 9 | Microstructure-based multiphysics modeling for semiconductor integration and packaging显示文摘Semiconductor technology and packaging is advancing rapidly toward system integration where the packaging is co-designed and co-manufactured along with the wafer fabrication.However,materials issues,in particular the mesoscale microstructure,have to date been excluded from the integrated product design cycle of electronic packaging due to the myriad of materials used and the complex nature of the material phenomena that require a multiphysics approach to describe.In the context of the materials genome initiative,we present an overview of a series of studies that aim to establish the linkages between the material microstructure and its responses by considering the multiple perspectives of the various multiphysics fields.The microstructure was predicted using thermodynamic calculations,sharp interface kinetic models,phase field,and phase field crystal modelingtechniques.Based on the predicted mesoscale microstructure,linear elastic mechanical analyses and electromigration simulations on the ultrafine interconnects were performed.The microstructural index extracted by a method based on singular value decomposition exhibits a monotonous decrease with an increase in the interconnect size.An artificial neural network-based fitting revealed a nonlinear relationship between the microstructure index and the average von Mises stress in the ultrafine interconnects.Future work to address the randomness of microstructure and the resulting scatter in the reliability is discussed in this study. | Zhiheng Huang Hua Xiong Zhiyong Wu Paul Conway Hugh Davies Alan Dinsdale Yunfei En Qingfeng Zeng | 2014 | Chinese Science Bulletin2014，59，15： | 2 |
| 10 | State of art control of dioxins/unintentional POPs in the secondary copper industry: A review to assist policy making with the implementation of the Stockholm Convention显示文摘Article 5 of the Stockholm Convention requires that each Party shall take measures to reduce the releases from anthropogenic sources of unintentional persistent organic pollutants(UPOPs),with the goal of their continuing minimization and,where feasible,their ultimate elimination.A major source of polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs)and other unintentional POPs releases,both in China and worldwide,is the metal industry in particular secondary metal industries such as copper smelting.More than 50%of the global secondary copper production is now in China and high levels of PCDD/Fs are released from these operations with the national inventory of China reporting a total of 1133.8 g toxic equivalents(TEQ)yr1.Consequently the Global Environment Facility(GEF)is supporting the project‘UPOPs Reduction through best available techniques and best environmental practices(BAT/BEP)in the secondary copper production sector’in China compromising>50%of the global secondary copper production.As part of this project,information on relevant UPOPs from the metal industry have been reviewed and is presented here.This information should also be useful for other(developing)countries for controlling UPOPs releases from metal industries.This review and the information it contains provides a robust resource for policy makers,the industry and researchers to improve secondary copper production to BAT/BEP standards in relation to the reduction of PCDD/Fs and other UPOPs release.The contents include the details required to assist the understanding of the formation of chlorinated UPOPs along with their brominated and brominated-chlorinated analogues.It reviews the international sources of information on BAT/BEP,including the integrated approach considered in the European BAT Reference document,and shows how this can be used to achieve an overall reduction of pollutant releases from the industry.The current national standards of PCDD/F limits to air,water and solid residues have been compiled and are also included.Challenges which need to be addressed,such as the current international lack to consider brominated and mixed bromo-chloro PXDD/Fs which might be more environmentally significant than PCDD/Fs in some facilities e are also discussed.The study includes a brief description of the steps China has taken to change the national regulatory framework and to improve the sustainability of its secondary metal industry.The Stockholm Convention BAT/BEP guidelines recommend consideration of integrated pollution prevention and control and sustainable production as general principles which parties may incorporate when applying the BAT/BEP guidelines and guidance.This holistic approach is considered in the current project and in the improvement of the pilot facilities and will also be considered in the replication of experiences in other facilities.Using this approach ensures the implementation of the Stockholm Convention can contribute to integrated pollution prevention and control,the development of a circular economy and consequently to genuinely sustainable development thus contributing to different sustainable development goals(SDGs).It is hoped this approach will be adopted in other developing and transition economies and thus help to achieve improvements of the secondary metal industry globally. | Guanglong Wu Roland Weber Yong Ren Zheng Peng Alan Watson Jiahong Xie | 2020 | Emerging Contaminants2020，6，1： | 2 |
| 11 | A rapid B-type natriuretic peptide assay accurately diagnoses left ventricular dysfunction and heart failure: A multicenter evaluation显示文摘 | Stacey J. Wieczorek Alan H.B. Wu Robert Christenson Padma Krishnaswamy Stephen Gottlieb Thomas Rosano David Hager Nancy Gardetto Albert Chiu Kathryn R. Ba illy Alan Maisel | 2002 | American Heart Journal2002，，5： | 2 |
| 12 | 高敏肌钙蛋白争论的十个要点显示文摘2000年和2007年,美国心脏病学院(American College of Cardiology,ACC)/欧洲心脏病学会(European Society of Cardiology,ESC)/美国心脏病学会基金会(American College of Cardiology Foundation,ACCF)/美国心脏协会(American Heart Association,AHA)/世界心脏联盟(World Heart Federation,WHF)等国际心脏病学术组织先后提出了对心肌梗死的重新定义,建议使用心肌肌钙蛋白(cTn)作为急性心肌梗死(acute myocardial infarction,AMI)的主要诊断指标之一,并以cTn第99百分位值及其动态变化作为主要判断标准。 | Alan WU | 2012 | 中华检验医学杂志2012，35，12： | 2 |
| 13 | Estimating impervious surface distribution by spectral mixture analysis显示文摘 | Changshan Wu Alan T. Murray | 2002 | Remote Sensing of Environment2002，，4： | 2 |
| 14 | Changes in manganese and lead in the environment and young children associated with the introduction of MMT in gasoline显示文摘 | Brian Gulson Karen Mizon Michael Korsch Honway Louie Michael Wu Jenny Stauber J. Michael Davis Alan Taylor | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 2 |
| 15 | Estimating impervious surface distribution by spectral mixture analysis显示文摘 | Changshan Wu Alan T. Murray | 2002 | Remote Sensing of Environment2002，，4： | 2 |
| 16 | Biological variation of galectin-3 and soluble ST2 for chronic heart failure: Implication on interpretation of test results显示文摘 | Alan H.B. Wu Frank Wians Allan Jaffe | 2013 | American Heart Journal2013，，6： | 1 |
| 17 | Prognostic value of cardiac troponin T in unstable angina pectoris 显示文摘 | Alan H B Wu S A Abbas S G | 1995 | Amer J Cardiol1995，76，97： | 1 |
| 18 | B-type natriuretic peptide and its clinical utility in patients with heart failure显示文摘 | Alan BY Wu HB PhD | 2001 | CE Cardiac Markers2001，10，1： | 1 |
| 19 | Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome显示文摘 | Apple FS Wu Alan HB Mair J | 2005 | Clin Chem2005，51，5： | 1 |
| 20 | Cluster Analysis of Gene Expression Data Based on Self-splitting and Merging Competitive Learning显示文摘 | Shuanhu Wu Alan Wee-Chung Liew Hong Yan | 2004 | IEEE Trans on Information Technology in Biomedicine2004，8，1： | 1 |
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