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| 1 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 2 | The role of vascular endothelial growth factor in ossification显示文摘Osteogenesis and angiogenesis are two closely correlated processes during bone growth,development,remodelling and repair. Vascular endothelial growth factor (VEGF) is an essential mediator during the process of angiogenesis. Based on an extensive literature search,which was carried out using the PubMed database and the Keywords of osteogenesis, VEGF, endochondral ossification and intramembranous ossification, this manuscript reviews the role of VEGF in ossification, with emphasis on its effect in endochondral and intramembranous ossification. Osteogenesis and angiogenesis are closely correlated processes. VEGF acts as an essential mediator during these processes. It not only functions in bone angiogenesis but also in various aspects of bone development. | Yan-Qi Yang Ying-Ying Tan Ricky Wong Alex Wenden Lin-Kun Zhang A bakr M Rabie | 2012 | International Journal of Oral Science2012，4，2： | 14 |
| 3 | Nature:揭示干细胞惊人异质性显示文摘论文作者George Daley教授说:"这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。"研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们的发育景观。随后,他们分析了每个细胞的遗传组成,观察了每个细胞多能状态的微小波动。他们发现内部、化学和环境信号影响干细胞方式的许多细微差异,揭示出了复杂的发育调控因子"决策"回路。 | Roshan M.Kumar Patrick Cahan Alex K.Shalek Rahul Satija A.Jay Daley Keyser Hu Li Jin Zhang Keith Pardee David Gennert John J.Trombetta Thomas C.Ferrante Aviv Regev George Q.Daley James J. Collins | 2014 | 岭南现代临床外科2014，14，6： | 10 |
| 4 | Sodium Stress in the Halophyte Thellungiella halophila and Transcriptional Changes in a thsos1-RNA Interference Line显示文摘The plasma membrane Na^+/H^+-antiporter salt overly sensitive1(SOS1)from the halophytic Arabidopsis-relative Thel-lungiella halophila(ThSOS1)shows conserved sequence and domain structure with the orthologous genes fromArabidopsis thaliana and other plants.When expression of ThSOS1 was reduced by RNA interference(RNAi),pronouncedcharacteristics of salt-sensitivity were observed.We were interested in monitoring altered transcriptional responsesbetween Thellungiella wild type and thsosl-4,a representative RNAi line with particular emphasis on root responses to saltstress at 350 mmol/L NaCl,a concentration that is only moderately stressful for mature wild type plants.Transcript profilingrevealed several functional categories of genes that were differently affected in wild-type and RNAi plants.Down-regulationof SOS1 resulted in different gene expression even in the absence of stress.The pattern of gene induction in the RNAi plantunder salt stress was similar to that of glycophytic Arabidopsis rather than that of wild type Thellungiella.The RNAi plantsfailed to down-regulate functions that are normally reduced in wild type Thellungiella upon stress and did not up-regulatefunctions that characterize the Thellungiella salt stress response.Metabolite changes observed in wild type Thellungiellaafter salt stress were less pronounced or absent in RNAi plants.Transcript and metabolite behavior suggested SOS1functions including but also extending its established function as a sodium transporter.The down-regulation of ThSOS1converted the halophyte Thellungiella into a salt-sensitive plant. | Dong-Ha Oh Qingqiu Gong Alex Ulanov Quan Zhang Youzhi Li Wenying Ma Dae-Jin Yun Ray A. Bressan Hans J. Bohnert | 2007 | Journal of Integrative Plant Biology2007，49，10： | 9 |
| 5 | Evaluation of the effect of air pollution control during the Beijing 2008 Olympic Games using Lidar data显示文摘To examine the effect of pollution control measures on Beijing air quality during the 2008 Olympic Games, this paper analyzes the variation of aerosol extinction coefficient observed with a Dual-wavelength Polarized Lidar in Beijing during the Olympic Games. The results show that (1) during the Beijing Olympic Games, the aerosol extinction coefficient decreased to about 42.3% in the surface layer (below 250 m) compared with that in 2007 under almost the same meteorological conditions, indicating the effectiveness of local air pollution control measures in Beijing areas; (2) the analysis of the aerosol extinction coefficient obtained before (Jul. 20–Aug. 7, 2008) and during the Beijing Olympic Games (Aug. 8–Aug. 24, 2008) shows a maximum decrease of daily aerosol extinction coefficient in layer of 0.5-1.5 km. To elucidate such a phenomenon, the transport of PM10 from surrounding areas to Beijing was simulated by NAQPMS (the Nested Air Quality Prediction Modeling System) during Jul. 20 to Aug. 24, 2008. Analysis of PM10 transport from neighboring areas indicated a decrease of 36.6% during the Olympic Games. This demonstrated the efficiency of pollution control measures in surrounding areas in improving air quality in Beijing. | YANG Ting WANG ZiFa ZHANG Bai WANG XiQuan WANG Wei GBAUIDI Alex GONG YanBang | 2010 | Chinese Science Bulletin2010，55，13： | 9 |
| 6 | Labeling of cynomolgus monkey bone marrow-derived mesenchymal stem cells for cell tracking by multimodality imaging显示文摘Recently,transplantation of allogeneic and autologous cells has been used for regenerative medicine.A critical issue is monitoring migration and homing of transplanted cells,as well as engraftment efficiency and functional capability in vivo.Monitoring of superparamagnetic iron oxide(SPIO) particles by magnetic resonance imaging(MRI) has been used in animal models and clinical settings to track labeled cells.A major limitation of MRI is that the signals do not show biological characteristics of transplanted cells in vivo.Bone marrow mesenchymal stem cells(MSCs) have been extensively investigated for their various therapeutic properties,and exhibit the potential to differentiate into cells of diverse lineages.In this study,cynomolgus monkey MSCs(cMSCs) were labeled with Molday ION Rhodamine-BTM(MIRB),a new SPIO agent,to investigate and characterize the biophysical and MRI properties of labeled cMSCs in vitro and in vivo.The results indicate that MIRB is biocompatible and useful for cMSCs labeling and cell tracking by multimodality imaging.Our method is helpful for detection of transplanted stem cells in vivo,which is required for understanding mechanisms of cell therapy. | REN ZhenHua WANG JiaYin ZOU ChunLin GUAN YunQian ZHANG Yu Alex | 2011 | Science China(Life Sciences)2011，54，11： | 9 |
| 7 | Effect of basic fibroblast growth factor on the proliferation, migration and phenotypic modulation of airway smooth muscle cells显示文摘背景:增长,细胞移行和航线平滑肌房间(ASMC ) 的表型的调整是航线在气喘改变的重要特征。在肺调整 ASMC 增长,移植和表型的调整的精确细胞、分子的机制仍然保持未知。基本成纤维细胞生长因素(bFGF ) ,为许多房间的一个高度特定的趋化性、致有丝分裂的因素打字,看起来涉及航线改变的发展。我们的学习估计了 bFGF 是否直接刺激增长,迁居和 ASMC 的表型的调整。方法:汇合并且生长逮捕了人的 ASMC 与人的 recombinant FGF 被对待。增长被 BrdU 加入并且房间数测量。移植用 Boyden 房间仪器被检验。平滑肌(sm ) 的表情 -alpha-actin 和 sm 肌浆球蛋白重链(MHC ) 对碘氧基苯甲醚 1 被 RT-PCR 和西方的污点分析决定。结果:当增加了 ASMC 时, hrbFGF (10 ng/ml ) 关于控制作为与在 ASMC 移植的控制和重要增加相比由 ASMC 在 BrdU 举起和房间数字导致了重要增加,这被发现。在与 hrbFGF 被刺激的 ASMC 的 sm-alpha-actin 和 sm-MHC 的 mRNA 和蛋白质表情关于控制减少了。结论:然而,看来, bFGF 能直接刺激 ASMC 的增长和移植房间的有收缩力的显型的表达式减少了。 | ZOU Hui NIE Xiu-hong ZHANG Yi HU Mu ZHANG Yu Alex | 2008 | Chinese Medical Journal2008，，5： | 9 |
| 8 | Long interspersed nuclear element ORF-1 protein promotes proliferation and resistance to chemotherapy in hepatocellular carcinoma显示文摘AIM:To clarify the specific roles and mechanisms of long interspersed nuclear element-1 ORF-1 protein [human long interspersed nuclear element-1(LINE-1),ORF-1p] in chemotherapeutic drug resistance and cell proliferation regulation in hepatocellular carcinoma(HCC) cells.METHODS:MTT assays were performed to identify the effect of the chemotherapeutic drug toxicity on HepG2 cells.Cell proliferation inhibition and the IC 50 were calculated by the Origin 8.0 software.Western blotting assays were performed to investigate whether LINE-1 ORF-1p modulates the expression of some important genes,including p53,p27,p15,Bcl-2,mdr,and p-gp.To corroborate the proliferation and anchor-independent growth results,the HepG2 cells were analyzed by flow cytometry to investigate the effect of LINE-1 ORF1p on the apoptosis regulation.RESULTS:LINE-1 ORF-1p contributed to the resistance to several chemotherapeutic drugs(cisplatin and epirubicin) in HepG2 cells.The IC 50 of the epirubicin and cisplatin increased from 36.04 nmol/L to 59.11 nmol/L or from 37.94 nmol/L to 119.32 nmol/L.Repression of LINE-1 ORF-1p expression by the siRNA could markedly enhance the response of HepG2 cells to the epirubicin and cisplatin.The IC 50 correspondingly decreased from 28.06 nmol/L to 3.83 nmol/L or from 32.04 nmol/L to 2.89 nmol/L.Interestingly,down-regulation of LINE-1 ORF-1p level by siRNA could promote the response of HepG2 cells to the paclitaxel.The IC 50 decreased from 35.90 nmol/L to 7.36 nmol/L.However,overexpression of LINE-1 ORF-1p did not modulate the paclitaxel toxicity in HepG2 cells.Further Western blotting revealed that LINE-1 ORF-1p enhanced mdr and p-gp gene expression.As a protein arrested in the nucleus,LINE-1 ORF-1p may function through modulating transcriptional activity of some important transcription factors.Indeed,LINE-1 ORF-1p promoted HepG2 cell proliferation,anchor-independent growth and protected the cells against apoptosis through modulating the expression of p15,p21,p53,and Bcl-2 genes.CONCLUSION:LINE-1 ORF-1p promotes HepG2 cell proliferation and plays an important role in the resistance of chemotherapeutic drugs.By establishing novel roles and defining the mechanisms of LINE-1 ORF1p in HCC chemotherapeutic drug resistance and cell proliferation regulation,this study indicates that LINE-1 ORF-1p is a potential target for overcoming HCC chemotherapeutic resistance. | Fan Feng Yin-Ying Lu Fan Zhang Xu-Dong Gao Chuan-Fu Zhang Alex Meredith Zhong-Xian Xu Yu-Tao Yang Xiu-Juan Chang Hong Wang Jian-Hui Qu Zhen Zeng Jun-Lan Yang Chun-Ping Wang Yun-Feng Zhu Jia-Jun Cui Yong-Ping Yang | 2013 | World Journal of Gastroenterology2013，19，7： | 8 |
| 9 | Healing time of incision infection after hepatobiliary surgery treated by needle-free incision suture closure显示文摘AIM:To compare the effectiveness of needle-free incision suture closure with butterfly tape and traditional secondary suturing techniques in treating incision infection.METHODS:Two hundred and twenty-three patients with incision infection following hepatobiliary surgery at a tertiary hospital were randomly divided into three groups:90 patients were closed by needle-free incision suture closure,which gradually closed the incision wound when drainage from incision infection was visibly decreased and healthy granulation tissues had grown;79 patients were closed by butterfly bandage;another 54 patients were closed by traditional secondary suturing technique.Healing time of incision infection was calculated from the beginning of dressing change to the healing of the incision.RESULTS:Healing time in the needle-free incision suture closure group(24.2±7.2 d)was significantly shorter than that in the butterfly bandage group(33.3±11.2 d)and the traditional secondary suturing group(36.2±15.3 d)(P<0.05).Healing time in the butterfly bandage group appeared to be slightly shorter than that in the secondary suture group,but the difference was not statistically significant(P>0.05).CONCLUSION:Needle-free incision suture closure could gradually close the infection wound at the same time of drainage and dressing change,thereby shortening the healing time. | Wen-Jie Ma Yong Zhou Hui Mao Rui-Hua Xu Anuj Shrestha Fu-Yu Li Alex Lorance Qin Yang Yong-Qiong Zhang Ting Jiang Huan Feng Wei Zhang Nan-Sheng Cheng | 2014 | World Journal of Gastroenterology2014，20，42： | 8 |
| 10 | One-step Crystallization Kinetic Parameters of the Glass-ceramics Prepared from Stainless Steel Slag and Pickling Sludge显示文摘One-step crystallization is one of the most energy conserving methods for glass-ceramics preparation.However,only a few kinetics studies focused on the glass-ceramics prepared by the one-step crystallization.The onestep crystallization kinetic parameters were studied using differential scanning calorimetry.The activation energy(Ea)and the Avrami parameter(n)were calculated as 152.79kJ·mol-1 and 4.39,respectively.These parameters indicate that continuous nucleation and three-dimensional crystal growth are the dominating mechanisms in the one-step crystallization process of the parent glass.The properties of the obtained glass-ceramics can be compared to the glass-ceramics prepared by the two-stage heat treatment and sintering method.This crystallization kinetics research can be used to evaluate the one-step crystallization potential of a parent glass. | Shen-gen ZHANG Jian YANG Bo LIU De-an PAN Chun-li WU Alex A.VOLINSKY | 2016 | Journal of Iron and Steel Research(International)2016，23，3： | 7 |
| 11 | Treatment method of hazardous pickling sludge by reusing as glass–ceramics nucleation agent显示文摘Heavy metal containing pickling sludge(PS) is one of the by-products of the stainless-steel-making industry,which has been considered hazardous due to contained chromium and nickel.Traditional methods of PS disposing are landfill and cement solidification.This research is aimed at disposing PS by solidification/stabilization and reusing it as a nucleation agent of glass–ceramics.The crystallization behavior and the properties of a glass in the CaO–MgO–SiO_2–Al_2O_3 system were studied by considering PS as the nucleation agent.Experimental results confirm that introducing 14 wt% PS as the nucleation agent of glass–ceramics can decrease crystallization temperature by 110.8 °C,refine the grain size by forming isometric crystals with size of 2 lm,enhance Vickers hardness by 2690 MPa and decrease water absorption from(1.21 ± 0.10) wt% to(0.04 ± 0.01) wt%.Therefore,it is reasonable to conclude that PS can be utilized as a nucleation agent to improve the crystallization and mechanical properties of the glass–ceramics.The testing results of US EPA toxicity characteristic leaching procedure(TCLP)confirm the safety of this reusing method. | Jian Yang Shen-Gen Zhang De-An Pan Bo Liu Chun-Li Wu Alex A.Volinsky | 2016 | Rare Metals2016，35，3： | 6 |
| 12 | High-performance hot-warm rolled Zn-0.8Li alloy with nano-sized metastable precipitates and sub-micron grains for biodegradable stents显示文摘Fabricated through a newly developed hot-warm rolling process,Zn-0.8 Li(wt%)alloy has ideal strength and ductility far beyond the mechanical benchmark of materials for biodegradable stents.Precipitation of needle-like Zn in primary p-LiZn4 phase is observed in Zn-Li alloy for the first time.Orientation relationship between them can be described as[1-213]β//[2-1-10](Zn),(10-10)βabout 4.5°from(0002)(Zn).Zn grains with an average size of 640 nm exhibit strong basal texture,detected by transmission electron back-scatter diffraction.Li distribution is determined by three-dimensional atom probe,which reveals the formation of nano-sized metastableα-Li2Zn3 precipitates with a number density of 7.16×10^22 m^-3.The fine lamellar Zn+β-LiZn4 structure,sub-micron grains and the nano-sized precipitates contribute to the superior mechanical properties. | Zhen Li Zhang-Zhi Shi Yuan Hao Hua-Fang Li Xue-Feng Liu Alex AVolinsky Hai-Jun Zhang Lu-Ning Wang | 2019 | Journal of Materials Science & Technology2019，35，11： | 6 |
| 13 | Initial formation of corrosion products on pure zinc in saline solution显示文摘Corrosion product formed on zinc sample during 2 weeks immersion in saline solution has been investigated.The corrosion layer morphology as well as its chemical composition,was analyzed using scanning electron microscopy(SEM),x-ray diffraction(XRD),x-ray photoelectron spectroscopy(XPS)and Fourier transform infrared spectroscopy(FTIR).Electrochemical measurement was used to analyze the corrosion behavior.Zinc oxide,zinc hydroxide and zinc hydroxide chloride were formed on zinc surface in saline solution.The thickness of corrosion layer increased with the time increased.The pure Zn has an estimated corrosion rate of 0.063mmy^−1 after immersion for 336 h.Probable mechanisms of zinc corrosion products formation are presented. | Yao Meng Lijun Liu Dawei Zhang Chaofang Dong Yu Yan Alex A.Volinsky Lu-Ning Wang | 2019 | Bioactive Materials2019，4，1： | 5 |
| 14 | Recycle of valuable products from oily cold rolling mill sludge显示文摘Oily cold rolling mill(CRM)sludge contains lots of iron and alloying elements along with plenty of hazardous organic components,which makes it as an attractive secondary source and an environmental contaminant at the same time.The compound methods of'vacuum distillation+oxidizing roasting'and'vacuum distillation+hydrogen reduction'were employed for the recycle of oily cold rolling mill sludge.First,the sludge was dynamically vacuum distilled in a rotating furnace at 50 r/min and 600 C for 3 h,which removed almost hazardous organic components,obtaining 89.2wt%ferrous resultant.Then,high purity ferric oxide powders(99.2wt%)and reduced iron powders(98.9wt%)were obtained when the distillation residues were oxidized and reduced,respectively.The distillation oil can be used for fuel or chemical feedstock,and the distillation gases can be collected and reused as a fuel. | Bo Liu Shen-gen Zhang Jian-jun Tian De-an Pan Yang Liu Alex A.Volinsky | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，10： | 5 |
| 15 | Cardioprotective mechanisms of salvianic acid A sodium in rats with myocardial infarction based on proteome and transcriptome analysis显示文摘Ischemic heart diseases(IHDs)cause great morbidity and mortality worldwide,necessitating effective treatment.Salvianic acid A sodium(SAAS)is an active compound derived from the well-known herbal medicine Danshen,which has been widely used for clinical treatment of cardiovascular diseases in China.This study aimed to confirm the cardioprotective effects of SAAS in rats with myocardial infarction and to investigate the underlying molecular mechanisms based on proteome and transcriptome profiling of myocardial tissue.The results showed that SAAS effectively protected against myocardial injury and improved cardiac function.The differentially expressed proteins and genes included important structural molecules,receptors,transcription factors,and cofactors.Functional enrichment analysis indicated that SAAS participated in the regulation of actin cytoskeleton,phagosome,focal adhesion,tight junction,apoptosis,MAPK signaling,and Wnt signaling pathways,which are closely related to cardiovascular diseases.SAAS may exert its cardioprotective effect by targeting multiple pathways at both the proteome and transcriptome levels.This study has provided not only new insights into the pathogenesis of myocardial infarction but also a road map of the cardioprotective molecular mechanisms of SAAS,which may provide pharmacological evidence to aid in its clinical application. | Dan Jia Cheng-zhong Zhang Yan Qiu Xiao-fei Chen Lin Jia Alex F.Chen Yi-feng Chai Zhen-yu Zhu Jin Huang Chuan Zhang | 2019 | Acta Pharmacologica Sinica2019，40，12： | 4 |
| 16 | Characterization of the Hot Deformation Behavior of Cu–Cr–Zr Alloy by Processing Maps显示文摘Hot deformation behavior of the Cu–Cr–Zr alloy was investigated using hot compressive tests in the temperature range of 650–850 °C and strain rate range of 0.001–10 s-1. The constitutive equation of the alloy based on the hyperbolic-sine equation was established to characterize the flow stress as a function of strain rate and deformation temperature. The critical conditions for the occurrence of dynamic recrystallization were determined based on the alloy strain hardening rate curves. Based on the dynamic material model, the processing maps at the strains of 0.3, 0.4 and 0.5were obtained. When the true strain was 0.5, greater power dissipation efficiency was observed at 800–850 °C and under0.001–0.1 s-1, with the peak efficiency of 47%. The evolution of DRX microstructure strongly depends on the deformation temperature and the strain rate. Based on the processing maps and microstructure evolution, the optimal hot working conditions for the Cu–Cr–Zr alloy are in the temperature range of 800–850 °C and the strain rate range of 0.001–0.1 s-1. | Yi Zhang Hui-Li Sun Alex A.Volinsky Bao-Hong Tian Zhe Chai Ping Liu Yong Liu | 2016 | Acta Metallurgica Sinica(English Letters)2016，29，5： | 3 |
| 17 | Single atom and defect engineering of CuO for efficient electrochemical reduction of CO_(2) to C_(2)H_(4)显示文摘Electrochemical CO_(2) transformation to high‐value ethylene(C_(2)H_(4))at high currents and efficiencies is desired and yet remains a grand challenge.We show for the first time that coupling single Sb atoms and oxygen vacancies of CuO enable synergistic electrocatalytic reduction of CO_(2) to C_(2)H_(4) at low overpotentials.Highly dispersed Sb atoms occupying metal substitutional sites of CuO are synthesized under mild conditions.The overall CO_(2) reduction faradaic efficiency(FE)reaches 89.3±1.1%with an FE toward C_(2)H_(4) exceeding 58.4%at a high‐current density of 500 mA/cm^(2).Addition of the p‐block metal is found to induce transformation of CuO from flakes to nanoribbons rich in nanoholes and oxygen vacancies,greatly enhancing CO_(2) adsorption and activation while suppressing hydrogen evolution.Further density functional theory calculations with in situ X‐ray diffraction reveal that combining Sb sites and oxygen vacancies prominently lessen the dimerization energy of adsorbed CO intermediate,thus boosting the conversion of CO_(2) to produce C_(2)H_(4).This study provides a new perspective for promoting selective C-C coupling for electrochemical CO_(2) reduction. | Senlin Chu Changwoo Kang Woonghyeon Park Yu Han Song Hong Leiduan Hao Hao Zhang Tsz Woon Benedict Lo Alex W.Robertson Yousung Jung Buxing Han Zhenyu Sun | 2022 | SmartMat2022，3，1： | 3 |
| 18 | Penile prosthesis implantation in Chinese patients wit severe erectile dysfunction: 10-year experience显示文摘我们回顾地与严重可勃起的机能障碍(SED ) 在中国病人评估了阴茎修复术培植(PPI ) 的临床的结果。从 2000 年 7 月到 2011 年 12 月, 224 个病人(吝啬的年龄:35.9 ± 11.8 年,变化:20-75 年) 在我们的中心根据标准 PPI 过程由富有经验的外科医生与 SED 经历了 PPI。韧性的修复术(AMS 650 ) 在 45 种情况中被植入(20.1 %) ,并且三片的可膨胀的修复术(AMS 700 CXM 或 AMS 700 CXR ) 在 179 种情况中被植入(79.9 %) 。包括手术后的复杂并发症,临床的功效和夫妇满足,外科的结果被评估在上比手术后地使用医药记录抽象的 6 个月, IIEF-5,生活(QoL ) 的质量分数,和病人 / 搭挡的性满足分数由 Bhojwani 等求婚了。为学习合格的 224 个病人, 201 使遭到(89.7 %) 完成的后续。所有能与吝啬的手术后的 IIEF-5 病人执行性交柱子 PPI, QoL 分数是 20.02 ± 2.32 和 5.28 ± 0.76,分别地它显著地与外科手术前的分数相比被改进(6.29 ± 1.5 和 2.13 ± 0.84, P< 0.01 ) 。201 个人,机械失灵发生在四种情况中(2.0 %) 并且三个盒子被重新植入新设备,和二个盒子(1.0 %) 开发了阴茎的温和弯曲。有感染的阴囊的侵蚀与糖尿病 mellitus 发生在一种情况中(0.5 %) 并且植入的 AMS 的要求的完全的移动 700 CXM。令人满意的性交被 178 个人两次至少每月报导(88.6 %) ,并且对 PPI 外科的全面满足被 89.0 % 报导;人和 82.5 %搭挡。在三片的可膨胀的修复术组的耐心的满足比在韧性的修复术组高(P< 0.05 ) 。然而,在 prostheses 的类型之间,满足没在搭挡调查不同。PPI 是一种安全、有效的治疗选择因为有 SED 和富有经验的外科医生的中国病人根据标准 PPI 执行 PPI 过程能减少 PPI 的手术后的复杂并发症并且能改进耐心的满足比率和 QoL。 | Wei-Dong Song Yi-Ming Yuan Wan-Shou Cui Alex K Wu Yi-Chen Zhu Jing Liu Lin Wang Guang-Yi Ba Jing Peng Zhi-Chao Zhang Bing Gao Ying-Lu Guo Tom F Lue Zhong-Cheng Xin | 2013 | Asian Journal of Andrology2013，15，5： | 3 |
| 19 | Tunica albuginea allograft: a new model of LaPeyronie's disease with penile curvature and subtunical ossification显示文摘LaPeyronie 的疾病(PD ) 的 pathophysiology 被认为是 multifactorial,包含愈合的基因倾向,损伤,发炎和改变的创伤。然而,这些因素还没用动物模型被验证了。在这研究,我们介绍了 tunica albuginea allograft 获得的一个新模型。40 的一个总数, 16-week-old 男性老鼠被使用。这些, 8 只老鼠用作控制并且经历了 10 ×有随后的 autografting 的 2-mm-wide tunical 切除,而留下 32 与另一只老鼠的 tunica 与缺点的 grafting 经历了一样的切除。词法、功能测试在 grafting 以后在 1, 3, 7 和 12 个星期被执行。Intracavernous 压力,阴茎弯曲的度和有弹性的纤维长度为在 allograft 和控制组之间的比较被评估。纸巾为组织学的检查被获得。阴茎弯曲作为与控制老鼠相比在 allografted 老鼠是显著地更大的。可勃起的功能在所有老鼠被维持,除了在在 12 个星期估计的那些。弹力素纤维长度作为与控制相比在 allografted tunica 被减少。SMAD2 表示在 allograft 的内部部分被检测,并且 collagen-II- 和 osteocalcin 积极的房间也被注意。在老鼠的 Tunica albuginea (TA ) allograft 是 PD 的一个优秀模型。在 12 个星期和在 TA 的内部层的骨化的存在以后的弯曲的坚持类似于与 PD 在人观察的那些。用这个动物模型的确认研究将为有效治疗学的干预帮助 PD pathophysiology 的理解。 | Ludovic Ferretti Thomas M Fandel Xuefeng Qiu Haiyang Zhang Hazem Orabi Alex K Wu Lia Banie Guifang Wang Guiting Lin Ching-Shwun Lin Tom FLue | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 20 | Soil Properties and Plant Growth Response to Litter in a Prolonged Enclosed Grassland of Loess Plateau, China显示文摘The enclosure and ungrazing practices for grassland management result in accumulation of plant litter on soil surface thus affecting the available soil water and nutrients for plant production. We experimentally investigated the effects of litter on soil properties and plant growth in a prolonged enclosure grassland of Loess Plateau, China. Three different litter manipulations were conducted including removal of all litter, an untreated in-situ control with original litter levels, and a double litter treatment. Litter treatment experiments demonstrated that plant litter affected the superficial soil water. Soil water content in plots with in-situ or double litter is generally higher than that with litter removal. The depletion of soil water up to five days post rainfall is fastest in litter removal plots for the top soil, but no evident difference for the deep ones. Different litter treatments have no significant impact on soil total carbon, nitrogen as well as carbon/nitrogen ratio for consecutive two years experiments. Both above-and below-ground biomasses in plots of litter removal were less than those in the plots of in-situ and double litter treatment. Litter affects plant production mainly through the mechanical barrier regulating root zone soil moisture. Therefore, prolonged litter manipulation experiments are desirable to understand the long-term response of plant growth on litter from nutrient aspect. | Yunwu Xiong Bing Yu Mengting Bai Xueyang Zhang Guanhua Huang Alex Furman | 2019 | Journal of Earth Science2019，30，5： | 2 |
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