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| 1 | 【原创论文】同侧和对侧大鼠睾丸缺血再灌注损伤的生化效应和褪黑激素对此的保护作用显示文摘睾丸扭转(TT),是一个多发于青春期男性的泌尿急症,如果不及时治疗,可致不孕不育。睾丸扭转所致缺血再灌注(I/R)损伤在睾丸损伤的病理生理过程中起一定作用。我们研究了褪黑激素在单侧睾丸扭转大鼠中同侧和对侧睾丸的氧化损伤效应:将21只青春期雄性Wistar大鼠分成三组,每组七只,处理如下:第1组(假手术组):行左睾丸和双边睾丸假切除术;第2组(I/R组):通过以下方式诱发缺血再灌注损伤(顺时针720°旋转左侧睾丸2小时,2小时后复位):第3组(I/R+MEL组):大鼠经诱导缺血再灌注损伤和一次性褪黑激素注射(50mgkg-1,i.p)。处理后离体分离各组大鼠双侧睾丸,用于检测睾丸组织中抗氧化过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶的活性,丙二醛、蛋白质羰基和一氧化氮的组织水平。较对照组,褪黑激素注射组同侧睾丸的脂质过氧化水平,相关酶活性降低,具有显著性(P〈0.05),而在对侧的睾丸中相关酶活性变化无统计学意义(P〉0.05)。在对侧睾丸中,丙二醛水平改变具有明显统计学意义(P=0.009)。应用褪黑素能减轻老鼠同侧睾丸扭转所致缺血再灌注损伤的不利影响,而对于对侧睾丸,睾丸扭转影响不大。 | Bekir S Parlaktas Dogan Atilgan Huseyin Ozyurt Yusuf Gencten Ali Akbas Fikret Erdemir Nihat Uluocak | 2014 | Asian Journal of Andrology2014，16，2： | 10 |
| 2 | Diagnosis and treatment of gallbladder perforation显示文摘AIM: To present our clinical experience with gallbladder perforation cases. METHODS: Records of 332 patients who received medical and/or surgical treatment with the diagnosis of acute cholecystitis in our clinic between 1997 and 2006 were reviewed retrospectively. Sixteen (4.8%) of those patients had gallbladder perforation. The parameters including age, gender, time from the onset of symptoms to the time of surgery, diagnostic procedures, surgical treatment, morbidity, and mortality were evaluated. RESULTS: Seven patients had typeⅠgallbladder perforation, 7 type Ⅱ gallbladder perforation, and 2 type Ⅲ gallbladder perforation according to Niemeier’ s classification. The patients underwent surgery after administration of intravenous electrolyte solutions, and were treated with analgesics and antibiotics within the first 36 h (mean 9 h) after admission. Two patients died of sepsis and multiple organ failure in the early postoperative period. Subhepatic abscess, pelvic abscess, pneumonia, pancreatitis, and acute renal failure were found in 6 patients. CONCLUSION: Early diagnosis and emergency surgical treatment of gallbladder perforation are of crucial importance. Upper abdominal computerized tomography for acute cholecystitis patients may contribute to the preoperative diagnosis of gallbladder perforation. | Hayrullah Derici Cemal Kara Ali Dogan Bozdag Okay Nazli Tugrul Tansug Esra Akca | 2006 | World Journal of Gastroenterology2006，12，48： | 9 |
| 3 | Association of inflammation with atrial fibrillation in hyperthyroidism显示文摘The aim of this studywas to evaluate the relationship between inflammation and development of atrial fibrillation (AF) in patients with hyperthyroidism.Methods A total of 65 patients with newly diagnosed hyperthyroidism, 35 of whom were in sinus rhythm and 30 of whom in AF. Thirty five age- and gender-matched patients in a control group were included in the study. Factors associated with the development of AF were evaluated by multivariate regression analysis. Results Factors associated with AF in multivariate analysis included high sensitivity C reactive protein (HsCRP) [odds ratio (OR): 11.19; 95% confidence interval (95% CI): 1.80–69.53; P = 0.003],free T4 (OR: 8.76; 95% CI: 2.09–36.7; P = 0.003), and left atrial diameter (OR: 1.25; 95% CI: 1.06–1.47; P = 0.008). Conclusions The results of the present study suggest that HsCRP, an indicator of inflammation, free T4 and left atrial diameter are associated with the development AF in patients with hyperthyroidism. | Mehmet Ozaydin Ali Kutlucan Yasin Turker Banu Koroglu Akif Arslan Bayram A. Uysal Dogan Erdogan Ercan Varol Abdullah Dogan | 2012 | Journal of Geriatric Cardiology2012，9，4： | 3 |
| 4 | Intraperitoneal dedifferentiated liposarcoma:A case report显示文摘Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. Mutations of the p53 gene have been found in different types of soft tissue sarcoma. It is generally accepted that p53 mutations in human malignant tumors are often related to a poor prognosis. In our case, analysis of p53 gene mutation in tumor samples was performed. p53 gene mutation was observed in dedifferentiated tumor tissue samples but not in well-differentiated tumor tissue samples. It has been reported that p53 gene mutation occurs most commonly in the retroperitoneum and rarely in other anatomic locations. Herein we report a case of dedifferentiated liposarcoma located at intraperitoneum. | Ali Karaman Mehmet Esref Kabalar nder zcan Timur Koca Dogan Nasir Binici | 2008 | World Journal of Gastroenterology2008，14，38： | 3 |
| 5 | Clinical evaluation of submucosal colonic lipomas: Decision making显示文摘甚至脂肪瘤是胃肠道的最普通的间充质的良性瘤,征兆的结肠的表示是稀罕的。此处,我们评估了受不了结肠的脂肪瘤的各种各样的尺寸的四个病人并且由不同治疗学的形式来临了。 | Oge Tascilar Güldeniz Karadeniz Cakmak Banu Dogan Gün Bülent Hamdi U(?)an Hakan Balbaloglu Ali Cesur Ali Ugur Emre Mustafa Comert Lütfü Oktay Erdem Selim Aydemir | 2006 | World Journal of Gastroenterology2006，12，31： | 2 |
| 6 | Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps显示文摘AIM:To determine,by counting micronucleus (MN) frequencies,whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS:We analyzed MN frequencies in 21 patients with CRC,24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. RESULTS:MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 ± 1.34,3.58 ± 1.21 vs 1.97 ± 0.81,P < 0.001). However,there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly,there was no difference in the MN frequency between NNP patients (2.06 ± 0.85) and controls (P > 0.05). CONCLUSION:Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC. | Ali Karaman Dogan Nas■r Binici Mehmet E■ref Kabalar Züleyha ■al■ku■u | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 7 | Platelet activation and inflammatory response in patients with non-dipper hypertension显示文摘 | Mehmet Gungor Kaya Mikail Yarlioglues Ozgur Gunebakmaz Ertugrul Gunturk Tugrul Inanc Ali Dogan Nihat Kalay Ramazan Topsakal | 2009 | Atherosclerosis2009，，1： | 2 |
| 8 | Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals显示文摘AIM: To investigate the oxidative-stress-related changes in rats with portal hypertension with particular emphasis on nitric oxide (NO) and trace metals. METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity assay.SOD activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase used asa superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under light microscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P<0.05 was considered statistically significant.RESULTS: Histopathological studies confirmed PVL induced cirrhotic changes. There was a statistically significant difference in portal pressure between PVL and control groups (P<0.001). The results showed significant increases in the levels of MDA and NO in both tissue and serum (P<0.05 and P<0.001, respectively in tissue; P<0.001 for each in serum), and Zn only in tissue (P<0.001)in rats with PVL compared with sham-operated rats. Besides, PVL rats exhibited reduced plasma and tissue GSH, CAT, SOD (P<0.001 for each). Serum and tissue Cu concentration did not change.CONCLUSION: Our findings suggest that PVL in rats induces important biochemical and molecular changes related to oxidative stress in the liver. | Titiz Izzet Krand Osman Unal Ethem Yavuz Nihat Kusaslan Ramazan Dogan Mustafa Uzun Hafize Kiziler Ali Riza Aydemir Birsen Genc Habibe Aydin Seval Simsek Gonul | 2005 | World Journal of Gastroenterology2005，11，23： | 1 |
| 9 | Color Doppler Imaging of Ocular Hemodynamic Changes in Beh?et Disease and Uveitis Patients with Different Etiologies显示文摘 | Ayse Oner Ali Akal Nuri Erdogan Hakki Dogan Mithat Oner | 2006 | Current Eye Research2006，，6： | 1 |
| 10 | Iloprost inhibits fracture repair in rats显示文摘 | Ali Dogan Fatih Duygun A. Murat Kalender Irfan Bayram Ibrahim Sungur | 2014 | Chinese Medical Journal2014，，16： | 1 |
| 11 | The Effect of Helicobacter pylori on Insulin Resistance显示文摘 | Selim Aydemir MD Taner Bayraktaroglu MD Mehmet Sert MD Coskun Sokmen MD Hulusi Atmaca MD Gorkem Mungan MD Banu Dogan Gun MD Ali Borazan MD Yucel Ustundag MD | 2005 | Digestive Diseases and Sciences2005，，11： | 1 |
| 12 | The Effect of Helicobacter pylori on Insulin Resistance显示文摘 | Selim Aydemir MD Taner Bayraktaroglu MD Mehmet Sert MD Coskun Sokmen MD Hulusi Atmaca MD Gorkem Mungan MD Banu Dogan Gun MD Ali Borazan MD Yucel Ustundag MD | 2005 | Digestive Diseases and Sciences2005，，11： | 1 |
| 13 | Is laparoscopic appendectomy going to be standard procedure for acute appendicitis; a 5-year single center experience with 1,788 patients显示文摘 | M. A. Bozkurt M. G. Unsal S. Kapan M. Gonenc M. Dogan M. U. Kalayci H. Alis | 2015 | European Journal of Trauma and Emergency Surgery2015，，： | 1 |
| 14 | Decreased plasma concentrations of adiponectin in patients with slow coronary flow显示文摘 | Hatice Selcuk Mehmet Timur Selcuk Ahmet Temizhan Orhan Maden Gul Sevim Saydam Hakan Ulupinar Mehmet Dogan Cengiz Ayd?n Deniz I. Topcu Ali Sasmaz | 2009 | Heart and Vessels2009，，1： | 1 |
| 15 | Enhanced postoperative recovery pathways in emergency surgery: a randomised controlled clinical trial显示文摘 | Murat Gonenc Ahmet Cem Dural Ferhat Celik Cevher Akarsu Ali Kocatas Mustafa Uygar Kalayci Yasar Dogan Halil Alis | 2014 | The American Journal of Surgery2014，，6： | 1 |
| 16 | Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H pylori infection显示文摘AIM: To determine, by counting sister chromatid exchange (SCE) frequencies, whether genetic impairment and DNA damage have an effect on the pathogenesis of gastric cancer (GC). METHODS: Analysis of SCE is a cytogenetic technique used to show DNA damage as a result of an exchange of DNA fragments between sister chromatids. We analyzed SCE frequency in 24 patients with GC, 26 patients with chronic atrophic gastritis (CAG), and 15 normal controls. The presence of H pylori was confirmed by urease test, toluidine-blue stain and hematoxylin-eosin stain. RESULTS: SCE was significantly increased in H pylori- negative GC patients, and in H pylori-negative CAG patients compared with controls (7.41 ± 1.36 and 6.92 ± 1.20, respectively, vs 5.54 ± 0.8, P < 0.001). There was no difference in the SCE frequency between H pylori- negative GC patients and H pylori-negative CAG patients (P > 0.05). On other hand, the SCE frequencies in H pylori-positive GC patients were higher than those in H pylori-positive CAG patients (9.20 ± 0.94 vs 7.93 ± 0.81, P < 0.01). Furthermore, H pylori-positive GC patients had a higher SCE frequency than H pylori- negative GC patients (9.20 ± 0.94 vs 7.41 ± 1.36, P < 0.001). Similarly, a significant difference was detected between H pylori-positive CAG patients and H pylori-negative CAG patients (7.93 ± 0.81 vs 6.92 ± 1.20, P < 0.05). CONCLUSION: We suggest the increased SCE in patients reflects a genomic instability that may be operative in gastric carcinogenesis. | Ali Karaman Dogan Nasir Binici Mehmet Esref Kabalar Hakan Dursun Ali Kurt | 2008 | World Journal of Gastroenterology2008，14，16： | 1 |
| 17 | The Effect of Helicobacter pylori on Insulin Resistance显示文摘 | Selim Aydemir MD Taner Bayraktaroglu MD Mehmet Sert MD Coskun Sokmen MD Hulusi Atmaca MD Gorkem Mungan MD Banu Dogan Gun MD Ali Borazan MD Yucel Ustundag MD | 2005 | Digestive Diseases and Sciences2005，，11： | 1 |
| 18 | Factors Affecting Complication Rates of Percutaneous Nephrolithotomy in Children: Results of a Multi-Institutional Retrospective Analysis by the Turkish Pediatric Urology Society显示文摘 | Bülent ?nal Hasan Serkan Dogan Nihat Satar Cenk Y. Bilen Ali Güne? Ender ?zden Ahmet Ozturk Deniz Demirci Okan ?stanbulluo?lu Serhat Gurocak Oktay Nazli Orhan Tanriverdi Aykut Kefi Esat Korgali Mesrur Selcuk Silay Kubilay Inci Volkan ?zol Ramazan Altintas | 2014 | The Journal of Urology2014，，3： | 1 |
| 19 | The role of nanoparticle geometry in flame retardancy of polylactide nanocomposites containing aluminium phosphinate显示文摘 | Nihat Ali Isitman Mehmet Dogan Erdal Bayramli Cevdet Kaynak | 2012 | Polymer Degradation and Stability2012，，8： | 1 |
| 20 | Does previous open nephrolithotomy affect the outcomes and complications of percutaneous nephrolithotomy in children?显示文摘 | Bulent Onal Fetullah Gevher Burak Argun Cagatay Dogan Sinharib Citgez Ali Ulvi Onder Ahmet Erozenci | 2013 | Journal of Pediatric Urology2013，，： | 1 |
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