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| 1 | Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases显示文摘Azoreductases are involved in the bioremediation by bacteria of azo dyes found in waste water.In the gut flora,they activate azo pro-drugs,which are used for treatment of inflammatory bowel disease,releasing the active component 5-aminosalycilic acid.The bacterium P.aeruginosa has three azoreductase genes,paAzoR1,paAzoR2 and paAzoR3,which as recombinant enzymes have been shown to have different substrate specificities.The mechanism of azoreduction relies upon tautomerisation of the substrate to the hydrazone form.We report here the characterization of the P.aeruginosa azoreductase enzymes,including determining their thermostability,cofactor preference and kinetic constants against a range of their favoured substrates.The expression levels of these enzymes during growth of P.aeruginosa are altered by the presence of azo substrates.It is shown that enzymes that were originally described as azoreductases,are likely to act as NADH quinone oxidoreductases.The low sequence identities observed among NAD(P)H quinone oxidoreductase and azoreductase enzymes suggests convergent evolution. | Ali Ryan Chan-Ju Wang Nicola Laurieri Isaac Westwood Edith Sim | 2010 | Protein & Cell2010，1，8： | 4 |
| 2 | 显示文摘 | Aliénard Rebouillat J P Ryan D H | 1988 | Appl Phys F: Met Phys1988，18，： | 1 |
| 3 | Efficacy and safety of non-vitamin K antagonist oral anticoagulants post-kidney transplantation显示文摘BACKGROUND Novel oral anticoagulants(NOACs)were developed as alternatives to vitamin K antagonists,primarily warfarin,as they do not require routine monitoring and have limited drug-drug and drug-food interactions.However,the efficacy and safety of these agents in kidney transplantation are not well studied.AIM To assess the profile and safety of NOACs for patients who had kidney transplantation,and to provide recommendations and guidelines on therapeutic strategies in these patients.METHODS This was a retrospective study carried out among adult patients who were actively on the following NOACs(apixaban,rivaroxaban or dabigatran)in our renal transplantation program from December 2015 to December 2016.The patients were identified primarily through electronic medical record system(patient data linkage).Data on the clinical and laboratory profile of the patients were retrieved and analyzed with SPSS 22.0.RESULTS Complete data on 42 renal transplant patients were retrieved:59.5%males,90.5%were whites and 66.7%were older than 60 years old.The mean duration since renal transplantation of the patients was 8.8±7.4 years.The most common risk factors for the development of end-stage renal disease in the subjects were hypertension(19.0%),polycystic kidney disease(19.0%),followed by diabetic nephropathy(16.7%)and chronic glomerulonephritis(16.7%).The main indications for NOACs use in the cohort were atrial fibrillation in 25 patients(59.5%)and venous thromboembolism in 10 patients(23.8%).Overall,29 patients(69%)were treated with apixaban,10 patients(23.8%)with rivaroxaban and 3 patients(7.14%)with dabigatran.No(0%)thromboembolic events were observed during the one-year period,but 3(7.1%)bleeding events occurred in the cohort consisting of 1 patient treated with rivaroxaban 15 mg daily and 2 patients who received apixaban 2.5 mg twice daily.There were no significant changes in serum tacrolimus level three days after the initiation of NOACs among patients treated with tacrolimus(pre-and post-NOACs tacrolimus levels were 7.2516 and 7.8867 ng/m L,P=0.55,respectively).Also,after one-year of treatment with NOACs there were no significant changes in the pre-and post-NOACs serum creatinine level(P=0.772)and estimated glomerular filtration rates(P=0.232).CONCLUSION No thromboembolic events or significant changes in renal profile were observed in our cohort of kidney transplant recipients who were treated with NOACs for at least a year.However,a few bleeding events were observed.This calls for further well-planned randomized controlled trials to assess the efficacy and safety of NOACs among renal transplant recipients. | Muhammad A Bukhari Abdulrahman Al-Theaby Mohammed Tawhari Ali Al-Shaggag Ryan Pyrke Azim Gangji Darin Treleaven Christine Ribic | 2019 | World Journal of Transplantation2019，9，6： | 1 |
| 4 | Clinical utility of troponin T levels and echocardiography in the emergency department显示文摘 | Emile R. Mohler III Thomas Ryan Douglas S. Segar Stephen G. Sawada Ali F. Sonel Laura Perkins Naomi Fineberg Harvey Feigenbaum Robert L. Wilensky | 1998 | American Heart Journal1998，，： | 1 |
| 5 | Incidence, correlates, management, and clinical outcome of coronary perforation: analysis of 16,298 procedures显示文摘 | Panayotis Fasseas James L Orford Carmelo J Panetta Malcolm R Bell Ali E Denktas Ryan J Lennon David R Holmes Peter B Berger | 2003 | American Heart Journal2003，，1： | 1 |
| 6 | Students' perceptions of on line learning: Implieations for teaching显示文摘 | Ali NS Hodson-Carlton K Ryan M | 2004 | Nurse Educ2004，29，3： | 1 |
| 7 | Evaluation of traditional classroom teaching methods versus course delivery via the World Wide Web显示文摘 | Ryan M Arlton KH Ali NS | 1999 | J Nurs Educ1999，38，6： | 1 |
| 8 | Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic β -Cell Mass in Middle-Aged Obese Diabetic Mice显示文摘 | Hana Alkhalidy William Moore Yanling Zhang Ryan McMillan Aihua Wang Mostafa Ali Kyung-Shin Suh Wei Zhen Zhiyong Cheng Zhenquan Jia Matthew Hulver Dongmin Liu Pedro M. Geraldes | 2015 | Journal of Diabetes Research2015，，： | 1 |
| 9 | Students'percep- tions of online learning: Implications for teaching 显示文摘 | Ali N S Hodson-Carlton K Ryan M S | 2004 | NurseEducation Today2004，29，3： | 1 |
| 10 | Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression显示文摘 | Eek Joong Park Jun Hee Lee Guann-Yi Yu Guobin He Syed Raza Ali Ryan G. Holzer Christoph H. ?sterreicher Hiroyuki Takahashi Michael Karin | 2010 | Cell2010，，2： | 1 |
| 11 | Critical care of obese patients during and after spine surgery显示文摘Obesity is one of the most prevalent health problems facing the United States today, with a recent JAMA articlepublished in 2014 estimating the prevalence of one third of all adults in the United States being obese. Also, due to technological advancements, the incidence of spine surgeries is growing. Considering these overall increases in both obesity and the performance of spinal surgeries, it can be inferred that more spinal surgery candidates will be obese. Due to this, certain factors must be taken into consideration when dealing with spine surgeries in the obese. Obesity is closely correlated with additional medical comorbidities, including hypertension, coronary artery disease, congestive heart failure, and diabetes mellitus. The pre-operative evaluation may be more difficult, as a more extensive medical evaluation may be needed. Also, adequate radiographic images can be difficult to obtain due to patient size and equipment limitations. Administering anesthesia becomes more difficult, as does proper patient positioning. Postoperatively, the obese patient is at greater risk for reintubation, difficulty with pain control, wound infection and deep vein thrombosis. However, despite these concerns, appropriate clinical outcomes can still be achieved in the obese spine surgical candidate. Obesity, therefore, is not a contraindication to spine surgery, and appropriate patient selection remains the key to obtaining favorable clinical outcomes. | Hossein Elgafy Ryan Hamilton Nicholas Peters Daniel Paull Ali Hassan | 2016 | World Journal of Critical Care Medicine2016，5，1： | 0 |
| 12 | An Intelligent Hybrid Mutual Authentication Scheme for Industrial Internet of Thing Networks显示文摘Internet of Things(IoT)network used for industrial management is vulnerable to different security threats due to its unstructured deployment,and dynamic communication behavior.In literature various mechanisms addressed the security issue of Industrial IoT networks,but proper maintenance of the performance reliability is among the common challenges.In this paper,we proposed an intelligent mutual authentication scheme leveraging authentication aware node(AAN)and base station(BS)to identify routing attacks in Industrial IoT networks.The AAN and BS uses the communication parameter such as a route request(RREQ),node-ID,received signal strength(RSS),and round-trip time(RTT)information to identify malicious devices and routes in the deployed network.The feasibility of the proposed model is validated in the simulation environment,where OMNeT++was used as a simulation tool.We compare the results of the proposed model with existing field-proven schemes in terms of routing attacks detection,communication cost,latency,computational cost,and throughput.The results show that our proposed scheme surpasses the previous schemes regarding these performance parameters with the attack detection rate of 97.7%. | Muhammad Adil Jehad Ali Muhammad Sajjad Khan Junsu Kim Ryan Alturki Mohammad Zakarya Mukhtaj Khan Rahim Khan Su Min Kim | 2021 | Computers, Materials & Continua2021，，7： | 0 |
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