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| 1 | K-ATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured Astrocytes显示文摘Increasing evidence, including from our laboratory, has revealed that opening of ATP sensitive potassium channels(K-ATP channels) plays the neuronal protective roles both in vivo and in vitro. Thus K-ATP channel openers(KCOs) have been proposed as potential neuroprotectants. Our previous studies demonstrated that K-ATP channels could regulate glutamate uptake activity in PC12 cells as well as in synaptosomes of rats. Since glutamate transporters(GluTs) of astrocytes play crucial roles in glutamate uptake and KATP channels are also expressed in astrocytes, the present study showed whether and how KATP channels regulated the function of GluTs in primary cultured astrocytes. The results showed that nonselective KCO pinacidil, selective mitochondrial KCO diazoxide, novel, and blood-brain barrier permeable KCO iptakalim could enhance glutamate uptake, except for the sarcolemmal KCO P1075. Moreover pinacidil, diazoxide, and iptakalim reversed the inhibition of glutamate uptake induced by 1-methyl-4-phenylpyridinium(MPP+). These potentiated effects were completely abolished by mitochondrial K-ATP blocker 5-hydroxydecanoate. Furthermore, either diazoxide or iptakalim could inhibit MPP+-induced elevation of reactive oxygen species (ROS) and phosphorylation of protein kinases C(PKC). These findings are the first to demonstrate that activation of K-ATP channel, especially mitochondrial K-ATP channel, improves the function of GluTs in astrocytes due to reducing ROS production and downregulating PKC phosphorylation. Therefore, the present study not only reveals a novel pharmacological profile of KCOs as regulators of GluTs, but also provides a new strategy for neuroprotection. | Sun, X. L. Zeng, X. N. Zhou, F. Dai, C. P. Ding, J. H. Hu, G. Nanjing Med Univ,Dept Anat Histol & Pharmacol,Neuropharmacol Lab,Nanjing 210029,Jiangsu,Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 7 |
| 2 | Pathological and biochemical alterations of astrocytes in ovariectomized rats injected with D-galactose:A potential contribution to Alzheimer's disease processes显示文摘Astrocytes are implicated in the pathological changes of Alzheimer's disease. Our previous studies have demonstrated that estrogen deprivation and oxidative stress act synergistically to accelerate the progress of Alzheimer's disease. Long-term D-galactose injection combined with ovariectomy may serve as a rodent model for Alzheimer's disease. To address the potential contribution of astroglia to the Alzheimer's disease pathogenesis, we investigated pathological and biochemical alterations of astrocytes under this animal model. Ovadectomized rats injected with D-galactose for 2 weeks showed extensive localization of glial fibrillary acidic protein immunoreactive astrocytes and slightly elevated glutathione levels in the hippocampus without significant impairments in the water maze test and deficits of the cholinergic analyses, compared to the saline-injected rats. Ovariectomized rats injected with D-galactose for 6 weeks, however, exhibited degeneration of astrocytes and decreased glutathione levels in the hippocampus, accompanied with severe dysfunction of behavioral test and deficiency of cholinergic terminals. Electron microscopy further confirmed the pathological changes of astrocytes, especially in the aggregated area of synapse and brain microvessels. Consistent with degeneration of perivascular astrocytic endfeet, analysis of the horseradish peroxidase demonstrated an impairment of the blood-brain barrier permeability. These findings indicate that biochemical and pathological alterations of astrocytes may partially contribute to exacerbating neuronal deficits in the course of Alzheimer's disease. Restoring neuroprotective potential of astrocytes may be a useful therapeutic target for Alzheimer's disease and other neurodegenerative diseases. | Hua, X. D. Lei, M. Ding, H. Han, Q. Y. Hu, G. Xiao, M. Nanjing Med Univ,Dept Anat Histol & Pharmacol,Jiangsu Prov Key Lab Neurodegenerat,Nanjing 210029,Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 4 |
| 3 | Cytokine gene polymorphisms in patients infected with hepatitis B virus显示文摘 | Ziv Ben-Ari Eytan Mor Orit Papo Batia Kfir Jaqueline Sulkes Anat R Tambur Ran Tur-Kaspa Tirza Klein | 2003 | The American Journal of Gastroenterology2003，，1： | 2 |
| 4 | Antifungal prophylaxis in cancer pa- tients after chemotherapy or hematopoietic stem - cell transplantation: Systematic review and Meta - analysis 显示文摘 | Eyal R Anat GG Elad G | 2007 | J Clin Oncol2007，25，34： | 1 |
| 5 | A theory of intraday patterns: volume and price variability显示文摘 | Admati Anat R Paul Pfleiderer | 1988 | Review of Financial Studies1988，，1： | 1 |
| 6 | ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage显示文摘 | ANAT B S SHARON R E LIAT Z | 2002 | Oncogene2002，21，5： | 1 |
| 7 | A Theory of Intraday Patterns: Volume and Price Variability 显示文摘 | ADMATI Anat R PFLEIDERER Paul | 1988 | Review of Financial Studies Oxford University Press for Society for Financial Studies1988，1，1： | 1 |
| 8 | Genetic polymorphism in platelet-derived growth factor and vascular endothelial growth fac- tor are significantly associated with cardiac allograft vasculopathy 显示文摘 | Anat R Tambur D Pamboukian S | 2006 | J Heart Lung Transplant2006，25，6： | 1 |
| 9 | Cytokine gene polymorphisms in patients infected with hepatitis B virus显示文摘 | Ziv Ben-Ari Eytan Mor Orit Papo Batia Kfir Jaqueline Sulkes Anat R Tambur Ran Tur-Kaspa Tirza Klein | 2003 | The American Journal of Gastroenterology2003，，1： | 1 |
| 10 | Emotion cycles: On the social in- fluence of emotion in organizations显示文摘 | Shlomo H Anat R | 2008 | Research in Or- ganizational Behavior2008，，28： | 1 |
| 11 | Large Shareholder Activism,Risk Sharing, and Financial Market Equilibrium 显示文摘 | Anat R Admati Paulfleiderer Josef Zechner | 1994 | Journal of Political Economy1994，，6： | 1 |
| 12 | A theory of intraday patterns: volume and price variability 显示文摘 | Anat R Admati Paul Pfleiderer | 1988 | Review of Financial Studies1988，，1： | 1 |
| 13 | Pfleiderer, Paul, Does It All Add Up?Benchmarks and the Compensation of Active Portfolio Managers显示文摘 | Admati Anat R | 1997 | Journal of Business1997，70，： | 1 |
| 14 | Large Shareholder Activism, Risk Sharing, and Financial Market Equilibrium 显示文摘 | Anat R A Paul P Zechner J | 1994 | Journal of Political Economy1994，102，6： | 1 |
| 15 | Robust Financial Contracting and the Role of Venture Capitalists显示文摘 | Admati Anat R and Paul Pfleider | 1994 | Journal of Finance1994，49，2： | 1 |
| 16 | Identifying differen-tially expressed genes using false discovery rate controlling procedures 显示文摘 | ANAT R DANIEL Y YOAV B R | 2003 | Bioinformatics2003，19，3： | 1 |
| 17 | Antifungal prophylax is in cancer patients after chemotherapy or hematopoietic stem-cell transplan- tation: systematic review and meta-analysis 显示文摘 | Eyal R Anat G Elad G | 2007 | J Clin Onco2007，25，34： | 1 |
| 18 | A theory of intraday patterns: Volume and price variability 显示文摘 | Anat R A Paul P | 1988 | The Review of Financial Studies1988，1，1： | 1 |
| 19 | A theory of intraday patterns: Volume and price variability 显示文摘 | Admati Anat R Paul C Pfleiderer | 1988 | Review of Financial Studies1988，1，： | 1 |
| 20 | Spectral matting 显示文摘 | Anat L Alex R A Dani L | 2008 | Pattern Analysis and Machine Intelligence2008，30，10： | 1 |
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