|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Optimizing energy efficiency and occupant comfort with climate specific design of the building显示文摘 | Christoph Mitterer Hartwig M. Kunzel Sebastian Herkel Andreas Holm | 2012 | Frontiers of Architectural Research2012，1，3： | 5 |
| 2 | Induced Deactivation of Genes Encoding Chlorophyll Biosynthesis Enzymes Disentangles Tetrapyrrole- Mediated Retrograde Signaling显示文摘在光合的有机体,调停 tetrapyrrole 后退信号被建议在叶绿体响应新陈代谢的活动贡献平衡原子 geneexpression (NGE ) 。我们跟随了一条试验性的短期的途径对修改 NGE 的那个 allowedthe 评价 tetrapyrrolebiosynthesis 在 Mg 的明确地修改的酶的步骤的第一个小时期间分叉,当另外的信号的多种的效果能被避免时。响应编码 Mg chelatase, Mg protoporphyrin methyltransferase 和 Mg protoporphyrin monomethylestercyclase 的 CHLH 子单元的 CHLH, CHLM,和 CHL27 的 24-h-induced silencing,分别地,撤销的基因表示很快导致了相应的酶和 alteredMg 卟啉层次的减少的活动。但是 NGE 实质地没被改变。这三基因什么时候连续地在 to4 d 上面被使失去活性为,原子基因的抄本层次的变化被决定。为在坏死的叶损害和调制抄本的超过 24h 结果的 CHL27 silencing 氧化 stress-responsiveand 铺平联系光合作用的原子基因(PhANGs ) 。CHLH 和 CHLM 的延长释放导致 PhANGs 和联系 tetrapyrrole 的基因的稍微提高的抄本层次。为 NGE 上的 tetrapyrrole 生合成的贡献的这些解决时间的研究 indicatea 建筑群情形由 1 O 2-induced 发信号和调整反馈的翼 synthesis.Key 词: | Hagen Schlicke Annabel Salinas Hartwig Vivien Firtzlaff Andreas S. Richter , Christine Glasser Klaus Maier Iris Finkemeier Bernhard Grimm | 2014 | Molecular Plant2014，7，7： | 3 |
| 3 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 4 | Mechanisms in cadmium-induced carcinogenicity: recent insights 显示文摘 | Andrea Hartwig | 2010 | BioMetals2010，10，： | 1 |
| 5 | The disturbed blood–brain barrier in human glioblastoma显示文摘 | Hartwig Wolburg Susan Noell Petra Fallier-Becker Andreas F. Mack Karen Wolburg-Buchholz | 2012 | Molecular Aspects of Medicine (-)2012，，5： | 1 |
| 6 | Tight junctions of the blood-brain barrier: development, composition and regulation 显示文摘 | Hartwig W Andrea L | 2002 | Vascul Pharmacol2002，38，6： | 1 |
| 7 | The relative contribution of symbiotic N2 fixation and other nitrogen sources to grassland ecosystems along an altitudinal gradient in the Alps显示文摘 | Katja A. Jacot Andreas Lüscher Josef N?sberger Ueli A. Hartwig | 2000 | Plant and Soil (-)2000，，1： | 1 |
| 8 | Brain endothelial cells and the glio-vascular complex显示文摘 | Hartwig Wolburg Susan Noell Andreas Mack Karen Wolburg-Buchholz Petra Fallier-Becker | 2009 | Cell and Tissue Research2009，，1： | 1 |
| 9 | Cross-linking of cationically polymerised epoxides by nanopa rticles显示文摘 | Andreas Hartwig Monika Sebald Malte Kleemeier | 2005 | Polymer2005，46，： | 1 |
| 10 | Adrenomedullin Reduces Endothelial Hyperpermeability显示文摘 | Stefan Hippenstiel Martin Witzenrath Bernd Schmeck Andreas Hocke Mathias Krisp Matthias Krüll Joachim Seybold Werner Seeger Wolfgang Rascher Hartwig Schütte Norbert Suttorp | 2002 | Circulation Research: Journal of The American Heart Association2002，，7： | 1 |
| 11 | Mechanisms in cadmium-induced carcinogenicity: recent insights显示文摘 | Andrea Hartwig | 2010 | BioMetals2010，，5： | 1 |
| 12 | Shape memory polyurethanes cross-linked by surface modified silica particles显示文摘 | Moon Kyoung Jang Andreas Hartwig ByungKyu Kim | 2009 | Journal of Materials Chemistry2009，19，： | 1 |
| 13 | Expression of Maspin in Non-Muscle Invasive Bladder Carcinoma: Correlation with Tumor Angiogenesis and Prognosis显示文摘 | Martin G Friedrich Marieta I Toma Susan Petri Jonathan C Cheng Peter Hammerer Andreas Erbersdobler Hartwig Huland | 2003 | European Urology2003，，6： | 1 |
| 14 | Loss of PSP94 expression is associated with early PSA recurrence and deteriorates outcome of PTEN deleted prostate cancers显示文摘Objective: Prostate secretory protein of 94 amino acids(PSP94) is a target gene of the EZH2 transcriptional repressor and is often downregulated in prostate cancer;however, its prognostic value is disputed.Methods: Immunohistochemical analysis of a tissue microarray of 12, 432 prostate cancer specimens was performed to evaluate PSP94 expression. Correlation of PSP94 expression with tumor phenotype, patient prognosis, TMPRSS2:ERG fusion status, EZH2 expression and PTEN deletion was studied.Results: PSP94 expression was increased in benign prostatic hyperplasia;however, it was downregulated in 48% and negative in42% of the 9, 881 interpretable prostate cancer specimens. The loss of PSP94 expression was inversely correlated to EZH2 expression(P < 0.0001) and largely unrelated to the ERG status, but strongly correlated with high Gleason grade, advanced tumor stage, and nodal metastasis(P <0.0001 each). The fraction of PSP94-negative cancer specimens increased from 40% in pT2 to 52%in pT3 b-pT4(P < 0.0001) and from 40% in Gleason 3+3 = 6 to 46% in Gleason 4+3 = 7 and 60% in Gleason ≥4+4 = 8(P <0.0001). Loss of PSP94 was linked to early prostate-specific antigen recurrence, but with little absolute effect(P < 0.0001).However, it provided additional prognostic impact in cancer specimens with PTEN deletion. Loss of PSP94 deteriorated prognosis of cancer patients with PTEN deletion by more than 10%(P < 0.0001). The combination of PTEN deletion and PSP94 loss provided independent prognostic information that was observed in several subgroups defined by classical and quantitative Gleason grade.Conclusions: The results of our study suggest that combined PSP94/PTEN analysis can be potentially used in the clinical prognosis of prostate cancer. | Andreas M. Luebke Ali Attarchi-Tehrani Jan Meiners Claudia Hube-Magg Dagmar S. Lang Martina Kluth Maria Christina Tsourlakis Sarah Minner Ronald Simon Guido Sauter Franziska Buscheck Frank Jacobsen Andrea Hinsch Stefan Steurer Thorsten Schlomm Hartwig Huland Markus Graefen Alexander Haese Hans Heinzer Till S. Clauditz Eike Burandt Waldemar Wilczak Doris Hoflmayer | 2019 | Cancer Biology & Medicine2019，16，2： | 1 |
| 15 | Effect of cadmium (II) on the extent of oxidative DNA damage in pri- mary brain cell cultures from pleurodeles larvae 显示文摘 | Federica Calevro Detmar Beyersmann Andrea Hartwig | 1998 | Toxicology Letters1998，94，： | 1 |
| 16 | Tight junctions of the bloodbrain barrier:development,composition and regulation显示文摘 | Hartwig W Andrea L | | 0，，6： | 1 |
| 17 | Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications显示文摘 | Andrea Hartwig Tanja Schwerdtle | 2002 | Toxicology Letters2002，，1： | 1 |
| 18 | A novel animal model of severe pancreatitis in mice and its differences to the rat显示文摘 | Werner Hartwig Eik Schimmel Thilo Hackert Franco Fortunato Frank Bergmann Andrea Baczako Oliver Strobel Markus W. Büchler Jens Werner | 2008 | Surgery2008，，3： | 1 |
| 19 | Cross-linking of cationically polymerised epoxides bynanoparticles显示文摘 | Andreas Hartwig Monik Sebald Malte Kleemeier | 2005 | Polymer2005，46，7： | 1 |
| 20 | Preparation and properties of elastomers based on a cycloaliphatic diepoxide and poly(tetrahydrofuran)显示文摘 | Andreas Hartwig Monika Sebald | 2003 | European Polymer Jounal2003，39，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员