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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | Radical prostatectomy in patients aged 75 years or older:review of the literature显示文摘Given the demographic trends toward a considerably longer life expectancy,the percentage of elderly patients with prostate cancer will increase further in the upcoming decades.Therefore,the question arises,should patients ≥75 years old be offered radical prostatectomy and under which circumstances? For treatment decision-making,life expectancy is more important than biological age.As a result,a patient's health and mental status has to be determined and radical treatment should only be offered to those who are fit.As perioperative morbidity and mortality in these patients is increased relative to younger patients,patient selection according to comorbidities is a key issue that needs to be addressed.It is known from the literature that elderly men show notably worse tumor characteristics,leading to worse oncologic outcomes after treatment.Moreover,elderly patients also demonstrate worse postoperative recovery of continence and erectile function.As the absolute rates of both oncological and functional outcomes are still very reasonable in patients ≥75 years,a radical prostatectomy can be offered to highly selected and healthy elderly patients. Nevertheless,patients clearly need to be informed about the worse outcomes and higher perioperative risks compared to younger patients. | Philipp Mandel Thenappan Chandrasekar Felix K Chun Hartwig Huland Derya Tilki | 2019 | Asian Journal of Andrology2019，21，1： | 2 |
| 3 | Winged helix genes in organogenesis 显示文摘 | Enerback S Cederber A Hulande M | 1999 | FASEB1999，13，4： | 1 |
| 4 | A comparison of systemic versus inhaled recombinant IL-2 administration for the treatment of metastatic ren al cell carcinoma显示文摘 | Heinzer H Huland H | 2000 | Folia Biol (Krakow)2000，46，6： | 1 |
| 5 | Open retropubic nerve-sparing radical prostatectomy 显示文摘 | Graefen M Walz J Huland H | 2006 | Eur Urol2006，49，1： | 1 |
| 6 | Residual tumor discovered in routine second transurethral resection in patients with stage T1 transitional cell carcinoma of the bladder显示文摘 | KLAN R LOY V HULAND H | 1991 | J Urology1991，146，2： | 1 |
| 7 | Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer显示文摘 | Nicole Fischer Olaf Hellwinkel Claudia Schulz Felix K.H. Chun Hartwig Huland Martin Aepfelbacher Thorsten Schlomm | 2008 | Journal of Clinical Virology2008，，3： | 1 |
| 8 | Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice显示文摘 | HULANDER M KIERNAN A E BLOMQVIST S R | 2003 | Development2003，130，： | 1 |
| 9 | The value of the ratio offree-to-total prostate specific antigen for staging purposes in previously untreated prostate cancer显示文摘 | NOLDUS J GRAEFEN M HULANDE | 1998 | J Urol1998，159，6： | 1 |
| 10 | Is intraoperative electrostimulation of erectile nerves possible显示文摘 | Michl U Dietz R Huland H | 1999 | J Urol1999，162，5： | 1 |
| 11 | Surgical anatomy of the pros- tate in the era of radical robotic prostatectomy 显示文摘 | Walz JJ Graefen MM Huland HH | 2011 | Curr Opin Urol2011，21，： | 1 |
| 12 | Die ureterorenoskopie (URS) in der behandlung yon hamleitersteinen 显示文摘 | FERNANDEZ-DELA-MAZA S NOLDUS J HULAND H | 1999 | Urology1999，38，： | 1 |
| 13 | Systematic sextant biopsies in 651 pa- tients referred for prostate evaluation显示文摘 | Hammerer P Huland H | 1994 | Uml1994，151，7： | 1 |
| 14 | Interleukin-2 inhalation therapy temporarily induces asthma-like airway inflammation 显示文摘 | Loppow D Huland E Heinzer H | 2007 | Eur J Med Res2007，12，11： | 1 |
| 15 | Comparison of different schedules of cytostatic intravesical instillations in patients with superficial bladder carcinoma: final evaluation of a prospective multicenter study with 419 patients显示文摘 | Huland H Kl?ppel G Feddersen I | 1990 | J Urol1990，144，1： | 1 |
| 16 | Lack of pendrin expression leads to deafness and expansion of the endolymphatie compartment in inner ears of Foxil null mutant miee显示文摘 | Hulander M Kiernan AE Blomqvist SR | 2003 | Development2003，130，： | 1 |
| 17 | Basic principles of anatomy for optimal surgical treatment of prostate cancer 显示文摘 | Walz J Graefen M Huland H | 2007 | World J Urol2007，25，1： | 1 |
| 18 | A comparison of systemic versus inhaled recombinant IL-2 administration for the treatment of metastatic renal cell carcinoma显示文摘 | Huland E Heinzer H Huland H | 2000 | Folia Biol2000，46，： | 1 |
| 19 | Enhanced discrimination of benign from malignant prostatic disease by selective measurements of cleaved forms of urokinase receptor in serum显示文摘 | Piironen T Haese A Huland H | 2006 | Clin Chem2006，52，5： | 1 |
| 20 | Systematic sextant biopsies in 651 patients referred for prostate evaluation显示文摘 | Hammerer P Huland H | 1994 | J Urol1994，151，1： | 1 |
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