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| 1 | Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis显示文摘Wnt/ 尾 - catenin 调整与肿瘤有关的细胞的功能开始和前进,房间增长,区别,幸存,和粘附。尾 -Catenin 独立的 Wnt 小径被建议了调整房间极性和移植,包括转移。在这评论,我们在肿瘤前进讨论 catenin 依赖的尾 - 和独立人士发信号小径的可能的角色,与他们 Rho 家庭 GTPases,改变的细胞骨架,和与房间房间粘附和 cilia/ciliogenesis 的关系的规定上的一个重音。 | Shih-Lei Lai Andy J Chien Randall T Moon | 2009 | Cell Research2009,19,5: | 15 |
| 2 | Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction显示文摘 | Mei Hua Jiang Bing Cai Ying Tuo Jiancheng Wang Zhi Jun Zang Xiang'an Tu Yong Gao Zhijian Su Weiqiang Li Guilan Li Min Zhang Jianwei Jiao Zi Wan Chunhua Deng Bruce T Lahn Andy Peng Xiang | 2014 | Cell Research2014,24,12: | 14 |
| 3 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016,26,9: | 13 |
| 4 | 秦巴山区仿生态培育大鲵亲本水温研究显示文摘分别对大鲵(Andrias davidanus)自然产苗点和鱼类和两栖类仿生态培育产苗点进行生境水温研究。自然产苗点水域中的鱼类和两栖类饵料丰富,常随季节、天气、河水流量的变化而波动。各出苗点水体有浊度和微量溶解固体,溶解氧含量高,水质可满足大鲵的生长繁育条件。选择连续多年批量出苗的仿生态培养池为监测对象,经过连续1年不间断的水温测定,查明了适于大鲵繁殖的水温条件。水温变幅为6.023~24.195℃,平均水温13.718℃,全年最高水温出现在秋季,最低水温出现在冬季;白昼温差较大,黑夜温差较小;全年的昼夜温差相当,适合大鲵生长,表明人工仿生态养殖环境也可实现大鲵的繁殖。 | 张红星 沈建忠 赵虎 王启军 Andy Kouba Scott T Willard | 2012 | 水生态学杂志2012,33,1: | 6 |
| 5 | Energy balance closure at FLUXNET sites显示文摘 | Kell Wilson Allen Goldstein Eva Falge Marc Aubinet Dennis Baldocchi Paul Berbigier Christian Bernhofer Reinhart Ceulemans Han Dolman Chris Field Achim Grelle Andreas Ibrom B.E Law Andy Kowalski Tilden Meyers John Moncrieff Russ Monson Walter Oechel John T | 2002 | Agricultural and Forest Meteorology2002,,1: | 4 |
| 6 | Establishment and characterization of two new human embryonic stem cell lines,SYSU-1 and SYSU-2显示文摘背景人的胚胎的干细胞能在 vitro 无止境地宣传并且能区分进所有三胚胎的细菌层的衍生物。主要在他们的潜力包围人的胚胎的干细胞谎言生产的兴奋专业化能被用于的房间移植治疗。然而,进一步的调查与改变基因背景要求另外的房间线。因此,导出并且建立更多的人的胚胎的干细胞线的努力是高度,从施主的 warranted.Methods 剩余胚胎(胚囊) 被用来由 immunosurgery 孤立内部房间团。所有房间在照耀的鼠科的胚胎的成纤维细胞上连续地是有教养的喂层和多半人的胚胎的干细胞殖民地被房间表面标记染色, karyotyping 和 teratoma formation.Results 随后描绘二根人的胚胎的干细胞线(SYSU-1 和 SYSU-2 ) 从剩余胚胎被建立。二根线表示包括碱的磷酸酶, SSEA- 4, Tra-1-60, Oct-4, Nanog 和 Rex-1.They 的标记在延长段落以后与正常 karyotype 处于无差别的状态仍然是的几 pluripotency 并且能在 vivo.Conclusion 在 vitro 和 teratoma 形成胚胎植物或动物身体二根新人的胚胎的干细胞线从剩余胚胎被建立了。他们能被用来理解 selfrenewal 和区分的机制并且为再生药提供更多的选择。 | HUANG Guo LI Wei-qiang CHEN Rui CHEN Zhen-guang ZHANG Xiu-ming MAO Fu-xiang HUANG Shao-liang LI Shu-nong Bruce T Lahn Andy Peng Xiang | 2007 | Chinese Medical Journal2007,,7: | 3 |
| 7 | Strategic guidelines for street canyon geometry to achieve sustainable street air quality显示文摘 | ANDY T C ELLEN S P SO | 2001 | Atmosphere Environment2001,35,: | 1 |
| 8 | Why web warriors might worry显示文摘 | Andie T | | 0,,02: | 1 |
| 9 | Preparation and Assembly of Colloidal Gold Nanoparticles in CTAB-stabilized Reverse Microemulsion显示文摘 | CHEN Feng-xi XU Guo-qin ANDY HOR T S | 2003 | Mater Lett2003,57,21: | 1 |
| 10 | Mycelial growth and substrate acidification of ectomycorrhizal fungi in response to different minerals 显示文摘 | Anna R Bjorn D L Andy F S T | 2004 | FEMS Microbiology Ecology2004,47,: | 1 |
| 11 | Review of operation and performance of the rapid degassing equipment for molten aluminum 显示文摘 | Duane T Hampton Andy Mores | 1991 | Light Metals1991,,: | 1 |
| 12 | Minimax and -minimax estimation for the Poisson distribution under LINEX loss when the parameter space is restricted显示文摘 | Alan T K WAN Guohua Zou Andy | 2000 | Statistics and Probability Letters2000,50,: | 1 |
| 13 | A 2W 100nV/sqrt (Hz) Chopper Stabilized Instrumentation Amplifier for Chronic Measurement of Neural Field Potentials 显示文摘 | Denison T Consoer K Wesley Santa AI-Thaddeus Avestruz John Cooley and Andy Kelly | 2007 | IEEE Journal of Solid-State Circuits2007,42,29: | 1 |
| 14 | Efficient route to organometallic cage formation via C-H activation-dirocted muff component assembly accompanying aromatic guest encapsulation显示文摘 | HAN Y F UN Y J ANDY HOR T S ct al | 2012 | Organometallics2012,3,3: | 1 |
| 15 | Preparation and assembly of colloidal gold nanoparticles in CTAB-stabilized reverse microemulsion 显示文摘 | Xu G Q Andy T S | 2003 | Mater Lett2003,57,: | 1 |
| 16 | A large - scale triaxial apparatus for prototype railroad ballast testing 显示文摘 | SEVI A F LOUIS G T ANDY W | 2009 | Geotechnical Testing Journal2009,32,4: | 1 |
| 17 | Attention-deficit/hyperactivity disorder in preschool children:An investigation of validation based on visual attention performance显示文摘 | Mini T Xuemei S Andy B | 2009 | J Child Adolesc Psychopharmacol2009,19,2: | 1 |
| 18 | Observationsof grain - scale inter - actions and simulation of dry granular flowsin a large - scale flume显示文摘 | Sarah K Bryant W Andy Take Elisabeth T Bowman | 2014 | Canadian Geotechnical Journal2014,52,5: | 1 |
| 19 | et al, Business privilege and the strategic planning agenda of the Greater London Authority 显示文摘 | ANDY T | 2005 | Urban Studies2005,42,11: | 1 |
| 20 | The quantity flexibility contract and supplier-customer incentives 显示文摘 | Andy A T | 1999 | Management Science1999,45,10: | 1 |