4篇
您的检索式：作者名="Annabianca"
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| 1 | WJH 6^(th) Anniversary Special Issues(4): Cirrhosis Role of vaptans in the management of hydroelectrolytic imbalance in liver cirrhosis显示文摘Ascites and hyponatremia are the most common complications in patients with liver cirrhosis and develop as a consequence of a severe impairment of liver function and portal hypertension. Increasing evidences support the central role of renal function alterations in the pathogenesis of hydroelectrolytic imbalances in cirrhotic patients, thus implying a dense cross-talk between liver and kidney in the systemic and splanchnic vascular homeostasis in such subjects. Since Arginin Vasopressin(AVP) hyperincretion occurs at late stage of cirrhosis and plays an important role in the development of refractory ascites, dilutional hyponatremia and finally hepato-renal syndrome, selective antagonists of AVP receptors V2(vaptans) have been recently introduced in the therapeutic algorithm of advanced cirrhotic patients. Despite the promising results of earlier phasetwo studies, randomized controlled trials failed to find significant results in terms of efficacy of such drugs both in refractory ascites and hyponatremia. Moreover, concerns on their safety profile arise, due to the number of potentially severe side effects of vaptans in the clinical setting, such as hypernatremia, dehydration, renal impairment, and osmotic demyelination syndrome. More robust data from randomized controlled trials are needed in order to confirm the potential role of vaptans in the management of advanced cirrhotic patients. | Antonio Facciorusso Annabianca Amoruso Viviana Neve Matteo Antonino Valentina Del Prete Michele Barone | 2014 | World Journal of Hepatology2014，6，11： | 4 |
| 2 | Conditional survival analysis of hepatocellular carcinoma patients treated with radiofrequency ablation显示文摘 | Antonio Facciorusso Valentina Del Prete Matteo Antonino Viviana Neve Annabianca Amoruso Nicola Crucinio Alfredo Di Leo Michele Barone | 2015 | Hepatol Res2015，，10： | 1 |
| 3 | Endothelial Dysfunction Correlates with Liver Fibrosis in Chronic HCV Infection显示文摘 | Michele Barone Maria Teresa Viggiani Annabianca Amoruso Serafina Schiraldi Annapaola Zito Fiorella Devito Francesca Cortese Michele Gesualdo Natale Brunetti Alfredo Di Leo Pietro Scicchitano Marco Matteo Ciccone Eiji Sakai | 2015 | Gastroenterology Research and Practice2015，，： | 1 |
| 4 | Lesson from an intriguing case of cryoglobulinemia显示文摘Cryoglobulinemia is a pathological condition usually associated with hepatitis C virus(HCV) chronic liver disease and less commonly with autoimmune or lymphoproliferative disorders.The possible association of cryoglobulinemia with hepatitis B virus(HBV) infection is not widely accepted.In our patient,serum negativity for HCV markers initially led us to consider two other causes of cryoglobulinemia.Myelodysplastic disorders were excluded on the basis of hematological studies,while serum markers for active HBV infection were positive.Surprisingly,the detection of HCV RNA in the cryocrit,even in the absence of anti-HCV antibodies suggested a pathogenetic role of HCV in this case of cryoglobulinemia.Negative 'first level' tests for HCV in the serum do not completely exclude HCV involvement in the pathogenesis of cryoglobulinemia.Analysis of the cryoprecipitate is always essential for diagnosis. | Michele Barone Raffaele Licinio Annabianca Amoruso Maria Teresa Viggiani Angela Maria Vittoria Larocca Alfredo Di Leo | 2013 | World Journal of Gastroenterology2013，19，2： | 0 |
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