维普中文期刊产品整合服务
3篇 您的检索式:作者名="Anne Glass"
    题名 作者 年代 出处 被引量
1Statins Enhance Formation of Phagocyte Extracellular Traps显示文摘Ohn A. Chow Maren von K?ckritz-Blickwede A. Taylor Bright Mary E. Hensler Annelies S. Zinkernagel Anna L. Cogen Richard L. Gallo Marc Monestier Yanming Wang Christopher K. Glass Victor Nizet 2010Cell Host & Microbe2010,,5:1
2Efficacy and safety of tenofovir disoproxil fumarate in pregnancy to prevent perinatal transmission of Hepatitis B Virus显示文摘Astrid-Jane Greenup Pok Kern Tan Vi Nguyen Anne Glass Scott Davison Ushmi Chatterjee Susan Holdaway Dev Samarasinghe Kathy Jackson Stephen Locarnini Miriam T. Levy 2014Journal of Hepatology2014,,:1
3Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn’s disease显示文摘BACKGROUND Crohn’s disease(CD)is characterized by a multifactorial etiology and a significant impact of genetic traits.While NOD2 mutations represent well established risk factors of CD,the role of other genes is incompletely understood.AIM To challenge the hypothesis that single nucleotide polymorphisms(SNPs)in the genes CLEC5 A and CLEC7 A,two members of the C-type lectin domain family of pattern recognition receptors,may be associated with CD.METHODS SNPs in CLEC5 A,CLEC7 A and the known CD risk gene NOD2 were studied using real time PCR-based SNP assays.Therefore,DNA samples from 175 patients and 157 healthy donors were employed.Genotyping data were correlated with clinical characteristics of the patients and the results of gene expression data analyses.RESULTS In accordance with previous studies,rs2066844 and rs2066847 in NOD2 were found to be significantly associated with CD(allelic P values=0.0368 and 0.0474,respectively).Intriguingly,for genotype AA of rs1285933 in CLEC5 A,a potential association with CD(recessive P=0.0523;odds ratio=1.90)was observed.There were no associations between CD and SNPs rs2078178 and rs16910631 in CLEC7 A.Variants of rs1285933 had no impact on CLEC5 A gene expression.In contrast,genotype-dependent differences of CXCL5 expression in peripheral blood mononuclear cells were observed.There is no statistical interactionbetween the tested SNPs of NOD2 and CLEC5 A,suggesting of a novel pathway contributing to the disease.CONCLUSION Our data encourage enlarged follow-up studies to further address an association of SNP rs1285933 in CLEC5 A with CD.The C-type lectin domain family member also deserves attention regarding a potential role in the pathophysiology of CD.Nagi Elleisy Sarah Rohde Astrid Huth Nicole Gittel Anne Glass Steffen Moller Georg Lamprecht Holger Schaffler Robert Jaster 2020World Journal of Gastroenterology2020,26,18:0
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费