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| 1 | BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells显示文摘 | Stephanie Beurlet Nader Omidvar Petra Gorombei Patricia Krief Carole Le Pogam Niclas Setterblad Pierre de la Grange Christophe Leboeuf Anne Janin Maria-Elena Noguera Florence Hervatin Laure Sarda-Mantel Marina Konopleva Michael Andreeff Andrea W. Tu Alice | 2013 | Blood2013，，16： | 1 |
| 2 | Characterization of two phosphate transporters from barley; evidence for diverse function and kinetic properties among members of the Pht1 family显示文摘 | Anne L. Rae Daisy H. Cybinski Janine M. Jarmey Frank W. Smith | 2003 | Plant Molecular Biology (-)2003，，1： | 1 |
| 3 | Histopathologic Diagnosis of Chronic Graft-versus-Host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report显示文摘 | Howard M. Shulman David Kleiner Stephanie J. Lee Thomas Morton Steven Z. Pavletic Evan Farmer J. Margaret Moresi Joel Greenson Anne Janin Paul J. Martin George McDonald Mary E.D. Flowers Maria Turner Jane Atkinson Jay Lefkowitch M. Kay Washington Victor G | 2006 | Biology of Blood and Marrow Transplantation2006，，1： | 1 |
| 4 | TP53 Status and Response to Treatment in Breast Cancers显示文摘 | Mariana Varna Guilhem Bousquet Louis-Fran?ois Plassa Philippe Bertheau Anne Janin Paul W. Doetsch | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 5 | Aeroallergen hypersensitivity:comparing patients with nasal polyps to those with allergic rhinitis显示文摘 | Janine AV Paul AY Anne MD | | 0，，02： | 1 |
| 6 | Advances in targeted therapy for malignant lymphoma显示文摘The incidence of lymphoma has gradually increased over previous decades,and it ranks among the ten most prevalent cancers worldwide.With the development of targeted therapeutic strategies,though a subset of lymphoma patients has become curable,the treatment of refractory and relapsed diseases remains challenging.Many efforts have been made to explore new targets and to develop corresponding therapies.In addition to novel antibodies targeting surface antigens and small molecular inhibitors targeting oncogenic signaling pathways and tumor suppressors,immune checkpoint inhibitors and chimeric antigen receptor T-cells have been rapidly developed to target the tumor microenvironment.Although these targeted agents have shown great success in treating lymphoma patients,adverse events should be noted.The selection of the most suitable candidates,optimal dosage,and effective combinations warrant further investigation.In this review,we systematically outlined the advances in targeted therapy for malignant lymphoma,providing a clinical rationale for mechanism-based lymphoma treatment in the era of precision medicine. | Li Wang Wei Qin Yu-Jia Huo Xiao Li Qing Shi John E.J.Rasko Anne Janin Wei-Li Zhao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 7 | 非霍奇金淋巴瘤BCL-XL基因表达及突变的研究显示文摘本研究探讨78例非霍奇金淋巴瘤BCL-XL表达和突变的发生率及其临床意义。应用激光微切割技术从淋巴结组织中特异地分离淋巴瘤细胞,用实时定量RT-PCR法检测淋巴瘤组织和淋巴瘤细胞中BCL-XL的表达,PCR直接测序法检测BCL-XL的突变情况。结果表明:与淋巴结反应性增生(15例)相比,滤泡性淋巴瘤(30例)组织和微切割的淋巴瘤细胞均高表达BCL-XL(P值分别为0.0064和<0.0001),而T细胞淋巴瘤(24例)和弥漫性大B细胞淋巴瘤(24例)中BCL-XL表达无明显升高。在滤泡性淋巴瘤中,BCL-XL高表达的患者常伴多个淋巴结外器官累及(P=0.0004),血清乳酸脱氢酶水平升高(P=0.0019),国际预后指数分组多为高危组(P=0.0013),患者总生存期短(P=0.0451)。突变检测发现1例滤泡性淋巴瘤BCL-XL的同义突变(密码子109ACA→ACC)。结论:BCL-XL表达与滤泡性淋巴瘤的疾病进展和患者预后密切相关。 | 刘元华 Christophe Leboeuf 金晓龙 肖家诚 Anne Janin 陈赛娟 赵维莅 | 2006 | 中国实验血液学杂志2006，14，5： | 1 |
| 8 | Design of a Beverage from Whey Permeate显示文摘 | JANINE BEUCLER MARY ANNE DRAKE | 2005 | Journal of Food Science2005，70，4： | 1 |
| 9 | Characterization of two phosphate transporters from barley; ecidence for diverse function and kinetic properties among members of Phtl famly显示文摘 | Anne L Rae Daisy H Cybinski Janine M | 2003 | Plant Molecular Biology2003，53，： | 1 |
| 10 | 乳腺癌α转化生长因子及表皮生长因子受体免疫组化双重标记研究显示文摘目的 :研究α转化生长因子 (TGFα)及其受体表皮生长因子受体 (EGFR)在乳腺癌中的表达特点 ,以及两者间的相互作用。并通过与已知预后因素的相关分析 ,研究它们各自在肿瘤发展中的作用。方法 :对 84例导管浸润型乳腺癌标本进行TGFα EGFR免疫组织化学双重标记 ,同时观察两者在非肿瘤及肿瘤组织的表达 ,并对结果进行单变量和多变量统计学分析。结果 :TGFα和EGFR在癌旁组织上皮细胞中均有表达 ,分别在 76 2 %和17 8%浸润癌细胞中表达 ,在 16 7%浸润癌细胞中同时表达。χ2 分析显示TGFα在浸润癌细胞中的表达只与ER阴性相关联 ,而EGFR的表达则与大体积肿瘤、炎性乳癌、腋窝淋巴结受累、不良肿瘤组织学分级 (SBRⅢ级 )以及雌孕激素受体阴性相关联。多变量统计分析显示 ,浸润癌细胞中TGFα的表达与炎性乳癌相关联 (P =0 0 48) ,而EGFR的表达则与雌激素受体阴性相关联 (P =0 0 0 2 )。结论 :TGFα和EGFR在乳腺癌组织中的表达与在非肿瘤组织中明显不同 ,并与乳腺癌不良愈后因素相关联 ,提示他们在乳腺癌的发展中起着重要作用。 | 马林 de ROQUANCOURT Anne BERTHEAU Philippe CHEVRET Sylvie JANIN Anne CAL VO Fabien | 2002 | 军医进修学院学报2002，23，4： | 1 |
| 11 | EMMPRIN、MMP-2和MMP-9在恶性淋巴瘤中的表达及其临床意义显示文摘目的探讨恶性淋巴瘤中细胞外基质金属蛋白酶诱导因子(EMMPRIN)的表达及其与基质金属蛋白酶(MMPs)表达和疾病进展的关系。方法运用实时定量PCR法检测了81例恶性淋巴瘤患者淋巴瘤组织中EMMPRIN、MMP-2和MMP-9的表达。同时通过电镜对淋巴瘤组织切片中肿瘤浸润血管情况进行观察。结果与淋巴结反应性增生(8例)相比,不同类型的恶性淋巴瘤均高表达EMMPRIN、MMP-2和MMP-9。EMMPRIN来自淋巴瘤细胞。Ann Arbor分期为III-IV、伴多个淋巴结外病变和国际预后指数分组为高危组的患者上述基因的表达水平显著升高。此外,EMM-PRIN、MMP-2和MMP-9高表达者可见淋巴瘤细胞浸润血管。结论EMMPRIN表达可促进恶性淋巴瘤MMPs的表达,并与疾病进展密切相关。 | 赵维莅 王黎 程澍 金晓龙 Anne JANIN 沈志祥 | 2007 | 中国实验诊断学2007，11，7： | 1 |
| 12 | BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells显示文摘 | Stephanie Beurlet Nader Omidvar Petra Gorombei Patricia Krief Carole Le Pogam Niclas Setterblad Pierre de la Grange Christophe Leboeuf Anne Janin Maria-Elena Noguera Florence Hervatin Laure Sarda-Mantel Marina Konopleva Michael Andreeff Andrea W. Tu Alice | 2013 | Blood2013，，16： | 1 |
| 13 | Aeroallergenhypersensitivity:comparing patients with nasal polyps tothose with allergic rhinitis显示文摘 | Janine A V Paul A Y Anne M D | 2005 | Allergy Asthma Proc2005，26，2： | 1 |
| 14 | 血管免疫母细胞性T细胞淋巴瘤患者血管内皮生长因子C表达的分析显示文摘目的探讨血管内皮生长因子 C(VEGF-C)在恶性淋巴瘤患者淋巴瘤组织中的表达及其与疾病进展的关系。方法运用实时定量 PCR 方法检测了81例恶性淋巴瘤患者淋巴瘤组织中VEGF-C 的表达。联合激光微切割技术和定量 PCR 法从淋巴瘤组织中特异性分离淋巴瘤细胞,检测淋巴瘤细胞中 VEGF-C 的表达。同时通过电镜对淋巴瘤组织切片中血管结构进行观察。结果与淋巴结反应性增生患者(8例)淋巴结的 VEGF-C 表达量(1.55±0.19)相比,血管免疫母细胞性 T 细胞淋巴瘤患者(18例)组织(15.35±9.07)和微切割的患者(10例)淋巴瘤细胞(15.19±4.28)均高表达VEGF-C(P 值分别为0.0020 和<0.01)。VEGF-C 高表达的患者常伴骨髓浸润(P=0.0039)和皮肤累及(P=0.0046),国际预后指数分组多为高危组(P=0.0302)。VEGF-C 高表达者存在血管结构异常,表现为血管内皮细胞肿胀,或缺乏周围细胞。结论 VEGF-C 表达与血管免疫母细胞性 T 细胞淋巴瘤的疾病进展密切相关。 | 赵维莅 刘艳艳 Francois PLASSA 金晓龙 王黎 Anne JANIN 沈志祥 | 2007 | 中华血液学杂志2007，28，10： | 0 |
| 15 | The germline genetics of mild-to-moderate penetrance:An intriguing role of PRAME in multiple carcinogenesis显示文摘Germline genetics of high penetrance such as BRCA genes,mutations might be sufficient for carcinogenesis,but this only explains fewer than 10%of cancers.We assume that most cancers are the result of germline mutations of low to moderate penetrance,combined with acquired mutations due to external carcinogenic stressors.With their accumulation over time,aging is associated with an increased risk of multiple cancer development in a given individual.For decades,germline genetics have been based on familial linkage studies enabling most high-penetrance genes to be identified.More recently,population-wide studies have led to the identification of considerable numbers of polymorphisms associated with cancer risk.However,most of them are of unknown functional value,thus limiting their translational application. | Diaddin Hamdan Van Tai Nguyen Justine Paris Christophe Leboeuf Morad El Bouchtaoui Marc Espie Anne Janin Geraldine Falgarone Melanie Di Benedetto Guithem Bousquet | 2024 | Genes & Diseases2024，11，3： | 0 |
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