|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair显示文摘间充质的干细胞(MSC ) 为治疗各种各样的疾病有大潜力,特别那些与织物有关损坏包含有免疫力的反应。各种各样的研究证明了 MSC 在 vitro 并且在 vivo 是强烈抑制免疫力的。我们的最近的研究证明了那未刺激的 MSC 确实不能免疫力的抑制;他们与 TNF- 伪, IL-1 伪或 IL-1 尾与激活的淋巴细胞的上层清液,或与 IFN- 纬的联合在刺激之上变得 potently 抑制免疫力。这观察表明在某些情形下面,煽动性的 cytokines 能实际上变得抑制免疫力。我们证明在调停 MSC 的免疫力的抑制的机制有一个种类变化:由告知 cytokine 的老鼠 MSC 的免疫力的抑制被氮的氧化物调停(没有) 而由告知 cytokine 的人的 MSC 的免疫力的抑制通过 indoleamine 被执行 2, 3-dioxygenase (伊多语) 。在有煽动性的 cytokines 的刺激之上,另外,老鼠和人的 MSC 分泌几白血球 chemokines 显然服务与 MSC 吸引有免疫力的房间进最近,在哪儿不或伊多语被预言很活跃。因此,由煽动性的刺激 cytokine 的 MSC 的免疫力的抑制经由 chemokines 的一致行动发生并且免疫者禁止没有或伊多语由 MSC 生产了。因此,我们的结果在对待有免疫力的回答导致的织物损害关于调停 MSC 的免疫力的抑制并且为 MSC 的更好的申请的机制提供新奇信息。 | Yufang Shi Gangzheng Hu Juanjuan Su Wenzhao Li Qing Chen Peishun Shou Chunliang Xu Xiaodong Chen Yin Huang Zhexin Zhu Xin Huang Xiaoyan Han Ningxia Xie Guangwen Ren | 2010 | Cell Research2010，20，5： | 72 |
| 3 | In vitro derivation of functional insulin-producing cells from human embryonic stem cells显示文摘为人的胚胎的茎(ES ) 的自强和区别的能力细胞为对待类型 Idiabetes mellitus 为胰腺的贝它细胞的产生使他们成为潜在的来源。这里,我们报导一最新发展了并且有效方法,在aserum免费的系统执行了,区分进生产胰岛素的 cells.Activin A 的导致的人的 ES 房间它在起始的阶段被使用从人的 EScells 导致权威的内胚叶区别,是由权威的内胚叶标记 Sox17 和 Brachyury.Further 的表示检测了, all-trans retinoic 酸( RA )被用来支持胰腺的区别,由早胰腺的抄写因素 pdx1 和 hlxb9 的表示显示了。在成熟 inDMEM/F12 以后有 bFGF 和菸碱的没有浆液的媒介,区分的房间表示了小岛特定的标记象 C 肽,胰岛素,胰高血糖素和 glut2 那样。百分比 ofC-peptide-positive 房间超过了 15% 。由这些房间的胰岛素和 C 肽的分泌物在葡萄糖层次对应于变化。当移植了进肾的囊时, ofStreptozotocin (STZ ) 对待裸体老鼠,这些区分的人的 ES 房间熬过并且维持贝它房间标记基因的表示包括 C 肽, pdx1, glucokinase, nkx6.1, IAPP, pax6and Tcf1。百分之三十只移植裸体老鼠展出了 stableeuglycemia 的明显的恢复;并且改正的显型被支撑超过六个星期。我们的新方法为学习人的胰开发的机制提供一个有希望的试管内区别模特儿并且说明为类型 Idiabetes mellitus 的处理使用人的 ES 房间的潜力。 | Wei Jiang Yan Shi Dongxin Zhao Song Chen Jun Yong Jing Zhang Tingting Qing Xiaoning Sun Peng Zhang Mingxiao Ding Dongsheng Li Hongkui Deng | 2007 | Cell Research2007，17，4： | 38 |
| 4 | Apoptosis induced by norcantharidin in human tumor cells显示文摘INTRODUCTIONThe antitumor activity of norcantharidin (NCTD),the demethylated analogue of cantharidin,wasstudied in the early 1980s in China.NCTD has noside effects on urinary organs which cantharidin hasshown and is easier to synthesize,and it can inhibitthe proliferation of several tumor cell lines as wellas transplanted tumors.Clinical trials with NCTD asa monotherapeutic agent indicated that NCTD hadbeneficial effects in patients with different kinds | Zhen Xiao Sun Qing Wen Ma Tian De Zhao Yu Lin Wei Guang Sheng Wang Jia Shi Li | 2000 | World Journal of Gastroenterology2000，6，2： | 31 |
| 5 | Telomerase activity in gastric cancer and its clinical implications显示文摘INTRODUCTIONThedevelopmentofcarcinomaresultsfrommultipleindependentgeneticchangesthatactivateprotooncogenesorinactivatetheac... | ZHAN Wen Hua, MA Jin Ping, PENG Jun Sheng, GAO Jing Song, CAI Shi Rong, WANG Jian Ping, ZHENG Zhang Qing and WANG Lei | 1999 | World Journal of Gastroenterology1999，5，4： | 25 |
| 6 | Advanced landfill leachate treatment using a two-stage UASB-SBR system at low temperature显示文摘A two-stage upflow anaerobic sludge blanket(UASB) and sequencing batch reactor(SBR) system was introduced to treat landfill leachate for advanced removal of COD and nitrogen at low temperature.In order to improve the total nitrogen(TN) removal efficiency and to reduce the COD requirement for denitrification,the raw leachate with recycled SBR nitrification supernatant was pumped into the first-stage UASB(UASB1) to achieve simultaneous denitrification and methanogenesis.The results showed that UASB1 played an important role in COD removal and UASB2 and SBR further enhanced the nutrient removal efficiency.When the organic loading rates of UASB1,UASB2 and SBR were 11.95,1.63 and 1.29 kg COD/(m3·day),respectively,the total COD removal efficiency of the whole system reached 96.7%.The SBR acted as the real undertaker for NH4+-N removal due to aerobic nitrification.The system obtained about 99.7% of NH4+-N removal efficiency at relatively low temperature(14.9-10.9°C).More than 98.3% TN was removed through complete denitrification in UASB1 and SBR.In addition,temperature had a significant effiect on the rates of nitrification and denitrification rather than the removal of TN and NH4+-N once the complete nitrification and denitrification were achieved. | Hongwei Sun,Qing Yang,Yongzhen Peng,Xiaoning Shi,Shuying Wang,Shujun Zhang Key Laboratory of Beijing Water Quality Science and Water Envirocnnment Recovery Engineering,Beijing University of Technology,Beijing 100124,China | 2010 | Journal of Environmental Sciences2010，22，4： | 26 |
| 7 | Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb/c nude mice显示文摘 | ZHANG Zhi-mian ZHONG Ning GAO Hai-qing ZHANG Shang-zhong WEI Yuan XIN Hua MEI Xing HOU Huai-shui LIN Xi-yun SHI Qing | 2006 | Chinese Medical Journal2006，，5： | 24 |
| 8 | Protective effects of polydatin against CCl_4-induced injury to primarily cultured rat hepatocytes显示文摘NTRODUCTIONPolygonumcuspidatumSieb.etZucc.(Polygonaceae)isatraditionalChineseherbaldrug,withbitertasteandcoldnature.Itmainly... | HUANG Zhao Sheng, WANG Zong Wei, LIU Ming Ping, ZHONG Shi Qing, LI Qiao Mei and RONG Xiang Lu | 1999 | World Journal of Gastroenterology1999，5，1： | 24 |
| 9 | Indoor Allergen Levels and Household Distributions in Nine Cities Across China显示文摘Objective Chinese allergic subjects have high levels of sensitization to house dust mite(HDM) and other indoor allergens. This study quantifies common indoor allergen levels in Chinese households. Methods Dust samples were collected from nine cities. Major allergens Der p 1 and Der f 1 from Dermatophagoides pteronyssinus and D. farinae, and specific antigens of Blomia tropicalis, Tyrophagus putrescentiae, Acarus siro, and cockroach species Blattella germanica and Periplaneta americana were measured by ELISA. Results HDM allergens were found in dust samples from bedding in 95% of the Chinese households. The median levels varied from <0.006 to 9.2 μg/g of dust, depending on the city. The percentages of households having HDM allergen levels associated with the risk of developing allergy sensitization and asthma were 65% and 25%, respectively. Specific antigens of the storage mite and cockroach were only found in samples from the southern and tropical regions of China. Levels of mite allergens were generally higher in samples from bedding compared to samples from the living room, even for storage mites, whereas levels of cockroach antigens were higher in the living room samples. Conclusion HDM allergens are present in bedding dust samples from most Chinese households. Cities in southern and central China have relatively high levels of HDM major allergens compared to cities in northern and western China. Antigens of storage mites and cockroaches are not as common as HDM allergens. | ZHENG Yi Wu LAI Xu Xin ZHAO De Yu ZHANG Chun Qing CHEN Jian Jun ZHANG Luo WEI Qing Yu CHEN Shi LIU En Mei NORBACK Dan GJESING Birgitte ZHONG Nan Shan SPANGFORT D.Michael | 2015 | Biomedical and Environmental Sciences2015，28，10： | 24 |
| 10 | Preliminary characterization of acute aortic dissection in the mainland of China显示文摘经济地在更少和更多之中在尖锐大动脉的解剖( AAD )的特征探索差别的目的从尖锐大动脉的解剖( IRAD )的国际注册表与各种各样的文化和赛跑数据来源报告开发了国家,中国( MC )的大陆由寻找 PubMed 数据库是镇定的并且从2000年1月的中国杂志全文的数据库到2009年3月 .Study 选择从包含大量案例和 comple 的 IRAD 和 MC 的那些报告并且从包含病人们在 MC 由一样的医学中心报导了的最大的数字的文章的数据从 MC 被拿进 statistics.Results AAD 病人是比 IRAD 国家和在中国组的男病人的百分比显著地年轻的比 IRAD 国家高(80.7%对68.6%, P 0.001 )。在 MC 的病人多半是更少除了任何焦点的神经病学的赤字与典型症状和符号介绍。与 IRAD 组,不同中国病人是容易的经历磁性的回声成像(MRI ) 做 AAD 的诊断(45.5%vs.11.6% , P 0.001 ) 。在里面医院死亡在 2 个组之间是类似的,但是在 MC 的 AAD 病人的仅仅更小的比例经历了外科或在 MC 的病人被给看的 AAD 和在在 MC 和 IRAD 之间的一些临床的变量的差别的一般特征组织的 medicaltreatment.Conclusions 仍然存在。 | WANG Dong-jin FAN Fu-dong WANG Qiang LI Qing-guo ZHOU Qing WU Zhong SHI Guang-fei | 2011 | Chinese Medical Journal2011，，11： | 23 |
| 11 | Epidemiology of Diabetes in Adults Aged 35 and Older from Shanghai,China显示文摘Objective This study aimed to investigate the epidemiology of diabetes in adults from Shanghai, aged 35 and older, in 2013. Methods We estimated the diabetes prevalence in a representative sample of 18,736 adults who were selected through a multistage stratified cluster sampling process. A standard questionnaire containing questions about demographic characteristics and lifestyle factors was distributed. After an overnight fast of at least 10 hours, a venous blood sample was collected from each participant. For each patient without a history of diabetes, another blood sample was drawn 120 min after an oral glucose tolerance test to identify undiagnosed diabetes and prediabetic condition. Results Among Shanghai residents aged 35 and above, the overall weighted prevalence of diabetes was 17.6% [95% confidence interval(CI): 16.4%-18.8%]. The prevalences were 19.3% in men and 15.8% in women as well as 19.1%, 15.4%, and 16.1% in urban, suburban, and rural residents, respectively. In addition, the weighted prevalence of prediabetes was 16.5%(95% CI: 15.3%-17.8%), with the prevalences of 16.5% in men, 16.6% in women, 15.2% in urban residents, 18.0% in suburban residents, and 18.5% in rural residents. Among all patients with diabetes, 68.1%(95% CI: 64.3%-71.6%) were aware of their status, 63.5%(95% CI: 60.0%-66.9%) received diabetes treatment, but only 35.1%(95% CI: 32.4%-37.8%) had adequate glycemic control. Conclusion In Shanghai, diabetes and prediabetes are highly prevalent. However, 1/3rd of diabetes cases are undiagnosed, and the rate of glycemic control is low. | RUAN Ye YAN Qing Hua XU Ji Ying YANG Qun Di YAO Hai Hong LI Rui SHI Yan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 22 |
| 12 | Clinical and experimental study on regional administration of phosphorus32 glassmicrospheres in treating hepatic carcinoma显示文摘AIM To study the therapeutical effectiveness, dosage range and toxic adverse effects of domestic phosphorus 32 glass microsphere and evaluate its clinical significance. METHODS Ⅰ. Fifty two BALB/*!c tumor bearing male nude mice were allocated into treatment group( n =38) and control group( n =14). In the former group different doses of 32 P GMS were injected into the tumor mass, while in the latter 31 P GMS or no treatment was given. The experimental animals were sacrificed in batches, and then the tumors and their nearby tissues were examined by light and electron microscopy. Ⅱ. Through selective catheterization of hepatic artery, 32 P GMS was infused to 5 healthy domestic pigs in a dosage equivalent to the therapeutic dose for human being, and 31 P GMS was infused to another 5 healthy domestic pigs. Two pigs infused with contrast medium served as whole course blank controls. One pig from each group was surrendered to euthanasia at week 1, 4, 8 and 16 respectively. The ultrastructural histopath ological changes in liver tissues taken from different sites were evaluated semiquan titatively. Ⅲ. One hundred and twenty seven times of 32 P GMS intrahepatic artery interventional therapies were performed on 93 patients with hepatic carcinoma, including 79 cases of primary hepatic carcinoma and 14 cases of secondary hepatic carcinoma. 32 P GMS ( n =30), and group B, 32 P GMS and half dose of trans hepatic artery embolization (TAE) ( n =49) , and 18 patients with HCC by TAE only as control group C. Fourteen patients with secondary hepatic carcinoma were treated in the same way as group B or C. RESULTS Ⅰ. Comparing with the control group, the treatment group of tumor bearing nude mice attained the tumor inhibition rates of 59 7%-93 7% ( F =579 62, P <0 01) at 14*!d . At an absorbed dose of 7320Gy, the tumor cells were completely destroyed. When the absorbed doses ranged from 1830Gy to 3660Gy, most of the tumor cells showed the evidences of injury or necrosis, but there appeared some well differentiated tumor cells and enhanced effect of the autoimmunocytes. At an absorbed dose of 366Gy or less, some tumor cells still remained active proliferative ability. The definite anticancer effect appeared as early as 3d after intratumoral injection of 32 P GMS. Ⅱ. The cumulative amount of 32 P GMS in the target tissue after trans hepatic artery instillation attained more than 90% of the total dose administrated. Semiquantitative analysis of ultrastructral morphology in the experimental group showed no statistical difference between the nuclear abnormality (N abn ) and mitochondrial variability (M var ) at week 1 or 2, but revealed prominent difference (χ 2=6 70-9 68, P <0 01 , χ 2=65 09-115 09, P <0 001 ) as compared with those in the other groups. In the experimental group the N abn in tissues showed no significant difference between week 8 and week 16. No apparent changes were found in the stomach, spleen, kidney and lung tissues of the experimental pigs. Ⅲ. The therapeutical results of HCC patients in group A were closely approximated to those of group C, no hematological toxic side effects were noted, and the systemic reaction was mild. In some patients 2*!mos - 3*!mos after treatment some secondary foci appeared around the periphery of the primary lesion. In general better effectiveness was obtained in patients with small lesion. After analyzing by RIDIT method, the therapeutic result in group B was significantly better than that in group C, and secondary foci around the original lesion were rarely seen at 3*!mos after treatment. In group C the collateral circulation was reestablished along the periphery of primary foci and the secondary foci appeared more frequently, and required to undergo several courses of treatment. In group B, 4 cases of HCC were treated surgically as their mass decreased in size after 32 P GMS treatment. | LIU Lu, JIANG Zao, TENG Gao Jun, SONG Ji Zhi, ZHANG Dong Sheng, GUO Qing Ming, FANG Wen, HE Shi Cheng and GUO Jin He | 1999 | World Journal of Gastroenterology1999，5，6： | 21 |
| 13 | Regeneration of 2-amino-2-methyl-1-propanol used for carbon dioxide absorption显示文摘为了改进二氧化碳的效率骑车,处理并且减少新生能量消耗,一个位的联盟者妨碍了 2-amino-2-methyl-1-propranol (安培) 的胺被调查作为 CO2 吸收剂决定它的新生行为。CO2 吸收和胺新生特征试验性地在各种各样的操作条件下面被检验。新生效率在 358 ~ 403 K 的温度范围期间从 86.2% ~ 98.3% 增加了。为安培的最合适的新生温度是 383 K,处于这个实验条件,并且吸收 / 新生的新生效率变从 98.3% ~ 94.0% 下降了。很多热马厩盐(HSS ) 能在 CO2 吸收容量和新生效率引起减小。结果显示水的安培更容易比另外的胺与吸收容量的更少的损失再生,例如,单音的乙醇胺(MEA ) , diethanolamine (DEA ) , diethylenetriamine (DETA ) ,和 N-methyldiethanolamine (MDEA ) 。 | ZHANG Pei SHI Yao WEI Jianwen ZHAO Wei YE Qing | 2008 | Journal of Environmental Sciences2008，20，1： | 21 |
| 14 | Systematic review of TCF2 anomalies in renal cysts and diabetes syndrome/maturity onset diabetes of the young type 5显示文摘在那里的目的是出版工作的少量系统地与肾的包囊和年轻类型的糖尿病症候群(RCAD )/maturity 发作糖尿病评估基因异例或病人的临床的特征 5 (MODY5 ) 。这评论的目的是系统地估计察觉率,基因并且异质接合的正染色体的主导的 TCF2 anomalies.Data 来源 MEDLINE 数据库的 phenotypic 含意被寻找选择从 1997 ~ 2008 用英语记录的文章。焦点是 monoallelic germline TCF2 基因变化 / 删除。 Biallelic inactivation ,多型性, DNA 修正( hypomethylation 和 hypermethylation ),与癌症风险联系的 loci ,和体的 TCF2 异例都是在寻找文学以后的 excluded.Study 选择, 50 篇文章是 TCF2 异例的察觉率是的 selected.Results 9.7%并且在 MODY (1.4%)之中更加变化了,肾的结构异例( RSA )(21.4%)和有 MODY (41.2%)亚群的 RSA 。变化惊人地位于 DNA 有约束力的域以内并且在 DNA 有约束力的域的 exons 之中变化了:exons 2 和 4 是最热的点,当变化在 exon 是偶发地分布式的时 3。一致显型是 RSA (89.6%) 和糖尿病 mellitus (DM )(45.0%) 。然而, RSA 和 DM 的同时发生是相对低的(27.5%) ,它妨碍基因测试和及时诊断的获得的最佳的表演。另外的机关参与为有 TCF2 异例的病人的早鉴定补足、必要。TCF2 点变化的显型的分析根据变化类型然而并非 utation location.Conclusion 处于 RSA,损害肾的功能(IRF ) 和 DM 的察觉率显示出重要差别以前没收到足够的注意的 TCF2 异例的这些珍贵特征不应该被忽视。 | CHEN Yi-zhi GAO Qing ZHAO Xue-zhi CHEN Ying-zhang Craig L Bennett XIONG Xi-shan MEI Chang-lin SHI Yong-quan CHEN Xiang-mei | 2010 | Chinese Medical Journal2010，，22： | 21 |
| 15 | Impact of CYP2C19 polymorphism and smoking on response to clopidogrel in patients with stable coronary artery disease显示文摘有阿司匹林和 clopidogrel 的背景双反血小板治疗是为经历经皮的冠的干预(一种总线标准) 阻止 thrombotic 事件的病人的确定的基础。现在的学习被进行检验 CYP2C19 681GA 多型性并且香烟吸烟是否在由于稳定的心绞痛经历选任的冠的 stent 放置的 722 个中国汉病人之中在对 clopidogrel.Methods 的反应上有独立或交互的效果, 300 mg clopidogrel 的装载剂量被给所有病人和 75 mg 的每日的维护剂量最少 12 个月。CYP2C19 681GA 多型性是 genotyped。血小板反应被轻发射度 aggregometry (LTA ) 与导致的 5 mol/L 腺苷 diphosphate (自动数据处理) 测量。差的反应被定义为 10% 或少些在在装载结果显示出的 clopidogrel.Results 的剂量以后的基线和 24 个小时的聚集之间的绝对差别对 clopidogrel 差反应在 105 个病人(14.5%) 被介绍。总的来说,遗传型 GA/AA 搬运人是可能的是穷人应答的盒子(19.6% 对 11.0% , P=0.001 ) 与机会比率(或) 1.971 (95% CI:1.296-2.998, P=0.002 ) ,与 GG 同质接合体相比。与不抽烟的人相比,同时,吸烟者显示出更低的率差反应(10.9% 对 17.3% , P=0.015 ) 与或 0.582 (95% CI:0.374-0.904, P=0.016 ) 。有 GG 遗传型的吸烟者有最低风险与或 0.487 (95% CI:0.246-0.961, P=0.038 ) 当有 GA/AA 遗传型的不抽烟的人有最高的风险时与或 1.823 差反应(95% CI:1.083-3.068, P=0.024 ) ,与有 GG 遗传型的不抽烟的人相比。然而,在我们的学习显示了的遗传型和 smoking.Conclusion 之间没有重要相互作用那两个 CYP2C19 多型性和吸烟独立地影响的反应到 clopidogrel。 | LIU Xiao-li WANG Zhi-jian YANG Qing GE Hai-long GAO Fei LIU Yu-yang SHI Dong-mei ZHAO Ying-xin ZHOU Yu-jie | 2010 | Chinese Medical Journal2010，，22： | 19 |
| 16 | Biphasic insulin aspart 30 improved glycemic control in Chinese patients with type 2 diabetes poorly controlled on oral glucose-lowering drugs: a subgroup analysis of the A1chieve study显示文摘 | Chen Liming Xing Xiaoyan Lei Minxiang Liu Jie Shi Yongquan Li Pengqiu Qin Guijun Li Chengjiang Li Yukun Wang Qing Gao Tianshu Hu Ling Wang Yangwei Yang Wenying | 2014 | Chinese Medical Journal2014，，2： | 19 |
| 17 | Genotyping for Kidd, Kell, Duffy, Scianna, and RHCE blood group antigens polymorphisms in Jiangsu Chinese Han显示文摘 | LIU Zhong ZENG Rong CHEN Qing LI Min SHI Guang-yao WEI Peng HUANG Cheng-yin TANG Rong-cai SUN Jun ZHANG Xue-guang | 2012 | Chinese Medical Journal2012，，6： | 18 |
| 18 | Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets显示文摘Autophagy 是由毁坏并且再循环细胞内部的内容帮助细胞的动态平衡的维护的一条重要 lysosomal 降级小径。autophagy 的 Dysregulation 被连接到越来越多的人的疾病。Beclin 1-Vps34 蛋白质蛋白质相互作用网络为 autophagy 规定是批评的并且对细胞的正直因此必要。特别地经由 Beclin 1-Vps34 建筑群的行动的调整, autophagy 的操作被认为一条有希望的线路与 autophagy 相关的疾病作斗争。这里,我们在核心部件和 Beclin 1-Vps34 建筑群的结构的建筑学上总结最近的调查结果,并且怎么这些调查结果提供珍贵卓见进位于这些建筑群并且为设计治疗学的策略的多重函数下面的分子的机制。 | Deanna H. Morris Calvin K. Yip Yi Shi Brian T. Chait Qing Jun Wang | 2015 | Frontiers in Biology2015，10，5： | 17 |
| 19 | Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-κB inhibition显示文摘 | Yue Shi Xiao-chun Liang Hong Zhang Qun-li Wu Ling Qu Qing Sun | 2013 | Acta Pharmacologica Sinica2013，34，9： | 16 |
| 20 | Three-year results of small incision lenticule extraction and wavefront-guided femtosecond laser-assisted laser in situ keratomileusis for correction of high myopia and myopic astigmatism显示文摘AIM: To compare and calculate the 3-year refractive results, higher-order aberrations(HOAs), contrast sensitivity(CS) and dry eye parameters after small incision lenticule extraction(SMILE) and wavefront-guided femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK) for correction of high myopia and myopic astigmatism.METHODS: In this prospective, non-randomized comparative study, 78 eyes with spherical equivalent(SE) of-8.11±1.09 diopters(D) received a SMILE surgery, and 65 eyes with SE of-8.05±1.12 D received a wavefront-guided FS-LASIK surgery with the Visu Max femtosecond laser(Carl Zeiss Meditec, Jena, Germany) for flap cutting. Visual acuity, manifest refraction, CS, HOAs, ocular surface disease index(OSDI) and tear break-up time(TBUT) were evaluated during a 3-year follow-up.RESULTS: The difference of uncorrected distance visual acuity(UDVA) postoperatively was achieved at 1 mo and at3 mo, whereas the difference of the mean UDVA between two groups at 3 y were not statistically significant(t=-1.59,P=0.13). The postoperative change of SE was 0.89 D in the FS-LASIK group(t=5.76, P=0.00), and 0.14 D in the SMILE group(t=0.54, P=0.59) from 1 mo to 3 y after surgery.At 3-year postoperatively, both HOAs and spherical aberrations in the SMILE group were obviously less than those in the FS-LASIK group(P=0.00), but the coma root mean square(RMS) was higher in the SMILE group(0.59±0.26) than in the FS-LASIK group(0.29±0.14, P=0.00).The mesopic CS values between two groups were not statistically significant at 3 y postoperatively. Comparedwith the FS-LASIK group, lower OSDI scores and longer TBUT values were found in the SMILE group at 1 mo and 3 mo postoperatively. With regard to safety, no eye lost any line of CDVA in both groups at 3 y after surgery. CONCLUSION: Both SMILE and wavefront-guided FSLASIK procedures provide good visual outcomes. Both procedures are effective and safe, but SMILE surgery achieve more stable long-term refractive outcome and better control of early postoperative dry eye as compared to FS-LASIK. | Li-Kun Xia Jing Ma He-Nan Liu Ce Shi Qing Huang | 2018 | International Journal of Ophthalmology(English edition)2018，11，3： | 16 |
您所在的机构暂未开通此部分的功能，请联系管理员