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| 1 | DICER-LIKE3 Activity in Physcomitrella patens DICER-LIKE4 Mutants Causes Severe Developmental Dysfunction and Sterility显示文摘交易的小介入 RNA (ta-siRNAs ) 是在 microRNA 依赖的劈开,进双 stranded RNA 的变换,和骰子依赖者分阶段执行处理以后,免除 TAS 先锋抄本的植物特定的 siRNAs。象 microRNAs (miRNAs ) 一样, ta-siRNAs 在广泛的补充的地点的目标 RNA 的直接地点特定的劈开。这里,我们证明像骰子 Physcomitrella 圣餐盘(PpDCL4 ) 的 4 蛋白质为 21 核苷酸(nt ) 的生物的续生说是必要的 ta-siRNAs。在 PpDCL4 异种,离开缩放 23 并且 24-nt ta-siRNAs 作为 PpDCL3 的结果积累了活动。PpDCL4 异种在整个 Physcomitrella 开发显示严重畸形,包括绝育,那充分在 PpDCL3/PpDCL4 双异种植物被颠倒。因此, PpDCL3 活动,不是 PpDCL4 功能本身的损失,是 PpDCL4 显型的原因。另外,我们描述几新 Physcomitrella 交易 siRNA loci,其三属于一个新家庭, TAS6。TAS6 loci 被切的 miR156 和 miR529 目标地点代表并且在到 PpTAS3 loci 的靠近的最近。 | M. Asif Arif Isam Fattash Zhaorong Ma Sung Hyun Cho Anna K. Beike Ralf Reski Michael J. Axtell Wolfgang Frank | 2012 | Molecular Plant2012，5，6： | 4 |
| 2 | Transcriptional control of gene expression by microRNAs 显示文摘 | Khraiwesh B Arif MA Seumel GI | 2010 | Cell2010，140，1： | 1 |
| 3 | Transcriptional control of gene expression by microRNAs显示文摘 | Khraiwesh B Arif MA Seumel GI | 2010 | Ceil2010，140，1： | 1 |
| 4 | Transcriptional control of gene expression by microRNAs 显示文摘 | Khraiwesh B Arif MA Seumel GI | 2010 | Cell2010，140，1： | 1 |
| 5 | Causative relation- ship between diabetes meUitus and breast cancer in various regions of Saudi Arabia: an overview 显示文摘 | Arif JM AL-Saif AM AL-Karrawi MA | 2011 | Asian Pac J Cancer Prey2011，12，3： | 1 |
| 6 | Causative relation- ship between diabetes mellitus and breast cancer in various regions of Saudi Arabia: an overview显示文摘 | Arif JM AL-Saif AM AL-Karrawi MA | 2011 | Asian Pac J Cancer Prey2011，12，3： | 1 |
| 7 | Albendazole as an adjuvant to the standard surgical management of hydatid cyst liver显示文摘 | Arif SH Shams-Ul-Bari NA Wani MA | 2008 | Int J Surg2008，6，6： | 1 |
| 8 | Characterizationof the 5-adenosylmethionine decarboxylase (SAMDC) gene ofpotato 显示文摘 | Arif SAM Taylor MA George LA | 1994 | Plant Mol Biol1994，26，： | 1 |
| 9 | Transcriptional control of gene expression by microRNAs 显示文摘 | Khraiwesh B Arif MA Seumel GI | 2010 | Cell2010，140，1： | 1 |
| 10 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 11 | Causative relation- ship between diabetes mellitus and breast cancer in various regions of Saudi Arabia: an overview显示文摘 | Arif JM AL-Saif AM AL-Karrawi MA | 2011 | Asian Pac J Cancer Prey2011，12，3： | 1 |
| 12 | Transcriptional control of gene expression by microRNAs 显示文摘 | Khraiwesh B Arif MA Seumel GI | 2010 | Cell2010，140，1： | 1 |
| 13 | Transcriptional control of gene expression by microRNAs显示文摘 | Khraiwesh B Arif MA Seumel GI | 2010 | Cell2010，140，1： | 1 |
| 14 | Transcriptional control of gene expression by microRNAs 显示文摘 | Khraiwesh B Arif MA Seumel GI | 2010 | Cell2010，140，1： | 1 |
| 15 | Transcriptional control of gene expression by microRNAs 显示文摘 | Khraiwesh B Arif MA Seumel GI | 2010 | Cell2010，140，1： | 1 |
| 16 | et al, Transcriptional control of gene expression by microRNAs 显示文摘 | Khraiwesh B Arif MA Seumel GI | 2010 | Cell2010，140，1： | 1 |
| 17 | Chemical constituents and anticoagulant activity from Delphinium brunonianum Royle显示文摘Delphinium brunonianum Royle belongs to Ranunculaceae family and has the effects of dispelling wind to relieve itching and cooling blood to detoxify.It was found that the extracts of D.brunonianum had good anticoagulant activity which was extracted with 70%ethanol in our previous researches.Then,16 compounds were isolated and identified from the extract of D.brunonianum,among which compounds 5,7-10,12,14,15-16 were isolated from this genus for the first time,and compounds 2-4 were isolated from this plant for the first time.And the coagulation activity assay showed that compounds 10,14 and 15 had good anticoagulant activity by activated partial thromboplastin time(APTT),thrombin time(TT)and prothrombin time(PT)in vitro. | Changyang Ma Sitan Chen Syed Arif Hussain Rizvi Huihui Zhou Wenyi Kang Xuefeng Xi Zhenhua Liu | 2024 | Journal of Future Foods2024，4，3： | 0 |
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