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| 1 | Influence of ellagic acid on prostate cancer cell proliferation:A caspase-dependent pathway显示文摘Objective:To evaluate the effect of allagic acid treatment on the cell viability of human prostate cancer cells.Methods:Ellagic acid(10-100 mol/L) treatment(48 h) of human prostate carcinoma PC3 cells was found to result in a dose-dependent inhibition of cell growth and apoptosis of PC3 cells as assessed by MTT assay,western blotting.flow cytometry and confocal microscopy.Results:We observed that ellagic acid treatment of PC3 cells resulted in a dose dependent inhibition of cell growth/cell viability.This ellagic acid caused cell growth inhibition was found to be accompanied by induction of apoptosis,as assessed by the cleavage of poly (ADP-ribose) polymerase(PARP) and morphological changes.Further,induction of apoptosis accompanied a decrease in the levels of antiapoptotic protein Bcl-2 and increase in proapoptotic protein Bax.thus shifting the Bax:Bcl-2 ratio in favor of apoptosis.Ellagic acid treatment of PC3 cells was also found to result in significant activation of caspases,as shown by the dose dependent decrease in the protein expression of procaspase-3,-6.-8 and -9.This ellagic acid-mediated induction of apoptosis was significantly(80%-90%) inhibited by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone(Z-VAD-FMK).Thus these data suggested an essential role of caspases in ellagic acid-mediated apoptosis of PC3 cells.Conclusions:It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer. | Arshi Malik Sarah Afaq Mohammad Shahid Kafil Akhtar Abdullah Assiri | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，7： | 18 |
| 2 | Granulocyte Colony–Stimulating Factor Mobilizes CD34 + Cells and Improves Survival of Patients With Acute-on-Chronic Liver Failure显示文摘 | Vishal Garg Hitendra Garg Arshi Khan Nirupama Trehanpati Ashish Kumar Barjesh Chander Sharma Puja Sakhuja Shiv Kumar Sarin | 2012 | Gastroenterology2012，，3： | 3 |
| 3 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 4 | Anopheline species composition in borderline of Iran–Azerbaijan显示文摘 | M.A. Oshaghi H. Vatandoost A. Gorouhi M.R. Abai A. Madjidpour S. Arshi H. Sadeghi M. Nazari A. Mehravaran | 2011 | Acta Tropica2011，，1： | 2 |
| 5 | Material optimization of femoral component of total hip prosthesis using fiber reinforced polymeric composites显示文摘 | Katoozian H Davy DT Arshi A | 2001 | Med Eng Phys2001，23，7： | 1 |
| 6 | Low levels of Her2/ neu expressed by Ewing's family tumor cell lines can redirect cy- tokine-induced killer cells 显示文摘 | Verneris MR Arshi A Edinger M | 2005 | Clin Cancer Res2005，11，12： | 1 |
| 7 | Mn-doped ZnO nanorod gas sensor for oxygen detection显示文摘 | Faheem Ahmed Nishat Arshi M.S. Anwar Rehan Danish Bon Heun Koo | 2013 | Current Applied Physics2013，，： | 1 |
| 8 | Flow cytometfic measurement of circulating endothelial cells:the effect of age and peripheral arterial disease on baseline levels of mature and progenitor populations 显示文摘 | Shaffer RG Greene S Arshi A | 2006 | Clinical Cytometry2006，70，2： | 1 |
| 9 | Cancer prevention through pomegranate fruit显示文摘 | Malik Arshi Mukhtar Hasan | 2006 | Cell Cycle2006，5，4： | 1 |
| 10 | Vitamin D serum leves in allergic rhinitis:any difference from normal population显示文摘 | ARSHI S GHALEHBAGHL B AMINLOU M | 2012 | Asia Pac Allergry2012，2，： | 1 |
| 11 | The effect of early ambulation on the incidence of neurological complication after spinal anesthesia with lidocaine显示文摘 | Talakoub R Golparvar M Arshi R | 2015 | J Res Med Sci2015，20，4： | 1 |
| 12 | Flow cytometric measurement of circulating endothelial cells:the effect of age and peripheral arterial disease on baseline levels of mature and progenitor populations显示文摘 | Shaffer RG Greene S Arshi A | 2006 | Cytometry B Clin Cytom2006，70，2： | 1 |
| 13 | Coupling CFAST fire modeling and SAPHIRE probabilistic assessment software for internal fire safety evaluation of a typical TRIGA research reactor显示文摘 | ARSHI S S NEMATOLLAHI M SEPANLOO K | 2010 | Reliability Engineering & System Safety2010，95，3： | 1 |
| 14 | Asthma and insulin resistance in children 显示文摘 | Arshi M Cardinal J Hill RJ | 2010 | Respirology2010，5，5： | 1 |
| 15 | Epidemiological aspects of canine visceral leishmaniosis in the Islamic Republic of Iran显示文摘 | Mehdi Mohebali Homa Hajjaran Yazdan Hamzavi Iraj Mobedi Shahnam Arshi Zabih Zarei Behnaz Akhoundi Koroush Manouchehri Naeini Reza Avizeh Mehdi Fakhar | 2005 | Veterinary Parasitology2005，，3： | 1 |
| 16 | Sennoside content and yield attributes of Cassia angustifolia Vahl. as affected by NaCl and CaCl 2显示文摘 | A. Arshi M.Z. Abdin M. Iqbal | 2006 | Scientia Horticulturae2006，，1： | 1 |
| 17 | Formation and charac-terization of ZnO nanopowder synthesized by sol-gel method 显示文摘 | Azam A Ahmed F Arshi N | 2010 | J Alloys Compd2010，496，： | 1 |
| 18 | Vitamin D serum levels in allergic rhinitis any difference from normal population? 显示文摘 | Arshi S Nabavi M Babie D | 2012 | Asia Pac Allergy2012，2，： | 1 |
| 19 | Flow cytometric measurement of circulating endothelial cells: the effect of age and peripheral arterial disease on baseline levels of mature and progenitor populations显示文摘 | SHAFFER R G GREENE S ARSHI A | 2006 | Cytometry B Clin Cytom2006，70，： | 1 |
| 20 | Modified COBRA-EN code to investigate ther mat-hydraulic analysis of the Iranian VVER-1000 core显示文摘 | ARSHI S S MIRVAKILI S M FAGHIHI F | 2010 | Progress in Nuclear Energy2010，52，6： | 1 |
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