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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Midterm experience with the endovascular treatment of isolated iliac aneurysms显示文摘 | Sanchez LA Patel AV Ohki T | 1999 | J Vasc Surg1999，30，5： | 1 |
| 3 | Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation显示文摘 | Molofsky AV Pardal R Iwashita T | 2003 | Nature2003，425，6961： | 1 |
| 4 | Complement C5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cells 显示文摘 | Cybulsky AV Takano T Papillon J | 2002 | Biol Chem2002，277，41： | 1 |
| 5 | Lysine requirements of healthy adult Indian subjects receiving long-term feeding measured with a 24-h indicator amino acid oxidation and balance technique 显示文摘 | Kurpad AV Regan MM Raj T | 2002 | Am J Clin Nutr2002，76，2： | 1 |
| 6 | Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation显示文摘 | Molofsky AV Pardal R Iwashita T | 2003 | Nature2003，425，6961： | 1 |
| 7 | Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury 显示文摘 | Cybulsky AV Takano T Papillon J | 2005 | Biol Chem2005，280，24： | 1 |
| 8 | Real-time continuous intraoperative electromyographic and somato-sensory evoked potential recordings in spinal surgery:correlation of clinical and electrophysiologic findings in a prospective,consecutive series of 213 cases显示文摘 | Gunnarsson T Krassioukov AV Sarjeant R | | 0，，06： | 1 |
| 9 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 10 | c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation显示文摘 | Varfolomeev E Goncharov T Fedorova AV | 2008 | J Biol Chem2008，283，24： | 1 |
| 11 | The LHRH antagonist cetrorelix:a review显示文摘 | Reissmann T Schally AV Bouchard P | 2000 | Hum Reprod Update2000，6，4： | 1 |
| 12 | Long-term cardiac memory in canine heart is associated with the evolution of a transmural repolarization gradient 显示文摘 | Coronel Opthof T Plotnikov AV | 2007 | Cardiovasc Res2007，74，3： | 1 |
| 13 | Antagonist of growth hormone-releasing hormone induces apoptosis in LNCaP human prostate cancer cells through a Ca2+-dependent pathway显示文摘 | Rekasi Z Czompoly T Schally AV | 2005 | Proc Natl Acad Sci U S A2005，102，9： | 1 |
| 14 | Effects of substrate stiffness on cell morphology, cytoskeletal structure and adhesion 显示文摘 | Yeung T Georges P C Flanagan L Av | 2005 | Cell Motol Cytoskel2005，60，1： | 1 |
| 15 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 16 | Computerized image analysis for quantitative measurement of vessel diameter from cineangiograms显示文摘 | Spears JR Sandor T Als AV | 1983 | Circulation1983，68，2： | 1 |
| 17 | Liver NF-KB and AP-1 DNA binding in obese patients 显示文摘 | Luis AV Gladys T Ram6n R | 2009 | Obesity2009，17，5： | 1 |
| 18 | Structure, function, and amyloidogenesis of fungal prions: filament polymorphism and prion variants 显示文摘 | Baxa U Cassese T Kajava AV | 2006 | Adv Protein Chem2006，73，： | 1 |
| 19 | Imaging of cervical lymphadenopathy显示文摘 | Kaji AV Mohuchy T Swartz JD | 1997 | Semin Ultrasound CT MR1997，18，3： | 1 |
| 20 | Imaging of cervical lymphadenopathy 显示文摘 | Kaji AV Mohuchy T Swartz JD | 1997 | Semin Ultrasound CT MR1997，18，3： | 1 |
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