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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease显示文摘 | Katsuya T Koike G Yee TW | 1995 | Lancet1995，345，： | 1 |
| 3 | Polymorphism of an giotensin converting enzyme, angiotensinogen, and apolipopro- tein E genes in a Japanese population with cerebrovascular disease显示文摘 | Nakata Y Katsuya T Rakugi H | 1997 | Am J Hypertens1997，10，12： | 1 |
| 4 | Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals显示文摘 | Takeuchi F Yamamoto K Katsuya T | 2011 | Diabetologia2011，54，6： | 1 |
| 5 | Polymorphism of angiotensin converting enzyme,angiotensinogen,and apoliporotein E genes in a Japanese population with cerebrovascular disease显示文摘 | Nakata Y Katsuya T Rakugi H | 1997 | Am J Hypertens1997，10，12： | 1 |
| 6 | Deletion allele of angiotensin-eonverting enzyme gene increases risk of essential hypertension in japanese men: the Suita study显示文摘 | Higaki J Baba S Katsuya T | 2000 | Circulation2000，101，17： | 1 |
| 7 | Hypoadiponectinemia is an independent risk factor for hypertension 显示文摘 | Iwashima Y Katsuya T Ishikawa K | 2004 | Hypertension2004，43，： | 1 |
| 8 | Low potentiality of angiotensin - converting enzyme gene inser-tion/deletion polymorphism as a useful predictive marker for carotid atherogenesis ina large general population of a Japanese city, the suita study显示文摘 | Mannami T Katsuya T Baba S | 2001 | Stroke2001，32，6： | 1 |
| 9 | Hypoadiponectinemia is an independent risk factor for hypertension 显示文摘 | Iwashima Y Katsuya T Ishikawa K | 2004 | Hypertension2004，43，6： | 1 |
| 10 | alpha-Adducin Gly460Trp polymorphism is associated with low renin hyperten- sion in younger subjects in the Ohasama study 显示文摘 | Sugimoto K Hozawa A Katsuya T | 2002 | J Hypertens2002，20，9： | 1 |
| 11 | Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease显示文摘 | Katsuya T Koike G Yee TW | 1995 | Lancet1995，345，8965： | 1 |
| 12 | Polymorphism of angiotensin converting enzy, angiotension and apolipoprotein E genes in a Japanese population with cerebrovascular disease显示文摘 | Nakata Y Katsuya T Rakugi H | 1997 | Am J Hypertens1997，10，1： | 1 |
| 13 | Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin Ⅱ显示文摘 | Yamamoto K Ohishi M Katsuya T | 2006 | Hypertension2006，47，4： | 1 |
| 14 | Growth of well-Developed Li4TisOn crystals by the cooling of a sodium chloride flux显示文摘 | KATSUYA T HIKARU I SYOHEI T | 2011 | Crystal Growth Design2011，，11： | 1 |
| 15 | Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: the suite study 显示文摘 | Tsujita Y Iwai N Katsuya T | 2001 | Hypertens Res2001，24，1： | 1 |
| 16 | Lack of association between genetic polymorphism of CYPI 1 B2 and hypertension in Japanese: the suite study 显示文摘 | Tsujita Y Iwai N Katsuya T | 2001 | Hypertens Res2001，24，2： | 1 |
| 17 | Beta2-adrenoceptor polymorphismsrelate to insulin resistance and sympathetic overactivity asearly markers of metabolic disease in nonobese, normotensiveindividuals显示文摘 | Masuo K Katsuya T Fu Y | 2005 | Am J Hypertens2005，18，7： | 1 |
| 18 | Blood pressure and hy- pertension are associated with 7 loci in the Japanese population 显示文摘 | Takeuchi F Isono M Katsuya T | 2010 | Circulation2010，121，21： | 1 |
| 19 | Polymorphism of angiotensin converting enzyme, angiotensinogen, and apolipoprotein E genes in a Japanese population with eerebrovascular disease 显示文摘 | Nakata Y Katsuya T Rakugi H | 1997 | Am J Hypertens1997，10，： | 1 |
| 20 | Estimation of body fat content from standard body length and body weight on cultured Red Sea bream显示文摘 | HARUE K MUTSUYSHI T KATSUYA M | 2000 | Fisheries Science2000，66，2： | 1 |
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