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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Increased risk of death and de novo chronic kidney disease following reversible acute kid-hey injury显示文摘 | Bucaloiu ID Kirchner HL Norfolk ER | 2012 | Kidney Int2012，81，： | 1 |
| 3 | Differences in poly- somnography predictors for hypertension and impaired glucose tolerance显示文摘 | Sulit L Storfer-Isser A Kirchner HL | 2006 | Sleep2006，29，6： | 1 |
| 4 | Developmental sequelae in preterm infants having a diagnosis of bronchopulmonary dysplasia:analysis using a severity-based classification system显示文摘 | Short EJ Kirchner HL Asaad GR | 2007 | Arch Pediatr Adolesc Med2007，161，11： | 1 |
| 5 | The effects of age, sex,ethnicity, and sleep-disordered breathing on sleep architecture 显示文摘 | Redline S Kirchner HL Quan SF | 2004 | Arch Intern Med2004，164，4： | 1 |
| 6 | Prevalence and risk factors for sleep-disordered breathing in 8-to 11-year-old childien:association with race and prematurity显示文摘 | Rosen CL Larkin EK Kirchner HL | 2003 | J Pediatr2003，142，： | 1 |
| 7 | Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury 显示文摘 | Bucaloiu ID Kirchner HL Norfolk ER | 2012 | Kidney Int2012，81，5： | 1 |
| 8 | Prevalence and risk factors for sleep-disordered breathing in 8-to 11-year-old children:association with race and prematurity显示文摘 | Rosen CL Larkin EK Kirchner HL | 2003 | Pediatrics2003，142，4： | 1 |
| 9 | The effects of age, sex, ethnicity, ,'rod sleep-disordered breathing on sleep architecture显示文摘 | Redline S Kirchner HL Quan SF | 2004 | Arch Intern Med2004，164，4： | 1 |
| 10 | Variation of C-reactiveprotein levels in adolescents : association with sleep disorderedbreathing and sleep during 显示文摘 | Larkin EK Rosen CL Kirchner HL ei al | 2005 | Circulation2005，111，15： | 1 |
| 11 | Sleep apnea in acute coronary syndrome: high prevalence but low impact on 6-month outcome显示文摘 | Mehra R Principe-Rodriguez K Kirchner HL | 2006 | Sleep Med2006，7，6： | 1 |
| 12 | Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep duration 显示文摘 | Larkin EK Rosen CL Kirchner HL Storfer-lsser A Emancipator JL Johnson NL | 2005 | Circulation2005，111，15： | 1 |
| 13 | Developmental sequelae in preterm infants having a diag- nosis of bronchopulmonary dysplasia: analysis using a severity- based classification system显示文摘 | Short EJ Kirchner HL Asaad GR Fulton SE Lewis BA Klein N | 2007 | Arch Pediatr Adolesc Med2007，161，11： | 1 |
| 14 | Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis显示文摘 | Bili A Sartorius JA Kirchner HL | | 0，，： | 1 |
| 15 | Prevalence and risk factors for sleep-disordered breathing in 8- to 11-year-old children : association with race and prematurity 显示文摘 | Rosen CL Larkin EK Kirchner HL | 2003 | Pediatr2003，142，4： | 1 |
| 16 | Obstructive sleep apnea is associated with increased urinary albumin excretion 显示文摘 | Faulx MD Storfer- Isser A Kirchner HL | 2007 | Sleep2007，30，7： | 1 |
| 17 | Sleep-disordered breathing and impaired glucose metabolism in normal-weight and overweight/obese individuals: the Sleep Heart Health Study 显示文摘 | Seicean S Kirchner HL Gottlieb DJ | 2008 | Diabetes Care2008，31，5： | 1 |
| 18 | Neighbor- hood disadvantage as a risk factor for pediatric obstructive sleep apnea显示文摘 | Spilsbury JC Storfer-Isser A Kirchner HL | 2006 | J Pediatr2006，149，： | 1 |
| 19 | Obstructive sleep apnea is associated with increased urinary albumin excretion显示文摘 | Faulx MD Storfer- Isser A Kirchner HL | 2007 | Sleep2007，30，7： | 1 |
| 20 | Obstructive sleep apnea is associated with increased urinary albumin excretion显示文摘 | Faulx MD Storfer-Isser A Kirchner HL | 2007 | Sleep2007，30，7： | 1 |
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