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| 1 | Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication显示文摘AIM To clarify the association between aldo-keto reductase family 1 member B10(AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus eradication.METHODS In this study,we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response(SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios(HRs) of AKR1B10 expression for hepatocellular carcinoma(HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank test.RESULTS Of the 303 chronic hepatitis C patients,153(50.5%) showed scarce hepatic AKR1B10 expression,quantified as 0%,which was similar to the expression in control normal liver tissues. However,the remaining 150 patients(49.5%) exhibited various degrees of AKR1B10 expression in the liver,with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years(range 1.0-10.0 years),8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression(≥ 8%) was an independent risk factor for HCC development(HR = 15.4,95%CI: 1. 8- 1 3 2. 5,P = 0. 0 1 2). T h e 5- y e a r c u m u l a t i v e incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression,respectively(P < 0.001). During the follow-up period after viral eradication,patients expressing high levels of AKR1B10 expressed markedly higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 expression.CONCLUSION Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR. | Ayato Murata Takuya Genda Takafumi Ichida Nozomi Amano Sho Sato Hironori Tsuzura Shunsuke Sato Yutaka Narita Yoshio Kanemitsu Yuji Shimada Katsuharu Hirano Katsuyori Iijima Ryo Wada Akihito Nagahara Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，33： | 2 |
| 2 | Avirulent avain influenza virus as a vaccine strain against a potential human pandemic 显示文摘 | Ayato Takada Noritaaka Kuboki katsunori Okazaki | 1999 | J of Virology1999，73，10： | 1 |
| 3 | Protective immune response of chickens against Newcastle disease, induced by the intranasal vaccination with inactivated virus显示文摘 | Ayato Takada Hiroshi Kida | 1996 | Veterinary Microbiology1996，50，： | 1 |
| 4 | The pathogenesis of Ebola hemorrhagic fever显示文摘 | Ayato Takada Yoshihiro Kawaoka | 2001 | Trends in Microbiology2001，，10： | 1 |
| 5 | Rapid and simple detection of Ebola virus by reverse transcription-loop-mediated isothermal amplification 显示文摘 | Yohei Ki Ayato T Hideki E etal | 2007 | J Virel Methods2007，141，1： | 1 |
| 6 | The amino-terminal residue of glyeoprotein B is critical for neutralization of Bovine herpesvirus 1显示文摘 | Katsunori O Sanae F Ayato T | 2006 | Virus Res2006，115，2： | 1 |
| 7 | Ac- celeration of catalytic activity of calcium oxide for biodieselproduction显示文摘 | Ayato Kawashima Koh Matsubara Katsuhisa Honda | 2009 | Bioresource Technology2009，，100： | 1 |
| 8 | Acceleration of catalytic activity of calcium oxide for biodiesel production显示文摘 | Ayato Kawashima Koh Matsubara Katsuhisa Honda | 2009 | Bioresource Technology2009，100，： | 1 |
| 9 | Effects of forest type and stand age on litterfall quality and soil N dynamics in Shikoku district, southern Japan显示文摘 | Yoshiyuki Inagaki Satoru Miura Ayato Kohzu | 2004 | Forest Ecology and Management2004，，1： | 1 |
| 10 | North Pacific Tropical Water: its climatology and temporal changes associated with the climate regime shift in the 1970s显示文摘 | Toshio Suga Ayato Kato Kimio Hanawa | 2000 | Progress in Oceanography2000，，2： | 1 |
| 11 | The amino-terminal residue of glycoprotein B is critical for neutralization of Bovine herpesvirus I 显示文摘 | Katsunori O Sanae F Ayato T and Hiroshi K | 2006 | Virus Research2006，115，： | 1 |
| 12 | Enhanced virulence of influenza Aviruses with the haemagglutininof the 1918 pandemic virus显示文摘 | Darwyn Kobasa Ayato Takada Kyoko Shinya | | 0，，07： | 1 |
| 13 | Development of heterogeneous base catalysts for biodiesel production 显示文摘 | AYATO K KOH M KATSUHISA H | 2008 | Bioresource Technology2008，99，9： | 1 |
| 14 | Removal of dioxins and dioxin- like PCBs from fish oil by countercurrent supercritical CO2 extraction and activated carbon treatment显示文摘 | AYATO KAWASHIMA SAKURA WATANABE RYOUJI IWAKIRI | 2009 | Chemosphere2009，75，6： | 1 |
| 15 | Seroepidemiological evidence of avian H4, H5, and H9 influenza A virus transmission to pigs in southeastern China显示文摘 | Ai Ninomiya Ayato Takada Katsunori Okazaki Kennedy F Shortridge Hiroshi Kida | 2002 | Veterinary Microbiology2002，，2： | 1 |
| 16 | Development of heterogeneous base catalysts for biodiesel production 显示文摘 | Ayato K Koh M Katsuhisa H | 2008 | Bioresource Technology2008，99，9： | 1 |
| 17 | Rapid and simple detection of Ebola virus by reverse transcription-loop-mediated isothermal amplification显示文摘 | Yohei Ki Ayato T Hideki E | 2007 | Journal of Virological Methods2007，141，1： | 1 |
| 18 | Combined effects of strain rate and temperature on consolidation behavior of clayey soils显示文摘 | Ayato Tsutsumi Hiroyuki Tanaka | 2012 | Soils and Foundations2012，，2： | 1 |
| 19 | Protective efficacy of neutralizing antibodies against Ebola virus infection显示文摘 | Ayato Takada Hideki Ebihara Steven Jones Heinz Feldmann Yoshihiro Kawaoka | 2006 | Vaccine2006，，： | 1 |
| 20 | The effect of impurity cations on the transport characteristics of perfluorosulfonated ionomer membranes 显示文摘 | OKADA T AYATO Y YUASA M | 1999 | Journal of Physical Chemistry B1999，103，： | 1 |
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