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| 1 | Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication显示文摘AIM To clarify the association between aldo-keto reductase family 1 member B10(AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus eradication.METHODS In this study,we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response(SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios(HRs) of AKR1B10 expression for hepatocellular carcinoma(HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank test.RESULTS Of the 303 chronic hepatitis C patients,153(50.5%) showed scarce hepatic AKR1B10 expression,quantified as 0%,which was similar to the expression in control normal liver tissues. However,the remaining 150 patients(49.5%) exhibited various degrees of AKR1B10 expression in the liver,with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years(range 1.0-10.0 years),8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression(≥ 8%) was an independent risk factor for HCC development(HR = 15.4,95%CI: 1. 8- 1 3 2. 5,P = 0. 0 1 2). T h e 5- y e a r c u m u l a t i v e incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression,respectively(P < 0.001). During the follow-up period after viral eradication,patients expressing high levels of AKR1B10 expressed markedly higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 expression.CONCLUSION Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR. | Ayato Murata Takuya Genda Takafumi Ichida Nozomi Amano Sho Sato Hironori Tsuzura Shunsuke Sato Yutaka Narita Yoshio Kanemitsu Yuji Shimada Katsuharu Hirano Katsuyori Iijima Ryo Wada Akihito Nagahara Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，33： | 2 |
| 2 | Prognostic Implication of Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer显示文摘 | Ryuichiro Doi Kazuhiro Kami Daisuke Ito Koji Fujimoto Yoshiya Kawaguchi Michihiko Wada Masafumi Kogire Ryo Hosotani Masayuki Imamura Shinji Uemoto | 2007 | World Journal of Surgery2007，，： | 2 |
| 3 | Induction of human cardiomyocyte-like cells from fibroblasts by defined factors显示文摘 | Rie Wada Naoto Muraoka Kohei Inagawa Hiroyuki Yamakawa Kazutaka Miyamoto Taketaro Sadahiro Tomohiko Umei Ruri Kaneda Tomoyuki Suzuki Kaichiro Kamiya Shugo Tohyama Shinsuke Yuasa Kiyokazu Kokaji Ryo Aeba Ryohei Yozu Hiroyuki Yamagishi Toshio Kitamura Keiic | 2013 | Proceedings of the National Academy of Sciences2013，，31： | 2 |
| 4 | Prognostic Implication of Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer显示文摘 | Ryuichiro Doi MD Kazuhiro Kami MD Daisuke Ito MD Koji Fujimoto MD Yoshiya Kawaguchi MD Michihiko Wada MD Masafumi Kogire MD Ryo Hosotani MD Masayuki Imamura MD Shinji Uemoto MD | 2007 | World Journal of Surgery2007，，1： | 2 |
| 5 | A follow-up report on a new method of segmental resection for small-sized early lung cancer显示文摘 | Toru Bando Ryo Miyahara Hiroaki Sakai Tsuyoshi Shoji Makoto Sonobe Kiyoshi Sato Takuji Fujinaga Fengshi Chen Kenichi Okubo Toshiki Hirata Hiromi Wada | 2008 | Lung Cancer2008，，1： | 1 |
| 6 | Multiple esophagogastric granular cell tumors显示文摘 | Hiroshi Maekawa Takeo Maekawa Kiyotaka Yabuki Kouichi Sato Yoshihisa Tamazaki Keizou Kudo Ryo Wada Michio Matsumoto | 2003 | Journal of Gastroenterology2003，，8： | 1 |
| 7 | Up‐regulated aldo‐keto reductase family 1 member B10 in chronic hepatitis C: association with serum alpha‐fetoprotein and hepatocellular carcinoma显示文摘 | Shunsuke Sato Takuya Genda Katsuharu Hirano Hironori Tsuzura Yutaka Narita Yoshio Kanemitsu Tetsu Kikuchi Katsuyori Iijima Ryo Wada Takafumi Ichida | 2012 | Liver Int2012，，9： | 1 |
| 8 | Intrazeolite Nanostrueture of Nd (Ⅲ) Complex Giving Strong Near - Infrared Luminescence 显示文摘 | Ryo Munenofi Wada Yuji Okubo Tatsuya | 2003 | J Phys Chem B2003，107，11： | 1 |
| 9 | ERC/mesothelin is expressed in human gastric cancer tissues and celllines显示文摘 | Tomoaki Ito Kazunori Kajino Masaaki Abe Koichi Sato Hiroshi Maekawa Mutsumi Sakurada Hajime Orita Ryo Wada Yoshiaki Kajiyama Okio Hino | 2014 | Oncology Reports2014，，： | 1 |
| 10 | The effect of core stability exercise on the reaction time of deep trunk muscles显示文摘This study aimed to clarify the immediate effect that trunk muscle exercise has on muscle reaction time, and to clarify the effect of 2-week exercise on muscle reaction time. The study showed that as for immediate effects, the muscle reaction time was significantly shortened in the TrA/OI (transversus abdominis muscle/obliquus internus muscle) of two exercise groups. However, the immediate effect seen before the 2-week trunk muscle exercise intervention disappeared after the intervention. In addition, trunk muscle exercise intervention for 2 weeks significantly shortened the muscle reaction time of TrA/OI in one exercise group. Furthermore, shortening of the muscle reaction time was also observed in the MF (multifidus muscle) of both exercise groups. The factors affecting the muscle reaction time of TrA observed in this study were considered to be an improvement of neuromuscular function by the central nervous system. It was also considered that 2-week exercise intervention has a lower value after 2 weeks due to an improvement of neuromuscular function by the central nervous system, and an immediate effect could not be obtained with the same exercise as at the time of intervention. | Yusuke Wada Koji Kaneoka Masahiro Takemura Yuki Yamamoto Ryo Ogaki Shumpei Miyakawa | 2018 | Journal of Sports Science2018，6，5： | 1 |
| 11 | Prediction of liver stiffness hepatocellular carcinoma in chronic hepatitis C patients on interferon‐based anti‐viral therapy显示文摘 | Yutaka Narita Takuya Genda Hironori Tsuzura Shunsuke Sato Yoshio Kanemitsu Sachiko Ishikawa Tetsu Kikuchi Katsuharu Hirano Katsuyori Iijima Ryo Wada Takafumi Ichida | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
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