|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice显示文摘Acetaminophen(APAP)overdose can induce liver injury and is the most frequent cause of acute liver failure in the United States.We investigated the role of p62/SQSTM1(referred to as p62)in APAP-induced liver injury(AILI)in mice.We found that the hepatic protein levels of p62 dramatically increased at 24 h after APAP treatment,which was inversely correlated with the hepatic levels of APAPadducts.APAP also activated mTOR at 24 h,which is associated with increased cell proliferation.In contrast,p62 knockout(KO)mice showed increased hepatic levels of APAP-adducts detected by a specific antibody using Western blot analysis but decreased mTOR activation and cell proliferation with aggravated liver injury at 24 h after APAP treatment.Surprisingly,p62 KO mice recovered from AILI whereas the wild-type mice still sustained liver injury at 48 h.We found increased number of infiltrated macrophages in p62 KO mice that were accompanied with decreased hepatic von Willebrand factor(VWF)and platelet aggregation,which are associated with increased cell proliferation and improved liver injury at 48 h after APAP treatment.Our data indicate that p62 inhibits the late injury phase of AILI by increasing autophagic selective removal of APAP-adducts and mitochondria but impairs the recovery phase of AILI likely by enhancing hepatic blood coagulation. | Hui Qian Qingyun Bai Xiao Yang Jephte Y.Akakpo Lili Ji Li Yang Thomas Rulicke Kurt Zatloukal Hartmut Jaeschke Hong-Min Ni Wen-Xing Ding | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 4 |
| 2 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 3 | Poly(ADP-ribose) mediates asymmetric division of mouse oocyte显示文摘在授精前,哺乳动物的卵母细胞经历取决于形成极的身体和一个鸡蛋的在卵母细胞外皮的锭子的怪癖的放的一个不对称的部门。因为中吣粒是不在的,作为结果,极的数组微导管充分没在卵母细胞被开发,微导管是为锭子的怪癖的放要求了很少被考虑了,当肌动朊相关的力量相反被建议了为这进程主要负责时。然而,存在模型大部分正在冲突,不对称的分割的内在的机制仍然是逃犯的。这里,我们证明(自动数据处理核糖)( 同等) 那 poly 在老鼠卵母细胞被充实在整个成熟分裂的外皮的区域。在一支宫外的锭子和不对称的分割的失败的外皮的同等结果的特定的移动。在锭子移植期间,当锭子由细胞质的肌动朊的推的力量从卵母细胞的中心背离时,从 juxtacortical 锭子杆发出的短极的数组微导管延长到外皮并且渗透进外皮的同等,停靠并且稳定在便于不对称的部门的外皮的锭子。这个过程取决于与同等和联系微导管的蛋白质例如的亲密关系细长纤弱,它为外皮的同等和锭子贡献一个物理连接。尤其是,熔化同等绑定域到结束绑定蛋白质 3,在极的数组微导管的正结束的追踪蛋白质,恢复卵母细胞的不对称的部门与细长纤弱击倒。因此,我们的工作为卵母细胞锭子放和不对称的分割表明全面机制。 | Bingteng Xie Lu Zhang Huiling Zhao Qingyun Bai Yong Fan Xiaohui Zhu Yang Yu Rong Li Xin Liang Qing-Yuan Sun Mo Li Jie Qiao | 2018 | Cell Research2018，28，4： | 2 |
| 4 | Effects of components in culture medium on glutamate decarboxylase activity and γ-aminobutyric acid accumulation in foxtail millet ( Setaria italica L.) during germination显示文摘 | Qingyun Bai Meiqing Chai Zhenxin Gu Xiaohong Cao Yan Li Kunlun Liu | 2009 | Food Chemistry2009，，1： | 2 |
| 5 | Rela- tionships between physical properties of brown rice and degree of milling and loss of selenium显示文摘 | LIU Kunlun CAO Xiaohong BAI Qingyun | 2009 | Journal of Food Engineering2009，94，： | 1 |
| 6 | Effects of components in culture medium on glutamate decarboxylase activity and γ-aminobutyric acid accumulation in foxtail millet ( Setaria italica L.) during germination显示文摘 | Qingyun Bai Meiqing Chai Zhenxin Gu Xiaohong Cao Yan Li Kunlun Liu | 2009 | Food Chemistry2009，，1： | 1 |
| 7 | Effects of culture conditions on γ-aminobutyric acid accumulation during germination of foxtail millet (Setaria italica L.)显示文摘 | Qingyun Bai Gongjian Fan Zhenxin Gu Xionghong Cao Feirong Gu | 2008 | European Food Research and Technology2008，，2： | 1 |
| 8 | Salt Stress Induces Accumulation of [gamma]-Aminobutyric Acid in Germinated Foxtail Millet (Setaria italica L.)显示文摘 | Bai Qingyun Yang Runqiang Zhang Lixia Gu Zhenxin | 2013 | Cereal Chemistry2013，，2： | 1 |
| 9 | Effects of culture conditions on γ-aminobutyric acid accumulation during germination of foxtail millet (Setaria italica L.)显示文摘 | Qingyun Bai Gongjian Fan Zhenxin Gu Xionghong Cao Feirong Gu | 2008 | European Food Research and Technology2008，，2： | 1 |
| 10 | Uncoupling protein-3: a muscle-specific gene upregulated by leptin in ob/ob mice显示文摘 | Qingyun Liu Chang Bai Fang Chen Ruiping Wang Terry MacDonald Mingcheng Gu Qing Zhang Manal A Morsy C.Thomas Caskey | 1998 | Gene1998，，1： | 1 |
| 11 | Relationships between physical properties of brown rice and degree of milling and loss of selenium显示文摘 | Kunlun Liu Xiaohong Cao Qingyun Bai Huanbin Wen Zhenxin Gu | 2009 | Journal of Food Engineering2009，，1： | 1 |
| 12 | Lymphoid-biased hematopoietic stem cells and myeloid-biased hematopoietic progenitor cells have radioprotection activity显示文摘Radioprotection was previously considered as a function of hematopoietic stem cells(HSCs).However,recent studies have reported its activity in hematopoietic progenitor cells(HPCs).To address this issue,we compared the radioprotection activity in 2 subsets of HSCs(nHSC1 and 2 populations)and 4 subsets of HPCs(nHPC1–4 populations)of the mouse bone marrow,in relation to their in vitro and in vivo colony-forming activity.Significant radioprotection activity was detected in the nHSC2 population enriched in lymphoid-biased HSCs.Moderate radioprotection activity was detected in nHPC1 and 2 populations enriched in myeloid-biased HPCs.Low radioprotection activity was detected in the nHSC1 enriched in myeloid-biased HSCs.No radioprotection activity was detected in the nHPC3 and 4 populations that included MPP4(LMPP).Single-cell colony assay combined with flow cytometry analysis showed that the nHSC1,nHSC2,nHPC1,and nHPC2 populations had the neutrophils/macrophages/erythroblasts/megakaryocytes(nmEMk)differentiation potential whereas the nHPC3 and 4 populations had only the nm differentiation potential.Varying day 12 spleen colony-forming units(day 12 CFU-S)were detected in the nHSC1,nHSC2,and nHPC1–3 populations,but very few in the nHPC4 population.These data suggested that nmEMk differentiation potential and day 12 CFU-S activity are partially associated with radioprotection activity.Reconstitution analysis showed that sufficient myeloid reconstitution around 12 to 14 days after transplantation was critical for radioprotection.This study implied that radioprotection is specific to neither HSC nor HPC populations,and that lymphoid-biased HSCs and myeloid-biased HPCs as populations play a major role in radioprotection. | Shanshan Zhang Aled O’Neill Miner Xie Peng Wu Xiaofang Wang Haitao Bai Fang Dong Jinhong Wang Qingyun Zhang Toshio Suda Hideo Ema | 2021 | Blood Science2021，3，4： | 0 |
| 13 | Hybrid Active–Passive Prosthetic Knee:A Gait Kinematics and Muscle Activity Comparison with Mechanical and Microprocessor-Controlled Passive Prostheses显示文摘Existing microprocessor-controlled passive prosthetic knees(PaPKs)and active prosthetic knees(AcPKs)cannot truly simulate the muscle activity characteristics of the active–passive hybrid action of the knee during the normal gait.Differences in EMG between normal and different prosthetic gait for different phases were never separately analyzed.In this study,a novel hybrid active–passive prosthetic knee(HAPK)is proposed and if and how muscle activity and kinematics changes in different prosthetic gait are analyzed.The hybrid hydraulic-motor actuator is adopted to fully integrate the advantages of hydraulic compliance damping and motor efficiency,and the hierarchical control strategy is adopted to realize the adaptive predictive control of the HAPK.The kinematic data and EMG data of normal gait and different prosthetic gait were compared by experiments,so as to analyze the changes in the muscle activity and spatio-temporal data per phase compared to normal walking and the adaptations of amputees when walking with a different kind of prosthesis(the mechanical prosthesis(MePK),the PaPK and the HAPK).The results show that changes in prosthetic gait mainly consisted of decreased self-selected walking speed,gait symmetry and maximum knee flexion,increased first double support phase duration,muscle activation in both opposed and prosthetic limb and inter-subject variability.The differences between controls and MePK,PaPK and HAPK decreases sequentially.These results indicate that the hybrid active–passive actuating mode can have positive effects on improving the approximation of healthy gait characteristics. | Xiaoming Wang Qiaoling Meng Shaoping Bai Qingyun Meng Hongliu Yu | 2023 | Journal of Bionic Engineering2023，20，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员