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| 1 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 2 | Clinical significance of stanniocalcin expression in tissue and serum of gastric cancer patients显示文摘Purpose: Stanniocalcin(STC) has been recognized as a potential biomarker in a variety of cancers. The aim of this study was to examine STC1 and STC2 expression in tumor and serum samples from gastric cancer(GC) patients.Methods: A total of 83 GC patients treated with radical resection were enrolled in this study. Immunohistochemistry was used to detect STC protein expression in paired tumor and adjacent normal tissues. Serum STC levels were determined by enzyme-linked immunosorbent assay(ELISA). The receiver operating characteristics(ROC) curve was constructed to describe diagnostic specificity and sensitivity. Results: Both of STC1 and STC2 protein expression were upregulated in GC tissues compared with that in normal ones. Moreover, the high/moderate of STC1 protein was significantly associated with lymph metastasis, clinical stage and adverse 3-year progression-free survival(PFS). In addition, serum STC1 and STC2 expression in GC patients were much higher than that in patients with benign gastric disease, which decreased at postoperative 7-10 days. The sensitivity of serum STC protein also showed superiority over CEA and CA19-9. Conclusions: STC upregulation plays an important role in GC development, and serum STC1 and STC2 might function as promising tumor markers for GC diagnosis and prognosis. | Zheng Fang Zhiqiang Tian Kunlun Luo Haizhu Song Jun Yi | 2014 | Chinese Journal of Cancer Research2014，26，5： | 12 |
| 3 | Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics显示文摘几个抄写因素的宫外的表示能恢复胚胎的房间命运到有教养的体的房间并且产生导致的 pluripotent 干细胞(iPSCs ) ,揭示到 pluripotency 的一条以前未知的小径。然而,这种技术被低效率,慢动力学和多因素的要求当前限制。这里,我们证明 reprogramming 能被优化文化条件改进并且戏剧性地加速了。首先,我们开发了优化定义媒介, iCD1,它允许 Oct4/Sox2/Klf4 (OSK ) 完成的调停的 reprogramming 超离频效率(~10% 在白天 8 点) 。我们也发现这个优化条件使 Sox2 和 Klf4 变为非必需,尽管这二个因素的消除导致更低的效率和更慢的动力学。我们的研究定义一条弄短的线路,两个在预定和因素要求,向 pluripotency。这个新范例不仅提供一个基本原理进一步改进 iPSC 产生而且由定义因素简化 reprogramming 的概念的理解。 | Jiekai Chen Jing Liu You Chen Jiaqi Yang Jing Chen He Liu Xiangjie Zhao Kunlun Mo Hong Song Lin Guo Shilong Chu Deping Wang Ke Ding Duanqing Pei | 2011 | Cell Research2011，21，6： | 9 |
| 4 | Pre-treatment of pyridine wastewater by new cathodic–anodic-electrolysis packing显示文摘A novel cathodic–anodic-electrolysis packing(CAEP) used in the treatment of pyridine wastewater was researched, which mainly consisted of 4,4′-diamino-2,2′-disulfonic acid(DSD acid) industrial iron sludge. The physical properties and morphology of the packing were studied. The CAEP was used in a column reactor during the pretreatment of pyridine wastewater. The influence of p H, hydraulic retention time(HRT), the air–liquid ratio(A/L)and the initial concentration of pyridine were investigated by measuring the removal of total organic carbon(TOC) and pyridine. The characterization results showed that the bulk density, grain density, water absorption percentage and specific surface area were 921 kg/m3,1086 kg/m3, 25% and 29.89 m^2/g, respectively; the removal of TOC and pyridine could reach50% and 58% at the optimal experimental conditions(p H = 3, HRT = 8 hr, A/L = 2). Notably,the surface of the packing was renewed constantly during the running of the filter, and the handling capacity was stable after running for three months. | Yang Jin Qinyan Yue Kunlun Yang Suqing Wu Shengjie Li Baoyu Gao Yuan Gao | 2018 | Journal of Environmental Sciences2018，30，1： | 6 |
| 5 | Recent research advances of self-discharge in supercapacitors:Mechanisms and suppressing strategies显示文摘Supercapacitors are one of the most promising energy storage devices in the fields of vehicle transportation,flexible electronic devices,aerospace,etc.However,the existed self-discharge that is the spontaneous voltage decay after supercapacitors are fully charged,brings about the wide gap between experimental studies and practical utilization of supercapacitors.Although eliminating the selfdischarge completely is not reachable,suppressing the self-discharge rate to the lowest point is possible and feasible.So far,the significant endeavors have been devoted to achieve this goal.Herein,we summary and discuss the possible mechanisms for the self-discharge and the underlying influence factors.Moreover,the strategies to suppress the self-discharge are systemically summed up by three independent but unified aspects:modifying the electrode,modulating the electrolyte and tuning the separator.Finally,the major challenges to suppress the self-discharge of supercapacitors are concluded and the promising strategies are also pointed out and discussed.This review is presented with the view of serving as a guideline to suppress the self-discharge of supercapacitors and to across-the-board facilitate their widespread application. | Kunlun Liu Chang Yu Wei Guo Lin Ni Jinhe Yu Yuanyang Xie Zhao Wang Yongwen Ren Jieshan Qiu | 2021 | Journal of Energy Chemistry2021，30，7： | 6 |
| 6 | Geospatial Service Web:towards integrated cyberinfrastructure for GIScience显示文摘A geospatial cyberinfrastructure is needed to support advanced GIScience research and education activities.However,the heterogeneous and distributed nature of geospatial resources creates enormous obstacles for building a unified and interoperable geospatial cyberinfrastructure.In this paper,we propose the Geospatial Service Web(GSW)to underpin the development of a future geospatial cyberinfrastructure.The GSW excels over the traditional spatial data infrastructure by providing a highly intelligent geospatial middleware to integrate various geospatial resources through the Internet based on interoperable Web service technologies.The development of the GSW focuses on the establishment of a platform where data,information,and knowledge can be shared and exchanged in an interoperable manner.Theoretically,we describe the conceptual framework and research challenges for GSW,and then introduce our recent research toward building a GSW.A research agenda for building a GSW is also presented in the paper. | GONG Jianya WU Huayi ZHANG Tong GUI Zhipeng LI Zhenlong YOU Lan SHEN Shengyu ZHENG Jie GENG Jing QI Kunlun YANG Wenjing LI Zhenqiang YU Jingmin | 2012 | Geo-Spatial Information Science2012，15，2： | 5 |
| 7 | Recombinant rabies virus expressing IL-15 enhances immunogenicity through promoting the activation of dendritic cells in mice显示文摘Rabies remains a public health threat that kills approximately 59,000 people worldwide each year,most of which are from the developing countries of Africa and Asia where dog rabies are endemic.Therefore, developing an affordable and efficacious vaccine is crucial for rabies control in these countries. Interleukin(IL)-15, an immunoregulatory cytokine, is a pluripotent molecule with therapeutic potential, which targets many cell types and links the innate and adaptive immune system. In this study, IL-15 gene was cloned and inserted into the genome of a recombinant rabies virus(RABV) strain LBNSE(designated as LBNSE-IL15), and the effect of over-expression of IL-15 on the immunogenicity of RABV was investigated. It was found that mice vaccinated with LBNSEIL15 could induce significantly higher level of virus-neutralizing antibody(VNA) than those immunized with LBNSE, resulting in the higher protection after challenge. Further investigation was performed to find out the possible role of IL-15 plays in the process of antibody induction, and it was found that LBNSE-IL15 could enhance the maturation of dendritic cells(DCs) in immunized mice. Furthermore, the mice immunized with LBNSE-IL15 could promote the T_(FH) cells differentiation and the generation of germinal center B cells and plasma cells. Together, these data indicated that IL-15 could be a potential adjuvant in enhancing the immunogenicity of RABV, contributing to the development of more-efficacious rabies vaccines. | Tiange Chen Yajing Zhang Zhao Wang Jie Yang Mingming Li Kunlun Wang Min Cui Zhen F.Fu Ling Zhao Ming Zhou | 2017 | Virologica Sinica2017，32，4： | 5 |
| 8 | Arabidopsis DET1 Represses Photomorphogenesis in Part by Negatively Regulating DELLA Protein Abundance in Darkness显示文摘DET1 否定地在黑暗中调整 DELLA 蛋白质丰富。 | Kunlun Li Zhaoxu Gao Hang He William Terzaghi Liu-Min Fan Xing Wang Deng Haodong Chen | 2015 | Molecular Plant2015，8，4： | 4 |
| 9 | Comprehensive utilization of corn starch processing by-products:A review显示文摘Corn is a high starchy cereal crop with the highest production and provides over 85%of the starch produced worldwide.Various by-products,differentiated by technological process features such as steep liquor,corn germ,corn bran,gluten,are created largely during corn starch processing.They are inexpensive,nutrient-rich,and vary widely in chemical composition such as proteins,oils,carbohydrates,and minerals.In an increasingly resource-constrained modern world,the utilization approach of these by-products for non-starch industrial processing is attractive widely considering both nutritive value and economic aspects.In fact,at present,applications of these by-products can often be found in feed,fermentation,nutrient extraction and other industries.For example,protein-rich corn gluten can be used as a good animal feed,and corn germ can be used as a raw material for the high-quality edible oil industry.Undoubtedly,increasing utilization means that these by-products will no longer be treated as waste but will be transformed into high value-added products.In this work,the separation process and chemical composition of several main by-products of the corn starch industry is briefly described,and the application in many industrial fields of these by-products over the last ten years are discussed in particular.This review attempts to summarize all aspects of the application and research of these by-products.For the by-products of the corn starch industry,the most promising way is to be utilized in high value and used to produce high value-added products.According to the characteristics of their chemical composition,they have a better application prospect and research significance in the industries directly related to human beings,such as medicine,green food and health care products.In fact,in recent years,some researchers have recognized this and carried out the research.It is clear fromthese studies that the main issues to be faced nowand in the future are how to produce efficiently while maintaining the quality of the product and using it effectively.The retrospective discussions also provide some ideas for other grain and oilseed crops to be fully utilized. | Runyang Zhang Sen Ma Li Li Minghui Zhang Shuangqi Tian Dongying Wang Kunlun Liu Huamin Liu Wenxue Zhu Xuede Wang | 2021 | Grain & Oil Science and Technology2021，4，3： | 3 |
| 10 | Multi-objective Optimization for Cloud Task Scheduling Based on the ANP Model显示文摘We propose a multi-objective optimization algorithm for cloud task scheduling based on the Analytic network process(ANP) model to solve the problems in cloud task scheduling,such as the deficiencies of mathematical description,limited optimization abilities of the traditional multi-objective optimization algorithm and the selection of the Pareto optimal solutions.Firstly,we present the mathematical description of cloud task scheduling using matrix theory.Then,the improved Nondominated sorting genetic algorithm II(NSGA-II) multiobjective evolutionary algorithm whose optimization ability is improved by Gene expression programming(GEP)algorithm has been introduced into the cloud task scheduling field to search the Pareto set among multi-objects.Finally,ANP model has been combined with the improved NSGA-II to solve the selection problems of Pareto solutions.Comparing with the multi-objective optimization algorithm based on the weighted polynomial,the proposed algorithm can optimize multiple goals at the same time,and can avoid the additional iterations due to the change of users preferences effectively.The simulation results indicate that the proposed algorithm is effective. | LI Kunlun WANG Jun | 2017 | Chinese Journal of Electronics2017，26，5： | 3 |
| 11 | Simulation and prediction of multi-scenario evolution of ecological space based on FLUS model: A case study of the Yangtze River Economic Belt, China显示文摘Building the Yangtze River Economic Belt(YREB)is one of China’s three national development policies in the new era.The ecological environment of the Yangtze River Economic Belt must be protected not only for regional economic development but also for regional ecological security and ecological progress in this region.This paper takes the ecological space of the Yangtze River Economic Belt as the research object,based on land use data in 2010 and 2015,and uses the FLUS model to simulate and predict the ecological space of the research area in 2035.The variation of the research area’s ecological space area and its four sub-zones has remarkable stability under diverse situations.Both the production space priority scenarios(S1)and living space priority scenarios(S2)saw a fall in ecological space area,with the former experiencing the highest reduction(a total reduction of 25,212 km^(2)).Under the ecological space priority scenarios(S3)and comprehensive space optimization scenario(S4),the ecological space area increased,and the ecological space area expanded even more under the former scenario(a total growth of 23,648 km^(2)).In Yunnan-Guizhou,the ecological space is relatively stable,with minimal signs of change.In Sichuan-Chongqing,the Sichuan Basin,Zoige Grassland,and Longmen Mountains were significant regions of area changes in ecological space.In the middle reaches of the Yangtze River,the ecological space changes mainly occur in the Wuyi Mountains,Mufu Mountains,and Dabie Mountains,as well as the surrounding waters of Dongting Lake.The Yangtze River Delta’s changes were mainly observed in the eastern Dabie Mountains and Jianghuai Hills. | LIU Xiaoqiong WANG Xu CHEN Kunlun LI Dan | 2023 | Journal of Geographical Sciences2023，33，2： | 3 |
| 12 | Hazard and vulnerability evaluation of water distribution system in cases of contamination intrusion accidents显示文摘在这份报纸,它为危险和水分发网络的危险评估建议了一个索引系统,基于在不同连接的污染物质注射引起的污染事件的模拟。它试图在污染事件的情况中回答下列二个问题:1 ) 最危险的连接是哪个?2 ) 最脆弱的连接是哪个?与 EPANET 工具箱,它模仿了沾染物的繁殖,并且计算了在不同节点交付的沾染物和团的山峰集中。根据消费者的类型,不同重量为在消费者上估计沾染物的影响被分到消费者节点。用此处建议的方法,危险索引和危险索引在管子网络为每个节点被计算。介绍方法因此被用于 Zhenjiang 的城市的水网络,它包含二水植物,有存储坦克的二个增强软件抽水站。在结论,反应时间,在沾染物和全部的吸收的山峰集中之间的关系是在危险和水分发网络的危险评估的最重要的因素。 | Kunlun XIN Tao TAO Yong WANG Suiqing LIU | 2012 | Frontiers of Environmental Science & Engineering2012，6，6： | 2 |
| 13 | Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances显示文摘Background Working memory(WM)deficit is considered a core feature and cognitive biomarker in patients with schizophrenia.Several studies have reported prominent object WM deficits in patients with schizophrenia,suggesting that visual WM in these patients extends to non-spatial domains.However,whether non-spatial WM is similarly affected remains unclear.Aim This study primarily aimed to identify the processing of visual object WM in patients with first-episode schizophrenia.Methods The study included 36 patients with first-episode schizophrenia and 35 healthy controls.Visual object WM capacity,including face and house WM capacity,was assessed by means of delayed matching-to sample visual WM tasks,in which participants must distribute memory so that they can discriminate a target sample.We specifically examined their anhedonia experience by the Temporal Experience of Pleasure Scale and the Snaith-Hamilton Pleasure Scale.Cognitive performance was measured by the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Results Both face and house WM capacity was significantly impaired in patients with schizophrenia.For both tasks,the performance of all the subjects was worse under the high-load condition than under the low-load condition.We found that WM capacity was highly positively correlated with the performance on RBANS total scores(r=−0.528,p=0.005),RBANS delayed memory scores(r=−0.470,p=0.013),RBANS attention scores(r=−0.584,p=0.001),RBANS language scores(r=−0.448,p=0.019),Trail-Making Test:Part A raw scores(r=0.465,p=0.015)and simple IQ total scores(r=−0.538,p=0.005),and correlated with scores of the vocabulary test(r=−0.490,p=0.011)and scores of the Block Diagram Test(r=−0.426,p=0.027)in schizophrenia.No significant correlations were observed between WM capacity and Positive and Negative Syndrome Scale symptoms.Conclusions Our research found that visual object WM capacity is dramatically impaired in patients with schizophrenia and is strongly correlated with other measures of cognition,suggesting a mechanism that is critical in explaining a portion of the broad cognitive deficits observed in schizophrenia. | Yi Liu Taiyong Bi Bei Zhang Qijie Kuang Haijing Li Kunlun Zong Jingping Zhao Yuping Ning Shenglin She Yingjun Zheng | 2021 | General Psychiatry2021，34，1： | 2 |
| 14 | D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration显示文摘Accumulated oxidative damage may lead to irreversible retinal pigmented epithelium(RPE)cell death,which is considered to be the primary cause of dry age-related macular degeneration(AMD),leading to blindness in the elderly.However,an effective therapy for this disease is lacking.Here,we described a robust high-content screening procedure with a library of 814 protective compounds and found that D609 strongly protected RPE cells from sodium iodate(SI)-induced oxidative cell death and prolonged their healthy survival.D609 effectively attenuated excessive reactive oxygen species(ROS)and prevented severe mitochondrial loss due to oxidative stress in the RPE cells.Surprisingly,the potent antioxidative effects of D609 were not achieved through its own reducibility but were primarily dependent on its ability to increase the expression of metallothionein.The injection of this small water-soluble molecule also showed an explicit protective effect of the RPE layer in an SI-induced AMD mouse model.These findings suggested that D609 could serve as a novel antioxidative protector of RPE cells both in vitro and in vivo and unveiled a novel antioxidative mechanism of D609,which may ultimately have clinical applications for the treatment of AMD. | Bowen Wang Li Wang Sijie Gu Yankun Yu Huaxing Huang Kunlun Mo He Xu Fanzhu Zeng Yichen Xiao Lulu Peng Chunqiao Liu Nan Cao Yizhi Liu Jin Yuan Hong Ouyang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 15 | Rock damage and fracturing induced by high static stress and slightly dynamic disturbance with acoustic emission and digital image correlation techniques显示文摘A series of coupled static-dynamic loading tests is carried out in this study to understand the effect of slightly dynamic disturbance on the rocks under high static stress.The acoustic emission(AE)and digital image correlation(DIC)techniques are combined to quantitatively characterize the damage and fracturing behaviors of rocks.The effects of three influencing factors,i.e.initial static stress,disturbance amplitude,and disturbance frequency,on the damage and fracturing evolution are analyzed.The experimental results reveal the great differences in AE characteristics and fracturing behaviors of rocks under static loads and coupled static-dynamic loads.Both the Kaiser effect and Felicity effect are observed during the disturbance loading process.The crack initiation,stable and unstable propagation in the highly-stressed rocks can be triggered by cyclic disturbance loads,and more local tensile splitting cracks are found in the rocks subjected to coupled static-dynamic loads.The damage and fracturing evolution of rocks during cyclic disturbances can be divided into two stages,i.e.steady and accelerated stages,and the increase rate and proportion of each stage are greatly affected by these influencing factors.High initial static stress,low disturbance frequency,and high disturbance amplitude are considered to be adverse factors to the stability of the rocks,which would induce a high increase rate of the steady stage and a high proportion of the accelerated stage within the whole disturbance period.Based on the two-stage damage evolution trend,a linear-exponential damage model is employed to predict the instability of the rocks under coupled static-dynamic loads. | Shuting Miao Peng-Zhi Pan Petr Konicek Peiyang Yu Kunlun Liu | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，5： | 2 |
| 16 | Effects of components in culture medium on glutamate decarboxylase activity and γ-aminobutyric acid accumulation in foxtail millet ( Setaria italica L.) during germination显示文摘 | Qingyun Bai Meiqing Chai Zhenxin Gu Xiaohong Cao Yan Li Kunlun Liu | 2009 | Food Chemistry2009，，1： | 2 |
| 17 | Rela- tionships between physical properties of brown rice and degree of milling and loss of selenium显示文摘 | LIU Kunlun CAO Xiaohong BAI Qingyun | 2009 | Journal of Food Engineering2009，94，： | 1 |
| 18 | Synthesis of a large-scale highly ordered porous carbon film by self-assembly of block copolymers 显示文摘 | Liang Chengdu Hong Kunlun Guiochon G A | 2004 | Angewandte Chemie International Edition2004，43，43： | 1 |
| 19 | Friction and wear behav- ior of self-lubricating and heavily loaded metal-PTFE composites 显示文摘 | Dinghan Xiang Kunlun Shan | 2006 | Wear2006，260，910： | 1 |
| 20 | Public health: A sustainable plan for China's drinking water显示文摘 | Tao Tao Kunlun Xin | 2014 | Nature2014，，511： | 1 |
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