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| 1 | Performance Optimization of Irreversible Air Heat Pumps Considering Size Effect显示文摘Considering the size of an irreversible air heat pump(AHP), heating load density(HLD) is taken as thermodynamic optimization objective by using finite-time thermodynamics. Based on an irreversible AHP with infinite reservoir thermal-capacitance rate model, the expression of HLD of AHP is put forward. The HLD optimization processes are studied analytically and numerically, which consist of two aspects:(1) to choose pressure ratio;(2) to distribute heat-exchanger inventory. Heat reservoir temperatures, heat transfer performance of heat exchangers as well as irreversibility during compression and expansion processes are important factors influencing on the performance of an irreversible AHP, which are characterized with temperature ratio, heat exchanger inventory as well as isentropic efficiencies, respectively. Those impacts of parameters on the maximum HLD are thoroughly studied. The research results show that HLD optimization can make the size of the AHP system smaller and improve the compactness of system. | BI Yuehong CHEN Lingen DING Zemin SUN Fengrui | 2018 | Journal of Thermal Science2018，27，3： | 3 |
| 2 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 3 | Ground heat exchanger temperature distribution analysis and experimental verification显示文摘 | Bi Yuehong Chen Lingen Wu Chih | 2002 | Applied Thermal Engineering2002，22，： | 1 |
| 4 | Comprehensive exergy analysis of a ground-source heat pump system for both building heating and cooling modes 显示文摘 | Bi Yuehong Wang Xinhong Liu Yun | 2009 | Applied Energy2009，86，12： | 1 |
| 5 | Comprehensive exergy analysis of a ground-source heat pump system for both building heating and cooling modes显示文摘 | Bi Yuehong Wang Xinhong Liu Yun | | 0，，12： | 1 |
| 6 | Comprehensive exergy analysis of a ground-source heat pump system for both building heating and cooling modes显示文摘 | Yuehong Bi Xinhong Wang | | 0，，： | 1 |
| 7 | Ground heat exchanger temperature distribution analysis and experimental verification 显示文摘 | Bi Yuehong Chen Lingen Wu Chih | 2002 | Applied Thermal Engineering2002，22，： | 1 |
| 8 | Solar ground source heat-pump system显示文摘 | Bi Yuehong Guo Tingwei Zhang Liang | 2004 | Applied Energy2004，78，2： | 1 |
| 9 | Ground heat exchanger temperature distribution analysis and experimental verification显示文摘 | Bi Yuehong Chen Lingen Wu Chih | 2002 | Applied Thermal Engineering2002，22，2： | 1 |
| 10 | Ground heat exchanger temperature distribution analysis and experimental verification显示文摘 | Bi Yuehong Chen Lingen Wu Chih | 2002 | Applied Thermal Engineering2002，22，： | 1 |
| 11 | Ground heat exchanger temperature distribution analysis and experimental verification显示文摘 | Yuehong Bi Lingen Chen Chih Wu | 2002 | Apply Thermal Engineering2002，22，： | 1 |
| 12 | Solar and ground source heat-pump system显示文摘 | BI Yuehong GUO Tingwei ZHANG Liang | 2004 | Applied Energy2004，78，2： | 1 |
| 13 | Ground heat exchanger temperature distribution analysis and experimental verification显示文摘 | Bi Yuehong Chen Lingen Wu Chih | 2002 | Applied Thermal Engineering2002，22，2： | 1 |
| 14 | Comprehen- sive energy analysis of a ground-source heat pump system for modes 显示文摘 | Bi Yuehong Wang Xinhong Lui Yun | 2009 | Applied Energy2009，，12： | 1 |
| 15 | Comprehensive exergy analysis of a ground-source heat pump system for both building heating and cooling modes显示文摘 | Bi Yuehong Wang Xinhong Liu Yun | 2009 | Applied Energy2009，86，12： | 1 |
| 16 | Ground heatexchanger temperature distribution analysis andexperimental verification显示文摘 | Bi Yuehong Chen Lingen Chih Wu | 2002 | Applied ThermalEngineering2002，22，2： | 1 |
| 17 | Solar and ground source heat-pump system 显示文摘 | Bi Yuehong Guo Tingwei Zhang Liang | 2004 | Applied Energy2004，78，2： | 1 |
| 18 | Solar Ground Source Heat Pump System显示文摘 | Bi Yuehong Guo Tingwei Zhang Liang | 2004 | Applied Energy2004，78，2： | 1 |
| 19 | Ground Heat Exchanger Temperature Distribution Analysis and Experimental Verification显示文摘 | Bi Yuehong Chen Lingen Wu Chih | 2002 | Applied Thermal Engineering2002，22，2： | 1 |
| 20 | Comprehensive exergy analysis of a ground-source heat pump system for both building heating and cooling modes 显示文摘 | Bi Yuehong Wang Xinhong Liu Yun | 2009 | Applied Energy2009，86，： | 1 |
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