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| 1 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 2 | Prognostic value and nomograms of proximal margin distance in gastric cancer with radical distal gastrectomy显示文摘Objective:The proximal margin(PM)distance for distal gastrectomy(DG)of gastric cancer(GC)remains controversial.This study investigated the prognostic value of PM distance for survival outcomes,and aimed to combine clinicopathologic variables associated with survival outcomes after DG with different PM distance for GC into a prediction nomogram.Methods:Patients who underwent radical DG from June 2004 to June 2014 at Department of General Surgery,Nanfang Hospital,Southern Medical University were included.The first endpoints of the prognostic value of PM distance(assessed in 0.5 cm increments)for disease-free survival(DFS)and overall survival(OS)were assessed.Multivariate analysis by Cox proportional hazards regression was performed using the training set,and the nomogram was constructed,patients were chronologically assigned to the training set for dates from June 1,2004 to January 30,2012(n=493)and to the validation set from February 1,2012 to June 30,2014(n=211).Results:Among 704 patients with p TNM stage I,p TNM stage II,T1-2,T3-4,N0,differentiated type,tumor size≤5.0 cm,a PM of(2.1-5.0)cm vs.PM≤2.0 cm showed a statistically significant difference in DFS and OS,while a PM>5.0 cm was not associated with any further improvement in DFS and OS vs.a PM of 2.1-5.0 cm.In patients with p TNM stage III,N1,N2-3,undifferentiated type,tumor size>5.0 cm,the PM distance was not significantly correlated with DFS and OS between patients with a PM of(2.1-5.0)cm and a PM≤2 cm,or between patients with a PM>5.0 cm and a PM of(2.1-5.0)cm,so there were no significant differences across the three PM groups.In the training set,the C-indexes of DFS and OS,were 0.721 and 0.735,respectively,and in the validation set,the C-indexes of DFS and OS,were 0.752 and 0.751,respectively.Conclusions:It is necessary to obtain not less than 2.0 cm of PM distance in early-stage disease,while PM distance was not associated with long-term survival in later and more aggressive stages of disease because more advanced GC is a systemic disease.Different types of patients should be considered for removal of an individualized PM distance intra-operatively.We developed a universally applicable prediction model for accurately determining the 1-year,3-year and 5-year DFS and OS of GC patients according to their preoperative clinicopathologic characteristics and PM distance. | Jun Luo Yuming Jiang Xinhua Chen Yuehong Chen Jhang Lopsang Gurung Tingyu Mou Liying Zhao Guoqing Lyu Tuanjie Li Guoxin Li Jiang Yu | 2020 | Chinese Journal of Cancer Research2020，32，2： | 8 |
| 3 | Family-level leaf nitrogen and phosphorus stoichiometry of global terrestrial plants显示文摘Leaf nitrogen(N) and phosphorus(P) concentrations are critical for photosynthesis, growth, reproduction and other ecological processes of plants. Previous studies on large-scale biogeographic patterns of leaf N and P stoichiometric relationships were mostly conducted using data pooled across taxa, while family/genus-level analyses are rarely reported. Here, we examined global patterns of family-specific leaf N and P stoichiometry using a global data set of 12,716 paired leaf N and P records which includes 204 families, 1,305 genera, and 3,420 species. After determining the minimum size of samples(i.e., 35 records), we analyzed leaf N and P concentrations, N:P ratios and N^P scaling relationships of plants for 62 families with 11,440 records. The numeric values of leaf N and P stoichiometry varied significantly across families and showed diverse trends along gradients of mean annual temperature(MAT) and mean annual precipitation(MAP). The leaf N and P concentrations and N:P ratios of 62 families ranged from 6.11 to 30.30 mg g–1, 0.27 to 2.17 mg g–1, and 10.20 to 35.40, respectively. Approximately 1/3–1/2 of the families(22–35 of 62) showed a decrease in leaf N and P concentrations and N:P ratios with increasing MAT or MAP, while the remainder either did not show a significant trend or presented the opposite pattern. Family-specific leaf N^P scaling exponents did not converge to a certain empirical value, with a range of 0.307–0.991 for 54 out of 62 families which indicated a significant N^P scaling relationship. Our results for the first time revealed large variation in the family-level leaf N and P stoichiometry of global terrestrial plants and that the stoichiometric relationships for at least one-third of the families were not consistent with the global trends reported previously. The numeric values of the family-specific leaf N and P stoichiometry documented in the current study provide critical synthetic parameters for biogeographic modeling and for further studies on the physiological and ecological mechanisms underlying the nutrient use strategies of plants from different phylogenetic taxa. | Di Tian Zhengbing Yan Suhui Ma Yuehong Ding Yongkai Luo Yahan Chen Enzai Du Wenxuan Han Emoke Dalma Kovacs Haihua Shen Huifeng Hu Jens Kattge Bernhard Schmid Jingyun Fang | 2019 | Science China(Life Sciences)2019，62，8： | 7 |
| 4 | Bioelectrochemical control mechanism with variable-frequency regulation for skeletal muscle contraction-Biomechanics of skeletal muscle based on the working mechanism of myosin motors(Ⅱ)显示文摘This paper presents a bioelectrochemical model for the activation of action potentials on sarcolemma and variation of Ca2+ concentration in sarcomeres of skeletal muscle fibers.The control mechanism of muscle contraction generated by collective motion of molecular motors is elucidated from the perspective of variable-frequency regulation,and action potential with variable frequency is proposed as the control signal to directly regulate Ca2+ concentration and indirectly control isometric tension.Furthermore,the transfer function between stimulation frequency and Ca2+ concentration is deduced,and the frequency domain properties of muscle contraction are analyzed.Moreover the conception of 'electro-muscular time constant' is defined to denote the minimum delay time from electric stimulation to muscle contraction.Finally,the experimental research aiming at the relation between tension and stimulation frequency of action potential is implemented to verify the proposed variable-frequency control mechanism,whose effectiveness is proved by good consistence between experimental and theoretical results. | YIN YueHong CHEN Xing | 2012 | Science China(Technological Sciences)2012，55，8： | 5 |
| 5 | Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach显示文摘Dear Editor,Hepatoid adenocarcinoma(HAC)is a rare pathological subtype of extrahepatic tumor,featured by hepatoid differentiation andα-fetoprotein(AFP)-production[1,2].Hepatoid adenocarcinoma of the stomach(HAS),accounting for 0.3%to 1.0%of all gastric cancers(GCs),has attracted increasing attention due to its high degree of malignancy[3].Compared with classic GC,HAS showed a higher rate of vascular invasion,lymph node metastasis,and liver metastasis,with only 9.0%survival rate at 5 years[4].Currently,there is no effective treatment for HAS,and little is known about its pathogenesis.Herein,we investigated the molecular features of HAS and identified potential therapeutic targets for HAS. | Mengxuan Zhu Erbao Chen Shan Yu Chen Xu Yiyi Yu Xin Cao Wei Li Pengfei Zhang Yan Wang Baofeng Lian Shuirong Zhang Yueting Qu Lujia Huang Weiwei Shi Yuehong Cui Li Qian Tianshu Liu | 2022 | Cancer Communications2022，42，10： | 3 |
| 6 | Performance Optimization of Irreversible Air Heat Pumps Considering Size Effect显示文摘Considering the size of an irreversible air heat pump(AHP), heating load density(HLD) is taken as thermodynamic optimization objective by using finite-time thermodynamics. Based on an irreversible AHP with infinite reservoir thermal-capacitance rate model, the expression of HLD of AHP is put forward. The HLD optimization processes are studied analytically and numerically, which consist of two aspects:(1) to choose pressure ratio;(2) to distribute heat-exchanger inventory. Heat reservoir temperatures, heat transfer performance of heat exchangers as well as irreversibility during compression and expansion processes are important factors influencing on the performance of an irreversible AHP, which are characterized with temperature ratio, heat exchanger inventory as well as isentropic efficiencies, respectively. Those impacts of parameters on the maximum HLD are thoroughly studied. The research results show that HLD optimization can make the size of the AHP system smaller and improve the compactness of system. | BI Yuehong CHEN Lingen DING Zemin SUN Fengrui | 2018 | Journal of Thermal Science2018，27，3： | 3 |
| 7 | Efficacy and Safety of Yanggan Jian in Hepatitis B Virusrelated Decompensated Cirrhosis:A Randomized,Doubleblind,Controlled Trial显示文摘Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated. | Long Chen Chaoqun Zhao Weili Yao Wei Liu Hua Zhang Yongping Mu Hong Cai Dongying Xue Chengbao Wang Wan’e Wang Yuehong Lin Jiamei Chen Ping Liu | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 3 |
| 8 | Modified vegetation-erosion dynamics model and its application in typical watersheds in the Loess Plateau显示文摘植被侵蚀模型在三个典型分水岭被使用多山并且在在到学习的西北的中国的黄土高原的溪谷区域在植被范围和土壤侵蚀率和各种各样的压力之间的动态关系。模型被介绍降雨和流量因素改进。然后,修改模型在 Luergou 和 Luoyugou 分水岭被使用。与修改模型一起的计算结果与原来的模型的结果相比。与修改模型一起的模仿的植被范围和土壤侵蚀率的精确极大地与原来的模型相比被改进。与增加植被范围和人的骚乱减少的土壤侵蚀率引起了高土壤侵蚀。 | CHEN Yuehong WANG Feixin LIU Guangquan YU Xinxiao JIA Guodong GAN Ping | 2011 | International Journal of Sediment Research2011，26，1： | 3 |
| 9 | Studies on biomechanics of skeletal muscle based on the working mechanism of myosin motors:An overview显示文摘Skeletal muscle is the source of human body motion.Many scholars have been studying in this field to reveal its contraction mechanism,and relevant achievements have been awarded the Nobel Prize.This paper reviewed the current researches on biomechanics of skeletal muscle,and concluded two strategies(top-down and bottom-up methods) for the biomechanical research of skeletal muscle.Moreover,this paper generalized two major aspects of muscle research:(1) the multi-force coupling mechanism and the collective operation mechanism of molecular motors;(2) the bioelectrochemical driving and control principium of muscle contraction.We discussed the solution for experimental verification and induced a novel idea to study the biomechanics of skeletal muscle based on the microscopic working mechanism of molecular motor,which is the origin of muscle contraction.Finally we analyzed the disadvantages in existent researches and explored future directions that need further studies. | YIN YueHong GUO Zhao CHEN Xing FAN YuanJie | 2012 | Chinese Science Bulletin2012，57，35： | 3 |
| 10 | Transarterial Embolization versus Translumber Embolization for Type Ⅱ Endoleak after Endovascular Abdomi nal Aortic Aneurysm Repair:A Meta-Analysis显示文摘Objective Type II endoleak is the most common subtype of endoleak as a complication after endovascular aneurysm repair(EVAR).The efficacy of transarterial(TA)embolization and translumber(TL)embolization in the management of type II endoleak remains equipoise.The aim of this study is to compare the technical and clinical success between TA embolization andTL embolization for type II endoleak after EVAR.Methods The protocol was registered(CRD 42018114453)and the electronic databases(Pubmed,Embase,Web of Science,and Cochrane)were systematically searched till March 2019.The search terms included EVAR,type II endoleak,and embolization.The articles were read and extracted by two authors independently to include randomized control trails and retrospective studies that compared TA embolization and TL embolization in patients who developed type II endoleak after EVAR.The technical and clinical success rates were metaanalyzed with random effect model.Results A total of 6 articles with 268 patients and 290 type II endoleaks were included.The pooled odds ratio(OR)of technical success rate for TA vs.TL was 0.56(95%C7,0.10-3.18;P=0.51)and the pooled OR of clinical success rate for TA vs.TL was 0.31(95%CI,0.07-1.29;P=0.11).As a limitation,6 articles were all retrospective studies which may lead to bias.Conclusion Both TA.andTL could be eflective procedure of embolizations to resolve the type II endoleak.The metaanalysis result indicated that TA embolization was not inferior toTL embolization in technical success and clinical success. | Xu Zhang Lei Ji Mengyin Chen Wei Wang Yuehong Zheng | 2020 | Chinese Medical Sciences Journal2020，35，2： | 3 |
| 11 | Impact of diabetes on prognosis of gastric cancer patients performed with gastrectomy显示文摘Objective: This study aimed to determine the impact of type 2 diabetes mellitus(T2 DM) on clinical outcomes of gastric cancer(GC) patients and explore whether metformin use and good glycemic control could reverse it.Methods: Clinicopathologic data of consecutive GC patients who underwent gastrectomy at Nanfang Hospital between October 2004 and December 2015 were included. Propensity score matching(PSM) was performed to balance the important factors of the disease status between non-T2 DM and T2 DM group. The last follow-up time was January 2019.Results: A total of 1,692 eligible patients(1,621 non-T2 DM vs. 71 T2 DM) were included. After PSM, nonT2 DM group(n=139) and T2 DM group(n=71) were more balanced in baseline variables. The 5-year cancerspecific survival(CSS) rate in T2 DM group(47.0%) was inferior to that in non-T2 DM group(58.0%), but did not reach statistical significance [hazard ratio(HR)=1.319, 95% confidence interval(95% CI): 0.868-2.005, P=0.192].While the 5-year progress-free survival(PFS) rate of T2 DM group(40.6%) is significantly worse than that in nonT2 DM group(56.3%)(HR=1.516, 95% CI: 1.004-2.290, P=0.045). Univariate and multivariate analyses showed that T2 DM was an independent risk factor for PFS but not for CSS. In T2 DM group, metformin use subgroup was associated with superior 5-year CSS and PFS in compared with non-metformin use subgroup, although the difference was not statistically significant(5-year CSS: 48.0% vs. 45.4%, HR=0.680, 95% CI: 0.352-1.313,P=0.246;5-year PFS: 43.5% vs. 35.7%, HR=0.763, 95% CI: 0.400-1.454, P=0.406). The 5-year CSS rate was47.5% in good glycemic control subgroup and 44.1% in poor glycemic control subgroup(HR=0.826, 95% CI:0.398-1.713, P=0.605). And both two subgroups yielded a similar 5-year PFS rate(42.2% vs. 36.3%, HR=0.908,95% CI: 0.441-1.871, P=0.792).Conclusions: DM promoted disease progress of GC after gastrectomy but had not yet led to the significant discrepancy of CSS. For GC patients with T2 DM, metformin use was associated with superior survival but without statistical significance, while better glycemic control could not improve the prognosis. | Xinhua Chen Yuehong Chen Tao Li Luo Jun Tian Lin Yanfeng Hu Huilin Huang Hao Chen Hao Liu Tuanjie Li Guoxin Li Jiang Yu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 2 |
| 12 | Nonvolatile reconfigurable dynamic Janus metasurfaces in the terahertz regime显示文摘Metasurfaces,especially tunable ones,have played a major role in controlling the amplitude,phase,and polarization of electromagnetic waves and attracted growing interest,with a view toward a new generation of miniaturized devices.However,to date,most existing reconfigurable devices are bounded in volatile nature with sustained external energy to maintain and single functionality,which restrict their further applications.Here,we demonstrate for the first time,to our knowledge,nonvolatile,reconfigurable,and dynamic Janus metasurfaces by incorporating phase-change material Ge_(2)Se_(2)Te_(5)(GST)in the terahertz(THz)regime.First,we experimentally show the reversible switching characteristic of GST on large areas by applying a single nanosecond laser pulse,which exhibits excellent contrast of THz properties in both states.Then,we present a multiplex metasurface scheme.In each metasurface,three sets of structures are adopted,in which two sets integrate GST.The effective structures can be reversely modulated by the amorphization and crystallization of GST.As a proof of concept,the dynamic beam splitter,bifocal metalens,dual-mode focusing optical vortex generators,and switchable metalens/focusing optical vortex generators are designed,fabricated,and experimentally characterized,and can be switched reversibly and repeatedly with the help of optical and thermal stimuli.Our scheme will pave the way toward the development of multifunctional and compact THz devices and may find use for applications in THz imaging,sensing,and communications. | SHOUJUN ZHANG XIEYU CHEN KUAN LIU HAIYANG LI YUEHONG XU XIAOHAN JIANG YIHAN XU QINGWEI WANG TUN CAO ZHEN TIAN | 2022 | Photonics Research2022，10，7： | 2 |
| 13 | Migration rate of river bends estimated by tree ring analysis for a meandering river in the source region of the Yellow River显示文摘Meandering rivers have dynamic evolution characteristics of lateral migration and longitudinal creeping movement, and studies on the migration rate of meandering rivers have both scientific and practical significance for understanding the evolution process. A river source region often is sparsely populated and lacks long-term monitoring data, making it difficult to estimate the migration rate of river bends. In the source region of the Yellow River, located in the northeastern part of the Qinghai-Tibet Plateau, China,meandering rivers have extensively developed. Combined with field investigation and sampling in the source region in 2016 and 2017, 9 river bends in the middle Baihe River were selected to attempt estimation of migration rates of the river bends using tree ring analysis. The tree core and disc samples were collected using an increment borer and a crosscut saw, and the ages of the trees were estimated based on tree ring analysis. A method for estimating the migration rate of river bends based on the relation between positions and ages of trees grown on the point bars in inner banks is proposed. The estimated migration rates of the 9 river bends of the Baihe River ranged 0.38 e6.10 m/yr, and the migration rates were found to be related to the flow rate, channel slope, height of the outer bank, and width of the river valley. The maximum migration rate was determined to be at the No. 9 River Bend where the ratio of the meander-bend radius to the channel width(R/W) was 2.31, which is consistent with previous findings that the bend migration is most rapid in the ‘migration phase’. The proposed method for estimating the migration rate of river bends provides a potential alternative option for future study on the morphodynamic process of a meandering river. | Cheng Liu An Liu Yun He Yuehong Chen | 2021 | International Journal of Sediment Research2021，36，5： | 2 |
| 14 | Application of Bayesian model and discriminant function analysis to the estimation of sediment source contributions显示文摘Bayesian and discriminant function analysis(DFA)models have recently been used as tools to estimate sediment source contributions.Unlike existing multivariate mixing models,the accuracy of these two models remains unclear.In the current study,four well-distinguished source samples were used to create artificial mixtures to test the performance of Bayesian and DFA models.These models were tested against the Walling-Collins model,a credible model used in estimation of sediment source contributions estimation,as a reference.The artificial mixtures were divided into five groups,with each group consisting of five samples with known source percentages.The relative contributions of the sediment sources to the individual and grouped samples were calculated using each of the models.The mean absolute error(MAE)and standard error of(SE)MAE were used to test the accuracy of each model and the robustness of the optimized solutions.For the individual sediment samples,the calculated source contributions obtained with the Bayesian(MAE?7.4%,SE?0.6%)and Walling-Collins(MAE?7.5%,SE?0.7%)models produced results which were closest to the actual percentages of the source contributions to the sediment mixtures.The DFA model produced the worst estimates(MAE?18.4%,SE?1.4%).For the grouped sediment samples,the Walling-Collins model(MAE?5.4%)was the best predictor,closely followed by the Bayesian model(MAE?5.9%).The results obtained with the DFA model were similar to the values for the individual sediment samples,with the accuracy of the source contribution value being the poorest obtained with any of the models(MAE?18.5%).An increase in sample size improved the accuracies of the Walling-Collins and Bayesian models,but the DFA model produced similarly inaccurate results for both the individual and grouped sediment samples.Generally,the accuracy of the Walling-Collins and Bayesian models was similar(p>0.01),while there were significant differences(p<0.01)between the DFA model and the other models.This study demonstrated that the Bayesian model could provide a credible estimation of sediment source contributions and has great practical potential,while the accuracy of the DFA model still requires considerable improvement. | Pengfei Du Donghao Huang Duihu Ning Yuehong Chen Bing Liu Jian Wang Jingjing Xu | 2019 | International Journal of Sediment Research2019，34，6： | 2 |
| 15 | Path Analysis of Agricultural Project Design Based on Function Expansion: A Case Study of Naya Mountain Villa显示文摘The expansion of agricultural function is one of the important means for modern agricultural projects to promote agricultural economic benefits. Successful modern agricultural projects require good creative ideas and design programs. While developing high-efficient modern agricultural production activities,we should fully explore the intangible value of agricultural production activities,combine agriculture with agricultural products,natural conditions,cultural conception and other effective resources,to expand agricultural functions,and promote comprehensive benefits. In order to build a sustainable modern agricultural project operation system,Naya Mountain Villa project planning is taken as an example for analysis. Naya Mountain Villa began construction in 2011; the creative planning based on the agricultural expansion function was carried out in 2013; it had successful access to the capital market in 2015. The project realizes the effective integration of agricultural production system and agricultural function expansion,constructs a set of long-term stable profiting models,and lays an important foundation for entering the capital market. The project is a representative example of the function-expanding modern agricultural project. Through the analysis of the design ideas of the project,this paper discusses the function expansion elements of basic resources,public welfare and agricultural function expansion methods,the formation of general ideas,source and construction logic of creative thinking,and summarizes and abstracts some inspiring design methods of agricultural function expansion. Through the analysis of the key points in the design of the specific technical aspects of the project,this paper provides a reference for solving common difficult problems in the practical design. The summary and refinement of the thinking logic,thinking construction and specific design method of the project is inspiring and repeatable to some extent,which can provide reference for the relevant researchers. | Yuehong SUN Yongsheng WU Rui CHEN Xue YANG | 2018 | Asian Agricultural Research2018，10，2： | 2 |
| 16 | Hybrid Channel Access Mechanism Based on Coexistence Scenario of NR-Unlicensed显示文摘With the rapid development of 5G NR(New Radio),the explosive increment of traffic amount is calling the utilization of unlicensed band.3GPP has proposed LAA(Licensed Assisted Access)to use LTE in unlicensed band and pointed out that NR-U(NR-Unlicensed)can reuse most designs of it.However,the existing channel access mechanism of LAA is conservative under the coexistence scenario of NR-U,which leads to the waste of time resource.To address the problem this paper proposes a hybrid channel access mechanism to take advantage of the LBT(Listen-Before-Talk)mechanism of LAA when channel is quite busy and transmit directly with reduced power when it is relatively idle.The channel busy degree is judged by a series of periodically updated adaptive thresholds.System-level simulation verifies that under the coexistence scenario of NR-U the proposed mechanism can achieve higher UPT(User Perceived Throughput)and lower delay than other channel access mechanisms. | Zhening Zhang Jingyi Chen Mingyang Dong Yuehong Gao Jingjing Wang | 2020 | China Communications2020，17，1： | 2 |
| 17 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 18 | Broadband terahertz rotator with an all-dielectric metasurface显示文摘Polarization manipulation is essential in developing cutting-edge photonic devices ranging from optical communication displays to solar energy harvesting. Most previous works for efficient polarization control cannot avoid utilizing metallic components that inevitably suffer from large ohmic loss and thus low operational efficiency.Replacing metallic components with Mie resonance-based dielectric resonators will largely suppress the ohmic loss toward high-efficiency metamaterial devices. Here, we propose an efficient approach for broadband, highquality polarization rotation operating in transmission mode with all-dielectric metamaterials in the terahertz regime. By separating the orthogonal polarization components in space, we obtain rotated output waves with a conversion efficiency of 67.5%. The proposed polarization manipulation strategy shows impressive robustness and flexibility in designing metadevices of both linear-and circular-polarization incidences. | QUANLONG YANG XIEYU CHEN QUAN XU CHUNXIU TIAN YUEHONG XU LONGQING CONG XUEQIAN ZHANG YANFENG LI CAIHONG ZHANG XIXIANG ZHANG JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，，11： | 2 |
| 19 | Ground heat exchanger temperature distribution analysis and experimental verification显示文摘 | Bi Yuehong Chen Lingen Wu Chih | 2002 | Applied Thermal Engineering2002，22，： | 1 |
| 20 | Dynamic analysis for peg - in - hole assembly with contact deformation显示文摘 | Xia Yanchun Yin Yuehong Chen Zhaoneng | 2006 | The International Journal of Advanced Manufacturing Technology2006，，30： | 1 |
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