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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | The Role of Service Guarantees in Service Development显示文摘 | Sara B L Bodil S | 2004 | The Service Industries Journal2004，24，4： | 1 |
| 3 | Customer loyalty and complex services:the impact of corporate image on quality,customer satisfaction and loyalty for customers with varying degrees of service experience显示文摘 | Andreassen T W Bodil L | 1998 | International Journal of Service Industry Management1998，9，1： | 1 |
| 4 | Probiotic Enterococcus faecium Strain is a Possible Recipient of the vanA Gene Cluster显示文摘 | BODIL L CHARLOTTA E | 2001 | Clin Infect Dis2001，32，： | 1 |
| 5 | Demonstration and Partial Purification of Lactoperoxidase from Human Colostrum显示文摘 | BODIL L TORGEIR F | 1984 | Febs Letters1984，2，174： | 1 |
| 6 | Potential Drug Related Prob- lems Detected by Electronic Expert Support System in Pa- tients with Multi - dose Drug Dispensing 显示文摘 | Tora H Bo H Bodil L | 2014 | Int J Clin Pharm2014，36，5： | 1 |
| 7 | Bubble size estimation for flotation processes显示文摘 | Bao L Bodil R | 2008 | Minerals Engineering2008，21，7： | 1 |
| 8 | Bubble size estimation for flotation processes 显示文摘 | BAO L BODIL R | 2008 | Minerals Engineering2008，21，7： | 1 |
| 9 | Sensitivity of MRI versus conventional screening in the diagnosis of BRCA-associated breast cancer in a national prospective series显示文摘 | Anne I. Hagen Kjell Arne Kvistad Lovise Maehle Marit Muri Holmen Hildegunn Aase Bodil Styr Anita Vab? Jaran Apold Per Skaane P?l M?ller | 2007 | The Breast2007，，4： | 1 |
| 10 | The Role of Service Guarantees in Service Development显示文摘 | SARA B L BODIL S | 2004 | The Service Industries Journal2004，24，4： | 1 |
| 11 | Improving marine water quality by mussel farming: A profitable solution for Swedish Society 显示文摘 | Odd L Rob H Bodil H | 2005 | A Journal of the Human Environment2005，34，2： | 1 |
| 12 | Customer loyalty and complex services:The impact of corporate image on quality, customer satisfaction and loyalty for customers with varying degrees of service expertise 显示文摘 | Tor W A Bodil L | 1998 | International Journal of Service Industry Management1998，9，1： | 1 |
| 13 | Gangliosides Protect Bowel in an Infant Model of Necrotizing Enterocolitis by Suppressing Proinflammatory Signals显示文摘 | Kareena L Schnabl Bodil Larsen John E Van Aerde Gordon Lees Mark Evans Miodrag Belosevic Catherine Field ABR Thomson Michael T Clandinin | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，4： | 1 |
| 14 | Vitellogenin in zoarces viviparous:purification,quantification by ELISA and induction by estradiol and 4-nonylphenol显示文摘 | Bodil K Knud L P | 1998 | Comp Biochem Physiol (Part C)1998，120，： | 1 |
| 15 | Greenhouse Gas Emissions in Norway: Do Carbon Taxes Work 显示文摘 | Annegrete B Bodil M L | 2004 | Energy Policy2004，32，： | 1 |
| 16 | The Iomplex Services:The Impact of Corporate Image on Quality,Customer Satisfaction and Loyalty for Customers with Varying Degrees of Service Expertise 显示文摘 | TOR W A BODIL L CUSTOMER L et at | 1997 | The International Journal of Service Industry Management1997，8，4： | 1 |
| 17 | Customer loyalty and complex services: The impact of corporate image on quality, customer satisfaction and loyalty for customers with varying degrees of service expertise显示文摘 | Tor W A Bodil L | 1998 | International Journal of Service Industry Management1998，1，： | 1 |
| 18 | 流域养分减排的综合模拟:不同情景的效果、潜力和措施成本显示文摘对瑞典南部的伦讷(Rnnea)河流域(1900km^2)应用水力模型HBV-NP分析了目前养分负荷情况的详细特征和改善处理措施或减少土壤淋溶的可能性。对几种不同的情景进行了模拟,以求找到实现瑞典环境目标的策略,其目标为将人类产生的氮的输送量减少30%,磷的输送量减少20%。可以通过不同的方法达到目标,这些方法将会影响不同的污染者和社会部门。然而,没有任何一种单一措施是足够的。相反,为了达到预期的目标,采取综合措施是必要的。氮的减排目标最难以实现。为了更达到更为经济的目的,这些措施应该应用于对于减少净的海洋负荷影响最大的地区。与在整个流域采取措施相比,这一策略能够使成本减少70%~80%。综合流域模型对于减少环境控制项目的成本来说是有用的工具。 | Berit Arheimer Marianne Lwgren Bodil Charlotta Pers Jrgen Rosberg 徐学华 | 2005 | AMBIO-人类环境杂志2005，34，B11： | 0 |
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