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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Pro- norm and anti-norm deviance within and between groups 显示文摘 | ABRAMS D MARQUES J M BOWN N | 2000 | Journal of Personality and Social Psychology2000，78，5： | 1 |
| 3 | Pro- norm and anti-norm deviance within and between groups显示文摘 | ABRAMS D MARQUES J M BOWN N | 2000 | Journal of personality and social psychology2000，78，5： | 1 |
| 4 | Ceramic coatings by anodic spark deposition显示文摘 | Writz G P Bown S D Kriven W M | 1991 | Materials and Manufacturing Processes1991，6，1： | 1 |
| 5 | Evaluating the effects of functional communication training in the presence and absence of establishing operations显示文摘 | BOWN K A WACKER D P DERBY K M | 2000 | J Appl Behavior Analysis2000，33，： | 1 |
| 6 | Subintimal angioplasty: meta-analytical evidence of clinical utility显示文摘 | Bown M J Bolia A Sutton A J | 2009 | Eur J Vasc Endovasc Surg2009，38，3： | 1 |
| 7 | Endovascular abdominal aortic aneurysm repair显示文摘 | NORWOOD M G LLOYD G M BOWN M J | 2007 | Postgrad Med J2007，83，975： | 1 |
| 8 | The uppermost Middle and Upper Albian succession at the Col de Palluel, Hautes-Alpes, France: An integrated study ( ammonites, inoceramid bivalves, planktonic foraminifera, nannofossils, geochemistry, stableoxygen and carbon isotopes, cyclostratigraphy) 显示文摘 | Gale A Bown P Caron M | 2011 | Creta- ceous Research2011，32，2： | 1 |
| 9 | Metabolism and functions of gamma-aminobutyric acid显示文摘 | SHELP B J BOWN A W MCLEAN M D | 1999 | Trends in Plant Science1999，4，11： | 1 |
| 10 | Metabolism and functions of gamma-aminobutyric acid显示文摘 | Shelp B J Bown A W McLean M D | | 0，，： | 1 |
| 11 | Cytogenetics of long -term survi- vors of ETV6 - RUNX1 fusion positive acute lymphoblastic leukemia 显示文摘 | Konn Z J Martineau M Bown N | 2010 | Genes Chromosomes Cancer2010，49，3： | 1 |
| 12 | Metabolism and functions of gamma-aminobutyric acid 显示文摘 | Shelp B J Bown A W Mclean M D | 1999 | Trends Plant Sci1999，4，11： | 1 |
| 13 | Development and evaluation of an in vitro detached leaf assay for pre-screening resistance to Fusarium head blight in wheat 显示文摘 | BOWNE R A COOKE B M | 2004 | European Journal of Plant Pathology2004，110，1： | 1 |
| 14 | The regulation of yp3 expression in theDrosophila melanogaster fat body显示文摘 | Hutson S F Bownes M | 2003 | Dev Genes Evol2003，213，1： | 1 |
| 15 | Metabolism and functions of gamma-aminobutyric acid显示文摘 | Shelp B J Bown A W Mclean M D | 1999 | Trends in Plant Sci1999，4，11： | 1 |
| 16 | Metabolism and functions of gamma-aminobutyrie acid显示文摘 | SHELP B J BOWN A W MCLEAN M D | 1999 | Trends in Plant Science1999，4，11： | 1 |
| 17 | Gain of chromo- some arm 17q and adverse outcome in patients with neuro- blastoma显示文摘 | Bown N Cotterill S Lastowska M | 1999 | N Engl J Med1999，340，25： | 1 |
| 18 | Enipin aluminum or-vegetable tannin combination on hide powder 显示文摘 | Ding K Taylor M Bown E M | 2007 | JALCA2007，102，5： | 1 |
| 19 | Patching: Restitching Busi- ness Portfolios in Dynamic Markets 显示文摘 | K M Eisenhardt S L Bown | 1999 | Harvard Review1999，77，： | 1 |
| 20 | Policy externalities:How US antidumping affects Japanese exports to the EU显示文摘 | Bown C P Crowley M A | 2006 | European Journal of Political Economy2006，22，3： | 1 |
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