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| 1 | XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer显示文摘DNA 修理能力(DRC ) 向基于铂的化疗与癌症房间的敏感被相关。我们假设那在 DNA 的基因多型性修理基因 XPA (干皮病 pigmentosum 组 A )和 XPG (干皮病 pigmentosum 组 G )( ERCC5 ,切除修理跨互补的组 5 ),它在 DNA 修理效率导致内部个人的差别,可以在先进非小的房间肺癌症( NSCLC )预言临床的反应到铂代理人病人。在这研究,我们发现 XPA A23G 多型性的 A G 变化显著地增加了反应到基于铂的化疗。在 XPG His46His 的多型性与减少的治疗回答被联系,但是不是统计上重要的。 | Jifeng Feng Xinchen Sun Ning Sun Shukui Qin Fan Li Hongyan Cheng Baoan Chen YuanDong Cao Jun Ma Lu Cheng Zuhong Lu Jiazhong Ji Yingfeng Zhou | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 8 |
| 2 | Phosphorus speciation in the sediment profile of Lake Erhai, southwestern China: Fractionation and ^(31)P NMR显示文摘The distribution characteristics of phosphorus(P) forms in the sediment profile of Lake Erhai,in southwestern China has been investigated by sequential extraction and 31P nuclear magnetic resonance spectroscopy(NMR) of NaOH extracts to understand P dynamics and its potential contribution to lake eutrophication.Contents of P fractions varied in the order of NH4Cl extracted P(NH4ClP) < bicarbonate-dithionite extracted P(BD-P) < HCl-P,Residual-P < NaOH extracted P(NaOH-P).The highly available NH4Cl-P represented less than 1% of total P(TP).BD-P and NaOH extracted reactive P(NaOH-rP) averaged 39%,while the ratio of Fe/P was higher than 15,indicating low P release from the sediments under permanent oxic condition.The less bio-available HCl-P,NaOH extracted nonreactive P(NaOH-nrP) and residual-P contributed 61% of TP.Regression analysis revealed that BD-P,NaOH-rP and HCl-P were positively correlated with the contents of Fe and Mn,Al and Fe,and Ca,respectively.The investigation of P compound groups in NaOH extracts by 31 P NMR showed that ortho-P and monoester-P were the largest two constituents of the P pool,followed by diester-P,phosphonate and pyro-P.A comparison of vertical variations of P groups in the sediment profile suggested that these compounds were involved in the P recycling to different extents in Lake Erhai.In particular,the lake exhibits high potential for labile P release from the surface sediments,which should be taken into consideration even after the outsourced P runoff ceased. | Runyu Zhang Liying Wang Fengchang Wu Baoan Song | 2013 | Journal of Environmental Sciences2013，25，6： | 7 |
| 3 | Remaining useful life estimation for deteriorating systems with time-varying operational conditions and condition-specific failure zones显示文摘Dynamic time-varying operational conditions pose great challenge to the estimation of system remaining useful life(RUL) for the deteriorating systems.This paper presents a method based on probabilistic and stochastic approaches to estimate system RUL for periodically monitored degradation processes with dynamic time-varying operational conditions and conditionspecific failure zones.The method assumes that the degradation rate is influenced by specific operational condition and moreover,the transition between different operational conditions plays the most important role in affecting the degradation process.These operational conditions are assumed to evolve as a discrete-time Markov chain(DTMC).The failure thresholds are also determined by specific operational conditions and described as different failure zones.The 2008 PHM Conference Challenge Data is utilized to illustrate our method,which contains mass sensory signals related to the degradation process of a commercial turbofan engine.The RUL estimation method using the sensor measurements of a single sensor was first developed,and then multiple vital sensors were selected through a particular optimization procedure in order to increase the prediction accuracy.The effectiveness and advantages of the proposed method are presented in a comparison with existing methods for the same dataset. | Li Qi Gao Zhanbao Tang Diyin Li Baoan | 2016 | Chinese Journal of Aeronautics2016，29，3： | 6 |
| 4 | Identification of differentially expressed genes in rat silicosis model by suppression subtractive hybridization analysis显示文摘在肺的纤维变性的发展的批评分子的机制仍然保持未知,让有差的预后的病人诊断。孤立在肺的纤维变性明确地起来调整的基因,我们建立了一个老鼠矽肺模型在有水晶的硅石暂停的治疗以后的 360 d。胸的拍证明一些散布高密度的阴影出现在肺地里。典型显微镜的小谎 rosing silicotic 小瘤在肺,牙槽的上皮的房间和支气管的上皮的房间形成了,特别地在部分 fibrosing silicotic 小瘤附近;他们中的一些显示出建议了在矽肺和肺癌症之间的关联的不正常的增生。抑制减少性的杂交分析被执行在肺织物把基因表示与矽肺和正常的肺织物作比较。反向的抄写聚合酶链反应证明七个新奇 cDNA 序列的表情由在有矽肺的肺织物的减少性的杂交不同于的抑制识别了正常的肺织物。生物信息学分析证明 47 积极克隆代表了包含二通常认为的蛋白质的 35 基因,四预言了类似的蛋白质。分析也证明一些在矽肺屏蔽了基因,例如 prolyl 4-hydroxylases,肌动朊相关的 protein-2/3 建筑群和酸的哺乳动物的 chitinase,以前没被报导。这些基因可以为在肺的纤维变性的发展调查分子的机制提供新线索。 | Zhongyuan Jin Baoan Liu Deyun Feng Chen Chen Xiang Li Yongbin Hu Jinwu Peng Yu Liu Jing Du Chunyan Fu Jifang Wen | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 6 |
| 5 | The cellular labeling and pH-sensitive responsive-drug release of celastrol in cancer cells based on Cys-CdTe QDs显示文摘As one of the active compounds derived from Traditional Chinese Medicine,Celastrol(CSL)had cytotoxicity for human leukemia cancer cells K562 and its multidrug-resistant cell line K562/A02.Here,we introduced cysteamine-modified CdTe QDs as the labeling and drug carrier into CSL research and found that the self-assembly and conjugation of anticancer molecular CSL with the Cys-CdTe QDs could significantly increase the drug’s cytotoxicity for K562 cells.More important,these CSL-Cys-CdTe nanocomposites could overcome the multidrug resistance of K562/A02 cells and efficiently inhibit the cancer cell proliferation by realizing the pH-sensitive responsive release of CSL to cancer cells.The enhanced cytotoxicity was caused by the increase of the G2/M phase arrest for K562/A02 cells as well as for K562 cells.Cys-CdTe QDs can readily bind on the cell plasma membranes and be internalized into cancer cells to trace and detect human leukemia cancer cells in real time.In addition,these Cys-CdTe QDs can facilitate the inhibition of the multidrug resistance of K562/A02 cells and readily induce apoptosis.As a good photosensitizer for the therapy,labeling,and tracing of cancer cells,the combination of CSL with Cys-CdTe QDs can optimize the use of and a new potential therapy method for CSL and yield new tools to explore the mechanisms of active compounds from Traditional Chinese Medicine. | LI JingYuan SHI LiXin SHAO YiXiang SELKE Matthias CHEN BaoAn JIANG Hui WANG XueMei | 2014 | Science China Chemistry2014，57，6： | 6 |
| 6 | Synthesis and antiviral bioactivities of novel chiral bis-thiourea-type derivatives containing α-aminophosphonate moiety显示文摘Starting from 1-((1R,2R)-2-aminocyclohexyl)-3-substituted thioureas (3a–c) and substituted isothiocyanates (9a–d),chiral bis-thiourea derivatives containing α-aminophosphonate moiety 10a–l were prepared and completely characterized by elemental analysis,physical and spectral (IR,1H NMR,13C NMR,31P NMR) data.The results of bioassay revealed that compounds 10a and 10e possessed appreciable curative bioactivities on cucumber mosaic virus (CMV) at 0.5 mg/mL in vivo (inhibitory rate = 60.3%,64.8% respectively) and tobacco mosaic virus (TMV) at 0.5 mg/mL in vivo (inhibitory rate = 50.3%,50.8% respectively),which were comparable to the values shown by standard reference (58.7%) and commercial product Ningnanmycin (56.3%),respectively.Chiral compound 10e displayed more potent antiviral activity (EC50 = 0.149 mg/mL) than Ningnanmycin (EC50 = 0.201mg/mL) against CMV. | YANG Xuan SONG BaoAn JIN LinHong WEI Xue BHADURY S Pinaki LI XiangYang YANG Song HU DeYu | 2011 | Science China Chemistry2011，54，1： | 5 |
| 7 | Synthesis, Nematicidal Activity, and 3D-QSAR of Novel 1,3,4-Oxadiazole/ Thiadiazole Thioether Derivatives显示文摘 | Jixiang Chen Xiuhai Gan Chongfen Yi Shaobo Wang Yuyuan Yang Fangcheng He Deyu Hu Baoan Song | 2018 | Chinese Journal of Chemistry2018，36，10： | 5 |
| 8 | Effects of antioxidants on homocysteine thiolactone-induced apoptosis in human umbilical vein endothelial cells显示文摘Background and objectives Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Homocysteine thiolactone (HcyT), one of the homocysteine metabolites in vivo, is toxic both in vivo and in vitro. The aim of this study was to investigate the effect of HcyT on apoptotic damage in human umbilical vein endothelial cells (HUVECs) and the role of antioxidants in the reduction of HcyT-induced apoptosis. Methods HUVECs were cultured in DMEM supplemented with 20% heat inactivated fetal bovine serum cell cultures were maintained in a humidified 5% CO2 atmosphere at 37 ℃. Cytotoxicity was determined by MTT assay,which consists of hypodiploid cells with propidium iodide labeling and intracellular reactive oxygen species levels using 2',7'-dichlorofluorescein diacetate as the probe by flow cytometry. Results HcyT (250-2000μM) induced HUVECs apoptosis in a time- and concentration-dependent manner. Reactive oxygen species levels rose in response to increasing HcyT concentrations at 24-h incubation.The reduction of cell apoptosis by N-acetylcysteine, vitamin E, or pyrrolidine dithiocarbamate, occurred simultaneously with a significant decrease in intracellular reactive oxygen species levels. Conclusion HcyT exerts its cytotoxic effects on endothelial cells through an apoptotic mechanism involving cellular reactive oxygen species production. The capacity of N-acetylcysteine, vitamin E, and pyrrolidine dithiocarbamate to scavenge HcyT-induced cellular reactive oxygen species correlates well with their efficiency to protect against HcyT-promoted apoptotic damage. The protective effect of pyrrolidine dithiocarbamate on cell apoptosis indicates HcyT-generated hydrogen peroxide may provoke cell apoptosis via activating nuclear factor-kappa binding protein. | Weijun GU Juming LU Guoqing YANG Qinghua GUO Baoan WANG Yiming MU Changyu PAN | 2006 | Journal of Geriatric Cardiology2006，3，2： | 3 |
| 9 | Solute clusters-promoted strength-ductility synergy in Al-Sc alloy显示文摘Sc solute clusters with a high number density were produced in an Al-0.3 wt.%Sc alloy when aged at250℃,while fine Al_(3)Sc precipitates were predominantly formed in the same alloy aged at 300℃.The alloy strengthened by Sc solute clusters displayed higher yield strength and simultaneously greater ductility than its counterpart strengthened by Al_(3)Sc precipitates.This clearly demonstrates a superior strengthductility synergy promoted by the Sc solute clusters in Al-Sc alloys.The effects of Al_(3)Sc precipitates and Sc solute clusters on ductility were discussed in comparison by using a micromechanics fracture model.Since the Sc clusters were stabilized at 250℃,the Al-Sc alloys strengthened by Sc solute clusters should find extensive application fields within a wide temperature range,due to their high temperature resistance. | Chong Yang Pengming Cheng Baoan Chen Jinyu Zhang Gang Liu Jun Sun | 2022 | Journal of Materials Science & Technology2022，，1： | 3 |
| 10 | Fabrication and characterization of superhydrophobic poly (vinylidene fluoride) membrane for direct contact membrane distillation显示文摘 | Jing Zhang Zhenyu Song Baoan Li Qin Wang Shichang Wang | 2013 | Desalination2013，，： | 2 |
| 11 | Nitrogen removal performance of municipal reverse osmosis concentrate with low C/N ratio by membrane-aerated biofilm reactor显示文摘A membrane-aerated biofilm reactor was employed to investigate the nitrogen removal of one typical municioal reverse osmosis(RO)concentrate with a high total nitrogen (TN)concentration and a low C/N ratio.The effects of operational conditions,including the aeration pressure,the hydraulic retention time and the C/N ratio,on the systematic performance were evaluated.The nitrogen removal mechanism was evaluated by monitoring the effluent concentrations of nitrogen contents.Furthermore,the microbial tolerance with elevated salinity was identified.The results indicated that the optimal TN removal efficiency of 79.2%was achieved of the aeration pressure of 0.02MPa, hydraulic retention time of 24h,and the C/N ratio of 5.8,respectively.It is essential to supplement the carbon source for the targeted RO concentrate to promote the denitrification process.The inhibitory effect of salinity on denitrifying bacteria and nitrite oxidizing bacteria was significant,revealing the limited TN removal capacity of the conditions in this work.The TN removal efficiency remained more than 70%with the addition of salt (NaCl)amount below 20g/L.This work preliminarily demonstrated the MABR feasibility for the nitrogen removal of municipal RO concentrate with low C/N ratio and provided technical guidance for further scale-up application. | Xiao Quan Kai Huang Mei Li Meichao Lan Baoan Li | 2018 | Frontiers of Environmental Science & Engineering2018，12，6： | 2 |
| 12 | Correlation between deformation behavior and atomic-scale heterogeneity in Fe-based bulk metallic glasses显示文摘The correlation betweent deformation behavior and atomic-scale heterogeneity of bulk metallic glasses(BMGs)is critical to understand the BMGs'deformation mechanism.In this work,three typical[(Fe_(0.5)Co_(0.5))_(0.75)B_(0.2)Si_(0.05)]_(96)Nb_4,Fe_(39)Ni_(39)B_(14.2)Si_(2.75)P_(2.75)Nb_(2.3),and Fe_(50)Ni_(30)P_(13)C_(7)BMGs exhibiting different plasticity were selected,and the correlation between deformation behavior and atomic-scale heterogeneity of Fe-based BMGs was studied.It is found that the serrated flow dynamics of Fe-based BMGs transform from chaotic state to self-organized critical state with increasing plasticity.This transformation is attributed to the increasing atomic-scale heterogeneity caused by the increasing free volume and short-to-medium range order,which facilitates a higher frequency of interaction and multiplication of shear bands,thereby results in a brittle to ductile transition in Fe-based BMGs.This work provides new evidence on heterogeneity in plastic Fe-based BMGs from the aspects of atomic-scale structure,and provides new insight into the plastic deformation of Fe-based BMGs. | Jing Zhou Siyi Di Baoan Sun Qiaoshi Zeng Baolong Shen | 2021 | Journal of Materials Science & Technology2021，，6： | 2 |
| 13 | Polymorphisms in hMSH2 and hMLH1 and response to platinum-based chemotherapy in advanced non-small-cell lung cancer patients显示文摘基于铂的 chemotherapeutics 是为先进 non-small-cell 肺癌症(NSCLC ) 的最普通的政体病人。然而,在临床的治疗识别铂抵抗是困难的。基因因素被认为代表药功效的重要决定因素。在这研究,我们调查了是否在人的傻瓜相当或相同的事物 2 的单个核苷酸的多型性(SNP )(hMSH2 ) 和人的 mutL 相当或相同的事物(hMLH1 ) 1 在先进 NSCLC 病人与肿瘤反应被联系用汉语的收到的基于铂的化疗人口。完全,有先进 NSCLC 的 96 个病人习惯性地与基于 cisplatin 或基于 carboplatin 的化疗被对待。三维(3D ) , polyacrylamide 基于胶化的 DNA microarray 方法被用来与外部淋巴细胞评估 hMSH2 gIVS12-6T/C 和 hMLH1-1151T/A 的遗传型。我们发现有对有 hMSH2 gIVS12-6T/C 多型性的基于铂的化疗的治疗反应的一个显著地增加的机会。3D polyacrylamide 基于胶化的 DNA microarray 方法精确、高产量、便宜,对在人口的 SNP genotyping 的大规模特别合适。 | Hongyan Cheng Ning Sun Xinchen Sun Baoan Chen Fan Li Jifeng Feng Lu Cheng Yuandong Cao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 2 |
| 14 | Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer显示文摘 | Rosa F. Hwang Todd T. Moore Maureen Mertens Hattersley Meghan Scarpitti Bin Yang Erik Devereaux Vijaya Ramachandran Thiruvengadam Arumugam Baoan Ji Craig D. Logsdon Jeffrey L. Brown Robert Godin | 2012 | Molecular Cancer Research2012，，9： | 2 |
| 15 | Green Plant Protection Innovation: Challenges and Perspectives显示文摘This issue of Engineering was compiled from papers presented at the First International Conference on Green Plant Protection Innovation(1st ICGPPI),held in Haikou in May 2018,and the Second International Conference on Green Plant Protection Innovation(2nd ICGPPI),held in Guiyang in October 2019.The conferences were sponsored by the Chinese Academy of Engineering,and the Academic Committee of the Forum of the ICGPPI,chaired by Professor Baoan Song,organized the conference.The 1st ICGPPI was attended by more than 800 people from seven countries,while the 2nd ICGPPI had more than 200 attendees from nine countries.The wide range of topics related to more environmentally sound crop protection was of great interest to all,and the meetings provided provided an opportunity for scientists from many disciplines of crop protection to exchange and share ideas and advances. | Baoan Song James NSeiber Stephen ODuke Qing XLi | 2020 | Engineering2020，6，5： | 2 |
| 16 | Primary aerobic biodegradation of cationic and amphoteric surfactants 显示文摘 | QIN Yong ZHANG Gaoyong KANG Baoan | 2005 | Journal of Surfactants and Detergents2005，8，1： | 1 |
| 17 | Feasibility Study of Aluminum Hydroxide Sol as Adjuvant to Prepare Stable Vaccine Using Newcastle Disease Virus as a Model显示文摘Aluminum hydroxide sol (consisting of aluminum hydroxide nano-particles) prepared by a hydrothermal method was used as nano-aluminum adjuvant adsorbed the inactived Newcastle disease virus (NDV). The zeta potential of aluminum hydroxide colloidal particles,the inactivated NDV and the nano-aluminum adjuvant NDV are +48.16 mV,?13.8 mV and +39.97 mV,respec-tively. The nano-aluminum adjuvant vaccine was transparent and stable without precipitate,whereas the conventional aluminum ad-juvant vaccine was turbid and a white precipitate was visible soon. The hemagglutination inhibition (HI) titers of the nano-aluminum adjuvant group were generally higher than those of the conventional aluminum group except the titer on day 29. The results show that the nano-aluminum adjuvant has better stability and higher levels of antibodies for a longer time than the conventional aluminum adjuvant. | SONG Meirong LI Xinsheng GAO Wenming FANG Shaoming CUI Baoan | 2011 | Wuhan University Journal of Natural Sciences2011，16，1： | 1 |
| 18 | APPLICATION AND DEVELOPMENT OF ‘GREEN’ PREVENTIVE AND CONTROL TECHNOLOGIES IN GUIZHOU TEA PLANTATIONS显示文摘The application and development of ‘green’ preventive technologies in teaplantations is an important means of ensuring tea quality and ecologicalsafety. Ecological, agronomic and biological controls are the main preventivemeasures used in Guizhou Province. This paper summarizes the ‘green’preventive technologies being applied in Guizhou tea plantations, including theuse of plant defense inducers to regulate tea plant responses to pathogens,natural enemies to control pest species causing damage to shoots andTrifolium repens to control the main weed species. In addition, it summarizesthe integrated ‘green’ preventive technologies being used in Guizhou andprovides a foundation for the ecological maintenance of tea plantations. | Xiangyang LI Linhong JIN Zhuo CHEN Baoan SONG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，1： | 1 |
| 19 | Low Temperature Sintering of 8YSZ Electrolyte Film for Intermediate Temperature Solid Oxide Fuel Cells 显示文摘 | Zhu Qingshan Fan Baoan | 2005 | Solid State Ionics2005，176，： | 1 |
| 20 | Pituitary adenylate ey- clase-activating peptide (PACAP) immunoreactivity distribution in the small intestine of the adult New Hampshire chicken显示文摘 | Pirone A Baoan D Piano I | 2011 | Acta Histochem2011，113，4： | 1 |
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