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| 1 | XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer显示文摘DNA 修理能力(DRC ) 向基于铂的化疗与癌症房间的敏感被相关。我们假设那在 DNA 的基因多型性修理基因 XPA (干皮病 pigmentosum 组 A )和 XPG (干皮病 pigmentosum 组 G )( ERCC5 ,切除修理跨互补的组 5 ),它在 DNA 修理效率导致内部个人的差别,可以在先进非小的房间肺癌症( NSCLC )预言临床的反应到铂代理人病人。在这研究,我们发现 XPA A23G 多型性的 A G 变化显著地增加了反应到基于铂的化疗。在 XPG His46His 的多型性与减少的治疗回答被联系,但是不是统计上重要的。 | Jifeng Feng Xinchen Sun Ning Sun Shukui Qin Fan Li Hongyan Cheng Baoan Chen YuanDong Cao Jun Ma Lu Cheng Zuhong Lu Jiazhong Ji Yingfeng Zhou | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 8 |
| 2 | LSECtin on tumor-associated macrophages enhances breast cancer sternness via interaction with its receptor BTN3A3显示文摘Macrophages have bee n suggested to con tribute to con structing a cancer stem cell(CSC)niche.However,whether and how macrophages regulate the activity of CSCs through juxtacrine signaling are poorly understood.Here we report LSECtin,a transmembrane protein highly expressed on tumor-associated macrophages(TAMs),enhances sternness of breast cancer cells(BCCs).We identified BTN3A3,a B7 family member with previously unknown functions as the receptor for LSECtin on BCCs responsible for stemness-promoting effect of LSECtin.In mice bearing human tumor xenografts,either macrophage-specific ablation of LSECtin or silencing of BTN3A3 in BCCs decreased CSC frequency and tumor growth.Admixture of LSECtin-positive macrophages increased the tumorigenic activity of BCCs dependent on BTN3A3.Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 mAb has a therapeutic effect on breast cancer.These findings define a juxtacrine signaling mechanism by which TAMs promote cancer stemness.Targeting this axis in the CSC niche may provide potential therapies to breast cancer. | Di Liu Qian Lu Xing Wang Jun Wang Ning Lu Zefei Jiang Xiaopeng Hao Jianbin Li Jing Liu Pengbo Cao Guilin Peng Yuandong Tao Dianyuan Zhao Fuchu He Li Tang | 2019 | Cell Research2019，29，5： | 8 |
| 3 | Effect of the current density on electrodepositing alpha-lead dioxide coating on aluminum substrate显示文摘The α-PbO2 electrodes are prepared by anodic electrodeposition on A1/conductive coating electrode from alkaline plumbite solutions in order to investigate the effect of the different current densities on the properties of α-PbO2 electrodes. The physic-ochemical properties of the α-PbO2 electrodes are analyzed by using SEM, EDS, XRD, Tafel plot, linear sweep voltammetry (LSV) and A.C. impedance. A compact and uniform layer of lead dioxide was obtained at the current density of 3 mA·cm-2. A further increase in current density results in smaller particles with high porosity. EDS and XRD analyses have shown that the PbO2 deposited in alkaline conditions is highly non stoichiometric, and the PbO impurities are formed on the surface layer besides the α-PbO2. The corrosion resistance of α-PbO2 at the low current density is superior to that of the high current density. It can be attributed to a porous layer of deposited films at high current densities. When used as anodes for oxygen evolution in aqueous Zn2+ 50 g·L-1, H2SO4 150 g·L-1, the Al/conductive coating/α-PbO2 exhibits lower potential compared to Pb electrode. Al/conductive coating/α-PbO2 electrode with the best electrocatalytic activity was obtained at current density of 1 mA·cm-2. The lowest roughness factor was obtained at 1 mA·cm-2. | Burning CHEN Zhongcheng GUO Hui HUANG Xianwan YANG Yuandong CAO | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，5： | 6 |
| 4 | Polymorphisms in hMSH2 and hMLH1 and response to platinum-based chemotherapy in advanced non-small-cell lung cancer patients显示文摘基于铂的 chemotherapeutics 是为先进 non-small-cell 肺癌症(NSCLC ) 的最普通的政体病人。然而,在临床的治疗识别铂抵抗是困难的。基因因素被认为代表药功效的重要决定因素。在这研究,我们调查了是否在人的傻瓜相当或相同的事物 2 的单个核苷酸的多型性(SNP )(hMSH2 ) 和人的 mutL 相当或相同的事物(hMLH1 ) 1 在先进 NSCLC 病人与肿瘤反应被联系用汉语的收到的基于铂的化疗人口。完全,有先进 NSCLC 的 96 个病人习惯性地与基于 cisplatin 或基于 carboplatin 的化疗被对待。三维(3D ) , polyacrylamide 基于胶化的 DNA microarray 方法被用来与外部淋巴细胞评估 hMSH2 gIVS12-6T/C 和 hMLH1-1151T/A 的遗传型。我们发现有对有 hMSH2 gIVS12-6T/C 多型性的基于铂的化疗的治疗反应的一个显著地增加的机会。3D polyacrylamide 基于胶化的 DNA microarray 方法精确、高产量、便宜,对在人口的 SNP genotyping 的大规模特别合适。 | Hongyan Cheng Ning Sun Xinchen Sun Baoan Chen Fan Li Jifeng Feng Lu Cheng Yuandong Cao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 2 |
| 5 | Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients显示文摘 | Xinchen Sun Fan Li Ning Sun Qin Shukui Chen Baoan Feng Jifeng Cheng Lu Lu Zuhong Cheng Hongyan Cao YuanDong Ji Jiazhong Zhou Yingfeng | 2008 | Lung Cancer2008，，2： | 1 |
| 6 | Key considerations on the development of biodegradable biomaterials for clinical translation of medical devices:With cartilage repair products as an example显示文摘With the interdisciplinary convergence of biology,medicine and materials science,both research and clinical translation of biomaterials are progressing at a rapid pace.However,there is still a huge gap between applied basic research on biomaterials and their translational products-medical devices,where two significantly different perspectives and mindsets often work independently and non-synergistically,which in turn significantly increases financial costs and research effort.Although this gap is well-known and often criticized in the biopharmaceutical industry,it is gradually widening.In this article,we critically examine the developmental pipeline of biodegradable biomaterials and biomaterial-based medical device products.Then based on clinical needs,market analysis,and relevant regulations,some ideas are proposed to integrate the two different mindsets to guide applied basic research and translation of biomaterial-based products,from the material and technical perspectives.Cartilage repair substitutes are discussed here as an example.Hopefully,this will lay a strong foundation for biomaterial research and clinical translation,while reducing the amount of extra research effort and funding required due to the dissonance between innovative basic research and commercialization pipeline. | Li Wang Xiaolei Guo Jiaqing Chen Zhen Zhen Bin Cao Wenqian Wan Yuandong Dou Haobo Pan Feng Xu Zepu Zhang Jianmei Wang Daisong Li Quanyi Guo Qing Jiang Yanan Du Jiakuo Yu Boon Chin Heng Qianqian Han Zigang Ge | 2022 | Bioactive Materials2022，7，3： | 0 |
| 7 | Hydrogen Trapping by Dislocations and Grain Boundaries in Fe-3%Si AHoy显示文摘In present work,Fe-3%Si alloy specimens with various degrees of cold working and various grainsizes were chosen to determine the effect of cold working and grain sizes on the hydrogendiffusivities by electrochemical permeation method and the mechanism of hydrogen trapping by dis-ocations and grain boundaries is discussed. | Yuandong DIAO Shenyang Institute of Chemical Technology,Shenyang,110021,ChinaMingzhou CAO Xiaojing WAN Institute of Metal Research,Academia Sinica,Shenyang,110015,China | 1993 | Journal of Materials Science & Technology1993，9，5： | 0 |
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