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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Rapamycin attenuates bleomycin-induced pulmonary fibrosis in rats and the expression of metalloproteinase-9 and tissue inhibitors of metalloproteinase-1 in lung tissue显示文摘 | Jin Xiaoguang | 2014 | Chinese Medical Journal2014，，7： | 20 |
| 3 | A genome-wide landscape of mRNAs,lncRNAs,and circRNAs during subcutaneous adipogenesis in pigs显示文摘Background: Preadipocyte differentiation plays a critical role in subcutaneous fat deposition in pigs.However,the roles of different RNAs,such as messenger RNAs(mRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs) in the differentiation process of subcutaneous preadipocytes,are still largely unclear.In the present study,a transcriptome analysis,including the analysis of mRNAs,lncRNAs,and circRNAs,during different differentiation stages,namely,day 0(D0),day 2(D2),day 4(D4),and day 8(D8),of subcutaneous preadipocytes from Chinese Erhualian pigs was performed.Results: A total of 1554,470,1344,1777,and 676 differentially expressed(DE) mRNAs,112,58,95,136,and 93 DE lncRNAs,and 902,787,710,932,and 850 DE circRNAs were identified between D2 and D0,between D4 and D2,between D8 and D4,between D4 and D0,and between D8 and D0,respectively.Furthermore,functional enrichment analysis showed that the common DE mRNAs during the entire differentiation process were mainly involved in lipid metabolic and cell differentiation processes.Additionally,co-expression network analysis identified the potential lncRNAs related to adipogenesis,e.g.,MSTRG.131380 and MSTRG.62128.Conclusions: Our study provides new insights of the expression changes of RNAs during adipogenic differentiation,which might contribute to the phenotype of subcutaneous adipogenesis.These results greatly improve our understanding of the molecular mechanisms regulating subcutaneous fat deposition in pigs. | Xin Liu Kaiqing Liu Baosen Shan Shengjuan Wei Dongfeng Li Haiyin Han Wei Wei Jie Chen Honglin Liu Lifan Zhang | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 5 |
| 4 | Study on the microstructure of 12%chromium low carbon stainless steel in a high temperature heat-affected zone显示文摘Coarsening,embrittlement and corrosion sensitization in a high temperature heat-affected zone(HTHAZ) are the major problems when 12%chromium low carbon stainless steel is being welded,which induce the deterioration of the impact toughness at a low temperature and intergranular corrosion resistance property.This study investigates the corresponding microstructures in HTHAZ with different chemical compositions and heat inputs through thermal simulation tests.The results show that the martensite content increases with the descending of ferrite factor(FF) when FF is below 9.0 and heat input influences the microstructure of high FF steel in HTHAZ.Martensite of 12%Cr stainless steel in HTHAZ with only Nb stabilization reticularly distributes at ferrite grain boundaries. | ZHENG Huaibei YE Xiaoning WANG Baosen JIANG Laizhu LIU Zhenyu WANG Guodong | 2010 | Baosteel Technical Research2010，4，1： | 4 |
| 5 | Analysis of the Temperature Characteristics of High-speed Train Bearings Based on a Dynamics Model and Thermal Network Method显示文摘High-speed trains often use temperature sensors to monitor the motion state of bearings.However,the temperature of bearings can be affected by factors such as weather and faults.Therefore,it is necessary to analyze in detail the relationship between the bearing temperature and influencing factors.In this study,a dynamics model of the axle box bearing of high-speed trains is established.The model can obtain the contact force between the rollers and raceway and its change law when the bearing contains outer-ring,inner-ring,and rolling-element faults.Based on the model,a thermal network method is introduced to study the temperature field distribution of the axle box bearings of high-speed trains.In this model,the heat generation,conduction,and dispersion of the isothermal nodes can be solved.The results show that the temperature of the contact point between the outer-ring raceway and rolling-elements is the highest.The relationships between the node temperature and the speed,fault type,and fault size are analyzed,finding that the higher the speed,the higher the node temperature.Under different fault types,the node temperature first increases and then decreases as the fault size increases.The effectiveness of the model is demonstrated using the actual temperature data of a high-speed train.This study proposes a thermal network model that can predict the temperature of each component of the bearings on a high-speed train under various speed and fault conditions. | Baosen Wang Yongqiang Liu Bin Zhang Wenqing Huai | 2022 | Chinese Journal of Mechanical Engineering2022，35，5： | 3 |
| 6 | Preparation,characterization,and tribological properties of silicananoparticle-reinforced B–N-co-doped reduced graphene oxide as a multifunctional additive for enhanced lubrication显示文摘Microwave-synthesized SiO_(2)-reinforced B–N-co-doped reduced graphene oxide(SiO_(2)–B–N–GO)nanocomposites were characterized by X-ray photon spectroscopy(XPS),X-ray diffraction(XRD),infrared(IR)spectroscopy,and transmission electron microscopy/energy dispersive X-ray(TEM/EDX)analysis.The tribological properties of the SiO2–B–N–GO prepared as anti-wear additives for enhanced lubrication were studied using a four-ball tester.The experiment results indicated that SiO_(2)–B–N–GO exhibits excellent load-carrying,anti-wear,and anti-friction properties in a base oil,especially at the optimal concentration of additives at 0.15 wt%.The wear scar diameter decreased from 0.70 to 0.37 mm and the coefficient of friction was reduced from 0.092 to 0.070,which reductions are attributed to the formation of B–N and graphene layer tribofilms of several tens of nanometers in thickness that prevented direct contact between metals. | Sang XIONG Baosen ZHANG Shuai LUO Hao WU Zhen ZHANG | 2021 | Friction2021，9，2： | 2 |
| 7 | Establishment of Dynamic Model for Axle Box Bearing of High-Speed Trains Under Variable Speed Conditions显示文摘In this study,a dynamic model for the bearing rotor system of a high-speed train under variable speed conditions is established.In contrast to previous studies,the contact stress is simplifed in the proposed model and the compensation balance excitation caused by the rotor mass eccentricity considered.The angle iteration method is used to overcome the challenge posed by the inability to determine the roller space position during bearing rotation.The simulation results show that the model accurately describes the dynamics of bearings under varying speed profles that contain acceleration,deceleration,and speed oscillation stages.The order ratio spectrum of the bearing vibration signal indicates that both the single and multiple frequencies in the simulation results are consistent with the theoretical results.Experiments on bearings with outer and inner ring faults under various operating conditions are performed to verify the developed model. | Yongqiang Liu Baosen Wang Bin Zhang Shaopu Yang | 2022 | Chinese Journal of Mechanical Engineering2022，35，4： | 2 |
| 8 | Research on Tribological Characteristics and Worn Surface Self-Repairing Performance of Nano Attapulgite Powders Used in Lubricant Oil as Addictive显示文摘As a kind of natural nanometer materials,the attapulgite has been widely used in industry,agriculture,environment,food substance,medicament and many other fields.Few researches about attapulgite used in lubricant oil as additive were made,and those were only at a preliminary stage of exploration.The tribological characteristics of attapulgite powders with the different contents added to CD 15W/40 lubricant oil were researched through'plane-on-plane'configuration friction and wear tester,and the self-repairing performance of 45#steel worn surface was examined via ring-on-block configuration test.XRD,SEM,EDS,TEM were employed to analyze the surface morphologies and elementary composition of the samples'worn surface.Furthermore,wear self-repairing mechanism of attapulgite additive to lubricant oil was explored.The results showed that:the optimal content of attapulgite powders in oil CD 15W/40 was 0.5 wt%,and the stable friction coefficient can be reduced to 0.02,then the friction reduction performance can be enhanced by 82.5%;Smooth worn surface were formed of the chemical reaction film containing elements O,Si,Fe;Friction reduction and self-repairing mechanism had a relation with the crystal structure of attapulgite. | Zhang Bo Xu Binshi Xu Yi Gao Fei Zhang Baosen | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 9 | Effects of common polymorphisms rs2910164 in miR-146a and rs3746444 in miR-499 on cancer susceptibility: a meta-analysis显示文摘 | Zhihua Yin Lei Yan Zhigang Cui Xuelian Li Yangwu Ren Baosen Zhou | 2013 | Molecular Biology Reports2013，，4： | 1 |
| 10 | Characteristics of Cr and Al Powders by High Energy Ball Milling显示文摘The variation of microstucture and phase structure of metal Cr and Al powders prepared by high energy mechanical milling was analyzed and investigated.The results show that with the continuous balling the average grain sizes of the brittle Cr powders are gradually decreased,and the diffraction peaks are widened and the peak values lower owing to the interrelation caused by both cold welding and breaking;the tough Al powders exhibit intense cold welding,and most of powders lead to adhesion to ball surface and pot wall,meanwhile,the Al powders subjected to intense deformation have led to many dislocation rings with non dislocation wind up found in the microstructure. | Qi Baosen,Wang Chengguo,Yao Xin and Xu Ying (College of Materials Science and Engineering,Shandong University of Technology,Jinan 250061,China) | 2000 | Rare Metals2000，19，3： | 1 |
| 11 | Evidence for cigarette smoke-induced oxidative stress in the rat pancreas显示文摘 | Jianyu Hao Guang Li Baosen pang | 2009 | Inhalation Toxicology2009，，12： | 1 |
| 12 | Sliding friction and wear behaviors of surface-coated natural serpentine mineral powders as lubricant additive显示文摘 | Baosen Zhang Yi Xu Fei Gao Peijing Shi Binshi Xu Yixiong Wu | 2010 | Applied Surface Science2010，，7： | 1 |
| 13 | The application of Petri nets to construction project management 显示文摘 | CHEN Zhaozhu SHAN Baosen | 2012 | Affective computing and intelligent interaction2012，137，： | 1 |
| 14 | Construction and application of an ontology-based domain-specific knowledge graph for petroleum exploration and development显示文摘The massive amount and multi-sourced,multi-structured data in the upstream petroleum industry impose great challenge on data integration and smart application.Knowledge graph,as an emerging technology,can potentially provide a way to tackle the challenges associated with oil and gas big data.This paper proposes an engineering-based method that can improve upon traditional natural language processing to construct the domain knowledge graph based on a petroleum exploration and development ontology.The exploration and development knowledge graph is constructed by assembling Sinopec’s multi-sourced heterogeneous database,and millions of nodes.The two applications based on the constructed knowledge graph are developed and validated for effectiveness and advantages in providing better knowledge services for the oil and gas industry. | Xianming Tang Zhiqiang Feng Yitian Xiao Ming Wang Tianrui Ye Yujie Zhou Jin Meng Baosen Zhang Dongwei Zhang | 2023 | Geoscience Frontiers2023，14，5： | 1 |
| 15 | Development of a roll-bonded UNS N08825 alloy clad pipeline steel in Baosteel显示文摘In this study,a roll-bonded UNS N088225 alloy clad pipeline steel was investigated and developed in Baosteel. Based on the requirements of a number of potential projects,we performed a series of strict evaluations including mechanical and corrosion tests. The results show the mechanical properties and corrosion resistance of this clad steel to be excellent and to meet the requirements of all the design parameters. | LIANG Xiaojun MA Tianjun FU Yanhong JIAO Sihai DING Jianhua YUAN Xiangqian WANG Baosen ZHANG Qingfeng | 2017 | Baosteel Technical Research2017，11，1： | 1 |
| 16 | The heat-affected zone microstructure of 12% chromium steel welds 显示文摘 | Baosen W Li M | 2007 | Baosteel Technology2007，132，3： | 1 |
| 17 | Laparoscopic ovarian endometriosis cyst surgery 106cases analysis显示文摘 | Liu Chunxian Li Baosen | 2009 | Journal of Huaxi Medical2009，23，7： | 1 |
| 18 | Geometry of injection regions of power networks 显示文摘 | ZHANG Baosen TSE D | 2013 | IEEE Trans on Power Systems2013，28，2： | 1 |
| 19 | Sliding friction and wear behaviors of surface-coated natural serpentine mineral powders as lubricant additive显示文摘 | Baosen Zhang Yi Xu Fei Gao Peijing Shi Binshi Xu Yixiong Wu | 2010 | Applied Surface Science2010，，7： | 1 |
| 20 | Quantum key distribution and quantum authentication based on entangled states 显示文摘 | Shi Baosen Li Jian Liu Jinming | 2001 | Physical Letters A2001，281，23： | 1 |
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