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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
| 3 | Development and Optimization of an Alternative Methodology for Detection of Milk Adulteration by Water显示文摘 | Wesley William Gongalves Nascimento Marcone Augusto Leal de Oliveira1 Marcone Augusto Leal de Oliveira Marco Antonio Moreira Furtado Virgilio de Carvalho dos Anjos Maria Jose Valenzuela Bell | 2013 | Journal of Food Science and Engineering2013，3，7： | 2 |
| 4 | Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic esophagitis: A prospective study显示文摘 | Alfredo J. Lucendo ángel Arias Livia C. De Rezende Jose Luis Yagüe-Compadre Teresa Mota-Huertas Sonia González-Castillo Rubén A. Cuesta José M. Tenias Teresa Bellón | 2011 | The Journal of Allergy and Clinical Immunology2011，，： | 2 |
| 5 | Postoperative Complications and Mortality Following Colectomy for Ulcerative Colitis显示文摘 | Shanika de Silva Christopher Ma Marie–Claude Proulx Marcelo Crespin Belle S. Kaplan James Hubbard Martin Prusinkiewicz Andrew Fong Remo Panaccione Subrata Ghosh Paul L. Beck Anthony MacLean Donald Buie Gilaad G. Kaplan | 2011 | Clinical Gastroenterology and Hepatology2011，，11： | 2 |
| 6 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 7 | Early prediction of endocrine therapy effect in advanced breast cancer patients using ^99mTc-depreotide scintigraphy 显示文摘 | VAN DEN BOSSCHE B VAN BELLE S DE WINTER F | 2006 | J Nucl Med2006，47，11： | 1 |
| 8 | Regret in decision making under uncertainty显示文摘 | Bell DE | 1982 | Operations Research1982，30，5： | 1 |
| 9 | p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53 - dependent apoptosis 显示文摘 | de Belle I Huang RP Fan Y | 1999 | Oncogene1999，18，24： | 1 |
| 10 | The association of patient trust and self-care among patients with diabetes mellitus显示文摘 | Camacho F Bell RA | 2004 | BMC Fam Pract2004，16，5： | 1 |
| 11 | The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11 显示文摘 | Bell TA de la Casa-Esperon E Doherty HE | 2006 | Genetics2006，172，1： | 1 |
| 12 | Chemical and microbiological tests to simulate sulfuric acid corrosion of polymer-modified concrete 显示文摘 | MONTENY J de BELLE N VINCKE E | 2001 | Cem Concr Res2001，31，： | 1 |
| 13 | Using surface elec- trodes for the evaluation of the rectus femoris,vastus medialis and vas- tus lateralis muscles in children with cerebral palsy 显示文摘 | QUNPUU S DE LUCA PA BELL K J DAVID RB | 1997 | Gait&Posture1997，，5： | 1 |
| 14 | Genetic localization of foraging(for):a major gene for larval behavior in Drosophila melanogaster显示文摘 | DE BELLE J S HILLIKER A J SOKOLOWSKI M B | 1989 | Genetics1989，123，1： | 1 |
| 15 | The transcription factor EGR-1 suppresses transformation of human fibrosareoma HT1080 cells by coordinated induction of transforming growth factorbl ,ibronectin,and plasminogen activator inhibitor-1 显示文摘 | Liu C Yao J de Belle I | 1999 | J Biol Chem1999，274，7： | 1 |
| 16 | Epoetin alpha prevents anaemia and reduces transfusion requirements in patients undergoing primarily platinum-based chemotherapy for small cell lung cancer显示文摘 | Thatcher N De Campos ES Bell DR | 1999 | Br J Cancer1999，80，34： | 1 |
| 17 | An alternative, nonapop- totic form of programmed cell death显示文摘 | Sperandio S de Belle I Bredesen DE | 2000 | Proc Natl Acad Sci USA2000，97，14： | 1 |
| 18 | The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11显示文摘 | Bell T A de la Casa-Esperon E Doherty H E | 2006 | Genetics2006，172，1： | 1 |
| 19 | Relationship between cigarette smoking and Alzheimer's disease in a population-bassed case-control study显示文摘 | Brenner DE Kukull WA van Belle G | 1993 | Neurology1993，43，： | 1 |
| 20 | nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory显示文摘 | Sandstrom D de Belle S | 2000 | Neuron2000，27，1： | 1 |
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