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| 1 | Anti-diabetic effects of Caulerpa lentillifera:stimulation of insulin secretion in pancreatic β-cells and enhancement of glucose uptake in adipocytes显示文摘Objective:To evaluate anti-diabetic effect of Caulrpa kntillifera(C.lentillifera).Methods:The inhibitory effect of C.lentillifera extract on dipeptidyl peptidase-IV and a-glucosidase enzyme was measured in a cell free system.Then,interleukin-1βand interferon-γinduced cell death and insulin secretion were measured in rat insulinoma(RIN)cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and ELISA kit,respectively.Glucose uptake and glucose transporter expression were measured by fluorometry and western blotting,using 3T3-Ll adipocytes.Results:C.lentillifera extract significantly decreased dipeptidyl peptidase-IV and a-glucosidase enzyme activities,and effectively inhibited cell death and iNOS expression in interleukin-1βand interfcron-γinduced RIK cells.Furthermore,C.lntillifera extract significantly enhanced insulin secretion in RTN cells and glucose transporter expression and glucose uptake in 3T3-L1adipocytes.Conclusions:Thus,our results suggest that C.lentillifera could be used as a potential antidiabetic agenl. | Bhesh Raj Sharma Dong Young Rhyu | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，7： | 12 |
| 2 | 山茱萸黄酮微胶囊制备工艺及性质显示文摘为提高山茱萸黄酮的稳定性和生物活性,应用喷雾干燥法,以乳清分离蛋白和阿拉伯胶作为壁材制备山茱萸黄酮微胶囊,以山茱萸黄酮包埋率为评价指标优化包埋工艺,并对微胶囊颗粒理化特性、热力学行为、微观形态、结构进行综合分析。优化得到的山茱萸黄酮微胶囊包埋工艺为:壁材质量分数9.34%、壁材添加物比例[m(WPI)∶m(GA)]1.07∶1、芯壁体积比1∶10、进料温度170℃、pH 3。在此条件下制备的山茱萸黄酮微胶囊呈现球形,表面光滑且结构完整,其包埋率可达到90.34%,平均粒径为23μm。差示扫描量热仪测示结果显示,微胶囊粉末具有良好热性能,可在室温贮藏。微胶囊红外、荧光以及紫外光谱分析表明,山茱萸黄酮完整地封装在胶囊内,保证其生物活性,同时具有良好感官价值和稳定性。 | 赵梦月 段续 任广跃 曹伟伟 李琳琳 徐一铭 楚倩倩 BHESH Bhandari | 2023 | 食品与发酵工业2023，49，7： | 4 |
| 3 | Nelumbo Nucifera leaf extract attenuated pancreatic β-cells toxicity induced by interleukin-1β and interferon-γ, and increased insulin secrection of pancreatic β-cells in streptozotocin-induced diabetic rats显示文摘OBJECTIVE: To evaluate the effect of Nelumbo Nucifera leaf water extract(NNLE) on insulinoma(RIN)cells induced by interleukin-1β(IL-1β) and interferon-g(IFN-γ), and injured pancreatic β-cells induced by Streptozotocin(STZ) in rats.METHODS: The anti-oxidative effects of NNLE were assessedusing 1,1-diphenyl-2-picrylhydrazyl(DPPH)and nitric oxide(NO) scavenging assays. The inhibitory effect of NNLE on α-glucosidase and DPP(dipeptidyl peptidase)-IV was measured in vitro. Pancreatic β-cell protective and insulin secretory effects were assessed, using IL-1β and IFN-γ-induced rat RIN cells. STZ-induced diabetic rats were treated with 50, 100, and 400 mg/kg NNLE for 4 weeks. The effects of NNLE on blood glucose(BG), body weight(BW), and lipid profiles were measured.RESULTS: NNLE inhibited DPPH, NO, α-glucosidase,and DPP-Ⅳ which were directly linked to the function of β-cells. Furthermore, NNLE protected RIN cells from toxicity induced by IL-1β and IFN-γ, decreased NO production, and increased insulin secretion. NNLE caused a significant reduction in blood glucose, triglyceride(TG), total cholesterol(TC),blood urea nitrogen(BUN), and creatinine in STZ-induced diabetic rats. Furthermore, it significantly decreased BW loss in STZ-induced diabetic rats.CONCLUSION: Our results suggest that NNLE reduced the toxicity in insulinoma cells and increased insulin secretion in pancreatic β-cells in STZ-induced diabetic rats. | Bhesh Raj Sharma Min Suk Kim Dong Young Rhyu | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 3 |
| 4 | Re-coalescence of emulsion droplets during high-energy emulsification显示文摘 | Seid Mahdi Jafari Elham Assadpoor Yinghe He Bhesh Bhandari | 2007 | Food Hydrocolloids2007，，7： | 1 |
| 5 | Production of sub-micron emulsions by ultrasound and microfluidization techniques显示文摘 | Seid Mahdi Jafari Yinghe He Bhesh Bhandari | 2007 | Journal of Food Engineering2007，，4： | 1 |
| 6 | Nano-Emulsion Production by Sonication and Microfluidization—A Comparison显示文摘 | Seid Mahdi Jafari Yinghe He Bhesh Bhandari | 2006 | International Journal of Food Properties2006，，3： | 1 |
| 7 | Rheology of selected Australian honeys显示文摘 | BHESH B BRUCE D SAMUEL C | 1999 | Journal of Food Engineering1999，41，： | 1 |
| 8 | Use of an Arrhenius model to predict rheological behaviour in some australian honeys显示文摘 | BRENDA M BHESH B BRUCE D | 2000 | Lebensm-Wiss u-Technol2000，33，： | 1 |
| 9 | Chemical and physical changes in milk protein concentrate (MPC80) powder during storage显示文摘 | Thao T L Bhesh B Hilton C D | 2011 | Journal of Agricultural and Food Chemistry2011，59，： | 1 |
| 10 | Encapsulation Efficiency of Food Flavours and Oils during Spray Drying显示文摘 | Seid Mahdi Jafari Elham Assadpoor Yinghe He Bhesh Bhandari | 2008 | Drying Technology2008，，7： | 1 |
| 11 | Role of Powder Particle Size on the Encapsulation Efficiency of Oils during Spray Drying显示文摘 | Seid Mahdi Jafari Yinghe He Bhesh Bhandari | 2007 | Drying Technology2007，，6： | 1 |
| 12 | Evaluation of encapsulation techniques of probiotics for yoghurt显示文摘 | Wunwisa krasaekoopt Bhesh Bhandari Hilton Deeth | 2003 | International Dairy Journal2003，13，1： | 1 |
| 13 | Production of sub-micron emulsions by ultrasound and microfluidization techniques显示文摘 | Seid Mahdi Jafari Yinghe He Bhesh Bhandari | 2007 | Journal of Food Engineering2007，82，4： | 1 |
| 14 | A proteomic approach to detect lactosylation and other chemical changes in stored milk protein concentrate 显示文摘 | Thao T L Hilton C D Bhesh B | 2012 | Food Chemistry2012，132，1： | 1 |
| 15 | Evaluation of encapsulation techniques of probiotics for yoghurt显示文摘 | Wunwisa Krasaekoopt Bhesh Bhandari Hilton Deeth | 2003 | International Dairy Journal2003，13，1： | 1 |
| 16 | Survival of probiotics encapsulated in chitosan-coated alginate beads in yoghurt from UHT- and conventionally treated milk during storage 显示文摘 | Wunwise Krasaekoopt Bhesh Bhandari Hilton C Deeth | 2006 | LWT - Food Science and Technology2006，39，2： | 1 |
| 17 | Nano-particle encapsulation of fish oil by spray dr- ying显示文摘 | Seid Mahdi Jafari a Elham Assadpoor Bhesh Bhandari | 2008 | Food Research International2008，41，： | 1 |
| 18 | Evaluation of various extraction methods of encapsulated oil from β-cyclodextrin lemon oil complex powder 显示文摘 | INDRA P K BHESH B D BRUCE D A | 2000 | Food Composition and Analysis2000，13，1： | 1 |
| 19 | A new method of producing date powder granules: Physicochemical characteristics of powder显示文摘 | Shyam S. Sablani Ashok K. Shrestha Bhesh R. Bhandari | 2008 | Journal of Food Engineering2008，，3： | 1 |
| 20 | Lemon oil to β- cyclodextrin ratio effect on the inclusion efficiency of cyclodextrin and the retention of oil valatiles in the complex显示文摘 | Bhesh R B | 1998 | J Agric Food Chem1998，46，4： | 1 |
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