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| 1 | Chemotherapy with laparoscope-assisted continuous circulatory hyperthermic intraperitoneal perfusion for malignant ascites显示文摘AIM:To investigate the procedure, feasibility and effects of laparoscopeassisted continuous circulatory hyperthermic intraperitoneal perfusion chemotherapy (CHIPC) in treatment of malignant ascites induced by peritoneal carcinomatosis from gastric cancers. METHODS: From August 2006 to March 2008, the laparoscopic approach was used to perform CHIPC on 16 patients with malignant ascites induced by gastric cancer or postoperative intraperitoneal seeding. Each patient underwent CHIPC three times after laparoscopeassisted perfusion catheters placing. The first session was completed in operative room under general anesthesia, 5% glucose solution was selected as perfusion liquid, and 1500 mg 5 fluorouracil (5FU) and 200 mg oxaliplatin were added in the perfusion solution. The second andthird sessions were performed in intensive care unit, 0.9% sodium chloride solution was selected as perfusion liquid, and 1500 mg 5FU was added in the perfusion solution alone. CHIPC was performed for 90 min at a velocity of 450600 mL/min and an in flow temperature of 43 ± 0.2℃.RESULTS: The intraoperative course was uneventful in all cases, and the mean operative period for laparoscopeassisted perfusion catheters placing was 80 min for each case. No postoperative deaths or complications related to laparoscopeassisted CHIPC occurred in this study. Clinically complete remission of ascites and related symptoms were achieved in 14 patients, and partial remission was achieved in 2 patients. During the followup, 13 patients died 29 mo after CHIPC, with a median survival time of 5 mo. Two patients with partial remission suffered from port site seeding and tumor metastasis,and died 2 and 3 mo after treatment. Three patients who are still alive today survived 4, 6 and 7 mo, respectively. The Karnofsky marks of patients (5090) increased significantly (P < 0.01) and the general status improved after CHIPC. Thus satisfactory clinical efficacy has been achieved in these patients treated by laparoscopic CHIPC. CONCLUSION: Laparoscopeassisted CHIPC is a safe, feasible and effective procedure in the treatment of debilitating malignant ascites induced by unresectable gastric cancers. | Ba, Ming-Chen Cui, Shu-Zhong Lin, Sheng-Qu Tang, Yun-Qiang Wu, Yin-Bing Wang, Bin Zhang, Xiang-Liang | 2010 | World Journal of Gastroenterology2010，16，15： | 50 |
| 2 | Prognostic evaluation of postoperative adjuvant therapy for operable cervical cancer:10 years'experience of National Cancer Center in China显示文摘Objective: The aim of this study was to investigate the prognostic factors and to evaluate the impact of adjuvant therapy on clinical outcome for early-stage cervical cancer.Methods: The clinical-pathological data of all 1,335 patients with the International Federation of Gynecology and Obstetrics(FIGO) Ib–IIa cervical cancer treated with primary radical surgery at the Chinese National Cancer Center between May 2007 and Dec 2013 were retrospectively reviewed.The median follow-up was 70 months.Results: Of all the patients,61.6% of the cases received adjuvant therapy,with 5-year disease-free survival(DFS)of 92.1% and 5-year overall survival(OS) of 95.0%.In multivariate analysis,differentiation of G3(P<0.05),lymph node metastasis(LNM,P<0.05) and lymphovascular space invasion(LVSI,P<0.05) were independent predictors for OS,while LNM(P<0.05),deep stroma invasion(DSI,P<0.05) and LVSI(P<0.05) were independent factors for DFS.The samples were stratified by histologic type,and cervical squamous cell carcinoma(SCC) was found to share the same independent factors except for differentiation of OS.As to patients with cervical adenocarcinoma/adenosquamous carcinoma(AC/ASC),differentiation was the independent predictor of OS(P<0.05); and LVSI of DFS(P<0.05).Of 236 patients with high-risk factors,there was no significant difference in survival between concurrent chemoradiotherapy(CCRT,n=195),radiotherapy(RT,n=24),and chemotherapy(CT,n=17).Among the 190 patients with LNM who underwent CCRT,124 cases showed improved DFS after sequential CT(P=0.118),with a recurrence rate decrease of 14%,though the difference was not statistically significant.Patients with single intermediate-risk factors like DSI or LVSI were found to partially benefit from adjuvant therapy,but the difference was not statistically significant.Conclusions: LNM,LVSI,DSI and differentiation were found to be independent prognostic factors for operable cervical cancer.Aggressive postoperative adjuvant therapy based on single risk factors in Chinese National Cancer Center could benefit survival.CCRT+CT outperformed CCRT in high-risk patients.For patients with single non-high-risk factor,the role of adjuvant therapy needs to be further discussed. | Tong Shu Dan Zhao Bin Li Yating Wang Shuanghuan Liu Pingping Li Jing Zuo Ping Ba i RongZhang Lingying Wu | 2017 | Chinese Journal of Cancer Research2017，29，6： | 12 |
| 3 | A direct position determination method with combined TDOA and FDOA based on particle filter显示文摘The localization of a stationary transmitter using moving receivers is considered.The original Direct Position Determination(DPD) methods, with combined Time Difference of Arrival(TDOA) and Frequency Difference of Arrival(FDOA), do not perform well under low Signal-toNoise Ratio(SNR), and worse still, the computation cost is difficult to accept when the computational capabilities are limited.To get better positioning performance, we present a new DPD algorithm that proves to be more computationally efficient and more precise for weak signals than the conventional approach.The algorithm partitions the signal received with the same receiver into multiple non-overlapping short-time signal segments, and then uses the TDOA, the FDOA and the coherency among the short-time signals to locate the target.The fast maximum likelihood estimation, one iterative method based on particle filter, is designed to solve the problem of high computation load.A secondary but important result is a derivation of closed-form expressions of the Cramer-Rao Lower Bound(CRLB).The simulation results show that the algorithm proposed in this paper outperforms the traditional DPD algorithms with more accurate results and higher computational efficiency, and especially at low SNR, it is more close to the CRLB. | Zhiyu LU Bin BA Jianhui WANG Wenchao LI Daming WANG | 2018 | Chinese Journal of Aeronautics2018，31，1： | 11 |
| 4 | Nonlinear Mathematical Modeling and Sensitivity Analysis of Hydraulic Drive Unit显示文摘The previous sensitivity analysis researches are not accurate enough and also have the limited reference value, because those mathematical models are relatively simple and the change of the load and the initial displacement changes of the piston are ignored, even experiment verification is not conducted. Therefore, in view of deficiencies above, a nonlinear mathematical model is established in this paper, including dynamic characteristics of servo valve, nonlinear characteristics of pressure-flow, initial displacement of servo cylinder piston and friction nonlinearity. The transfer function block diagram is built for the hydraulic drive unit closed loop position control, as well as the state equations. Through deriving the time-varying coefficient items matrix and time-varying free items matrix of sensitivity equations respectively, the expression of sensitivity equations based on the nonlinear mathematical model are obtained. According to structure parameters of hydraulic drive unit, working parameters, fluid transmission characteristics and measured friction-velocity curves, the simulation analysis of hydraulic drive unit is completed on the MATLAB/Simulink simulation platform with the displacement step 2 mm, 5 mm and 10 mm, respectively. The simulation results indicate that the developed nonlinear mathematical model is sufficient by comparing the characteristic curves of experimental step response and simulation step response under different constant load. Then, the sensitivity function time-history curves of seventeen parameters are obtained, basing on each state vector time-history curve of step response characteristic. The maximum value of displacement variation percentage and the sum of displacement variation absolute values in the sampling time are both taken as sensitivity indexes. The sensitivity indexes values above are calculated and shown visually in histograms under different working conditions, and change rules are analyzed. Then the sensitivity indexes values of four measurable parameters, such as supply pressure, proportional gain, initial position of servo cylinder piston and load force, are verified experimentally on test platform of hydraulic drive unit, and the experimental research shows that the sensitivity analysis results obtained through simulation are approximate to the test results. This research indicates each parameter sensitivity characteristics of hydraulic drive unit, the performance-affected main parameters and secondary parameters are got under different working conditions, which will provide the theoretical foundation for the control compensation and structure optimization of hydraulic drive unit. | KONG Xiangdong YU Bin QUAN Lingxiao BA Kaixian WU Liujie | 2015 | Chinese Journal of Mechanical Engineering2015，28，5： | 10 |
| 5 | Force Control Compensation Method with Variable Load Stiffness and Damping of the Hydraulic Drive Unit Force Control System显示文摘Each joint of hydraulic drive quadruped robot is driven by the hydraulic drive unit(HDU), and the contacting between the robot foot end and the ground is complex and variable, which increases the difficulty of force control inevitably. In the recent years, although many scholars researched some control methods such as disturbance rejection control, parameter self-adaptive control, impedance control and so on, to improve the force control performance of HDU, the robustness of the force control still needs improving. Therefore, how to simulate the complex and variable load characteristics of the environment structure and how to ensure HDU having excellent force control performance with the complex and variable load characteristics are key issues to be solved in this paper. The force control system mathematic model of HDU is established by the mechanism modeling method, and the theoretical models of a novel force control compensation method and a load characteristics simulation method under different environment structures are derived, considering the dynamic characteristics of the load stiffness and the load damping under different environment structures. Then, simulation effects of the variable load stiffness and load damping under the step and sinusoidal load force are analyzed experimentally on the HDU force control performance test platform, which provides the foundation for the force control compensation experiment research. In addition, the optimized PID control parameters are designed to make the HDU have better force control performance with suitable load stiffness and load damping, under which the force control compensation method is introduced, and the robustness of the force control system with several constant load characteristics and the variable load characteristics respectively are comparatively analyzed by experiment. The research results indicate that if the load characteristics are known, the force control compensation method presented in this paper has positive compensation effects on the load characteristics variation, i.e., this method decreases the effects of the load characteristics variation on the force control performance and enhances the force control system robustness with the constant PID parameters, thereby, the online PID parameters tuning control method which is complex needs not be adopted. All the above research provides theoretical and experimental foundation for the force control method of the quadruped robot joints with high robustness. | KONG Xiangdong BA Kaixian YU Bin CAO Yuan ZHU Qixin ZHAO Hualong | 2016 | Chinese Journal of Mechanical Engineering2016，29，3： | 10 |
| 6 | Drilling Combined with Adipose-derived Stem Cells and Bone Morphogenetic Protein-2 to Treat Femoral Head Epiphyseal Necrosis in Juvenile Rabbits显示文摘 | Zi-li WANG Rong-zhen HE Bin TU Jin-shen HE Xu CAO Han-song XIA Hong-liang BA Song WU Cheng PENG Kun XIONG | 2018 | Current Medical Science2018，38，2： | 7 |
| 7 | Parameters Sensitivity Characteristics of Highly Integrated Valve-Controlled Cylinder Force Control System显示文摘Nowadays, a highly integrated valve?controlled cylinder(HIVC) is applied to drive the joints of legged robots. Although the adoption of HIVC has resulted in high?performance robot control, the hydraulic force system still has problems, such as strong nonlinearity, and time?varying parameters. This makes HIVC force control very diffcult and complex. How to improve the control performance of the HIVC force control system and find the influence rule of the system parameters on the control performance is very significant. Firstly, the mathematical model of HIVC force control system is established. Then the mathematical expression for parameter sensitivity matrix is obtained by applying matrix sensitivity analysis(PSM). Then, aimed at the sinusoidal response under(three factors and three levels) working conditions, the simulation and the experiment are conducted. While the error between the simulation and experiment can't be avoided. Therefore, combined with the range analysis, the error in the two performance indexes of sinusoidal response under the whole working condition is analyzed. Besides, the sensitivity variation pattern for each system parameter under the whole working condition is figured out. Then the two sensitivity indexes for the three system parameters, which are supply pressure, proportional gain and initial displacement of piston, are proved experimentally. The proposed method significantly reveals the sensitivity characteristics of HIVC force control system, which can make the contribution to improve the control performance. | Kai-Xian Ba Bin Yu Xiang-Dong Kong Chun-He Li Qi-Xin Zhu Hua-Long Zhao Ling-Jian Kong | 2018 | Chinese Journal of Mechanical Engineering2018，31，2： | 6 |
| 8 | Cytochrome P450 2E1 RsaI/PstI and DraI Polymorphisms Are Risk Factors for Lung Cancer in Mongolian and Han Population in Inner Mongolia显示文摘Objective: To explore the relationship between cytochrome P450 2E1 (CYP2E1) RsaI/PstI and DraI polymorphism and lung cancer susceptibility in Mongolian and Han population in Inner Mongolia of China. Methods: CYP2E1 RsaI/PstI and DraI polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism in 64 lung cancer patients, 150 healthy Mongolian and 150 healthy Han individuals. The distribution of genotype and allele frequencies of CYP2E1 RsaI/PstI and DraI polymorphisms were studied. Results: The risk of lung cancer was increased in individuals with CYP2E1 (cl/cl) and CYP2E1 (DD) with OR values of 2.431 (95%CI=1.082-5.460) and 2.778 (95%CI=1.358-5.683) respectively (P<0.05). When CYP2E1 RsaI/PstI and DraI polymorphisms were combined, the risk of lung cancer was reduced in individuals with CYP2E1 (cl/c2+c2/c2 and DD+CC) with OR values of 0.233 (95%CI=0.088-0.615, P<0.05). In smokers, the susceptibility to lung cancer was higher in the individuals with CYP2E1 (c1/c1) and CYP2E1 (DD) than in the individuals with c2 and C allele (P<0.05, OR=2.643 and 4.308 respectively). There was no significant difference in distribution of CYP2E1 genotype frequency between healthy Mongolian, Han population and lung cancer patients, healthy controls in Inner Mongolia. Conclusion: CYP2E1 (c1/c1) and CYP2E1 (DD) are predisposing factors of lung cancer in population in Inner Mongolia. CYP2E1 (c2﹢C) co-mutation may decrease the risk of lung cancer. Smoking exerts synergetic effect with CYP2E1 (c1/c1) and CYP2E1 (DD) on the occurrence of lung cancer. | Xiu-lan Su Ba Bin Hong-wei Cui Mei-rong Ran | 2011 | Chinese Journal of Cancer Research2011，23，2： | 3 |
| 9 | Microstructure design of C/C composites through electrochemical corrosion for brazing to Nb显示文摘Surface structure of C/C composites has been regulated through electrochemical corrosion at room temperature to modify the residual stress and improve the joining strength when brazed to Nb.The unique crevice corrosion in C/C composites is investigated to reveal the change of corrosion depth and fiber size.The interlacing zone of carbon fiber reinforced brazing alloy replaces the reaction layer in the original joint.Joining area is increased dramatically and the continuous crack will be hindered.The interlacing zone eliminates the stress concentration and relieves the residual stress through reducing the property mismatch.All advantages contribute to the joining quality of C/C–Nb.Shear strength of C/C–Nb joint with 80μm depth reached 37.7 MPa,which was 1.2 times higher than that of original joint.Surface structure design of C/C composites not only expands the application in structure component,but also exhibits the promising application in energy field. | Jin Ba Xu Ji Bin Wang Peixin Li Jinghuang Lin Jian Cao Junlei Qi | 2022 | Journal of Materials Science & Technology2022，，9： | 2 |
| 10 | A Unified Trajectory Optimization Approach for Long-Term and Reactive Motion Planning of Legged Locomotion显示文摘This paper proposes a unified trajectory optimization approach that simultaneously optimizes the trajectory of the center of mass and footholds for legged locomotion.Based on a generic point-mass model,the approach is formulated as a nonlinear optimization problem,incorporating constraints such as robot kinematics,dynamics,ground reaction forces,obstacles,and target location.The unified optimization approach can be applied to both long-term motion planning and the reactive online planning through the use of model predictive control,and it incorporates vector field guidance to converge to the long-term planned motion.The effectiveness of the approach is demonstrated through simulations and physical experiments,showing its ability to generate a variety of walking and jumping gaits,as well as transitions between them,and to perform reactive walking in obstructed environments. | Yapeng Shi Bin Yu Kaixian Ba Mantian Li | 2023 | Journal of Bionic Engineering2023，20，5： | 1 |
| 11 | Trajec- tory Sensitivity Analysis of First Order and Second Order on Position Control System of Highly Inte- grated Valve-controlled Cylinder显示文摘 | Kong Xiangdong Ba Kaixian Yu Bin | 2015 | Journal of Me- chanical Science and Technology2015，29，10： | 1 |
| 12 | B ultrasound-guided hyperthermic intraperitoneal perfusion chemotherapyfor the treatment of malignant ascites显示文摘 | Shuzhong Cui Mingchen Ba Yunqiang Tang Jifang Liu Yinbing Wu Bin Wang Xiangliang Zhang Hongsheng Tang Shizhen Zhong | 2012 | Oncology Reports2012，，4： | 1 |
| 13 | 2021-2022 monitoring,early warning,and forecasting of global infectious diseases显示文摘Background:COVID-19 has had a considerable impact on society since 2019,and the disease has high mortality and infection rates.There has been a particular focus on how to best manage COVID-19 and how to analyze and predict the epidemic status of infectious diseases in general.Methods The present study analyzed the COVID-19 epidemic patterns and made predictions of future trends based on the statistics obtained from a global infectious disease network data monitoring and early warning system(OBN,http://27.115.41.130:8888/OBN/).The development trends of other major infectious diseases were also examined.Results The global COVID-19 pandemic showed periodic increases throughout 2021.At present,there is a high incidence in European countries,especially in Eastern Europe,followed by in Africa.The risk of contracting COVID-19 was divided into high,medium–high,medium,medium–low,and low grades depending on the stage of the epidemic in each examined region over the current period.The occurrence and prevalence of major infectious diseases throughout the world did not significantly change in 2021.Conclusions The COVID-19 pandemic has strongly impacted people’s lives and the economy.The effects of global infectious diseases can be ameliorated by strengthening monitoring and early warning systems and by facilitating the international exchange of information. | Jie Luan Jianbo Ba Bin Liu Xiongli Xu Dong Shu | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 0 |
| 14 | Direction finding for two-dimensional incoherently distributed sources with Hadamard shift invariance in non-uniform orthogonal arrays显示文摘This paper proposes a novel algorithm for Two-Dimensional(2D) central Directionof-Arrival(DOA) estimation of incoherently distributed sources. In particular, an orthogonal array structure consisting of two Non-uniform Linear Arrays(NLAs) is considered. Based on first-order Taylor series approximation, the Generalized Array Manifold(GAM) model can first be established to separate the central DOAs from the original array manifold. Then, the Hadamard rotational invariance relationships inside the GAMs of two NLAs are identified. With the aid of such relationships, the central elevation and azimuth DOAs can be estimated through a search-free polynomial rooting method. Additionally, a simple parameter pairing of the estimated 2D angular parameters is also accomplished via the Hadamard rotational invariance relationship inside the GAM of the whole array. A secondary but important result is a derivation of closed-form expressions of the Cramer-Rao lower bound. The simulation results show that the proposed algorithm can achieve a remarkably higher precision at less complexity increment compared with the existing low-complexity methods, which benefits from the larger array aperture of the NLAs. Moreover, it requires no priori information about the angular distributed function. | Zhengliang DAI Weijia CUI Daming WANG Bin BA Chao WANG Yankui ZHANG | 2018 | Chinese Journal of Aeronautics2018，31，12： | 0 |
| 15 | FOXG1 Directly Suppresses Wnt5a During the Development of the Hippocampus显示文摘The Wnt signaling pathway plays key roles in various developmental processes.Wnt5a,which activates the non-canonical pathway,has been shown to be particularly important for axon guidance and outgrowth as well as dendrite morphogenesis.However,the mechanism underlying the regulation of Wnt5a remains unclear.Here,through conditional disruption of Foxg1 in hippocampal progenitors and postmitotic neurons achieved by crossing Foxg1~(fl/fl)with Emx1-Cre and Nex-Cre,respectively,we found that Wnt5a rather than Wnt3a/Wnt2b was markedly upregulated.Overexpression of Foxg1 had the opposite effects along with decreased dendritic complexity and reduced mossy fibers in the hippocampus.We further demonstrated that FOXG1 directly repressed Wnt5a by binding to its promoter and one enhancer site.These results expand our knowledge of the interaction between Foxg1 and Wnt signaling and help elucidate the mechanisms underlying hippocampal development. | Yang Ni Bin Liu Xiaojing Wu Junhua Liu Ru Ba Chunjie Zhao | 2021 | Neuroscience Bulletin2021，37，3： | 0 |
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