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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats显示文摘AIM To explore the exact interaction between Notch and transforming growth factor(TGF)-β signaling in liver fibrosis. METHODS We established a rat model of liver fibrosis induced by concanavalin A. Peripheral blood mononuclear cells(PBMCs) were isolated from the modeled rats, and cultured with γ-secretase inhibitor DAPT and TGF-β inhibitor for 24 h. The m RNA levels of Notch and TGF-β signaling were detected by quantitative real-time polymerase chain reaction. Expression of Notch and TGF-β proteins was analyzed by western blotting.RESULTS Compared to control rats, Notch and TGF-β signaling was activated in PBMCs of model rats. Administration of DAPT and TGF-β inhibitor suppressed Notch and TGF-β signal transducer in PBMCs of model rats. DAPT reduced m RNA and protein expression of TGF-β signaling, such as TGF-β1 and Smad3. TGF-β inhibitor also downregulated Notch1, Hes1 and Hes5, and m RNA and protein expression of the Notch signaling pathway.CONCLUSION Notch and TGF-β signaling play a role in liver fibrosis. TGF-β signaling upregulates Notch signaling, which promotes TGF-β signaling. | Yi Wang Ruo-Wu Shen Bing Han Zhen Li Le Xiong Feng-Yu Zhang Bei-Bei Cong Bei Zhang | 2017 | World Journal of Gastroenterology2017，23，13： | 25 |
| 3 | Nedaplatin concurrent with three-dimensional conformal radiotherapy for treatment of locally advanced esophageal carcinoma显示文摘AIM:To evaluate the efficacy and toxicity of nedaplatin(NDP)concurrent with radiotherapy in the treatment of locally advanced esophageal carcinoma.METHODS:Sixty-eight patients with locally advanced esophageal carcinoma were randomized into either a NDP group(n=34)or a cisplatin(DDP)group(n=34).The NDP group received NDP 80-100 mg/m2iv on day 1+leucovorin(CF)100 mg/m2iv on days 1-5+5-fluorouracil(5-FU)500 mg/m2iv on days 1-5.The DDP group received DDP 30 mg/m2iv on days 1-3+CF 100 mg/m2on days 1-5+5-FU 500 mg/m2iv on days 1-5.The treatment was repeated every 4 wk in both groups.Concurrent radiotherapy[60-66 Gy/(30-33f)/(6-7 wk)]was given during chemotherapy.RESULTS:There was no significant difference in the short-term response rate between the NDP group and DDP group(90.9%vs 81.3%,P=0.528).Although the 1-and 2-year survival rates were higher in the NDP group than in the DDP group(75.8%vs 68.8%,57.6%vs 50.0%),the difference in the overall survival rate was not statistically significant between the two groups(P=0.540).The incidences of nausea,vomiting and nephrotoxicity were significantly lower in the NDP group than in the DDP group(17.6%vs 50.0%,P=0.031;11.8%vs 47.1%,P=0.016;8.8%vs 38.2%,P=0.039).There was no significant difference in the incidence of myelosuppression,radiation-induced esophagitis or radiation-induced pneumonia between the two groups.CONCLUSION:NDP-based concurrent chemoradiotherapy is effective and well-tolerated in patients with locally advanced esophageal carcinoma.NDP-based regimen has comparable efficacy to DDP-based regimen but is associated with lower incidences of gastrointestinal and renal toxicity. | Ze-Tian Shen Xin-Hu Wu Bing Li Jun-Shu Shen Zhen Wang Jing Li Xi-Xu Zhu | 2013 | World Journal of Gastroenterology2013，19，48： | 23 |
| 4 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 5 | A Pricing Model for Big Personal Data显示文摘Big Personal Data is growing explosively. Consequently, an increasing number of internet users are drowning in a sea of data. Big Personal Data has enormous commercial value; it is a new kind of data asset. An urgent problem has thus arisen in the data market: How to price Big Personal Data fairly and reasonably. This paper proposes a pricing model for Big Personal Data based on tuple granularity, with the help of comparative analysis of existing data pricing models and strategies. This model is put forward to implement positive rating and reverse pricing for Big Personal Data by investigating data attributes that affect data value, and analyzing how the value of data tuples varies with information entropy, weight value, data reference index, cost, and other factors. The model can be adjusted dynamically according to these parameters. With increases in data scale, reductions in its cost,and improvements in its quality, Big Personal Data users can thereby obtain greater benefits. | Yuncheng Shen Bing Guo Yan Shen Xuliang Duan Xiangqian Dong Hong Zhang | 2016 | Tsinghua Science and Technology2016，21，5： | 19 |
| 6 | MicroRNA-21 in the pathogenesis of acute kidney injury显示文摘Acute kidney injury(AKI),associated with significant mor-bidity and mortality,is widely known to involve epithelial apoptosis,excessive inflammation,and fibrosis in re-sponse to ischemia or reperfusion injury,which results in either chronic pathological changes or death.Therefore,it is imperative that investigations are conducted in order to fi nd effective,early diagnoses,and therapeutic targets needed to help prevent and treat AKI.However,the mech-anisms modulating the pathogenesis of AKI still remain largely undetermined.MicroRNAs(miRNAs),small non-coding RNA molecules,play an important role in several fundamental biological and pathological processes by a post transcriptional regulatory function of gene expres-sion.MicroRNA-21(miR-21)is a recently identifi ed,typi-cal miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fi brotic signaling pathways in AKI.As a result,miR-21 is now considered a novel biomarker when diagnosing and treat-ing AKI.This article reviews the correlative literature and research progress regarding the roles of miR-21 in AKI. | Ya-Feng Li Ying Jing Jielu Hao Nathan C Frankfort Xiaoshuang Zhou Bing Shen Xinyan Liu Lihua Wang Rongshan Li | 2013 | Protein & Cell2013，4，11： | 18 |
| 7 | Review grain yield and nitrogen use efficiency in rice production regions in China显示文摘As one of the staple food crops, rice(Oryza sativa L.) is widely cultivated across China, which plays a critical role in guaranteeing national food security. Most previous studies on grain yield or/and nitrogen use efficiency(NUE) of rice in China often involved site-specific field experiments, or small regions with insufficient data, which limited the representation for the current rice production regions. In this study, a database covering a wide range of climate conditions, soil types and field managements across China, was developed to estimate rice grain yield and NUE in various rice production regions in China and to evaluate the relationships between N rates and grain yield, NUE. According to the database for rice, the values of grain yield, plant N accumulation, N harvest index(HIN), indigenous N supply(INS), internal N efficiency(IE_N), reciprocal internal N efficiency(RIE_N), agronomic N use efficiency(AE_N), partial N factor productivity(PEPN), physiological N efficiency(PE_N), and recover efficiency of applied N(RE_N) averaged 7.69 t ha^(–1), 152 kg ha^(–1), 0.64 kg kg^(–1), 94.1 kg kg^(–1), 53.9 kg kg^(–1), 1.98 kg kg^(–1), 12.6 kg kg^(–1), 48.6 kg kg^(–1), 33.8 kg kg^(–1), and 39.3%, respectively. However, the corresponding values all varied tremendously with large variation. Rice planting regions and N rates had significant influence on grain yield, N uptake and NUE values. Considering all observations, N rates of 200 to 250 kg ha^(–1) commonly achieved higher rice grain yield compared to less than 200 kg N ha^(–1) and more than 250 kg N ha^(–1) at most rice planting regions. At N rates of 200 to 250 kg ha^(–1), significant positive linear relationships were observed between rice grain yield and AE_N, PE_N, RE_N, IE_N, and PFPN, and 46.49, 24.64, 7.94, 17.84, and 88.24% of the variation in AE_N, PE_N, RE_N, IE_N, and PFPN could be explained by grain yield, respectively. In conclusion, in a reasonable range of N application, an increase in grain yield can be achieved accompanying by an acceptable NUE. | CHE Sheng-guo ZHAO Bing-qiang LI Yan-ting YUAN Liang LI Wei LIN Zhi-an HU Shu-wen SHEN Bing | 2015 | Journal of Integrative Agriculture2015，14，12： | 12 |
| 8 | Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM] and GSTT1显示文摘AIM In order to study the association betweenthe null genotypes of GSTM1 and GSTT1 and thegenetic susceptibility to hepatocellularcarcinoma(HCC).METHODS The genotypes of GSTM1 and GSTT1of 63 cases of HCC and 88 controls were detectedwith the multiple PCR technique.RESULTS The frequency of GSTM1 nullgenotype was 57.1% among the cases,and42.0% among the controls,the difference beingstatistically significant(χ~2=3.35,P=0.067),but χ~2 value approaching the significance level.The odds ratio was 1.84(95% Cl= 0.91-3.37).The frequency of GSTT1 non-null genotype was87.3% among the cases and 52.5% among thecontrols,the difference being statisticallysignificant(χ~2=11.42,P=0.0007274).The oddsratio was 4.13(95% Cl=1.64-10.70).According to the cross analysis,the GSTT1 non-null genotype was more closely associated withHCC than GSTM1 null genotype,and these twofactors play an approximate additive interactionin the occurrence of HCC.CONCLUSION The persons with GSTM1 nullgenotype and GSTT1 non-null genotype have theincreased risk to HCC. | Jian Chao Bian Fu Min Shen Li Shen Tian Ru Wang Xiao Hong Wang Gong Chao Chen Jin Bing Wang Department of Epidemiology,Shanghai Medical University,Shanghai 200032,China Haimen Municipal Anti-Epidemic and Health Station,Haimen 226201,Jiangsu Province,China Qidong Institute for Liver Cancer,Qidong 226200,Jiangsu Province,China | 2000 | World Journal of Gastroenterology2000，6，2： | 12 |
| 9 | Effect of non-point source pollution on water quality of the Weihe River显示文摘非点来源污染是影响 Weihe 河的水质量的一个重要因素。为了在非洪水期间在 Weihe 河,五个洪水事件和三个正常分泌物事件的水质量上学习污染的效果,时期在 2006 从 7 月被监视到 12 月,在 Lin-tong 节。以便识别沉积怎么影响了河的水质量,未加工并且从监视事件拿的上层清液样品被分析。上层清液样品以后在实验室在未加工的样品的水表面下面从 5 厘米被吸未加工的样品被重组并且在烧杯为 30 放分钟。结果显示了那 1 ) 在从洪水事件的未加工的样品的 SS,货到付款, TP 和 TN 的集中比从正常分泌物事件的那些高。在未加工的样品的 COD, TP 和 TN 的更高的价值从自然的腐殖的事导致了表面土壤。2 ) 分析的水质量索引的负担运输率逐渐地增加了到它的最大值然后落下在下面,在分泌物自记水位计匹配那。在未加工的样品的 SS, NH3-N, NO2-N, NO3-N,货到付款,和 TP 的集中开始增加了然后减少,当在未加工的样品的溶解 orthophosphate 和 TN 的集中逐渐地减少了然后增加时。集中的黄金时间和在未加工的样品的 SS 以及货到付款, TP 和 TN 的负担运输率接近了或落后于山峰流动的时间。通常,集中的黄金时间和负担运输溶解 orthophosphate 评价,溶解全部磷酸盐, NH3-N, NO2-N,和 NO3-N 发生在山峰流动的时间以前。3 ) 吝啬的集中方法被用来在 Lin-tong 节计算 NPS 污染负担,并且结果是可信的。在 2006,到为货到付款, TP, TN 和无机的氮的全部的负担的 NPS 污染负担的比例是超过 30% 。 | LI Jiake LI Huaien SHEN Bing LI Yajiao | 2011 | International Journal of Sediment Research2011，26，1： | 11 |
| 10 | Surgical operation and re-operation for hepatocellular carcinoma with bile duct thrombosis显示文摘很少报告评估了的背景为在为有这研究的 .The 目的是调查起始的外科的功效的胆汁管血栓( BDT )的 hepatocellular 癌( HCC )的起始的外科以后的恶化的重新操作和为有 BDT 的 HCC 的随后的重新操作的功效,并且他们 prognosis.Methods 上的效果包括在我们的医院里经历了在 1998 和 2008 之间的激进的 hepatectomy 的有 BDT 的 28 个病人,有 HCC 的 880 个病人的临床的数据是 BDT 的 reviewed.The | WANG Ya-dong XUE Huan-zhou JIANG Qing-feng SHEN Quan WANG Lian-cai ZHANG Xiao LU Bing YU Miao LI Ke | 2010 | Chinese Medical Journal2010，，16： | 11 |
| 11 | Inhibition of pancreatic carcinoma cell growth in vitro by DPC4 gene transfection显示文摘AIM: To detect the expression of DPC4 in malignant and non-malignant specimens of human pancreas,and observe the inhibition of retroviral pLXSN containing DPC4 on pancreatic carcinoma cells in vitro.METHODS: The expression of DPC4 was determined in 40 pancreatic adenocarcinoma and 36 non-malignant pancreatic specimens by reverse-transcriptase polymerase chain reaction (RT-PCR) and immunohisto-chemistry.Furthermore,we constructed retroviral vectors containing DPC4,which then infected the pancreatic carcinoma cell line BxPC-3.Cell growth in vitro after being infected was observed,and the vascular endothelial growth factor (VEGF) mRNA level in the daughter cells was determined by semi-quantitative PCR assay.RESULTS: The RT-PCR assay showed a positive rate of DPC4 mRNA in 100% (36/36) of normal specimens,compared to 40% (16/40) in adenocarcinoma specimens.The regional and intense positive cases of DPC4 expression in adenocarcinoma detected by immunohistochemistry were 10 and four,whereas it was all positive expression in normal tissues.There was a significant difference of DPC4 expression between them.The stable expression of DPC4 in the pancreatic carcinoma cells BxPC-3 could be resumed by retroviral vector pLXSN transfection,and could inhibit cell growth in vitro.Rather,DPC4 could decrease VEGF mRNA transcription levels.CONCLUSION: The deletion of DPC4 expression in pancreatic carcinoma suggests that loss of DPC4 may be involved in the development of pancreatic carcinoma.The retroviral vector pLXSN containing DPC4 can inhibit the proliferation of pancreatic carcinoma cells,and down-regulate the level of VEGF. | Wei Shen Guo-Qing Tao Bing Cai De-Chun Li Xing-Guo Zhu Xia Bai | 2008 | World Journal of Gastroenterology2008，14，40： | 11 |
| 12 | Effect of coating modification of cordierite carrier on catalytic performance of supported NiMnO_3 catalysts for VOCs combustion显示文摘NiMnO_3 perovskite catalysts supported on cordierite modified by Ce_xZr_(1-x)O_2 coatings were prepared using impregnation and sol-gel methods for catalytic combustion of single/double component VOCs at different concentrations and GHSV of 15,000 h^(-1), which were characterized by BET, XRD, SEM, FT-IR, H_2-TPR and O_2-TPD. After coating modification, the specific surface area of catalysts is improved obviously.Among the catalysts, the Ce_(0.75)Zr_(0.25)O_2 coating modified NiMnO_3 catalyst exhibits the best catalytic activity for VOCs combustion with 95.6% conversion at 275 ℃ and has stable activity when catalyst is embalmed at 800 ℃. In addition, the catalyst also presents the excellent water-resistant and conversion stability over time-on-stream condition. The reason is that Ce_(0.75)Zr_(0.25)O_2 coating can promote more lattice distortion and defects and smaller crystal size, which improve oxygen transfer capability and dispersion of active component. | Lei Deng Chao Huang Jiawei Kan Bing Li Yingwen Chen Shemin Zhu Shubao Shen | 2018 | Journal of Rare Earths2018，36，3： | 10 |
| 13 | Tumorigenesis and spontaneous metastasis by luciferase-labeled human xenograft osteosarcoma cells in nude mice显示文摘 | DU Lin XU Wen-ting FAN Qi-ming TU Bing SHEN Yang YAN Wei TANG Ting-ting WANG You | 2012 | Chinese Medical Journal2012，，22： | 9 |
| 14 | First proof-of-principle experiment with the post-accelerated isotope separator on-line beam at BRIF:measurement of the angular distribution of ^(23)Na+^(40)Ca elastic scattering显示文摘The reaction dynamics of exotic nuclei near the drip line is one of the main research topics of current interest.Elastic scattering is a useful probe for investigating the size and surface diffuseness of exotic nuclei.The development of rare isotope accelerators offers opportunities for such studies.To date,many relevant measurements have been performed at accelerators using the projectile fragmentation technique,while the measurements at accelerators using isotope separator on-line(ISOL)systems are still quite scarce.In this work,we present the first proof-of-principle experiment with a post-accelerated ISOL beam at the Beijing Radioactive Ion Beam Facility(BRIF)by measuring the angular distribution of elastic scattering for the stable nucleus^(23)Na from the doubly magic nucleus^(40)Ca at energies above the Coulomb barrier.The angular distribution measured by a silicon strip detector array in a scattering chamber using the ISOL beam at BRIF is in good agreement with that measured by the high-precision Q3 D magnetic spectrograph using the nonISOL beam at nearly the same energy.This work provides useful background for making BRIF a powerful tool for the investigation of the reaction dynamics of exotic nuclei. | Wei Nan Bing Guo Cheng-Jian Lin Lei Yang Dong-Xi Wang Yang-Ping Shen Bing Tang Bao-Qun Cui Tao Ge Yin-Long Lyu Hui-Ming Jia Yun-Ju Li Chen Chen Li-Hua Chen Qi-Wen Fan Xin-Yue Li Gang Lian Jian-Cheng Liu Tian-Peng Luo Nan-Ru Ma Rui-Gang Ma Xie Ma Ying-Jun Ma Wei-Ke Nan Dan-Yang Pang You-Bao Wang Pei-Wei Wen Feng Yang Yong-Jin Yao Sheng Zeng Hao Zhang Fu-Peng Zhong Shan-Hao Zhong Zhi-Hong Li Tian-Jue Zhang Wei-Ping Liu BRIF Collaboration | 2021 | Nuclear Science and Techniques2021，32，5： | 9 |
| 15 | Induction of the apoptosis of cancer cell by sonodynamic therapy:a review显示文摘Ultrasound can be used not only in examination,but also in therapy,especially in the therapy of cancer.Sonodynamic therapy is an experimental cancer therapy method which uses ultrasound to enhance the cytotoxic effects of agents known as sonosensitizers.It has been tested in vitro and in vivo.The ultrasound could penetrate the tissue and cell under some of conditions which directly changes cell membrane permeability,thereby allowing the delivery of exogenous molecules into the cells in some degree.Ultrasound could inhibit the proliferation or induce the apoptosis of cancer cells in vitro or in vivo.Recent researches indicated low-frequency and low-intensity ultrasound could induce cell apoptosis,which could be strengthened by sonodynamic sensitivity,microbubbles,chemotherapeutic drugs and so on.Most kinds of ultrasound suppressed the proliferation of cancer cells through inducing the apoptosis of cancer cells.The mechanism of apoptosis is not clear.In this review,we will focus on and discuss the mechanisms of the induction of cancer cell apoptosis by ultrasound. | Wen-Kun Bai E Shen Bing Hu | 2012 | Chinese Journal of Cancer Research2012，24，4： | 9 |
| 16 | New Re-Os Isotopic Constrains on the Formation of the Metalliferous Deposits of the Lower Cambrian Niutitang Formation显示文摘The Terreneuvian Epoch(541–521 Ma)is also an important period for metallogenesis in South China, as was represented by the widespread occurrences of Ni-Mo polymetallic layers on the antecedent shallow platform margin and the V-enriched black shales in deeper slope-basin settings. In this study, we have measured Re-Os isochron ages of Ni-Mo polymetallic layers(Songlin, Niuchang, Sancha, Chuanpengwan), V-rich black shales(Bahuang), and non-metalliferous black shales(Shuidong) in the basal Niutitang Formation in Guizhou and Hunan province, South China. The Ni-Mo polymetallic layers and V-enriched black shales have similar Re-Os isochron ages, suggesting concurrent deposition of these two types of metalliferous ores. This suggestion is consistent with the traditional stratigraphic correlation by using the nodular phosphorite bed directly underlying these metalliferous layers as a stratigraphic marker. Furthermore, the metalliferous ores and non-metalliferous black shales have similar initial ^(187)Os/^(188) Os ratios of 0.8–0.9, arguing for a dominant seawater origin with minor contribution of hydrothermal activity. Furthermore, Re-Os isotopic data also imply that Ni-Mo and V ore might have derived from the same source. We suggest that the spatial distribution of metalliferous ores can be explained by the development of non-sulfidic anoxic-suboxic wedge(NSASW) in the slope-basin and sulfidic wedge in the previous platform margin. Upwelling of deep water first transects the mildly reduced, organic rich NSASW, in which V(V) is reduced to V(IV), and is preferentially removed from seawater by organometallic complex formation. As a result, V-rich black shale deposits in the slope-basin of Yangtze Platform. Further movement of deep water into the sulfidic platform margin results in Ni-Mo polymetallic layer formation. | Yong Fu Lin Dong Chao Li Wenjun Qu Haoxiang Pei Wenlang Qiao Bing Shen | 2016 | Journal of Earth Science2016，27，2： | 9 |
| 17 | Research and Development of Electro‑hydraulic Control Valves Oriented to Industry 4.0:A Review显示文摘Electro-hydraulic control valves are key hydraulic components for industrial applications and aerospace,which controls electro-hydraulic motion.With the development of automation,digital technology,and communication technology,electro-hydraulic control valves are becoming more digital,integrated,and intelligent in order to meet the requirements of Industry 4.0.This paper reviews the state of the art development for electro-hydraulic control valves and their related technologies.This review paper considers three aspects of state acquisition through sensors or indirect acquisition technologies,control strategies along with digital controllers and novel valves,and online maintenance through data interaction and fault diagnosis.The main features and development trends of electro-hydraulic control valves oriented to Industry 4.0 are discussed. | Bing Xu Jun Shen Shihao Liu Qi Su Junhui Zhang | 2020 | Chinese Journal of Mechanical Engineering2020，33，2： | 9 |
| 18 | Analysis of reference gene expression for real-time PCR based on relative quantitation and dual spike-in strategy in the silkworm Bombyx mori显示文摘为即时量的聚合酶链反应(qPCR ) ,一般来说,正规化策略把引用基因用作控制并且不应该响应改变条件变化避免这基因的试验性的错误表示的介绍。然而,许多参考基因的表示被报导了更加变化,没有适当正规化,目标基因的表示侧面能被曲解。在这研究,七的表达式层次通常使用了引用基因(行为, GAPDH, 28srRNA, RPL3, -tubulin, UBC,和 TBP ) 与 20-hydroxyecdysone (20E ) 并且与卢丁在不同开发时间点并且响应处理被检测。表示稳定性用 geNorm 和 NormFinder 软件被分析。重要变化在正常纸巾之中并且在试验性地对待的纸巾之间被发现。双刺在里面策略也在正常纸巾之中并且在试验性地对待的纸巾之间揭示了参考基因的表示层次的重要变化。Glutathione-S-transferase 西格马 1 (GSTs1 ) ,它在胖身体有高表达式水平并且与抵抗的机制有关,被用作目标基因验证这二条途径的可行性和差别。 | Ran Peng Yuanfen Zhai Hua Ding Tianyuan Di Ting Zhang Bing Li Weide Shen Zhengguo Wei | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 8 |
| 19 | Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution显示文摘The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits,which is of fundamental importance for neuroscience research.Here,we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R)for high-throughput,high-quality brain mapping.Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion,the VISo R system effectively eliminates motion blur to obtain undistorted images.By continuously imaging moving samples without stopping,the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours,at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation,imaging,3D image reconstruction and quantification.Our approach is compatible with immunofluorescence methods,enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains.Using this system,we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming conditions.Our results indicate the involvement of multiple subcortical areas in stress response.Intriguingly,neuronal activation in these areas exhibits striking individual variability among different animals,suggesting the necessity of sufficient cohort size for such studies. | Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-Ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-Ning Zhou Fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi | 2019 | National Science Review2019，6，5： | 7 |
| 20 | Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation显示文摘Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired'stress-response'method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells. | Wentao Song Yiming Wang Bing Wang Yingfang Yao Wenguang Wang Jinhui Wu Qing Shen Wenjun Luo Zhigang Zou | 2020 | Nano Research2020，13，3： | 7 |
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