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| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | Facile synthesis of ultrathin metal-organic framework nanosheets for Lewis acid catalysis显示文摘Ultrathin metalorganic framework (MOF) nanosheets are attracting great interest in catalysis due to their unique and intriguing two-dime nsional (2D) features. Although many progresses have been achieved, it is still highly desirable to develop novel strategies for controllable synthesis of the well-defined ultrathin MOF nanosheets. Herein we report a polyvinylpyrrolidone (PVP)-assisted route to synthesize the ultrathin Ni-MOF nanosheets characteristic of 1.5 nm in thickness, in which PVP is reacted with 2-aminoterephthalic acid (H2BDC-NH2) via formation of C=N bon d, followed by coord inatio n with Ni2+ io ns to form the ultrathi n MOF n anosheets. Impressively, when used in the Kno eve nagel condensation reactions of propane dinitrile with different aldehydes, ultrathin Ni-MOF nanosheets display the significantly enhanced catalytic activity and good stability in respect with the bulk Ni-MOF, mainly owing to the exposed active sites as well as facile mass transfer and diffusion of substrates and products. | Xiaofei Zhang Lin Chang Zhongjie Yang Yanan Shi Chang Long Jianyu Han Binhao Zhang Xueying Qiu Guodong Li Zhiyong Tang | 2019 | Nano Research2019，12，2： | 11 |
| 3 | Low-overpotential selective reduction of CO2 to ethanol on electrodeposited CuxAuy nanowire arrays显示文摘Direct electrochemical reduction of CO2 to multicarbon products is highly desirable, yet challenging. Here, we present a potentiostatic pulse-electrodeposition of high-aspect-ratio CuxAuy nanowire arrays (NWAs) as high-performance electrocatalysts for the CO2 reduction reaction (CO2RR). The surface electronic structure related to the Cu:Au ratio in the CuxAuy NWAs could be facilely modulated by controlling the electrodeposition potential and the as-fabricated CuxAuy NWAs could be directly used as the catalytic electrode for the CO2RR. The morphology of the high-aspect-ratio nanowire array significantly lowers the onset potential of the alcohol formation due to the diffusion-induced enhancement of the local pH and CO concentration near the nanowire surface. Besides, the properly adjusted surface electronic structure of the CuxAuy NWA enables the adsorption of CO and facilitates the subsequent CO reduction to ethanol via the C-C coupling pathway. Owing to the synergistic effect of morphology and electronic structure, the optimized CuxAuy NWA selectively reduces CO2 to ethanol at low potentials of -0.5——0.7 V vs. RHE with a highest Faradaic efficiency of 48%. This work demonstrates the feasibility to optimize the activity and selectivity of the Cu-based electrocatalysts toward multicarbon alcohols for the CO2RR via simultaneous adjustment of the electronic structure and morphology of the catalysts. | Weiwei Zhu Kuangmin Zhao Suqin Liu Min Liu Feng Peng Pengda An Binhao Qin Huimin Zhou Hongmei Li Zhen He | 2019 | Journal of Energy Chemistry2019，28，10： | 4 |
| 4 | Surgical treatment of hepato-pancreato-biliary disease in China:the Tongji experience显示文摘Hepato-pancreato-biliary(HPB) tumors are common in China. However, these tumors are often diagnosed at intermediate/advanced stages because of the lack of a systemic surveillance program in China. This situation creates many technical challenges for surgeons and increases the incidence of postoperative complications. Therefore, Dr. Xiao-Ping Chen has made many important technical improvements, such as Chen's hepatic portal occlusion method, the anterior approach for liver resection of large HCC tumors, the modified technique of Belghiti's liver-hanging maneuver, inserting biliary-enteric anastomosis technique, and invaginated pancreaticojujunostomy with transpancreatic U-sutures. These techniques are simple, practical, and easy to learn. Owing to these advantages, complicated surgical procedures can be simplified, and the curative effects are greatly improved. These improved techniques have been widely applied in China and will benefit many additional patients. In this review, we introduce our experience of surgically treating intermediate/advanced hepatocellular carcinoma(HCC), hilar cholangiocarcinoma(HC), and pancreatic carcinoma, mainly focusing on technical innovations established by Dr. Chen in HPB surgery. | binhao zhang wei dong hongping luo xuanru zhu lin chen changhai li wei zhang shuai xiang wanguang zhang zhiyong huang xiao-ping chen | 2016 | Science China(Life Sciences)2016，59，10： | 2 |
| 5 | 64 Gb/s low-voltage waveguide SiGe avalanche photodiodes with distributed Bragg reflectors显示文摘We demonstrate low-voltage waveguide silicon-germanium avalanche photodiodes(APDs)integrated with distributed Bragg reflectors(DBRs).The internal quantum efficiency is improved from 60%to 90%at 1550 nm assisted with DBRs while still achieving a 25 GHz bandwidth.A low breakdown voltage of 10 V and a gain bandwidth product of near 500 GHz are obtained.APDs with DBRs at a data rate of 64 Gb/s pulse amplitude modulation with four levels(PAM4)show a 30%–40%increase in optical modulation amplitude(OMA)compared to APDs with no DBR.A sensitivity of around-13 d Bm at a data rate of 64 Gb/s PAM4 and a bit error rate of 2.4×10^-4 is realized for APDs with DBRs,which improves the sensitivity by^2 d B compared to APDs with no DBR. | Binhao Wang Zhihong Huang Yuan Yuan Di Liang Xiaoge Zeng Marco Fiorentino Raymond G.Beausoleil | 2020 | Photonics Research2020，8，7： | 2 |
| 6 | Naturally teaching a humanoid Tri-Co robot in a real-time scenario using first person view显示文摘Dear editor,As a direct method of endowing robots with human knowledge, teaching renders the development of robot intelligence to an extraordinary extent.However, as we inevitably encounter complicated motions with multiple degrees of freedom (DOFs),traditional teaching methods continue to face a number of challenges. | Liang GONG Xudong LI Wenbin XU Binhao CHEN Zelin ZHAO Yixiang HUANG Chengliang LIU | 2019 | Science China(Information Sciences)2019，62，5： | 1 |
| 7 | Metagenomic insights into the effects of submerged plants on functional potential of microbial communities in wetland sediments显示文摘Submerged plants in wetlands play important roles as ecosystem engineers to improve self-purification and promote elemental cycling.However,their effects on the functional capacity of microbial communities in wetland sediments remain poorly understood.Here,we provide detailed metagenomic insights into the biogeochemical potential of microbial communities in wetland sediments with and without submerged plants(i.e.,Vallisneria natans).A large number of functional genes involved in carbon(C),nitrogen(N)and sulfur(S)cycling were detected in the wetland sediments.However,most functional genes showed higher abundance in sediments with submerged plants than in those without plants.Based on the comparison of annotated functional genes in the N and S cycling databases(i.e.,NCycDB and SCycDB),we found that genes involved in nitrogen fixation(e.g.,nifD/H/K/W),assimilatory nitrate reduction(e.g.,nasA and nirA),denitrification(e.g.,nirK/S and nosZ),assimilatory sulfate reduction(e.g.,cysD/H/J/N/Q and sir),and sulfur oxidation(e.g.,glpE,soeA,sqr and sseA)were significantly higher(correctedp<0.05)in vegetated vs.unvegetated sediments.This could be mainly driven by environmental factors including total phosphorus,total nitrogen,and C:N ratio.The binning of metagenomes further revealed that some archaeal taxa could have the potential of methane metabolism including hydrogenotrophic,acetoclastic,and methylotrophic methanogenesis,which are crucial to the wetland methane budget and carbon cycling.This study opens a new avenue for linking submerged plants with microbial functions,and has further implications for understanding global carbon,nitrogen and sulfur cycling in wetland ecosystems. | Binhao Wang Xiafei Zheng Hangjun Zhang Xiaoli Yu Yingli Lian Xueqin Yang Huang Yu Ruiwen Hu Zhili He Fanshu Xiao Qingyun Yan | 2021 | Marine Life Science & Technology2021，3，4： | 1 |
| 8 | Numerical simulation of the gas-solid flow in a fluidized bed by combining discrete particle method with computational fluid dynamics 显示文摘 | Xu Binhao Yu Aibing | 1997 | Chemical Engineering Science1997，52，16： | 1 |
| 9 | Numerical simulation of the gas-solid flow in a bed with lateral gas blasting 显示文摘 | Xu Binhao Yu Aibing Chew S J | 2000 | Powder Technology2000，109，123： | 1 |
| 10 | Indispensable but Insufficient Role of Renal D‐Amino Acid Oxidase in Chiral Inversion of N<sup>G</sup>‐Nitro‐D‐arginine显示文摘 | Yan‐FeiXin XinLi BinHao NianGong Wen‐QiangSun RyuichiKonno Yong‐XiangWang | 2010 | Chemistry & Biodiversity2010，，6： | 1 |
| 11 | Organ function support in patients with coronavirus disease 2019:Tongji experience显示文摘Coronavirus disease 2019(COVID-19)is a highly contagious disease and a serious threat to human health.COVID-19 can cause multiple organ dysfunction,such as respiratory and circulatory failure,liver and kidney injury,disseminated intravascular coagulation,and thromboembolism,and even death.The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%.Currently,the number of severe cases worldwide has increased rapidly,but the experience in the treatment of infected patients is still limited.Given the lack of specific antiviral drugs,multi-organ function support treatment is important for patients with COVID-19.To improve the cure rate and reduce the mortality of patients with severe-and critical-type COVID-19,this paper summarizes the experience of organ function support in patients with severe-and criticaltype COVID-19 in Optical Valley Branch of Tongji Hospital,Wuhan,China.This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems,including respiratory,circulatory,renal,hepatic,and hematological systems,among patients with severe-and critical-type COVID-19.This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide. | Yong Li Fan He Ning Zhou Jia Wei Zeyang Ding Luyun Wang Peng Chen Shuiming Guo Binhao Zhang Xiaoning Wan Wei Zhu 无 Xiaoping Chen Xiaomei Guo Rui Li Shengqing Li Daowen Wang Hui Wang Gang Xu Zhenyu Yin Wenkui Yu Bixiang Zhang Jianping Zhao Jianfeng Zhou | 2020 | Frontiers of Medicine2020，14，2： | 1 |
| 12 | Combined treatment is the hope to improve prognosis of liver cancer显示文摘Liver cancer is the fifth most common malignancy and the second leading cause of cancer-related mortality worldwide.Surgical resection is widely accepted as the only potentially curative therapy for hepatocellular carcinoma(HCC),the most predominant type of primary liver cancer worldwide.Despite this,the prognosis and 5-year disease-free survival rate of HCC remain poor. | Xiaoping Chen Binhao Zhang | 2015 | Oncology and Translational Medicine2015，1，6： | 1 |
| 13 | Graphene incorporated nanocrystalline TiO 2 films for the photocathodic protection of 304 stainless steel显示文摘 | Xingqin Guo Wei Liu Lixin Cao Ge Su Hongmei Xu Binhao Liu | 2013 | Applied Surface Science2013，，： | 1 |
| 14 | Modifications in aroma characteristics of'Merlot'dry red wines aged in American,French and Slovakian oak barrels with different toasting degrees显示文摘Aging in oak barrels is widely used in enology which could bring flavor changes and aromatic complexity to wines.In the present study,the aroma compounds were analyzed from the‘Merlot’dry red wines,which were fermented in two types of fermenters(stainless steel tank and rotated oak barrel)and aged in six types of oak barrels(three geographic origins×two toasting degrees)for different time(0,3,6 and 9 months,respectively).Results showed that 30 volatiles were associated with barrels and increased during oak aging.The fermenters could influence the intensities of the toast,leathery,smoky,fruity,floral and caramel aromas.The concentration of whisky lactone,eugenol,cis-isoeugenol,and the intensities of the toast and spicy aromas were highest in the wines aged in American oak and were lowest in the wines aged in French oak barrels.The concentrations of guaiacol,syringol,trans-isoeugenol,furfural alcohol,vanilla,cis-whisky lactone enabled the medium toasting barrels to be distinguished from the light toasting ones.The compounds originating from the barrels could be used to distinguish the types of different barrels,but the other general grape-derived and fermentation-derived volatiles could not.The fermenters,oak species and toasting degrees of the barrels all had significant effects on the aroma profiles of the aged‘Merlot’dry red wines,but the influence of the geographic origin was not obvious. | Haocheng Lu Binhao Cheng Yibin Lan Changqing Duan Fei He | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
| 15 | Facile preparation of Fe-Y catalyst under water-free conditions for selective catalytic reduction of NO_x by ammonia显示文摘A series of Fe-Y zeolite catalysts with different Fe loading were prepared by ferrocene sublimation under solvent and water-free conditions.The dispersion,structure and morphology of the iron species on the Fe-Y catalysts were characterized by XRD,TEM and UV-Vis.The catalytic activities of Fe-Y samples were measured in selective catalytic reduction of NO with ammonia(NH3-SCR).The results showed that the iron species on the HY zeolite support were mainly made up of isolated Fe3+ions,Fex Oy oligomers and a little amount of<3 nm spherical Fe2O3particles.Isolated Fe3+ions are predominating among all the Fe-Y catalysts.The sum of isolated Fe3+ions and Fex Oy oligomers took up more than 90%percent of total iron species on the Fe-Y till 10.0 wt%loading of Fe. | ZHANG ZeKai ZHANG BinHao LIU HuaYan CHEN YinFei | 2013 | Science China Chemistry2013，56，10： | 0 |
| 16 | Expert consensus on organizing the multidisciplinary team(MDT) diagnosis and treatment of hepato-pancreato-biliary diseases in China显示文摘Multidisciplinary team(MDT) discussion has been well established in some European countries and widely carried out in various clinical professional fields(Festen et al.,2021;Fleissig et al.,2006).Many studies have reported the benefits of MDT,including improving survival and quality of cancer care(Munro et al.,2015;Nixon et al.,2021;Tsai et al.,2020). | Binhao Zhang Jian Zhou Weifen Xie Kaishan Tao Shichun Lu Xianglin Yuan Lianxin Liu Weilin Wang Yilei Mao Ping Bie Jingfeng Liu Xinyu Bi Zhiwei Zhang Changhong Liang Jianqiang Cai Zhixiang Jian Yi Lv Peng Zhu Wei Zhang Hongqiang Yang Weiping Zhou Bixiang Zhang Xiaoping Chen | 2022 | Science China(Life Sciences)2022，65，5： | 0 |
| 17 | Guanine nucleotide-binding protein subunit beta-4 promotes gastric cancer progression via activating Erk1/2显示文摘Gastric cancer(GC)is one of the most comm on and lethal malig nancies worldwide,and its poor prognosis is mainly due to the rapid tumor progression including tumor invasion,distant metastasis,etc.Understanding the molecular mechanisms regulating GC progression lays the basis for the development of targeted therapeutic agents.Increasing evidence suggests that guanine nucleotide-binding protein subunit beta-4(GNB4),a key subunit of heterotrimeric G protein,plays a crucial role in the initiation and progression of multiple malignancies.However,whether and how GNB4 promotes GC progression are still unknown.In this study,we found that GNB4 was highly expressed in GC tissues compared to that in non-tumor tissues and was significantly associated with tumor invasion depth,pathological stage and poor survival rate of GC patients.Both gain-of-function and loss-of-function studies revealed that GNB4 significantly enhanced GC cell growth and motility both in vitro and in vivo.Further studies revealed that GNB4 overexpression induced G1-S transition and promoted the process of epithelial-mesenchymal transformation.These tumor promoting effects were mediated by GNB4 which activates the Erk1/2 pathway through upregulating Erk1/2 phosphorylation,as U0126,an Erk1/2 phosphorylation inhibitor,could sigrdficantly inhibit GNB4-mediated cell proliferation,migration and invasion.In summary,GNB4 contributes to the proliferation and metastasis of GC cells by activating the Erk1/2 signaling pathway,and it may serve as a potential therapeutic target of GC. | Jianpeng Gao Hongda Pan Zhenglun Zhu Teng Yu Binhao Huang Ye Zhou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 0 |
| 18 | ASTE1 frameshift mutation triggers the immune response in Epstein-Barr virus-associated gastric cancer显示文摘Dear Editor,Epstein-Barr virus-associated gastric cancer(EBVaGC)is a subtype of GC that is characterized by the presence of EBV in cancer cells.1 EBVaGC is a relatively rare malignancy,accounting for only 10%of GC cases.Compared to other types of GC,EBVaGC presents a distinct tumor microenvironment with ample immune infiltration and increased expression of immune response genes.This unique microenvironment is assumed to have a better response to immunotherapy.However,the efficacy of immunotherapy in EBVaGC is inconsistent.2,3 In some studies,the PR rates were hardly to exceed 30%.Therefore,to improve efficacy and achieve precise treatment under the background of low response rate,it is urgent to identify the specific subgroup of EBVaGC which could benefit from immune therapy. | Binhao Huang Qin Li Qirong Geng Jiawen Lao Jing Guo Shenglin Huang Dazhi Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 19 | High-rate sodium-ion storage of vanadium nitride via surface-redox pseudocapacitance显示文摘Vanadium nitride(VN)electrode displays high-rate,pseudocapacitive responses in aqueous electrolytes,however,it remains largely unclear in nonaqueous,Na+-based electrolytes.The traditional view supposes a conversion-type mechanism for Na+storage in VN anodes but does not explain the phenomena of their size-dependent specific capacities and underlying causes of pseudocapacitive charge storage behaviors.Herein,we insightfully reveal the VN anode exhibits a surface-redox pseudocapacitive mechanism in nonaqueous,Na+-based electrolytes,as demonstrated by kinetics analysis,experimental observations,and first-principles calculations.Through ex situ X-ray photoelectron spectroscopy and semiquantitative analyses,the Na+storage is characterized by redox reactions occurring with the V5+/V4+to V3+at the surface of VN particles,which is different from the well-known conversion reaction mechanism.The pseudocapacitive performance is enhanced through nanoarchitecture design via oxidized vanadium states at the surface.The optimized VN-10 nm anode delivers a sodium-ion storage capability of 106 mAh g−1 at the high specific current of 20 A g−1,and excellent cycling performance of 5000 cycles with negligible capacity losses.This work demonstrates the emerging opportunities of utilizing pseudocapacitive charge storage for realizing high-rate sodium-ion storage applications. | Qiulong Wei Tingyi Huang Xiaojuan Huang Binhao Wang Yalong Jiang Dafu Tang Dong-Liang Peng Bruce Dunn Liqiang Mai | 2023 | Interdisciplinary Materials2023，2，3： | 0 |
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