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| 1 | Fabrication of sharp silicon hollow microneedles by deep-reactive ion etching towards minimally invasive diagnostics显示文摘Microneedle technologies have the potential for expanding the capabilities of wearable health monitoring from physiology to biochemistry.This paper presents the fabrication of silicon hollow microneedles by a deep-reactive ion etching(DRIE)process,with the aim of exploring the feasibility of microneedle-based in-vivo monitoring of biomarkers in skin fluid.Such devices shall have the ability to allow the sensing elements to be integrated either within the needle borehole or on the backside of the device,relying on capillary filling of the borehole with dermal interstitial fluid(ISF)for transporting clinically relevant biomarkers to the sensor sites.The modified DRIE process was utilized for the anisotropic etching of circular holes with diameters as small as 30μm to a depth of>300μm by enhancing ion bombardment to efficiently remove the fluorocarbon passivation polymer.Afterward,isotropic wet and/or dry etching was utilized to sharpen the needle due to faster etching at the pillar top,achieving tip radii as small as 5μm.Such sharp microneedles have been demonstrated to be sufficiently robust to penetrate porcine skin without needing any aids such as an impact-insertion applicator,with the needles remaining mechanically intact after repetitive penetrations.The capillary filling of DRIE-etched through-wafer holes with water has also been demonstrated,showing the feasibility of use to transport the analyte to the target sites. | Yan Li Hang Zhang Ruifeng Yang Yohan Laffitte Ulises Schmill Wenhan Hu Moufeed Kaddoura Eric J.M.Blondeel Bo Cui | 2019 | Microsystems & Nanoengineering2019，5，1： | 4 |
| 2 | Faceted Kurdjumov-Sachs interface-induced slip continuity in the eutectic high-entropy alloy,AlCoCrFeNi_(2.1)显示文摘Recently,the eutectic high-entropy alloy(EHEA),AlCoCrFeNi_(2.1),can reach a good balance of strength and ductility.The dual-phase alloy exhibits a eutectic lamellar microstructure with large numbers of interfaces.However,the role of the interfaces in plastic deformation have not been revealed deeply.In the present work,the orientation relationship(OR)of the interfaces has been clarified as the Kurdjumov-Sachs(KS)interfaces presenting〈111〉_(B2) 〈110〉_(FCC)and {110} _(B2){111}_(FCC) independent of their morphologies.There exist three kinds of interfaces in the EHEA,namely,The dominating interface and the secondary interface are both non-slip planes and atomistic-scale faceted,facilitating the nucleation and slip transmission of the dislocations.The formation mechanism of the preferred interfaces is revealed using the atomistic geometrical analysis according to the criteria of the low interfacial energy based on the coincidence-site lattice(CSL)theory.In particular,the ductility of the dual-phase alloy originates from the KS interface-induced slip continuity across interfaces,which provides a high slip-transfer geometric factor.Moreover,the strengthening effect can be attributed to the interface resistance for the dislocation transmission due to the mismatches of the moduli and lattice parameters at the interfaces. | Ting Xiong Wenfan Yang Shijian Zheng Zhaorui Liu Yiping Lu Ruifeng Zhang Yangtao Zhou Xiaohong Shao Bo Zhang Jun Wang Fuxing Yin Peter K.Liaw Xiuliang Ma | 2021 | Journal of Materials Science & Technology2021，，6： | 2 |
| 3 | Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study显示文摘Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors(FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designing a hybrid between the FGFR-selectivity-enhancing motif dimethoxybenzene group and our previously identified novel scaffold, we discovered a new series of potent FGFR inhibitors, with the best one showing sub-nanomolar enzymatic activity. After several round of optimization and with the solved crystal structure, detailed structure–activity relationship was elaborated. Together with in vitro metabolic stability tests and in vivo pharmacokinetic profiling, a representative compound(35) was selected and tested in xenograft mouse model, and the result demonstrated that inhibitor 35 was effective against tumors with FGFR genetic alterations, exhibiting potential for further development. | Peng Wei Bo Liu Ruifeng Wang Yinglei Gao Lanlan Li Yuchi Ma Zhiwei Qian Yuelei Chen Maosheng Cheng Meiyu Geng Jingkang Shen Dongmei Zhao Jing Ai Bing Xiong | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 4 | Hierarchical Colored Petri Nets Based Components for Workflow Systems显示文摘 | Zhou Feng Bo Ruifeng Huang Hongzhong | 2006 | Journal of Mechanical Science and Technology2006，20，10： | 1 |
| 5 | Fast algorithm of image matching based on projection显示文摘 | Du Zhiguo Bo Ruifeng Han Yan | 2000 | Journal of Test and Measurement Technology of NCIT2000，14，1： | 1 |
| 6 | Structural features of binary microporous zeolite composite Y-Beta and its hydrocracking performance显示文摘 | Xiwen Zhang Qun Guo Bo Qin Zhizhi Zhang Fengxiang Ling Wanfu Sun Ruifeng Li | 2009 | Catalysis Today2009，，1： | 1 |
| 7 | OTFS Modulation and PAPR Reduction for IoT-Railways显示文摘The internet of things(IoT)has been widely considered to be integrated with high-speed railways to improve safety and service.It is important to achieve reliable communication in IoT for railways(IoT-R)under high mobility scenarios and strict energy constraints.Orthogonal time frequency space(OTFS)modulation is a two-dimensional modulation technique that has the potential to overcome the challenges in high Doppler environments.In addition,OTFS can have lower peak-to-average power ratio(PAPR)compared to orthogonal frequency division multiplexing,which is especially important for the application of IoT-R.Therefore,OTFS modulation for IoT-R is investigated in this paper.In order to decrease PAPR of OTFS and promote the application of OTFS modulation in IoT-R,the peak windowing technique is used in this paper.This technique can reduce the PAPR of OTFS by reducing the peak power and does not require multiple iterations.The impacts of different window functions,window sizes and clipping levels on PAPR and bit error rate of OTFS are simulated and discussed.The simulation results show that the peak windowing technique can efficiently reduce the PAPR of OTFS for IoT-R. | Huichao Shang Ruifeng Chen Haoxiang Zhang Guoyu Ma Ruisi He Bo Ai Zhangdui Zhong | 2023 | China Communications2023，20，1： | 1 |
| 8 | An integrated computational intelligence approach to product concept generation and evaluation显示文摘 | HUANG Hongzhong BO Ruifeng CHEN Wei | 2006 | Mechanism and Machine Theory2006，41，5： | 1 |
| 9 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 10 | Acidity Evaluation of Industrially Dealuminated Y Zeolite via Methylcyclohexane Transformation显示文摘The catalytic transformation of methylcyclohexane as an accepted probe reaction to evaluate zeolitic acidity(concentration,strength,and accessibility)is employed to study the acidity and the reactivity of three commercial dealuminated Y zeolites(DAY)with different Si/Al ratios and meso/microporosities,with their properties analyzed by N_(2) adsorption/desorption,pyridine-IR,and hydroxyl-IR spectroscopy technologies.The global activity(conversion)is largely dependent on the concentration of the acid sites,and the activity of the protonic sites in terms of turnover frequency(TOF)reflects the accessibility of acid sites.The products of aromatics and isomers,and the yield of cracking products increase with the increase of concentration of strong protonic sites in zeolite micropores.Moreover,the decrease of aromatics with the reduction of the concentration of acid sites and the diffusion length within DAY zeolites are observed due to the decrease of the secondary reaction.For the same reason,it results in the increasing of C_(7)products and alkenes/alkanes ratios in the cracking products.The high i-C_(4)product selectivity is a unique reflection of the high percentage of very strong acid sites,which is characterized by the hydroxyl-IR band at 3600 cm^(-1). | Hou Kaige Qin Bo Han Junjie Du Yanze Ma Jinghong Li Ruifeng | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，3： | 0 |
| 11 | Radio Communication Scenarios in 5G-Railways显示文摘With the rapid development of railways,especially high-speed railways,there is an increasingly urgent demand for new wireless communication system for railways.Taking the mature 5G technology as an opportunity,5G-railways(5G-R)have been widely regarded as a solution to meet the diversified demands of railway wireless communications.For the design,deployment and improvement of 5GR networks,radio communication scenario classification plays an important role,affecting channel modeling and system performance evaluation.In this paper,a standardized radio communication scenario classification,including 18 scenarios,is proposed for 5GR.This paper analyzes the differences of 5G-R scenarios compared with the traditional cellular networks and GSM-railways,according to 5G-R requirements and the unique physical environment and propagation characteristics.The proposed standardized scenario classification helps deepen the research of 5G-R and promote the development and application of the existing advanced technologies in railways. | Ruisi He Bo Ai Zhangdui Zhong Mi Yang Chen Huang Ruifeng Chen Jianwen Ding Hang Mi Zhangfeng Ma Guiqi Sun Changzhu Liu | 2023 | China Communications2023，20，9： | 0 |
| 12 | Generative Adversarial Networks Based Digital Twin Channel Modeling for Intelligent Communication Networks显示文摘Integration of digital twin(DT)and wireless channel provides new solution of channel modeling and simulation,and can assist to design,optimize and evaluate intelligent wireless communication system and networks.With DT channel modeling,the generated channel data can be closer to realistic channel measurements without requiring a prior channel model,and amount of channel data can be significantly increased.Artificial intelligence(AI)based modeling approach shows outstanding performance to solve such problems.In this work,a channel modeling method based on generative adversarial networks is proposed for DT channel,which can generate identical statistical distribution with measured channel.Model validation is conducted by comparing DT channel characteristics with measurements,and results show that DT channel leads to fairly good agreement with measured channel.Finally,a link-layer simulation is implemented based on DT channel.It is found that the proposed DT channel model can be well used to conduct link-layer simulation and its performance is comparable to using measurement data.The observations and results can facilitate the development of DT channel modeling and provide new thoughts for DT channel applications,as well as improving the performance and reliability of intelligent communication networking. | Yuxin Zhang Ruisi He Bo Ai Mi Yang Ruifeng Chen Chenlong Wang Zhengyu Zhang Zhangdui Zhong | 2023 | China Communications2023，20，8： | 0 |
| 13 | Neural Network Based Multi-level Fuzzy Evaluation Model for Mechanical Kinematic Scheme显示文摘To implement a quantificational evaluation for mechanical kinematic scheme more effectively,a multi-level and multi-objective evaluation model is presented using neural network and fuzzy theory. Firstly,the structure of evaluation model is constructed according to evaluation indicator system. Then evaluation samples are generated and provided to train this model. Thus it can reflect the relation between attributive value and evaluation result,as well as the weight of evaluation indicator. Once evaluation indicators of each candidate are fuzzily quantified and fed into the trained network model,the corresponding evaluation result is outputted and the best alternative can be selected. Under this model,expert knowledge can be effectively acquired and expressed,and the quantificational evaluation can be implemented for kinematic scheme with multi-level evaluation indicator system. Several key problems on this model are discussed and an illustration has demonstrated that this model is feasible and can be regarded as a new idea for solving kinematic scheme evaluation. | BO Ruifeng,LI Ruiqin (Department of Mechanical Engineering,North University of China,Taiyuan 030051,China) | 2006 | 武汉理工大学学报2006，28，S1： | 0 |
| 14 | Thalassinoides Ichnofabrics of Lower Cambrian Longwangmiao Formation(Stage 4,Toyonian)on the Yangtze Platform,South China:Improving Paleoenvironmental Interpretations显示文摘An analysis of Thalassinoides ichnofabrics in the Cambrian Stage 4 Longwangmiao Formation from six sections near Chonqing in the Middle and Upper Yangtze Block of South China was conducted to promote the understanding of the paleoenvironment of this period.Thalassinoides ichnofabrics are divided into three types according to their morphology,bioturbation index,abundance and related parameters:banded,mottled and grid.The completeness of the ichnofabrics gradually increases from banded to grid,the scale of the burrows expands,and the structure transitions from twodimensional to three-dimensional.Malacostracans,phyllocarids and enteropneusts are the most likely burrowers.The findings reveal that frequent changes in paleoenvironmental conditions are the dominant factors for generating the various Thalassinoides ichnofabrics.The changes in depositional rate,substrate properties and nutrient levels affect the behavior and building patterns of the burrowers,thus leading to the diversity of Thalassinoides ichnofabrics.In the lower Longwangmiao Formation beds,many incomplete Thalassinoides burrow systems were built in the substrates with terrigenous detrital minerals,revealing significant environmental pressure on the burrowers.Later,the Thalassinoides burrows went into complete three-dimensional boxworks.At the end of the stage,bioturbation almost disappeared,which indicates that burrowers were finding it difficult to survive in the harsh environment. | TANG Ruifeng ZHANG Jizhi DU Yao WEN Siying ZHONG Bo JIANG Huachuan | 2023 | Acta Geologica Sinica(English Edition)2023，97，1： | 0 |
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