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| 1 | Development of Land Surface Model BCC_AVIM2.0 and Its Preliminary Performance in LS3MIP/CMIP6显示文摘The improvements and validation of several parameterization schemes in the second version of the Beijing Climate Center Atmosphere–Vegetation Interaction Model(BCC_AVIM2.0) are introduced in this study. The main updates include a replacement of the water-only lake module by the common land model lake module(Co LM-lake) with a more realistic snow–ice–water–soil framework, a parameterization scheme for rice paddies added in the vegetation module, renewed parameterizations of snow cover fraction and snow surface albedo to accommodate the varied snow aging effect during different stages of a snow season, a revised parameterization to calculate the threshold temperature to initiate freeze(thaw) of soil water(ice) rather than being fixed at 0°C in BCC_AVIM1.0, a prognostic phenology scheme for vegetation growth instead of empirically prescribed dates for leaf onset/fall, and a renewed scheme to depict solar radiation transfer through the vegetation canopy. The above updates have been implemented in BCC_AVIM2.0 to serve as the land component of the BCC Climate System Model(BCC_CSM). Preliminary results of BCC_AVIM in the ongoing Land Surface, Snow, and Soil Moisture Model Intercomparison Project(LS3 MIP) of the Coupled Model Intercomparison Project Phase 6(CMIP6) show that the overall performance of BCC_AVIM2.0 is better than that of BCC_AVIM1.0 in the simulation of surface energy budgets at the seasonal timescale. Comparing the simulations of annual global land average before and after the updates in BCC_AVIM2.0 reveals that the bias of net surface radiation is reduced from-12.0 to-11.7 W m-2 and the root mean square error(RMSE) is reduced from 20.6 to 19.0 W m-2;the bias and RMSE of latent heat flux are reduced from 2.3 to-0.1 W m-2 and from 15.4 to14.3 W m-2, respectively;the bias of sensible heat flux is increased from 2.5 to 5.1 W m-2 but the RMSE is reduced from 18.4 to 17.0 W m-2. | Weiping LI Yanwu ZHANG Xueli SHI Wenyan ZHOU Anning HUANG Mingquan MU Bo QIU Jinjun JI | 2019 | Journal of Meteorological Research2019，33，5： | 14 |
| 2 | On extended state based Kalman filter design for a class of nonlinear time-varying uncertain systems显示文摘This paper considers the filtering problem for a class of multi-input multi-output systems with nonlinear time-varying uncertain dynamics, random process and measurement noise. An extended state based Kalman filter, with the idea of timely estimating the unknown dynamics, is proposed for better robustness and higher estimation precision. The stability of the proposed filter is rigorously proved for nonlinear timevarying uncertain system with weaker stability condition than the extended Kalman filter, i.e., the initial estimation error, the uncertain dynamics and the noises are only required to be bounded rather than small enough. Moreover, quantitative precision of the proposed filter is theoretically evaluated. The proposed algorithm is proved to be the asymptotic unbiased minimum variance filter for constant uncertainty. The simulation results of some benchmark examples demonstrate the feasibility and effectiveness of the method. | Wenyan BAI Wenchao XUE Yi HUANG Haitao FANG | 2018 | Science China(Information Sciences)2018，61，4： | 7 |
| 3 | Precipitation Responses to Radiative Effects of Ice Clouds:A Cloud-Resolving Modeling Study of a Pre-Summer Torrential Precipitation Event显示文摘The precipitation responses to the radiative effects of ice clouds are investigated through analysis of five-day and horizontally averaged data from 2D cumulus ensemble model experiments of a pre-summer torrential precipitation event.The exclusion of the radiative effects of ice clouds lowered the precipitation rate through a substantial reduction in the decrease of hydrometeors when the radiative effects of water clouds were switched on,whereas it increased the precipitation rate through hydrometeor change from an increase to a decrease when the radiative effects of ice clouds were turned off.The weakened hydrometeor decrease was associated with the enhanced longwave radiative cooling mainly through the decreases in the melting of non-precipitating ice to non-precipitating water.The hydrometeor change from an increase to a decrease corresponded to the strengthened longwave radiative cooling in the upper troposphere through the weakened collection of non-precipitating water by precipitation water. | Xinyong SHEN Wenyan HUANG Chunyan GUO Xiaocen JIANG | 2016 | Advances in Atmospheric Sciences2016，33，10： | 3 |
| 4 | Algae-lysing Effect of Algicidal Bacteria on Microcystis in Bloom Water显示文摘The Microcystis sample was selected from natural bloom water,then the algicidal effects of the bacterial strain fluid of the two algicidal bacteria,supernatant and bacterial liquid were studied. Moreover,the changes of microalgae colony and morphology in the process of algae-lysing were observed using neutral red staining and scanning electron microscope. It showed that AA06 bacteria had certain algicidal effect while AA10 bacteria had no effect. All the supernatants of the two bacterial strains had obvious algicidal effects,and the algicidal effects between the bacterial liquid and supernatant had no significant differences( P < 0. 05). The effects of algae-lysing mainly owed to the chemical substances secreted by algicidal bacteria. During the algae-lysing process,the algae colony did not disperse into individual cells. The segments of the dead cells still aggregated together. | Fan Qianlong Zhang Hengfeng Huang Juan Zhao Liang Xu Jun Jia Zijing Liang Wenyan | 2016 | Meteorological and Environmental Research2016，7，6： | 3 |
| 5 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 6 | Analysis of SVEIR worm attack model with saturated incidence and partial immunization显示文摘Internet worms can propagate across networks at terrifying speeds,reduce network security to a remarkable extent,and cause heavy economic losses.Thus,the rapid elimination of Internet worms using partial immunization becomes a significant matter for sustaining Internet infrastructure.This paper addresses this issue by presenting a novel worm susceptible-vaccinated-exposed-infectious-recovered model,named the SVEIR model.The SVEIR model extends the classical susceptible-exposed-infectious-recovered model(refer to SEIR model)through incorporating a saturated incidence rate and a partial immunization rate.The basic reproduction number in the SVEIR model is obtained.By virtue of the basic reproduction number,we prove the global stabilities of an infection-free equilibrium point and a unique endemic equilibrium point.Numerical methods are used to verify the proposed SVEIR model.Simulation results show that partial immunization is highly effective for eliminating worms,and the SVEIR model is viable for controlling and forecasting Internet worms. | WANG Fangwei HUANG Wenyan SHEN Yulong WANG Changguang | 2016 | Journal of Communications and Information Networks2016，1，4： | 2 |
| 7 | Microstructure and interfacial evaluation of Co-based alloy coating on copper by pulsed Nd:YAG multilayer laser cladding显示文摘 | Hua Yan Aihua Wang Kaidong Xu Wenyan Wang Zaowen Huang | 2010 | Journal of Alloys and Compounds2010，，2： | 1 |
| 8 | Green‑Solvent Processed Blade‑Coating Organic Solar Cells with an Efficiency Approaching 19%Enabled by Alkyl‑Tailored Acceptors显示文摘Power-conversion-efficiencies(PCEs)of organic solar cells(OSCs)in laboratory,normally processed by spin-coating technology with toxic halogenated solvents,have reached over 19%.However,there is usually a marked PCE drop when the bladecoating and/or green-solvents toward large-scale printing are used instead,which hampers the practical development of OSCs.Here,a new series of N-alkyl-tailored small molecule acceptors named YR-SeNF with a same molecular main backbone are developed by combining selenium-fused central-core and naphthalene-fused endgroup.Thanks to the N-alkyl engineering,NIR-absorbing YR-SeNF series show different crystallinity,packing patterns,and miscibility with polymeric donor.The studies exhibit that the molecular packing,crystallinity,and vertical distribution of active layer morphologies are well optimized by introducing newly designed guest acceptor associated with tailored N-alkyl chains,providing the improved charge transfer dynamics and stability for the PM6:L8-BO:YRSeNF-based OSCs.As a result,a record-high PCE approaching 19%is achieved in the blade-coating OSCs fabricated from a greensolvent o-xylene with high-boiling point.Notably,ternary OSCs offer robust operating stability under maximum-power-point tracking and well-keep>80%of the initial PCEs for even over 400 h.Our alkyl-tailored guest acceptor strategy provides a unique approach to develop green-solvent and blade-coating processed high-efficiency and operating stable OSCs,which paves a way for industrial development. | Hairui Bai Ruijie Ma Wenyan Su Top Archie Dela Pea Tengfei Li Lingxiao Tang Jie Yang Bin Hu Yilin Wang Zhaozhao Bi Yueling Su Qi Wei Qiang Wu Yuwei Duan Yuxiang Li Jiaying Wu Zicheng Ding Xunfan Liao Yinjuan Huang Chao Gao Guanghao Lu Mingjie Li Weiguo Zhu Gang Li Qunping Fan Wei Ma | 2023 | Nano-Micro Letters2023，15，12： | 1 |
| 9 | Development of an up-converting phosphor technology-based 10-channel lateral flow assay for profiling antibodies against Yersinia pestis显示文摘 | HONG Wenyan HUANG Lihua WANG Haoran | 2010 | J Microbiol Methods2010，83，2： | 1 |
| 10 | Development of an up-converting phosphor technology-based 10-channel lateral flow assay for profiling antibodies against Yersinia pestis显示文摘 | Wenyan Hong Lihua Huang Haoran Wang Jianfeng Qu Zhaobiao Guo Chengke Xie Ziwen Zhu Youbao Zhang Zongmin Du Yanfeng Yan Yan Zheng Huijie Huang Ruifu Yang Lei Zhou | 2010 | Journal of Microbiological Methods2010，，2： | 1 |
| 11 | TOA estimation in IR UWB ranging with energy detection receiver using received signal characteristics 显示文摘 | Liu Wenyan Ding Hong Huang Xiaotao | 2012 | IEEE Communications Letters2012，16，5： | 1 |
| 12 | Using inorganic coagulants to control membrane fouling in a submerged membrane bioreactor显示文摘 | Jinling Wu Futai Chen Xia Huang Wenyan Geng Xianghua Wen | 2006 | Desalination2006，，1： | 1 |
| 13 | The national multi-center artificial intelligent myopia prevention and control project显示文摘In recent years,the incidence of myopia has increased at an alarming rate among children and adolescents in China.The exploration of an effective prevention and control method for myopia is in urgent need.With the development of information technology in the past decade,artificial intelligence with the Internet of Things technology(AIoT)is characterized by strong computing power,advanced algorithm,continuous monitoring,and accurate prediction of long-term progression.Therefore,big data and artificial intelligence technology have the potential to be applied to data mining of myopia etiology and prediction of myopia occurrence and development.More recently,there has been a growing recognition that myopia study involving AIoT needs to undergo a rigorous evaluation to demonstrate robust results. | Xun Wang Yahan Yang Yuxuan Wu Wenbin Wei Li Dong Yang Li Xingping Tan Hankun Cao Hong Zhang Xiaodan Ma Qin Jiang Yunfan Zhou Weihua Yang Chaoyu Li Yu Gu Lin Ding Yanli Qin Qi Chen Lili Li Mingyue Lian Jin Ma Dongmei Cui Yuanzhou Huang Wenyan Liu Xiao Yang Shuiming Yu Jingjing Chen Dongni Wang Zhenzhe Lin Pisong Yan Haotian Lin Chinese Association of Artificial Intelligence,Medical Artificial Intelligence Branch of Guangdong Medical Association | 2021 | Intelligent Medicine2021，1，2： | 1 |
| 14 | Robust optimization design on impeller of mixed-flow pump显示文摘To increase the robustness of the optimization solutions of the mixed-flow pump,the impeller was firstly indirectly parameterized based on the 2D blade design theory.Secondly,the robustness of the optimization solution was mathematically defined,and then calculated by Monte Carlo sampling method.Thirdly,the optimization on the mixed-flow pump′s impeller was decomposed into the optimal and robust sub-optimization problems,to maximize the pump head and efficiency and minimize the fluctuation degree of them under varying working conditions at the same time.Fourthly,using response surface model,a surrogate model was established between the optimization objectives and control variables of the shape of the impeller.Finally,based on a multi-objective genetic optimization algorithm,a two-loop iterative optimization process was designed to find the optimal solution with good robustness.Comparing the original and optimized pump,it is found that the internal flow field of the optimized pump has been improved under various operating conditions,the hydraulic performance has been improved consequently,and the range of high efficient zone has also been widened.Besides,with the changing of working conditions,the change trend of the hydraulic performance of the optimized pump becomes gentler,the flow field distribution is more uniform,and the influence degree of the varia-tion of working conditions decreases,and the operating stability of the pump is improved.It is concluded that the robust optimization method proposed in this paper is a reasonable way to optimize the mixed-flow pump,and provides references for optimization problems of other fluid machinery. | ZHAO Binjuan LIAO Wenyan XIE Yuntong HAN Luyao FU Yanxia HUANG Zhongfu | 2021 | 排灌机械工程学报2021，39，7： | 0 |
| 15 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 16 | Durability of Hepatitis B surface antigen seroclearance in patients experienced nucleoside analogs or interferon monotherapy: A real-world data from Electronic Health Record显示文摘Little is known about the difference in durability of HBsAg seroclearance induced by nucleoside analogs (NAs) or by interferon (IFN). A real-world, retrospective cohort study was conducted. Patients were assigned into two groups: NAs monotherapy-induced HBsAg seroclearance subjects and IFN monotherapy induced-HBsAg seroclearance subjects. A total of 198 subjects, comprised by 168 NAs monotherapy-induced and 30 IFN monotherapy-induced, who achieved HBsAg seroclearance were included in this study. The one-year probabilities of confirmed HBsAg seroclearance were significantly different in patients with NAs monotherapy and IFN monotherapy (0.960 (with 95% CI 0.922–0.999) vs. 0.691 (with 95% CI 0.523–0.913), log-rank-P = 4.04e-4). 73.3% (11 of 15) HBsAg recurrence occurred within one year after HBsAg seroclearance. The one-year probabilities of confirmed HBsAg seroclearance were higher in IFN monotherapy patients with anti-HBs than in IFN monotherapy patients without anti-HBs (0.839 (with 95% CI 0.657–1.000) vs. 0.489 (with 95% CI 0.251–0.953), log-rank test, P = 0.024). Our study thus provided novel insights into the durability of HBsAg seroclearance induced by NAs or IFN monotherapy. In particular, the HBsAg seroreversion rate was relatively high in IFN monotherapy subjects. The presence of anti-HBs was significantly correlated with a longer durability of functional cure induced by IFN treatment. And one-year follow-up in HBsAg seroclearance achieved individuals is proper for averting HBsAg seroreversion and other liver disease. | Zongqi Shi Huizhi Zheng Miaomiao Han Jieli Hu Yuan Hu Xiaosong Li Wenyan Zhu Xinjun He Haijun Deng Quanxin Long Ailong Huang | 2023 | Genes & Diseases2023，10，3： | 0 |
| 17 | Prediction of Online Consumers’Repeat Purchase Behavior via BERT-MLP Model显示文摘It is an effective means for merchants to carry out precision marketing and improve ROI by using historical user behavior data obtained from promotional activities in order to build a model to predict the repeat purchase behavior of users after promotional activities.Most of the existing prediction models are supervised learning,which does not work well with a small amount of labeled data.This paper proposes a BERT-MLP prediction model that uses“large-scale data unsupervised pre-training+small amount of labeled data fine-tuning.”The experimental results on Alibaba real dataset show that the accuracy of the BERT-MLP model is better than the baseline model. | Junchao Dong Tinghui Huang Liang Min Wenyan Wang | 2022 | Journal of Electronic Research and Application2022，6，3： | 0 |
| 18 | Integrating Multiple Linear Regression and Infectious Disease Models for Predicting Information Dissemination in Social Networks显示文摘Social network is the mainstream medium of current information dissemination,and it is particularly important to accurately predict its propagation law.In this paper,we introduce a social network propagation model integrating multiple linear regression and infectious disease model.Firstly,we proposed the features that affect social network communication from three dimensions.Then,we predicted the node influence via multiple linear regression.Lastly,we used the node influence as the state transition of the infectious disease model to predict the trend of information dissemination in social networks.The experimental results on a real social network dataset showed that the prediction results of the model are consistent with the actual information dissemination trends. | Junchao Dong Tinghui Huang Liang Min Wenyan Wang | 2023 | Journal of Electronic Research and Application2023，7，2： | 0 |
| 19 | Overexpression of auxin/indole-3-acetic acid gene MdIAA24 enhances Glomerella leaf spot resistance in apple(Malus domestica)显示文摘Auxin is throughout the entire life process of plants and is involved in the crosstalk with other hormones,yet its role in apple disease resistance remains unclear.In this study,we investigated the function of auxin/indole-3-acetic acid(IAA)gene Md IAA24 overexpression in enhancing apple resistance to Glomerella leaf spot(GLS)caused by Colletotrichum fructicola(Cf).Analysis revealed that,upon Cf infection,35S::Md IAA24 plants exhibited enhanced superoxide dismutase(SOD)and peroxidase(POD)activity,as well as a greater amount of glutathione(reduced form)and ascorbic acid accumulation,resulting in less H_(2)O_(2)and superoxide anion(O_(2)^(-))in apple leaves.Furthermore,35S::Md IAA24 plants produced more protocatechuic acid,proanthocyanidins B1,proanthocyanidins B2 and chlorogenic acid when infected with Cf.Following Cf infection,35S::Md IAA24 plants presented lower levels of IAA and jasmonic acid(JA),but higher levels of salicylic acid(SA),along with the expression of related genes.The overexpression of Md IAA24 was observed to enhance the activity of chitinase andβ-1,3-glucanase in Cfinfected leaves.The results indicated the ability of Md IAA24 to regulate the crosstalk between IAA,JA and SA,and to improve reactive oxygen species(ROS)scavenging and defense-related enzymes activity.This jointly contributed to GLS resistance in apple. | Qian Wang Dong Huang Wenyan Tu Fengwang Ma Changhai Liu | 2024 | Horticultural Plant Journal2024，10，1： | 0 |
| 20 | Role of the periotic mesenchyme in the development of sensory cells in early mouse cochlea显示文摘Objective:To investigate the role of the periotic mesenchyme(POM)in the development of sensory cells of developing auditory epithelium.Methods:Developing auditory epithelium with or without periotic mesenchyme was isolated from mice at embryonic days 11.5(E11.5),E12.5 and E13.5,respectively,and cultured in vitro to an equivalent of E18.5’s epithelium in vivo.Then,the explants were co-stained with antibodies targeting myosin VIIA,Sox2 and BrdU.Results:More hair cells in E11.5 t 7 DIV,E12.5 t 6 DIV and E13.5 t 5 DIV auditory epithelia were found upon culture with POM(225.90±62.44,476.94±100.81,and 1386.60±202.38,respectively)compared with the non-POM group(68.17±23.74,205.00±44.23,and 1266.80±38.84,respectively).Moreover,regardless of developmental stage,the mesenchymal tissue increased the amount of cochlear sensory cells as well as the ratio of differentiated hair cells to total sensory cells.Conclusions:The periotic mesenchyme promotes the development of cochlear sensory cells,and its effect depends on the developmental stage of the auditory epithelium. | Jingjiang Huang Na Zuo Cheng Wu Peipei Chen Jun Ma Chuanxi Wang Wenyan Li Shaofeng Liu | 2020 | Journal of Otology2020，15，4： | 0 |
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